$VAR1 = undef;

Summary for peptidase M03.002: neurolysin

Names
MEROPS Name	neurolysin
Other names	endopeptidase 24.16, microsomal endopeptidase, mitochondrial oligopeptidase, NLN g.p. (Homo sapiens), neurotensin-degrading enzyme, neurotensin endopeptidase, oligopeptidase M, soluble angiotensin II-binding protein, thimet oligopeptidase II

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M3 >> Subfamily A >> M03.002
Holotype	neurolysin (Rattus norvegicus), Uniprot accession P42676 (peptidase unit: 26-704), MERNUM MER0001942
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00137
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.16
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Barrett & Dando, 2004) mouse: active (by similarity to rat) (Serizawa et al., 1995)
Physiology	Intracellular oligopeptide degradation. Proposed role in destruction of several bioactive peptides.
Pathways	KEGG	Renin-angiotensin system
Other databases	TREEFAM	http://www.treefam.org/family/TF300459
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	G/F/spgr/PFsr/Rpi/Q/- (based on 128 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	70	2	15	0	1	1	0	2
Pro	14	8	23	68	1	28	1	0
Ala	2	3	3	5	3	3	2	1
Val	0	0	0	0	0	0	0	0
Leu	1	2	1	5	3	6	12	2
Ile	1	1	3	1	6	11	4	0
Met	0	0	0	0	0	0	1	1
Phe	1	60	3	17	59	3	13	2
Tyr	0	0	1	6	11	0	1	0
Trp	0	0	0	0	1	2	2	1
Ser	0	2	56	4	21	1	2	1
Thr	0	1	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	9	2	2	1	1	1	1	2
Gln	0	1	1	1	2	3	74	5
Asp	0	1	1	1	1	0	2	2
Glu	0	1	1	1	1	1	2	1
Lys	3	14	4	2	1	2	0	0
Arg	7	14	13	15	14	61	4	7
His	0	1	1	1	1	2	0	1