$VAR1 = undef;
Summary for peptidase M09.002: collagenase G/A (Clostridium histolyticum)
| Names | |
|---|---|
| MEROPS Name | collagenase G/A (Clostridium histolyticum) |
| Other names | bacterial collagenase, class I, clostridiopeptidase A, Clostridium histolyticum collagenase, colA g.p. (Clostridium perfringens), collagenase A, collagenase Clostridium histolyticum, collagenase I, colG g.p. (Clostridium histolyticum), microbial collagenase, class I, Xiaflex |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(E) >> Family M9 >> Subfamily B >> M09.002 |
| Holotype | collagenase G/A (Clostridium histolyticum) (Hathewaya histolytica), Uniprot accession Q9X721 (peptidase unit: 319-798), MERNUM MER0005663 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00153 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.3 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (2 cleavages) | ||
| Biotechnology | Many uses, including tissue cell dispersion. | ||
| Physiology | Required for bacterial nutrition; may act in tissue invasion by this pathogen. | ||
| Pharmaceutical relevance | Agent under investigation for treatment of bed sores, and for chemonucleolysis of herniated intervertebral disks. | ||
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | -/G/pa/- Ga/p/-/g (based on 167 cleavages) | ||
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