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Literature for peptidase M03.001: thimet oligopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Climer,S.<br>THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer's Disease<br>Biomolecules (2025) 15 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Cavalcanti,D.M.L.P., Teofilo,T.S., Rodrigues,D., Barbosa,T.N.S. and Fontenele-Neto,J.D.<br>Thimet oligopeptidase (THOP 1) distribution in cane toad (Bufo Marinus, Linnaeus, 1758) brain<br>J Chem Neuroanat (2023) 133, 102345-102345. PubMed  Europe PubMed DOI
  3. Neves,R.L., Marem,A., Carmona,B., Arata,J.G., Cyrillo Ramos,M.P., Justo,G.Z., Machado de Melo,F.H., Oliveira,V. and Icimoto,M.Y.<br>Expression of thimet oligopeptidase (THOP) modulated by oxidative stress in human multidrug resistant (MDR) leukemia cells<br>Biochimie (2023) 212, 21-30. PubMed  Europe PubMed DOI
    4. 2022
  4. Marcondes,M.F.M., Santos,G.S., Bronze,F., Machado,M.F.M., Perez,K.R., Hesselink,R., de Vries,M.P., Broos,J. and Oliveira,V.<br>Probing the Conformational States of Thimet Oligopeptidase in Solution<br>Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2021
  5. Al-Mohanna,T., Nejat,N., Iannetta,A.A., Hicks,L.M., Popescu,G.V. and Popescu,S.C.<br>Arabidopsis thimet oligopeptidases are redox-sensitive enzymes active in the local and systemic plant immune response<br>J Biol Chem (2021) , 100695-100695. PubMed  Europe PubMed DOI
    6. 2020
  6. Dalio,F.M., Machado,M.F.M., Marcondes,M.F., Juliano,M.A., Chagas,J.R., Cunha,R.L.O.R. and Oliveira,V.<br>CPP-Ala-Ala-Tyr-PABA inhibitor analogs with improved selectivity for neurolysin or thimet oligopeptidase<br>Biochem Biophys Res Commun (2020) 522, 368-373. PubMed  Europe PubMed DOI  I
  7. Ferro,E.S., Gewehr,M.C.F. and Navon,A.<br>Thimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions<br>Biomolecules (2020) 10 PubMed  Europe PubMed DOI
  8. Gewehr,M.C.F., Teixeira,A.A.S., Santos,B.A.C., Biondo,L.A., Gozzo,F.C., Cordibello,A.M., Eichler,R.A.S., Reckziegel,P., Da Silva,R.N.O., Dos Santos,N.B., Camara,N.O.S., Castoldi,A., Barreto-Chaves,M.L.M., Dale,C.S., Senger,N., Lima,J.D.C.C., Seelaender,M.C.L., Inada,A.C., Akamine,E.H., Castro,L.M., Rodrigues,A.C., Neto,J.C.R. and Ferro,E.S.<br>The relevance of thimet oligopeptidase in the regulation of energy metabolism and diet-induced obesity<br>Biomolecules (2020) 10 PubMed  Europe PubMed DOI
    9. 2019
  9. Ichihashi,Y., Komatsu,T., Kyo,E., Matsuzaki,H., Hata,K., Watanabe,T., Ueno,T., Hanaoka,K. and Urano,Y.<br>Separation-based enzymomics assay for the discovery of altered peptide-metabolizing enzymatic activities in biosamples<br>Anal Chem (2019) 91, 11497-11501. PubMed  Europe PubMed DOI  A
  10. Santos,N.B.D., Franco,R.D., Camarini,R., Munhoz,C.D., Eichler,R.A.S., Gewehr,M.C.F., Reckziegel,P., Llanos,R.P., Dale,C.S., Silva,V.R.O.D., Borges,V.F., Lima,B.H.F., Cunha,F.Q., Visniauskas,B., Chagas,J.R., Tufik,S., Peres,F.F., Abilio,V.C., Florio,J.C., Iwai,L.K., Rioli,V., Presoto,B.C., Guimaraes,A.O., Pesquero,J.B., Bader,M., Castro,L.M. and Ferro,E.S.<br>Thimet oligopeptidase (EC 3.4.24.15) key functions suggested by knockout mice phenotype characterization<br>Biomolecules (2019) 9 PubMed  Europe PubMed DOI  K
  11. Visniauskas,B., Simoes,P.S.R., Dalio,F.M., Naffah-Mazzacoratti,M.D.G., Oliveira,V., Tufik,S. and Chagas,J.R.<br>Sleep deprivation changes thimet oligopeptidase (THOP1) expression and activity in rat brain<br>Heliyon (2019) 5, e02896-e02896. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2017
  12. Icimoto,M.Y., Ferreira,J.C., Yokomizo,C.H., Bim,L.V., Marem,A., Gilio,J.M., Oliveira,V. and Nantes,I.L.<br>Redox modulation of thimet oligopeptidase activity by hydrogen peroxide<br>FEBS Open Bio (2017) 7, 1037-1050. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2016
  13. Wagner,L., Bjorkqvist,M., Lundh,S.H., Wolf,R., Borgel,A., Schlenzig,D., Ludwig,H.H., Rahfeld,J.U., Leavitt,B., Demuth,H.U., Petersen,A. and von Horsten,S.<br>Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30 fragment<br>J Neurochem (2016) 137, 820-837. PubMed  Europe PubMed DOI
  14. Woitowich,N.C., Philibert,K.D., Leitermann,R.J., Wungjiranirun,M., Urban,J.H. and Glucksman,M.J.<br>EP24.15 as a potential regulator of kisspeptin within the neuroendocrine hypothalamus<br>Endocrinology (2016) 157, 820-830. PubMed  Europe PubMed DOI
    15. 2014
  15. Qi,L., Li,S.H., Si,L.B., Lu,M. and Tian,H.<br>Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer<br>PLoS ONE (2014) 9, e106665-e106665. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Simoes,P.S., Visniauskas,B., Perosa,S.R., Yacubian,E.M., Centeno,R., Canzian,M., Lopes-Cendes,I., Maurer Morelli,C.V., Carrete,H., Jr., Cavalheiro,E.A., Tufik,S., Chagas,J.R. and Naffah Mazzacoratti,M.G.<br>Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE)<br>Epilepsia (2014) 55, 754-762. PubMed  Europe PubMed DOI
    17. 2013
  17. Ferreira,J.C., Icimoto,M.Y., Marcondes,M.F., Oliveira,V., Nascimento,O.R. and Nantes,I.L.<br>Recycling of the high valence states of heme proteins by cysteine residues of thimet-oligopeptidase<br>PLoS ONE (2013) 8, e79102-e79102. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Gamrekelashvili,J., Kapanadze,T., Han,M., Wissing,J., Ma,C., Jaensch,L., Manns,M.P., Armstrong,T., Jaffee,E., White,A.O., Citrin,D.E., Korangy,F. and Greten,T.F.<br>Peptidases released by necrotic cells control CD8+ T cell cross-priming<br>J Clin Invest (2013) 123, 4755-4768. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Guinan,A.F., Rochfort,K.D., Fitzpatrick,P.A., Walsh,T.G., Pierotti,A.R., Phelan,S., Murphy,R.P. and Cummins,P.M.<br>Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels<br>Cardiovasc Res (2013) 99, 545-554. PubMed  Europe PubMed DOI
  20. Pereira,M.G., Souza,L.L., Becari,C., Duarte,D.A., Camacho,F.R., Oliveira,J.A., Gomes,M.D., Oliveira,E.B., Salgado,M.C., Garcia-Cairasco,N. and Costa-Neto,C.M.<br>Angiotensin II-independent angiotensin-(1-7) formation in rat hippocampus: involvement of thimet oligopeptidase<br>Hypertension (2013) 62, 879-885. PubMed  Europe PubMed DOI
    21. 2012
  21. Barrett,A.J. and Chen,J.M.<br>Thimet oligopeptidase<br>[ISSN:978-0-12-407744-7] (2012) 3, 504-509. DOI
  22. Malvezzi,A., Higa,P.M., Amaral,A.T., Silva,G.M., Gozzo,F.C., Ferro,E.S., Castro,L.M., de Rezende,L., Monteiro,G. and Demasi,M.<br>The cysteine-rich protein thimet oligopeptidase as a model of the structural requirements for S-glutathiolation and oxidative oligomerization<br>PLoS ONE (2012) 7, e39408-e39408. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Russo,L.C., Castro,L.M., Gozzo,F.C. and Ferro,E.S.<br>Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction<br>FEBS Lett (2012) 586, 3287-3292. PubMed  Europe PubMed DOI  K
    24. 2011
  24. Kessler,J.H., Khan,S., Seifert,U., Le Gall,S., Chow,K.M., Paschen,A., Bres-Vloemans,S.A., de Ru,A., van Montfoort,N., Franken,K.L., Benckhuijsen,W.E., Brooks,J.M., van Hall,T., Ray,K., Mulder,A., Doxiadis,I.I., van Swieten,P.F., Overkleeft,H.S., Prat,A., Tomkinson,B., Neefjes,J., Kloetzel,P.M., Rodgers,D.W., Hersh,L.B., Drijfhout,J.W., van Veelen,P.A., Ossendorp,F. and Melief,C.J.<br>Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes<br>Nat Immunol (2011) 12, 45-53. PubMed  Europe PubMed DOI
    25. 2008
  25. Sanden,C., Enquist,J., Bengtson,S.H., Herwald,H. and Leeb-Lundberg,L.M.<br>Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation<br>J Pharmacol Exp Ther (2008) 326, 24-32. PubMed  Europe PubMed DOI
    26. 2007
  26. Lim,E.J., Sampath,S., Coll-Rodriguez,J., Schmidt,J., Ray,K. and Rodgers,D.W.<br>Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase<br>J Biol Chem (2007) 282, 9722-9732. PubMed  Europe PubMed DOI  S
    27. 2006
  27. [YEAR:24-4-2006]Dubois,V., Nieder,M., Collot,F., Negrouk,A., Nguyen,T.T., Gangwar,S., Reitz,B., Wattiez,R., Dasnois,L. and Trouet,A.<br>Thimet oligopeptidase (EC 3.4.24.15) activates CPI-0004Na, an extracellularly tumour-activated prodrug of doxorubicin<br>Eur J Cancer (24-4-2006) 42, 3049-3056. PubMed  Europe PubMed DOI
  28. [YEAR:8-8-2006]Kitabgi,P.<br>Inactivation of neurotensin and neuromedin N by Zn metallopeptidases<br>Peptides (8-8-2006) 27, 2515-2522. PubMed  Europe PubMed DOI  V
    29. 2005
  29. Carreno,F.R., Goni,C.N., Castro,L.M. and Ferro,E.S.<br>14-3-3 epsilon modulates the stimulated secretion of endopeptidase 24.15<br>J Neurochem (2005) 93, 10-25. PubMed  Europe PubMed DOI
    30. 2004
  30. Barrett,A.J. and Chen,J.M.<br>Thimet oligopeptidase<br>[ISSN:0-12-079610-4] (2004) 2, 352-356.  V
  31. Ferro,E.S., Hyslop,S. and Camargo,A.C.<br>Intracellullar peptides as putative natural regulators of protein interactions<br>J Neurochem (2004) 91, 769-777. PubMed  Europe PubMed DOI
  32. Jeske,N.A., Glucksman,M.J. and Roberts,J.L.<br>Metalloendopeptidase EC3.4.24.15 is constitutively released from the exofacial leaflet of lipid rafts in GT1-7 cells<br>J Neurochem (2004) 90, 819-828. PubMed  Europe PubMed DOI
  33. [YEAR:13-8-2004]Marinova,Z., Yakovleva,T., Melzig,M.F., Hallberg,M., Nylander,I., Ray,K., Rodgers,D.W., Hauser,K.F., Ekstrom,T.J. and Bakalkin,G.<br>A novel soluble protein factor with non-opioid dynorphin A-binding activity<br>Biochem Biophys Res Commun (13-8-2004) 321, 202-209. PubMed  Europe PubMed DOI
  34. [YEAR:7-5-2004]Ray,K., Hines,C.S., Coll-Rodriguez,J. and Rodgers,D.W.<br>Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization<br>J Biol Chem (7-5-2004) 279, 20480-20489. PubMed  Europe PubMed DOI  S
  35. Rock,K.L., York,I.A. and Goldberg,A.L.<br>Post-proteasomal antigen processing for major histocompatibility complex class I presentation<br>Nat Immunol (2004) 5, 670-677. PubMed  Europe PubMed DOI
  36. [YEAR:24-8-2004]Saric,T., Graef,C.I. and Goldberg,A.L.<br>Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases<br>J Biol Chem (24-8-2004) 279, 46723-46732. PubMed  Europe PubMed DOI
    37. 2003
  37. Gioli-Pereira,L., Fontenele-Neto,J.D., Borges,D.R. and Kouyoumdjian,M.<br>Localization of EP24.15, a major liver kininase<br>J Histochem Cytochem (2003) 51, 125-127. PubMed  Europe PubMed
  38. [YEAR:1-11-2003]Jeske,N.A., Glucksman,M.J. and Roberts,J.L.<br>EP24.15 is associated with lipid rafts<br>J Neurosci Res (1-11-2003) 74, 468-473. PubMed  Europe PubMed DOI
  39. [YEAR:1-11-2003]Kim,S.I., Grum-Tokars,V., Swanson,T.A., Cotter,E.J., Cahill,P.A., Roberts,J.L., Cummins,P.M. and Glucksman,M.J.<br>Novel roles of neuropeptide processing enzymes: EC3.4.24.15 in the neurome<br>J Neurosci Res (1-11-2003) 74, 456-467. PubMed  Europe PubMed DOI
  40. [YEAR:1-10-2003]Kim,S.I., Pabon,A., Swanson,T.A. and Glucksman,M.J.<br>Regulation of cell-surface major histocompatibility complex class I expression by the endopeptidase EC3.4.24.15 (thimet oligopeptidase)<br>Biochem J (1-10-2003) 375, 111-120. PubMed  Europe PubMed DOI  PMC  EPMC
  41. [YEAR:15-11-2003]Morrison,L.S. and Pierotti,A.R.<br>Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences<br>Biochem J (15-11-2003) 376, 189-197. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Norman,M.U., Reeve,S.B., Dive,V., Smith,A.I. and Lew,R.A.<br>Endopeptidases 3.4.24.15 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism<br>Am J Physiol Heart Circ Physiol (2003) 284, H1978-H1984. PubMed  Europe PubMed DOI
  43. Norman,M.U., Lew,R.A., Smith,A.I. and Hickey,M.J.<br>Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature<br>Am J Physiol Heart Circ Physiol (2003) 284, H1942-H1948. PubMed  Europe PubMed DOI  I
  44. [YEAR:24-4-2003]Oliveira,V., Araujo,M.C., Rioli,V., de Camargo,A.C., Tersariol,I.L., Juliano,M.A., Juliano,L. and Ferro,E.S.<br>A structure-based site-directed mutagenesis study on the neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) catalysis<br>FEBS Lett (24-4-2003) 541, 89-92. PubMed  Europe PubMed DOI
  45. [YEAR:7-3-2003]Rioli,V., Gozzo,F.C., Heimann,A.S., Linardi,A., Krieger,J.E., Shida,C.S., Almeida,P.C., Hyslop,S., Eberlin,M.N. and Ferro,E.S.<br>Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme<br>J Biol Chem (7-3-2003) 278, 8547-8555. PubMed  Europe PubMed DOI
  46. [YEAR:1-11-2003]Shrimpton,C.N., Wolfson,A.J., Smith,A.I. and Lew,R.A.<br>Regulators of the neuropeptide-degrading enzyme, EC 3.4.24.15 (thimet oligopeptidase), in cerebrospinal fluid<br>J Neurosci Res (1-11-2003) 74, 474-478. PubMed  Europe PubMed DOI
  47. Sigman,J.A., Sharky,M.L., Walsh,S.T., Pabon,A., Glucksman,M.J. and Wolfson,A.J.<br>Involvement of surface cysteines in activity and multimer formation of thimet oligopeptidase<br>Protein Eng (2003) 16, 623-628. PubMed  Europe PubMed
  48. [YEAR:19-6-2003]Sigman,J.A., Edwards,S.R., Pabon,A., Glucksman,M.J. and Wolfson,A.J.<br>pH dependence studies provide insight into the structure and mechanism of thimet oligopeptidase (EC 3.4.24.15)<br>FEBS Lett (19-6-2003) 545, 224-228. PubMed  Europe PubMed DOI
  49. York,I.A., Mo,A.X., Lemerise,K., Zeng,W., Shen,Y., Abraham,C.R., Saric,T., Goldberg,A.L. and Rock,K.L.<br>The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation<br>Immunity (2003) 18, 429-440. PubMed  Europe PubMed DOI
    50. 2002
  50. Goldberg,A.L., Cascio,P., Saric,T. and Rock,K.L.<br>The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides<br>Mol Immunol (2002) 39, 147-164. PubMed  Europe PubMed DOI
  51. Oliveira,V., Gatti,R., Rioli,V., Ferro,E.S., Spisni,A., Camargo,A.C., Juliano,M.A. and Juliano,L.<br>Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase<br>Eur J Biochem (2002) 269, 4326-4334. PubMed  Europe PubMed DOI
  52. Ray,K., Hines,C.S. and Rodgers,D.W.<br>Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition<br>Protein Sci (2002) 11, 2237-2246. PubMed  Europe PubMed DOI  PMC  EPMC  S
  53. Shrimpton,C.N., Smith,A.I. and Lew,R.A.<br>Soluble metalloendopeptidases and neuroendocrine signaling<br>Endocr Rev (2002) 23, 647-664. PubMed  Europe PubMed DOI
  54. [YEAR:3-9-2002]Steer,D., Lew,R., Perlmutter,P., Smith,A.I. and Aguilar,M.I.<br>Inhibitors of metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 stabilized against proteolysis by the incorporation of beta-amino acids<br>Biochemistry (3-9-2002) 41, 10819-10826. PubMed  Europe PubMed DOI  I
    55. 2001
  55. [YEAR:1-10-2001]Fontenele-Neto,J.D., Massarelli,E.E., Garrido,P.A.G., Beaudet,A. and Ferro,E.S.<br>Comparative fine structural distribution of endopeptidase 24.15 (EC3.4.24.15) and 24.16 (EC3.4.24.16) in rat brain<br>J Comp Neurol (1-10-2001) 438, 399-410. PubMed  Europe PubMed DOI
  56. [YEAR:29-5-2001]Lew,R.A., Boulos,E., Stewart,K.M., Perlmutter,P., Harte,M.F., Bond,S., Reeve,S.B., Norman,M.U., Lew,M.J., Aguilar,M.I. and Smith,A.I.<br>Substrate analogs incorporating beta-amino acids: potential application for peptidase inhibition<br>FASEB J (29-5-2001) 15, 1664-1666. PubMed  Europe PubMed
  57. [YEAR:10-4-2001]Oliveira,V., Campos,M., Melo,R.L., Ferro,E.S., Camargo,A.C., Juliano,M.A. and Juliano,L.<br>Substrate specificity characterization of recombinant metallo oligo-peptidases thimet oligopeptidase and neurolysin<br>Biochemistry (10-4-2001) 40, 4417-4425. PubMed  Europe PubMed DOI
  58. Portaro,F.C., Hayashi,M.A., Silva,C.L. and de Camargo,A.C.<br>Free ATP inhibits thimet oligopeptidase (EC 3.4.24.15) activity, induces autophosphorylation in vitro, and controls oligopeptide degradation in macrophage<br>Eur J Biochem (2001) 268, 887-894. PubMed  Europe PubMed DOI
  59. [YEAR:28-9-2001]Saric,T., Beninga,J., Graef,C.I., Akopian,T.N., Rock,K.L. and Goldberg,A.L.<br>Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase<br>J Biol Chem (28-9-2001) 276, 36474-36481. PubMed  Europe PubMed DOI
    60. 2000
  60. Koike,H., Kouchi,Z., Kinouchi,T., Maeda,T., Sorimachi,H., Saido,T.C., Maruyama,K., Okuyama,A., Suzuki,K. and Ishiura,S.<br>Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate<br>Cytotechnology (2000) 33, 213-219. PubMed  Europe PubMed DOI
  61. Lew,R.A., Boulos,E., Stewart,K.M., Perlmutter,P., Harte,M.F., Bond,S., Aguilar,M.I. and Smith,A.I.<br>Bradykinin analogues with beta-amino acid substitutions reveal subtle differences in substrate specificity between the endopeptidases EC 3.4.24.15 and EC 3.4.24.16<br>J Pept Sci (2000) 6, 440-445. PubMed  Europe PubMed DOI
  62. McCool,S. and Pierotti,A.R.<br>Expression of the thimet oligopeptidase gene is regulated by positively and negatively acting elements<br>DNA Cell Biol (2000) 19, 729-738. PubMed  Europe PubMed DOI
  63. [YEAR:23-6-2000]Molina,H.M., Carmona,A.K., Kouyoumdjian,M. and Borges,D.R.<br>Thimet oligopeptidase EC 3.4.24.15 is a major liver kininase<br>Life Sci (23-6-2000) 67, 509-520. PubMed  Europe PubMed DOI
  64. Okida,N., Tokumoto,M., Tokumoto,T., Nagahama,Y., Ohe,Y., Miyamoto,K. and Ishikawa,K.<br>Cloning of cDNA encoding thimet oligopeptidase from Xenopus oocytes and regulation of the mRNA during oogenesis<br>Zoolog Sci (2000) 17, 431-436.
  65. [YEAR:15-1-2000]Shrimpton,C.N., Abbenante,G., Lew,R.A. and Smith,I.<br>Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15<br>Biochem J (15-1-2000) 345, 351-356. PubMed  Europe PubMed DOI  PMC  EPMC  I
  66. [YEAR:24-11-2000]Tullai,J.W., Cummins,P.M., Pabon,A., Roberts,J.L., Lopingco,M.C., Shrimpton,C.N., Smith,A.I., Martignetti,J.A., Ferro,E.S. and Glucksman,M.J.<br>The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation<br>J Biol Chem (24-11-2000) 275, 36514-36522. PubMed  Europe PubMed DOI
    67. 1999
  67. [YEAR:24-7-1999]Crack,P.J., Wu,T.J., Cummins,P.M., Ferro,E.S., Tullai,J.W., Glucksman,M.J. and Roberts,J.L.<br>The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane<br>Brain Res (24-7-1999) 835, 113-124. PubMed  Europe PubMed DOI
  68. [YEAR:4-6-1999]Cummins,P.M., Pabon,A., Margulies,E.H. and Glucksman,M.J.<br>Zinc coordination and substrate catalysis within the neuropeptide processing enzyme endopeptidase EC 3.4.24.15. Identification of active site histidine and glutamate residues<br>J Biol Chem (4-6-1999) 274, 16003-16009. PubMed  Europe PubMed DOI
  69. Ferro,E.S., Tullai,J.W., Glucksman,M.J. and Roberts,J.L.<br>Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15)<br>DNA Cell Biol (1999) 18, 781-789. PubMed  Europe PubMed DOI
  70. Garrido,P.A., Vandenbulcke,F., Ramjaun,A.R., Vincent,B., Checler,F., Ferro,E. and Beaudet,A.<br>Confocal microscopy reveals thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.16) in the classical secretory pathway<br>DNA Cell Biol (1999) 18, 323-331. PubMed  Europe PubMed DOI
  71. Koike,H., Seki,H., Kouchi,Z., Ito,M., Kinouchi,T., Tomioka,S., Sorimachi,H., Saido,T.C., Maruyama,K., Suzuki,K. and Ishiura,S.<br>Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells<br>J Biochem (1999) 126, 235-242. PubMed  Europe PubMed
  72. [YEAR:18-12-1999]Massarelli,E.E., Casatti,C.A., Kato,A., Camargo,A.C., Bauer,J.A., Glucksman,M.J., Roberts,J.L., Hirose,S. and Ferro,E.S.<br>Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain<br>Brain Res (18-12-1999) 851, 261-265. PubMed  Europe PubMed DOI
  73. [YEAR:24-2-1999]Portaro,F.C., Gomes,M.D., Cabrera,A., Fernandes,B.L., Silva,C.L., Ferro,E.S., Juliano,L. and de Camargo,A.C.<br>Thimet oligopeptidase and the stability of MHC class I epitopes in macrophage cytosol<br>Biochem Biophys Res Commun (24-2-1999) 255, 596-601. PubMed  Europe PubMed DOI
  74. [YEAR:24-2-1999]Silva,C.L., Portaro,F.C., Bonato,V.L., de Camargo,A.C. and Ferro,E.S.<br>Thimet oligopeptidase (EC 3.4.24.15), a novel protein on the route of MHC class I antigen presentation<br>Biochem Biophys Res Commun (24-2-1999) 255, 591-595. PubMed  Europe PubMed DOI
  75. [YEAR:25-6-1999]Yamin,R., Malgeri,E.G., Sloane,J.A., McGraw,W.T. and Abraham,C.R.<br>Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation<br>J Biol Chem (25-6-1999) 274, 18777-18784. PubMed  Europe PubMed DOI
    76. 1998
  76. [YEAR:11-9-1998]Chen,J.M., Stevens,R.A., Wray,P.W., Rawlings,N.D. and Barrett,A.J.<br>Thimet oligopeptidase: site-directed mutagenesis disproves previous assumptions about the nature of the catalytic site<br>FEBS Lett (11-9-1998) 435, 16-20. PubMed  Europe PubMed DOI
  77. Jacchieri,S.G., Gomes,M.D., Juliano,L. and Camargo,A.C.<br>A comparative conformational analysis of thimet oligopeptidase (EC 3.4.24.15) substrates<br>J Pept Res (1998) 51, 452-459. PubMed  Europe PubMed
  78. McCool,S. and Pierotti,A.R.<br>Promoter sequence of rat thimet oligopeptidase<br>Biochem Soc Trans (1998) 26, S15-S15. PubMed  Europe PubMed
  79. [YEAR:8-9-1998]Rioli,V., Kato,A., Portaro,F.C., Cury,G.K., te Kaat,K., Vincent,B., Checler,F., Camargo,A.C., Glucksman,M.J., Roberts,J.L., Hirose,S. and Ferro,E.S.<br>Neuropeptide specificity and inhibition of recombinant isoforms of the endopeptidase 3.4.24.16 family: comparison with the related recombinant endopeptidase 3.4.24.15<br>Biochem Biophys Res Commun (8-9-1998) 250, 5-11. PubMed  Europe PubMed DOI
  80. [YEAR:15-10-1998]Torres,M.P., Prange,C. and Lennon,G.<br>Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease<br>Genomics (15-10-1998) 53, 239-240. PubMed  Europe PubMed DOI
    81. 1997
  81. Camargo,A.C., Gomes,M.D., Reichl,A.P., Ferro,E.S., Jacchieri,S., Hirata,I.Y. and Juliano,L.<br>Structural features that make oligopeptides susceptible substrates for hydrolysis by recombinant thimet oligopeptidase<br>Biochem J (1997) 324, 517-522. PubMed  Europe PubMed  PMC  EPMC
  82. Chevallier,N., Jiracek,J., Vincent,B., Baur,C.P., Spillantini,M.G., Goedert,M., Dive,V. and Checler,F.<br>Examination of the role of endopeptidase 3.4.24.15 in Abeta secretion by human transfected cells<br>Br J Pharmacol (1997) 121, 556-562. PubMed  Europe PubMed DOI  PMC  EPMC
  83. Montiel,J.L., Cornille,F., Roques,B.P. and Noble,F.<br>Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15<br>J Neurochem (1997) 68, 354-361. PubMed  Europe PubMed
  84. Noble,F. and Roques,B.P.<br>Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice<br>FEBS Lett (1997) 401, 227-229. PubMed  Europe PubMed DOI
  85. Shrimpton,C.N., Glucksman,M.J., Lew,R.A., Tullai,J.W., Margulies,E.H., Roberts,J.L. and Smith,A.I.<br>Thiol activation of endopeptidase EC 3.4.24.15. A novel mechanism for the regulation of catalytic activity<br>J Biol Chem (1997) 272, 17395-17399. PubMed  Europe PubMed DOI
  86. Vincent,B., Jiracek,J., Noble,F., Loog,M., Roques,B., Dive,V., Vincent,J.P. and Checler,F.<br>Contribution of endopeptidase 3.4.24.15 to central neurotensin inactivation<br>Eur J Pharmacol (1997) 334, 49-53. PubMed  Europe PubMed DOI
    87. 1996
  87. Lew,R.A., Tomoda,F., Evans,R.G., Lakat,L., Boublik,J.H., Pipolo,L.A. and Smith,A.I.<br>Synthetic inhibitors of endopeptidase EC 3.4.24.15: potency and stability in vitro and in vivo<br>Br J Pharmacol (1996) 118, 1269-1277. PubMed  Europe PubMed  PMC  EPMC  I
    88. 1995
  88. Barrett,A.J., Brown,M.A., Dando,P.M., Knight,C.G., McKie,N., Rawlings,N.D. and Serizawa,A.<br>Thimet oligopeptidase and oligopeptidase M or neurolysin<br>Methods Enzymol (1995) 248, 529-556. PubMed  Europe PubMed DOI  V
  89. Chen,J.M., Changco,A., Brown,M.A. and Barrett,A.J.<br>Immunolocalization of thimet oligopeptidase in chicken embryonic fibroblasts<br>Exp Cell Res (1995) 216, 80-85. PubMed  Europe PubMed DOI
  90. Jiracek,J., Yiotakis,A., Vincent,B., Lecoq,A., Nicolaou,A., Checler,F. and Dive,V.<br>Development of highly potent and selective phosphinic peptide inhibitors of zinc endopeptidase 24-15 using combinatorial chemistry<br>J Biol Chem (1995) 270, 21701-21706. PubMed  Europe PubMed DOI  I
  91. Knight,C.G., Dando,P.M. and Barrett,A.J.<br>Thimet oligopeptidase specificity: evidence of preferential cleavage near the C-terminus and product inhibition from kinetic analysis of peptide hydrolysis<br>Biochem J (1995) 308, 145-150. PubMed  Europe PubMed  PMC  EPMC
  92. McKie,N., Dando,P.M., Brown,M.A. and Barrett,A.J.<br>Rat thimet oligopeptidase: large-scale expression in Escherichia coli and characterization of the recombinant enzyme<br>Biochem J (1995) 309, 203-207. PubMed  Europe PubMed  PMC  EPMC
  93. Thompson,A., Huber,G. and Malherbe,P.<br>Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide<br>Biochem Biophys Res Commun (1995) 213, 66-73. PubMed  Europe PubMed DOI
    94. 1994
  94. Kato,A., Sugiura,N., Hagiwara,H. and Hirose,S.<br>Cloning, amino acid sequence and tissue distribution of porcine thimet oligopeptidase. A comparison with soluble angiotensin-binding protein<br>Eur J Biochem (1994) 221, 159-165. PubMed  Europe PubMed
  95. Mentlein,R. and Dahms,P.<br>Endopeptidases 24.16 and 24.15 are responsible for the degradation of somatostatin, neurotensin, and other neuropeptides by cultivated rat cortical astrocytes<br>J Neurochem (1994) 62, 27-36. PubMed  Europe PubMed
    96. 1993
  96. Dando,P.M., Brown,M.A. and Barrett,A.J.<br>Human thimet oligopeptidase<br>Biochem J (1993) 294, 451-457. PubMed  Europe PubMed  PMC  EPMC
  97. McKie,N., Dando,P.M., Rawlings,N.D. and Barrett,A.J.<br>Thimet oligopeptidase: similarity to 'soluble angiotensin II-binding protein' and some corrections to the published amino acid sequence of the rat testis enzyme<br>Biochem J (1993) 295, 57-60. PubMed  Europe PubMed  PMC  EPMC
    98. 1992
  98. Checler,F., Dauch,P., Barelli,H., Nahon,J.L. and Vincent,J.P.<br>Hydrolysis of rat melanin-concentrating hormone by endopeptidase 24.11 (neutral endopeptidase)<br>Biochem J (1992) 286, 217-221. PubMed  Europe PubMed  PMC  EPMC
  99. Sugiura,N., Hagiwara,H. and Hirose,S.<br>Molecular cloning of porcine soluble angiotensin-binding protein<br>J Biol Chem (1992) 267, 18067-18072. PubMed  Europe PubMed
    100. 1991
  100. Barrett,A.J.<br>Thimet oligopeptidase (EC 3.4.24.15): the same by any name?<br>Biochem J (1991) 277, 295-296. PubMed  Europe PubMed  PMC  EPMC
  101. Knight,C.G. and Barrett,A.J.<br>N-[1(RS)-carboxy-3-phenylpropyl]peptides as inhibitors of thimet oligopeptidase<br>Biochem Soc Trans (1991) 19, 290S-290S. PubMed  Europe PubMed  I
  102. Knight,C.G.<br>A quenched fluorescent substrate for thimet peptidase containing a new fluorescent amino acid, DL-2-amino-3-(7-methoxy-4-coumaryl)propionic acid<br>Biochem J (1991) 274, 45-48. PubMed  Europe PubMed  PMC  EPMC
  103. Tao,Z., Sakurada,C. and Yokosawa,H.<br>Evidence for thiol-dependent metallo-endopeptidase involved in degradation of luteinizing hormone-releasing hormone in glioma cells<br>Neuropeptides (1991) 20, 125-131. PubMed  Europe PubMed DOI
    104. 1990
  104. Barrett,A.J. and Brown,M.A.<br>Chicken liver Pz-peptidase, a thiol-dependent metallo-endopeptidase<br>Biochem J (1990) 271, 701-706. PubMed  Europe PubMed  PMC  EPMC  I
  105. Choi,H.S., Lesser,M., Cardozo,C. and Orlowski,M.<br>Immunohistochemical localization of endopeptidase 24.15 in rat trachea, lung tissue, and alveolar macrophages<br>Am J Respir Cell Mol Biol (1990) 3, 619-624. PubMed  Europe PubMed DOI
  106. Molineaux,C.J. and Ayala,J.M.<br>An inhibitor of endopeptidase-24.15 blocks the degradation of intraventricularly administered dynorphins<br>J Neurochem (1990) 55, 611-618. PubMed  Europe PubMed
  107. Pierotti,A., Dong,K.W., Glucksman,M.J., Orlowski,M. and Roberts,J.L.<br>Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15<br>Biochemistry (1990) 29, 10323-10329. PubMed  Europe PubMed
  108. Tisljar,U., Knight,C.G. and Barrett,A.J.<br>An alternative quenched fluorescence substrate for Pz-peptidase<br>Anal Biochem (1990) 186, 112-115. PubMed  Europe PubMed
  109. Tisljar,U. and Barrett,A.J.<br>Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit<br>Biochem J (1990) 267, 531-533. PubMed  Europe PubMed  PMC  EPMC
    110. 1989
  110. Barrett,A.J., Knight,C.G., Brown,M.A. and Tisljar,U.<br>A continuous fluorimetric assay for clostridial collagenase and Pz-peptidase activity<br>Biochem J (1989) 260, 259-263. PubMed  Europe PubMed  PMC  EPMC
  111. Orlowski,M., Reznik,S., Ayala,J. and Pierotti,A.R.<br>Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides<br>Biochem J (1989) 261, 951-958. PubMed  Europe PubMed  PMC  EPMC
    112. 1986
  112. Bergmann,A. and Bauer,K.<br>A membrane bound substance P degrading endopeptidase from rat brain<br>NIDA Res Monogr (1986) 75, 283-286. PubMed  Europe PubMed  I
    113. 1985
  113. Chu,T.G. and Orlowski,M.<br>Soluble metalloendopeptidase from rat brain: action on enkephalin-containing peptides and other bioactive peptides<br>Endocrinology (1985) 116, 1418-1425. PubMed  Europe PubMed DOI
    114. 1984
  114. [YEAR:31-7-1984]Chu,T.G. and Orlowski,M.<br>Active site directed N-carboxymethyl peptide inhibitors of a soluble metalloendopeptidase from rat brain<br>Biochemistry (31-7-1984) 23, 3598-3603. PubMed  Europe PubMed  I
    115. 1983
  115. Orlowski,M., Michaud,C. and Chu,T.G.<br>A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides<br>Eur J Biochem (1983) 135, 81-88. PubMed  Europe PubMed
    116. 1977
  116. Lukac,J. and Koren,E.<br>The metalloenzymic nature of collagenase-like peptidase of the rat testis<br>J Reprod Fertil (1977) 49, 95-99. PubMed  Europe PubMed

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