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Literature for peptidase M09.002: collagenase G/A (Clostridium histolyticum)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, I Inhibitor, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Cevik,J., Rajaram,R., Pollock,M., Seth,I. and Rozen,M.
    Collagenase clostridium histolyticum for Dupuytren's disease: a comprehensive systematic review and comparative analysis against percutaneous needle aponeurotomy and limited fasciectomy
    J Plast Surg Hand Surg (2025) 60, 27-34. PubMed  Europe PubMed DOI
  2. Zhu,S., Mi,J., Sun,J., Yao,J. and Huang,H.
    Discovery and characterization a new collagenase from Hathewaya massiliensis for effective subcutaneous adipolysis
    Bioorg Med Chem Lett (2025) 128, 130324-130324. PubMed  Europe PubMed DOI
    3. 2024
  3. Barrett,J.M. and Callaghan,J.P.
    Strain inhibition of bacterial collagenase is consistent with a collagen fibril uncrimping mechanism in rat tail tendons
    J Biomech (2024) 162, 111892-111892. PubMed  Europe PubMed DOI
  4. Deng,Y., Herrmann,J., Wang,Y., Nguyen,M., Hall,J.K., Kim,J.H., Smith,M.L., Lutchen,K.R., Bartolak-Suki,E. and Suki,B.
    Physiological mechanical forces accelerate the degradation of bovine lung collagen fibers by bacterial collagenase
    Sci Rep (2024) 14, 29008-29008. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Serwanja,J., Wieland,A.C., Haubenhofer,A., Brandstetter,H. and Schonauer,E.
    A conserved strategy to attack collagen: The activator domain in bacterial collagenases unwinds triple-helical collagen
    Proc Natl Acad Sci U S A (2024) 121, e2321002121-e2321002121. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Ansbacher,T., Tohar,R., Cohen,A., Cohen,O., Levartovsky,S., Arieli,A., Matalon,S., Bar,D.Z., Gal,M. and Weinberg,E.
    A novel computationally engineered collagenase reduces the force required for tooth extraction in an ex-situ porcine jaw model
    J Biol Eng (2023) 17, 47-47. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Alhayek,A., Abdelsamie,A.S., Schonauer,E., Camberlein,V., Hutterer,E., Posselt,G., Serwanja,J., Blochl,C., Huber,C.G., Haupenthal,J., Brandstetter,H., Wessler,S. and Hirsch,A.K.H.
    Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases
    J Med Chem (2022) 65, 12933-12955. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Alhayek,A., Khan,E.S., Schonauer,E., Dainghaus,T., Shafiei,R., Voos,K., Han,M.K.L., Ducho,C., Posselt,G., Wessler,S., Brandstetter,H., Haupenthal,J., Del Campo,A. and Hirsch,A.K.H.
    Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections
    Adv Ther (Weinh) (2022) 5, 2100222-2100222. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2021
  9. Leontovyc,I., Koblas,T., Berkova,Z., Bittenglova,K., Leontovyc,A., Benesik,M. and Saudek,F.
    A Preliminary Characterization of a Novel Recombinant Clostridial Collagenase Blend
    Folia Biol (Praha) (2021) 67, 82-89. PubMed  Europe PubMed
  10. Ziegelmann,M.J. and Yafi,F.A.
    Collagenase clostridium histolyticum is no longer available in Europe: what does this mean for our patients with Peyronie's Disease?
    Int J Impot Res (2021) 33, 376-377. PubMed  Europe PubMed DOI
    11. 2020
  11. Cocci,A., Russo,G.I., Salamanca,J.I.M., Ralph,D., Palmieri,A. and Mondaini,N.
    The end of an era: withdrawal of Xiapex (Clostridium histolyticum collagenase) from the European market
    Eur Urol (2020) 77, 660-661. PubMed  Europe PubMed DOI
  12. Passiatore,M., De Vitis,R. and Taccardo,G.
    Xiapex will no longer be distributed in Europe: our concerns and our hopes relative to collagenase
    Hand Surg Rehabil (2020) PubMed  Europe PubMed DOI
  13. Wei,D.H., Cantlon,M.B., Wakefield,D.B. and Vitale,M.A.
    Risk Factors for Skin Tears Following Collagenase Clostridium histolyticum to Treat Dupuytren Contractures
    J Hand Surg Am (2020) 45, 989.e1-989.e10. PubMed  Europe PubMed DOI
    14. 2019
  14. O'Flanagan,C.H., Campbell,K.R., Zhang,A.W., Kabeer,F., Lim,J.L.P., Biele,J., Eirew,P., Lai,D., McPherson,A., Kong,E., Bates,C., Borkowski,K., Wiens,M., Hewitson,B., Hopkins,J., Pham,J., Ceglia,N., Moore,R., Mungall,A.J., McAlpine,J.N., Shah,S.P. and Aparicio,S.
    Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses
    Genome Biol (2019) 20, 210-210. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2018
  15. Caviness,P., Bauer,R., Tanaka,K., Janowska,K., Roeser,J.R., Harter,D., Sanders,J., Ruth,C., Matsushita,O. and Sakon,J.
    Ca(2+)-Induced orientation of tandem collagen binding domains from clostridial collagenase ColG permits two opposing functions of collagen fibril formation and retardation
    FEBS J (2018) 285, 3254-3269. PubMed  Europe PubMed DOI
  16. Ganeshpurkar,A., Kumar,D. and Singh,S.K.
    Design, synthesis and collagenase inhibitory activity of some novel phenylglycine derivatives as metalloproteinase inhibitors
    Int J Biol Macromol (2018) 107, 1491-1500. PubMed  Europe PubMed DOI  I
  17. Waycaster,C., Carter,M.J., Gilligan,A.M., Mearns,E.S., Fife,C.E. and Milne,C.T.
    Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers
    J Comp Eff Res (2018) 7, 149-165. PubMed  Europe PubMed DOI
    18. 2016
  18. Duarte,A.S., Correia,A. and Esteves,A.C.
    Bacterial collagenases - a review
    Crit Rev Microbiol (2016) 42, 106-126. PubMed  Europe PubMed DOI  U
  19. Rafael,S.C., Diego,G.H. and Javier,C.H.F.
    Mechanism of action of collagenase clostridium histolyticum for clinical application
    European j clin pharm (2016) 18, 263-272.  V
  20. Shima,H., Inagaki,A., Imura,T., Yamagata,Y., Watanabe,K., Igarashi,K., Goto,M. and Murayama,K.
    Collagen V is a potential substrate for clostridial collagenase G in pancreatic islet isolation
    J Diabetes Res (2016) 2016, 4396756-4396756. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Verstreken,F., Degreef,I., Decramer,A., Libberecht,K., Vanhove,W., Datco,A., Vanhaecke,J., Clermont,D. and Duerinckx,J.
    Effectiveness and safety of collagenase Clostridium histolyticum in Dupuytren's disease: an observational study in Belgium
    Acta Orthop Belg (2016) 82, 405-411.  U
  22. Watanabe-Nakayama,T., Itami,M., Kodera,N., Ando,T. and Konno,H.
    High-speed atomic force microscopy reveals strongly polarized movement of clostridial collagenase along collagen fibrils
    Sci Rep (2016) 6, 28975-28975. PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2015
  23. McCallon,S.K. and Frilot,C.
    A retrospective study of the effects of clostridial collagenase ointment and negative pressure wound therapy for the treatment of chronic pressure ulcers
    Wounds (2015) 27, 44-53. PubMed  Europe PubMed  U
  24. Motley,T.A., Gilligan,A.M., Lange,D.L., Waycaster,C.R. and Dickerson,J.E., Jr.
    Cost-effectiveness of clostridial collagenase ointment on wound closure in patients with diabetic foot ulcers: economic analysis of results from a multicenter, randomized, open-label trial
    J Foot Ankle Res (2015) 8, 7-7. PubMed  Europe PubMed DOI  PMC  EPMC  U
  25. Peimer,C.A., Wilbrand,S., Gerber,R.A., Chapman,D. and Szczypa,P.P.
    Safety and tolerability of collagenase Clostridium histolyticum and fasciectomy for Dupuytren's contracture
    J Hand Surg Eur Vol (2015) 40, 141-149. PubMed  Europe PubMed DOI  U
  26. Velmurugan,P., Jonnalagadda,R.R. and Unni Nair,B.
    Engineering D-amino acid containing collagen like peptide at the cleavage site of Clostridium histolyticum collagenase for its inhibition
    PLoS ONE (2015) 10, e0124398- PubMed  Europe PubMed DOI
  27. Verheyden,J.R.
    Early outcomes of a sequential series of 144 patients with Dupuytren's contracture treated by collagenase injection using an increased dose, multi-cord technique
    J Hand Surg Eur Vol (2015) 40, 133-140. PubMed  Europe PubMed DOI  U
  28. Warwick,D., Arner,M., Pajardi,G., Reichert,B., Szabo,Z., Masmejean,E.H., Fores,J., Chapman,D.S., Gerber,R.A., Huard,F., Seghouani,A. and Szczypa,P.P.
    Collagenase Clostridium histolyticum in patients with Dupuytren's contracture: results from POINT X, an open-label study of clinical and patient-reported outcomes
    J Hand Surg Eur Vol (2015) 40, 124-132. PubMed  Europe PubMed DOI  U
  29. Yang,K.K. and Bennett,N.
    The history of collagenase Clostridium histolyticum
    Sex Med Rev (2015) 3, 289-297. PubMed  Europe PubMed DOI  U
  30. Zhang,D., Zhang,Y., Wang,Z., Zhang,X. and Sheng,M.
    Target radiofrequency combined with collagenase chemonucleolysis in the treatment of lumbar intervertebral disc herniation
    Int J Clin Exp Med (2015) 8, 526-532. PubMed  Europe PubMed  PMC  EPMC  U
  31. Zhang,Y.Z., Ran,L.Y., Li,C.Y. and Chen,X.L.
    Diversity, structures, and collagen-degrading mechanisms of bacterial collagenolytic proteases
    Appl Environ Microbiol (2015) 81, 6098-6107. PubMed  Europe PubMed DOI  V
    32. 2014
  32. Alberton,F., Corain,M., Garofano,A., Pangallo,L., Valore,A., Zanella,V. and Adani,R.
    Efficacy and safety of collagenase Clostridium histolyticum injection for Dupuytren contracture: report of 40 cases
    Musculoskelet Surg (2014) 98, 225-232. PubMed  Europe PubMed DOI  U
  33. Eckhard,U., Huesgen,P.F., Brandstetter,H. and Overall,C.M.
    Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen
    J Proteomics (2014) 100, 102-114. PubMed  Europe PubMed DOI  P
  34. Tokmina-Roszyk,M., Tokmina-Roszyk,D., Bhowmick,M. and Fields,G.B.
    Development of a Forster resonance energy transfer assay for monitoring bacterial collagenase triple-helical peptidase activity
    Anal Biochem (2014) 453, 61-69. PubMed  Europe PubMed DOI  A
    35. 2013
  35. Eckhard,U., Schonauer,E. and Brandstetter,H.
    Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T
    J Biol Chem (2013) 288, 20184-20194. PubMed  Europe PubMed DOI  PMC  EPMC  S
  36. Gelbard,M., Goldstein,I., Hellstrom,W.J., McMahon,C.G., Smith,T., Tursi,J., Jones,N., Kaufman,G.J. and Carson,C.C., III
    Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies
    J Urol (2013) 190, 199-207. PubMed  Europe PubMed DOI  U
  37. Oshima,N., Narukawa,Y., Takeda,T. and Kiuchi,F.
    Collagenase inhibitors from Viola yedoensis
    J Nat Med (2013) 67, 240-245. PubMed  Europe PubMed DOI  I
  38. Peimer,C.A., Skodny,P. and Mackowiak,J.I.
    Collagenase clostridium histolyticum for Dupuytren contracture: Patterns of use and effectiveness in clinical practice
    J Hand Surg Am (2013) 38, 2370-2376. PubMed  Europe PubMed DOI  U
  39. Witthaut,J., Jones,G., Skrepnik,N., Kushner,H., Houston,A. and Lindau,T.R.
    Efficacy and safety of collagenase clostridium histolyticum injection for Dupuytren contracture: short-term results from 2 open-label studies
    J Hand Surg Am (2013) 38, 2-11. PubMed  Europe PubMed DOI  U
    40. 2012
  40. Adhikari,A.S., Glassey,E. and Dunn,A.R.
    Conformational dynamics accompanying the proteolytic degradation of trimeric collagen I by collagenases
    J Am Chem Soc (2012) 134, 13259-13265. PubMed  Europe PubMed DOI
  41. Balamurugan,A.N., Loganathan,G., Bellin,M.D., Wilhelm,J.J., Harmon,J., Anazawa,T., Soltani,S.M., Radosevich,D.M., Yuasa,T., Tiwari,M., Papas,K.K., McCarthy,R., Sutherland,D.E. and Hering,B.J.
    A new enzyme mixture to increase the yield and transplant rate of autologous and allogeneic human islet products
    Transplantation (2012) 93, 693-702. PubMed  Europe PubMed DOI
  42. Rozen,W.M., Edirisinghe,Y. and Crock,J.
    Late complications of clinical Clostridium histolyticum collagenase use in Dupuytren's disease
    PLoS ONE (2012) 7, e43406-e43406. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Sides,C.R., Liyanage,R., Lay,J.O., Jr., Philominathan,S.T., Matsushita,O. and Sakon,J.
    Probing the 3-D structure, dynamics, and stability of bacterial collagenase collagen binding domain (apo- versus holo-) by limited proteolysis MALDI-TOF MS
    J Am Soc Mass Spectrom (2012) 23, 505-519. PubMed  Europe PubMed DOI
  44. Syed,F., Thomas,A.N., Singh,S., Kolluru,V., Emeigh Hart,S.G. and Bayat,A.
    In vitro study of novel collagenase (XIAFLEX(R)) on Dupuytren's disease fibroblasts displays unique drug related properties
    PLoS ONE (2012) 7, e31430-e31430. PubMed  Europe PubMed DOI  PMC  EPMC  U
  45. Van Wart,H.E.
    Clostridium collagenases
    [ISSN:978-0-12-407744-7] (2012) 3, 607-611. DOI
    46. 2011

  46. Collagenase clostridium histolyticum. Short-term benefit in Dupuytren's contracture, unknown long-term risks
    Prescrire Int (2011) 20, 285-287. PubMed  Europe PubMed  U
  47. Aysan,E., Bektas,H., Ersoz,F. and Behzat,K.
    Role of single-dose clostridiopeptidase A collagenase in peritoneal adhesions
    Eur Surg Res (2011) 47, 130-134. PubMed  Europe PubMed DOI  U
  48. Eckhard,U., Schonauer,E., Nuss,D. and Brandstetter,H.
    Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis
    Nat Struct Mol Biol (2011) 18, 1109-1114. PubMed  Europe PubMed DOI  S
  49. Holzer,L. and Holzer,G.
    [Collagenase clostridum histolyticum in the management of Dupuytren's contracture]
    Handchir Mikrochir Plast Chir (2011) 43, 269-274. PubMed  Europe PubMed DOI  U
  50. Kaplan,F.T.
    Collagenase clostridium histolyticum injection for the treatment of Dupuytren's contracture
    Drugs Today (Barc) (2011) 47, 653-667. PubMed  Europe PubMed DOI  U
  51. Karagol,B.S., Okumus,N., Dursun,A., Karadag,N. and Zenciroglu,A.
    Early and successful enzymatic debridement via collagenase application to pinna in a preterm neonate
    Pediatr Dermatol (2011) 28, 600-601. PubMed  Europe PubMed DOI  U
  52. Wang,Y., Paushter,D., Wang,S., Barbaro,B., Harvat,T., Danielson,K.K., Kinzer,K., Zhang,L., Qi,M. and Oberholzer,J.
    Highly purified versus filtered crude collagenase: comparable human islet isolation outcomes
    Cell Transplant (2011) 20, 1817-1825. PubMed  Europe PubMed DOI
  53. Watt,A.J. and Hentz,V.R.
    Collagenase clostridium histolyticum: a novel nonoperative treatment for Dupuytren's disease
    Int J Clin Rheumatol (2011) 6, 123-133. DOI  U
    54. 2010
  54. Gilpin,D., Coleman,S., Hall,S., Houston,A., Karrasch,J. and Jones,N.
    Injectable collagenase Clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease
    J Hand Surg Am (2010) 35, 2027-2038. PubMed  Europe PubMed DOI  U
  55. Nikolic,D.M., Djordjevic,P.B., Sreckovic,V.D., Paunovic,I., Kalezic,N., Popovic,S., Nikolic,B. and Stefanovic,D.
    Comparative analysis of collagenase XI and liberase H1 for the isolation of human pancreatic islets
    Hepatogastroenterology (2010) 57, 1573-1578. PubMed  Europe PubMed
  56. Shi,L., Ermis,R., Garcia,A., Telgenhoff,D. and Aust,D.
    Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration
    Int Wound J (2010) 7, 87-95. PubMed  Europe PubMed DOI
  57. Singh,J., Singh,K., Shaik,B., Singh,N. and Agrawal,V.K.
    QSAR studies on some protease inhibitors incorporating sulphonyl-l-alanine hydroxamate moieties
    Oxid Commun (2010) 33, 631-651.  I
  58. Spiriti,J. and van der Vaart,A.
    Mechanism of the calcium-induced trans-cis isomerization of a non-prolyl peptide bond in Clostridium histolyticum collagenase
    Biochemistry (2010) 49, 5314-5320. PubMed  Europe PubMed DOI
  59. Thomas,A. and Bayat,A.
    The emerging role of Clostridium histolyticum collagenase in the treatment of Dupuytren disease
    Ther Clin Risk Manag (2010) 6, 557-572. PubMed  Europe PubMed DOI  PMC  EPMC  U
  60. Watt,A.J., Curtin,C.M. and Hentz,V.R.
    Collagenase injection as nonsurgical treatment of Dupuytren's disease: 8-year follow-up
    J Hand Surg Am (2010) 35, 534-539. PubMed  Europe PubMed DOI  U
    61. 2009
  61. Philominathan,S.T., Matsushita,O., Gensure,R. and Sakon,J.
    Ca2+-induced linker transformation leads to a compact and rigid collagen-binding domain of Clostridium histolyticum collagenase
    FEBS J (2009) 276, 3589-3601. PubMed  Europe PubMed DOI
  62. Philominathan,S.T., Koide,T., Hamada,K., Yasui,H., Seifert,S., Matsushita,O. and Sakon,J.
    Unidirectional binding of clostridial collagenase to triple helical substrates
    J Biol Chem (2009) 284, 10868-10876. PubMed  Europe PubMed DOI  PMC  EPMC
    63. 2008
  63. Eckhard,U., Nuss,D., Ducka,P., Schonauer,E. and Brandstetter,H.
    Crystallization and preliminary X-ray characterization of the catalytic domain of collagenase G from Clostridium histolyticum
    Acta Crystallograph Sect F Struct Biol Cryst Commun (2008) 64, 419-421. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Saikumari,Y.K. and Balaram,P.
    An internally quenched fluorescent substrate for collagenase
    Biopolymers (2008) 90, 131-137. PubMed  Europe PubMed DOI  A
    65. 2007
  65. Antonioli,B., Fermo,I., Cainarca,S., Marzorati,S., Nano,R., Baldissera,M., Bachi,A., Paroni,R., Ricordi,C. and Bertuzzi,F.
    Characterization of collagenase blend enzymes for human islet transplantation
    Transplantation (2007) 84, 1568-1575. PubMed  Europe PubMed DOI
    66. 2005
  66. [YEAR:27-9-2005]Barnett,M.J., Zhai,X., LeGatt,D.F., Cheng,S.B., Shapiro,A.M. and Lakey,J.R.
    Quantitative assessment of collagenase blends for human islet isolation
    Transplantation (27-9-2005) 80, 723-728. PubMed  Europe PubMed DOI
  67. Brandhorst,D., Huettler,S., Alt,A., Raemsch-Guenther,N., Kurfuerst,M., Bretzel,R.G. and Brandhorst,H.
    Adjustment of the ratio between collagenase class II and I improves islet isolation outcome
    Transplant Proc (2005) 37, 3450-3451. PubMed  Europe PubMed DOI
    68. 2004
  68. Van Wart,H.E.
    Clostridial collagenases
    [ISSN:0-12-079610-4] (2004) 2, 416-419.  V
    69. 2002
  69. [YEAR:8-3-2002]Hu,Y., Webb,E., Singh,J., Morgan,B.A., Gainor,J.A., Gordon,T.D. and Siahaan,T.J.
    Rapid determination of substrate specificity of Clostridium histolyticum beta-collagenase using an immobilized peptide library
    J Biol Chem (8-3-2002) 277, 8366-8371. PubMed  Europe PubMed DOI
    70. 2001
  70. [YEAR:21-6-2001]Clare,B.W., Scozzafava,A. and Supuran,C.T.
    Protease inhibitors: Synthesis of a series of bacterial collagenase inhibitors of the sulfonyl amino acyl hydroxamate type
    J Med Chem (21-6-2001) 44, 2253-2258. PubMed  Europe PubMed DOI  I
  71. [YEAR:23-3-2001]Matsushita,O., Koide,T., Kobayashi,R., Nagata,K. and Okabe,A.
    Substrate recognition by the collagen-binding domain of Clostridium histolyticum class I collagenase
    J Biol Chem (23-3-2001) 276, 8761-8770. PubMed  Europe PubMed DOI
    72. 2000
  72. Awad,M.M., Ellemor,D.M., Bryant,A.E., Matsushita,O., Boyd,R.L., Stevens,D.L., Emmins,J.J. and Rood,J.I.
    Construction and virulence testing of a collagenase mutant of Clostridium perfringens
    Microb Pathog (2000) 28, 107-117. PubMed  Europe PubMed DOI
  73. [YEAR:6-3-2000]Scozzafava,A. and Supuran,C.T.
    Protease inhibitors: Synthesis of Clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L-alanine hydroxamate moieties
    Bioorg Med Chem Lett (6-3-2000) 10, 499-502. PubMed  Europe PubMed DOI  I
  74. [YEAR:4-5-2000]Scozzafava,A. and Supuran,C.T.
    Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties
    J Med Chem (4-5-2000) 43, 1858-1865. PubMed  Europe PubMed DOI  I
  75. Supuran,C.T., Briganti,F., Mincione,G. and Scozzafava,A.
    Protease inhibitors: synthesis of L-alanine hydroxamate sulfonylated derivatives as inhibitors of Clostridium histolyticum collagenase
    J Enzyme Inhib (2000) 15, 111-128. PubMed  Europe PubMed  I
    76. 1999
  76. Matsushita,O., Jung,C.M., Katayama,S., Minami,J., Takahashi,Y. and Okabe,A.
    Gene duplication and multiplicity of collagenases in Clostridium histolyticum
    J Bacteriol (1999) 181, 923-933. PubMed  Europe PubMed  PMC  EPMC
    77. 1998
  77. [YEAR:6-2-1998]Matsushita,O., Jung,C.M., Minami,J., Katayama,S., Nishi,N. and Okabe,A.
    A study of the collagen-binding domain of a 116-kDa Clostridium histolyticum collagenase
    J Biol Chem (6-2-1998) 273, 3643-3648. PubMed  Europe PubMed DOI
    78. 1997
  78. Ohtani,K., Bando,M., Swe,T., Banu,S., Oe,M., Hayashi,H. and Shimizu,T.
    Collagenase gene (colA) is located in the 3'-flanking region of the perfringolysin O (pfoA) locus in Clostridium perfringens
    FEMS Microbiol Lett (1997) 146, 155-159. PubMed  Europe PubMed DOI
    79. 1995
  79. Wolters,G.H., Vos-Scheperkeuter,G.H., Lin,H.C. and van Schilfgaarde,R.
    Different roles of class I and class II Clostridium histolyticum collagenase in rat pancreatic islet isolation
    Diabetes (1995) 44, 227-233. PubMed  Europe PubMed
    80. 1994
  80. Matsushita,O., Yoshihara,K., Katayama,S., Minami,J. and Okabe,A.
    Purification and characterization of Clostridium perfringens 120-kilodalton collagenase and nucleotide sequence of the corresponding gene
    J Bacteriol (1994) 176, 149-156. PubMed  Europe PubMed  PMC  EPMC
    81. 1992
  81. French,M.F., Bhown,A. and Van Wart,H.E.
    Identification of Clostridium histolyticum collagenase hyperreactive sites in type I, II, and III collagens: lack of correlation with local triple helical stability
    J Protein Chem (1992) 11, 83-97. PubMed  Europe PubMed
  82. Hedtmann,A., Fett,H., Steffen,R. and Kramer,J.
    [Chemonucleolysis using chymopapain and collagenase. 3-year results of a prospective randomized study]
    Z Orthop Ihre Grenzgeb (1992) 130, 36-44. PubMed  Europe PubMed DOI
  83. Mallya,S.K., Mookhtiar,K.A. and Van Wart,H.E.
    Kinetics of hydrolysis of type I, II, and III collagens by the class I and II Clostridium histolyticum collagenases
    J Protein Chem (1992) 11, 99-107. PubMed  Europe PubMed
  84. Mookhtiar,K.A. and Van Wart,H.E.
    Clostridium histolyticum collagenases: a new look at some old enzymes
    Matrix Suppl (1992) 1, 116-126. PubMed  Europe PubMed
  85. Schwartz,M.A. and Van Wart,H.E.
    Synthetic inhibitors of bacterial and mammalian interstitial collagenases
    Prog Med Chem (1992) 29, 271-334. PubMed  Europe PubMed DOI  I
    86. 1990
  86. Dive,V., Yiotakis,A., Nicolaou,A. and Toma,F.
    Inhibition of Clostridium histolyticum collagenases by phosphonamide peptide inhibitors
    Eur J Biochem (1990) 191, 685-693. PubMed  Europe PubMed DOI  I
    87. 1989
  87. Barrett,A.J., Knight,C.G., Brown,M.A. and Tisljar,U.
    A continuous fluorimetric assay for clostridial collagenase and Pz-peptidase activity
    Biochem J (1989) 260, 259-263. PubMed  Europe PubMed  PMC  EPMC
    88. 1988
  88. [YEAR:20-9-1988]Angleton,E.L. and Van Wart,H.E.
    Preparation by direct metal exchange and kinetic study of active site metal substituted class I and class II Clostridium histolyticum collagenases
    Biochemistry (20-9-1988) 27, 7413-7418. PubMed  Europe PubMed
  89. [YEAR:20-9-1988]Angleton,E.L. and Van Wart,H.E.
    Preparation and reconstitution with divalent metal ions of class I and class II Clostridium histolyticum apocollagenases
    Biochemistry (20-9-1988) 27, 7406-7412. PubMed  Europe PubMed
  90. Mookhtiar,K.A., Grobelny,D., Galardy,R.E. and Van Wart,H.E.
    Ketone-substrate analogues of Clostridium histolyticum collagenases: tight-binding transition-state analogue inhibitors
    Biochemistry (1988) 27, 4299-4304. PubMed  Europe PubMed  I
  91. Yiotakis,A., Hatgiyannacou,A., Dive,V. and Toma,F.
    New thiol inhibitors of Clostridium histolyticum collagenase: importance of the P3' position
    Eur J Biochem (1988) 172, 764-766. DOI  I
    92. 1987
  92. [YEAR:10-2-1987]French,M.F., Mookhtiar,K.A. and Van Wart,H.E.
    Limited proteolysis of type I collagen at hyperreactive sites by class I and II Clostridium histolyticum collagenases: complementary digestion patterns
    Biochemistry (10-2-1987) 26, 681-687. PubMed  Europe PubMed
    93. 1985
  93. [YEAR:22-10-1985]Grobelny,D. and Galardy,R.E.
    Aldehyde and ketone substrate analogues inhibit the collagenase of Clostridium histolyticum
    Biochemistry (22-10-1985) 24, 6145-6152. PubMed  Europe PubMed  I
  94. [YEAR:5-11-1985]Mookhtiar,K.A., Steinbrink,D.R. and Van Wart,H.E.
    Mode of hydrolysis of collagen-like peptides by class I and class II Clostridium histolyticum collagenases: evidence for both endopeptidase and tripeptidylcarboxypeptidase activities
    Biochemistry (5-11-1985) 24, 6527-6533. PubMed  Europe PubMed
  95. [YEAR:10-3-1985]Steinbrink,D.R., Bond,M.D. and Van Wart,H.E.
    Substrate specificity of beta-collagenase from Clostridium histolyticum
    J Biol Chem (10-3-1985) 260, 2771-2776. PubMed  Europe PubMed  P
  96. Van Wart,H.E. and Steinbrink,D.R.
    Complementary substrate specificities of class I and class II collagenases from Clostridium histolyticum
    Biochemistry (1985) 24, 6520-6526. PubMed  Europe PubMed
  97. Vencill,C.F., Rasnick,D., Crumley,K.V., Nishino,N. and Powers,J.C.
    Clostridium histolyticum collagenase: development of new thio ester, fluorogenic, and depsipeptide substrates and new inhibitors
    Biochemistry (1985) 24, 3149-3157. PubMed  Europe PubMed  I
    98. 1984
  98. Bond,M.D. and Van Wart,H.E.
    Characterization of the individual collagenases from Clostridium histolyticum
    Biochemistry (1984) 23, 3085-3091. PubMed  Europe PubMed
  99. Bond,M.D. and Van Wart,H.E.
    Relationship between the individual collagenases of Clostridium histolyticum: evidence for evolution by gene duplication
    Biochemistry (1984) 23, 3092-3099. PubMed  Europe PubMed
    100. 1982
  100. Peterkofsky,B.
    [21] Bacterial collagenase
    Methods Enzymol (1982) 82, 453-471. DOI  V
    101. 1981
  101. [YEAR:15-5-1981]Van Wart,H.E. and Steinbrink,D.R.
    A continuous spectrophotometric assay for Clostridium histolyticum collagenase
    Anal Biochem (15-5-1981) 113, 356-365. PubMed  Europe PubMed
    102. 1980
  102. Heindl,M.C., Fermandjian,S. and Keil,B.
    Circular dichroism comparative studies of two bacterial collagenases and thermolysin
    Biochim Biophys Acta (1980) 624, 51-59. PubMed  Europe PubMed
    103. 1979
  103. Lecroisey,A. and Keil,B.
    Differences in the degradation of native collagen by two microbial collagenases
    Biochem J (1979) 179, 53-58. PubMed  Europe PubMed  PMC  EPMC  P
    104. 1976
  104. Gilles,A.M. and Keil,B.
    Cleavage of beta-casein by collagenases from Achromobacter iophagus and Clostridium histolyticum
    FEBS Lett (1976) 65, 369-372. PubMed  Europe PubMed DOI
  105. [YEAR:19-10-1976]Lwebuga-Mukasa,J.S., Harper,E. and Taylor,P.
    Collagenase enzymes from Clostridium: characterization of individual enzymes
    Biochemistry (19-10-1976) 15, 4736-4741. PubMed  Europe PubMed
    106. 1973
  106. Hanada,K., Mizutani,T., Yamagishi,M., Tsuji,H., Misaki,T. and Sawada,J.
    The isolation of collagenase and its enzymological and physico-chemical properties
    Agric Biol Chem (1973) 37, 1771-1781.
    107. 1971
  107. Morihara,K. and Tsuzuki,H.
    Comparative study of various neutral proteinases from microorganisms: specificity with oligopeptides
    Arch Biochem Biophys (1971) 146, 291-296. PubMed  Europe PubMed
    108. 1970
  108. [YEAR:23-10-1970]Harper,E. and Kang,A.H.
    Studies on the specificity of bacterial collagenase
    Biochem Biophys Res Commun (23-10-1970) 41, 482-487. PubMed  Europe PubMed
  109. Seifter,S. and Harper,E.
    The collagenases
    Methods Enzymol (1970) 19, 613-635.
    110. 1968
  110. Kono,T.
    Purification and partial characterization of collagenolytic enzymes from Clostridium histolyticum
    Biochemistry (1968) 7, 1106-1114. PubMed  Europe PubMed
    111. 1965
  111. Greenberg,J., Fishman,L. and Levy,M.
    Positions of amino acids in mixed peptides produced from collagen by the action of collagenase
    Biochemistry (1965) 3, 1826-1831.
  112. [YEAR:20-9-1965]Yoshida,E. and Noda,H.
    Isolation and characterization of collagenases I and II from Clostridium histolyticum
    Biochim Biophys Acta (20-9-1965) 105, 562-574. PubMed  Europe PubMed
    113. 1964
  113. Mandl,I., Keller,S. and Manahan,J.
    Multiplicity of Clostridium histolyticum collagenases
    Biochemistry (1964) 3, 1737-1741. PubMed  Europe PubMed
    114. 1961
  114. Conklin,D.A., Webster,M.E., Altieri,P.L., Berman,S., Lowenthal,J.P. and Gochenour,R.B.
    Large scale purification of proteinases from Clostridium histolyticum filtrates
    J Bacteriol (1961) 82, 589-594. PubMed  Europe PubMed  PMC  EPMC
    115. 1959
  115. Grant,N.H. and Alburn,H.E.
    Studies on the collagenases of Clostridium histolyticum
    Arch Biochem Biophys (1959) 82, 245-255. PubMed  Europe PubMed
    116. 1958
  116. Mandl,I., Zipper,H. and Ferguson,L.T.
    Clostridium histolyticum collagenase: its purification and properties
    Arch Biochem Biophys (1958) 74, 465-475. PubMed  Europe PubMed
    117. 1953
  117. Mandl,I., Maclennan,J.D. and Howes,E.L.
    Isolation and characterization of proteinase and collagenase from Cl. histolyticum
    J Clin Invest (1953) 32, 1323-1329. PubMed  Europe PubMed DOI  PMC  EPMC
    118. 1948
  118. Oakley,C.L., Warrack,G.H. and Warren,M.E.
    The kappa and lambda antigens of Clostridium welchii
    J Pathol Bacteriol (1948) 60, 495-503.
    119. 1945
  119. Jennison,M.W.
    Bacterial collagenase
    J Bacteriol (1945) 50, 369-370. PubMed  Europe PubMed

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