$VAR1 = undef;

Summary for peptidase M03.001: thimet oligopeptidase

Names
MEROPS Name	thimet oligopeptidase
Other names	endo-oligopeptidase A, endopeptidase 24.15, oligopeptidase A, Pz-peptidase, THOP1 g.p. (Homo sapiens), TOP, soluble metalloendopeptidase

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M3 >> Subfamily A >> M03.001
Holotype	thimet oligopeptidase (Rattus norvegicus), Uniprot accession P24155 (peptidase unit: 2-687), MERNUM MER0001149
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00136
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.15
Enzymology	BRENDA database
Proteolytic events	CutDB database (2 cleavages)
Activity status	human: active (Barrett & Chen, 2004) mouse: active (by similarity)
Physiology	Proposed for a role in pericellular destruction of several bioactive peptides, but is primarily located in the cytosol where it plays an important role in degrading peptides released by proteasomes and is a significant factor limiting the extent of antigen presentation (York et al., 2003).
Pathways	KEGG	African trypanosomiasis
	KEGG	Renin-angiotensin system
Other databases	TREEFAM	http://www.treefam.org/family/TF300459
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	G/Fk/spg/PfrFsr/rp/Q/- (based on 124 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	65	2	16	1	6	3	1	2
Pro	5	6	18	57	0	31	2	1
Ala	1	5	2	4	3	3	1	2
Val	1	1	4	1	0	3	2	0
Leu	0	2	3	6	1	5	10	0
Ile	0	2	1	0	4	5	3	3
Met	2	0	0	1	0	0	2	1
Phe	3	53	7	20	56	2	14	4
Tyr	1	3	0	2	2	3	4	1
Trp	0	0	0	0	1	0	0	0
Ser	2	3	56	2	20	4	2	1
Thr	0	1	2	0	1	0	1	4
Cys	0	0	0	0	0	0	0	0
Asn	11	1	1	3	2	1	2	4
Gln	1	3	4	1	2	2	68	5
Asp	3	1	1	4	2	1	1	1
Glu	1	1	1	1	1	1	4	2
Lys	2	14	2	2	3	2	0	0
Arg	5	7	3	17	19	55	5	9
His	1	2	2	2	1	3	0	1