$VAR1 = undef;

Summary for peptidase C14.005: caspase-6

Names
MEROPS Name	caspase-6
Other names	Mch2

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.005
Holotype	caspase-6 (Homo sapiens), Uniprot accession P55212 (peptidase unit: 9-292), MERNUM MER0002708
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00102
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.59
Enzymology	BRENDA database
Proteolytic events	CutDB database (173 cleavages)
Activity status	human: active (Garcia-Calvo et al., 1999) mouse: active (by similarity)
Pharmaceutical relevance	Proposed as effector for a tumor-cell-killing system (Komata et al., 2001).
Pathways	KEGG	Apoptosis
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Caspase_6
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/e/-/Dgsa/-/-/- (based on 1307 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	25	34	29	0	464	78	108	119
Pro	27	8	52	0	12	11	139	112
Ala	74	67	62	0	195	173	111	119
Val	231	66	183	0	34	236	95	69
Leu	99	46	151	0	24	157	93	89
Ile	71	21	78	0	7	74	47	46
Met	20	16	48	0	23	31	21	11
Phe	14	18	32	0	37	79	28	19
Tyr	13	14	41	0	23	51	18	15
Trp	2	0	11	0	7	10	8	9
Ser	93	84	80	0	344	120	154	151
Thr	145	45	142	0	20	60	80	65
Cys	17	22	23	0	13	16	22	25
Asn	29	26	45	0	13	20	60	33
Gln	34	94	32	0	8	32	50	62
Asp	121	148	55	1307	26	38	82	111
Glu	154	465	135	0	27	69	108	178
Lys	2	3	10	0	13	23	43	28
Arg	1	3	6	0	7	14	21	19
His	12	17	15	0	9	14	16	24

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Homo sapiens	recombinant	V/T	-	-	D	G	-	-	-	VxxDGxxx	Abz-Tyr(NO2)	Stennicke et al., 2000
Homo sapiens	recombinant	V/T/I	E	H/V/I	D	-	-	-	-	VEHD	AMC	Thornberry et al., 1997