Structure for peptidase M03.002: neurolysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

PDB Organism Resolution Comment
1I1I_P Rattus norvegicus 2.30 Å mature
The catalytic and structural zinc ions are shown as light grey CPK spheres. The zinc ligands are shown in ball-and-stick representation: His497 and His501 in purple and Glu526 in dark blue. The catalytic Glu498 is shown in ball-and-stick representation in blue.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
Glu475Gln mutant; complex with neurotensin peptide products 2.70 Å 5LUZ 5LUZ 5LUZ 5LUZ 5LUZ 5LUZ
Glu475Gln mutant; complex with amyloid-beta 35-40 peptide product 2.70 Å 5LV0 5LV0 5LV0 5LV0 5LV0 5LV0
Rattus norvegicus
mature  peptidase 2.30 Å 1I1I 1I1I 1I1I 1I1I 1I1I 1I1I Brown et al., 2001
engineered with thimet oligopeptidase specificity for neurotensin cleavage site 2.20 Å 2O3E 2O3E 2O3E 2O3E 2O3E 2O3E Lim et al., 2007
mature  peptidase 2.80 Å 4FXY 4FXY 4FXY 4FXY 4FXY 4FXY Hines et al., 2014