$VAR1 = undef;

Summary for peptidase C54.003: autophagin-1

Names
MEROPS Name	autophagin-1
Other names	autophagy-related 4B, HsApg4B protein (obs.), HsAtg4B protein, ATG4B g.p. (Homo sapiens), Mername-AA007 peptidase

Domain architecture

MEROPS Classification
Classification	Clan CA >> Subclan (none) >> Family C54 >> Subfamily (none) >> C54.003
Holotype	autophagin-1 (Homo sapiens), Uniprot accession Q9Y4P1 (peptidase unit: 28-342), MERNUM MER0013561
History	Identifier created: MEROPS 5.4 (23 March 2001)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Marino et al., 2003) mouse: active (by similarity to human)
Pathways	KEGG	Regulation of autophagy
Other databases	TREEFAM	http://www.treefam.org/family/TF314847
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	segn/Tvl/F/G-/-/-/- (based on 15 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	0	0	15	0	0	0	0
Pro	0	0	0	0	0	0	0	0
Ala	0	0	0	0	0	0	0	0
Val	0	4	0	0	0	0	0	0
Leu	0	2	0	0	1	1	1	0
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	1	0	0	0
Phe	0	0	13	0	1	0	0	0
Tyr	0	0	2	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	5	0	0	0	0	0	0	2
Thr	0	9	0	0	0	0	0	0
Cys	0	0	0	0	1	0	0	0
Asn	3	0	0	0	0	0	0	0
Gln	0	0	0	0	0	0	0	0
Asp	0	0	0	0	0	0	0	0
Glu	4	0	0	0	0	0	1	0
Lys	0	0	0	0	1	1	0	0
Arg	0	0	0	0	0	0	0	0
His	0	0	0	0	0	0	0	0