Literature for peptidase C14.005: caspase-6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Zulqarnain,A., Ukasha,M. and Shah,S.Z.A. The Intricate Role of Caspase-6 and Death Receptor-6 in Neurodegenerative Diseases Cell Biochem Biophys (2025) PubMed Europe PubMed DOI

2024

Deng,Y., Yu,L., Lai,W., Xiao,S. and Zhang,W. Knocking down macrophages Caspase-6 through HMGB1 coordinates macrophage trophoblast crosstalk to suppress ferroptosis and alleviate preeclampsia Int Immunopharmacol (2024) 140, 112859-112859. PubMed Europe PubMed DOI
Vesela,B., Sevcikova,A., Holomkova,K., Ramesova,A., Kratochvilova,A., Sharpe,P.T. and Matalova,E. Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells Pflugers Arch (2024) PubMed Europe PubMed DOI

2023

Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K. A Review on Caspases: Key Regulators of Biological Activities and Apoptosis Mol Neurobiol (2023) 60, 5805-5837. PubMed Europe PubMed DOI V

2022

Chu,H., Hou,Y., Yang,D., Wen,L., Shuai,H., Yoon,C., Shi,J., Chai,Y., Yuen,T.T., Hu,B., Li,C., Zhao,X., Wang,Y., Huang,X., Lee,K.S., Luo,C., Cai,J.P., Poon,V.K., Chan,C.C., Zhang,A.J., Yuan,S., Sit,K.Y., Foo,D.C., Au,W.K., Wong,K.K., Zhou,J., Kok,K.H., Jin,D.Y., Chan,J.F. and Yuen,K.Y. Coronaviruses exploit a host cysteine-aspartic protease for replication Nature (2022) 609, 785-792. PubMed Europe PubMed DOI
Hung,M.C., Wang,W.P. and Chi,Y.H. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer Cell Biosci (2022) 12, 122-122. PubMed Europe PubMed DOI PMC EPMC

2021

Kim,Y.H., Hwang,J.S., Yoon,I.N., Lee,J.H., Lee,J., Park,K.C., Seok,H. and Kim,H. The insect peptide CopA3 blocks programmed cell death by directly binding caspases and inhibiting their proteolytic activation Biochem Biophys Res Commun (2021) 547, 82-88. PubMed Europe PubMed DOI
Soni,I.V. and Hardy,J.A. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence Biochemistry (2021) 60, 2824-2835. PubMed Europe PubMed DOI
Zheng,M., Karki,R., Kancharana,B., Berns,H., Pruett-Miller,S.M. and Kanneganti,T.D. Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections J Biol Chem (2021) 297, 101379-101379. PubMed Europe PubMed DOI PMC EPMC
Zhu,Y., Zhou,J., Niu,P., Chen,H. and Shi,D. Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor Naunyn Schmiedebergs Arch Pharmacol (2021) 394, 809-817. PubMed Europe PubMed DOI I

2020

Angel,A., Volkman,R., Royal,T.G. and Offen,D. Caspase-6 knockout in the 5xFAD model of Alzheimer's disease reveals favorable outcome on memory and neurological hallmarks Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI K
Corrigan,T.S., Lotti Diaz,L.M., Border,S.E., Ratigan,S.C., Kasper,K.Q., Sojka,D., Fajtova,P., Caffrey,C.R., Salvesen,G.S., McElroy,C.A., Hadad,C.M. and Dogan Ekici,O. Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors J Enzyme Inhib Med Chem (2020) 35, 1387-1402. PubMed Europe PubMed DOI I
Cui,W., Li,Y., Wang,Z., Song,C., Yu,Y., Wang,G., Li,J., Wang,C. and Zhang,L. Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity via netrin-1 in postoperative pain following orthopedic surgery for tibial fracture in mice Pain (2020) PubMed Europe PubMed DOI K
Islam,M.I., Hossain,M.S. and Park,I.S. Differential involvement of caspase-6 in amyloid-beta-induced fragmentation of lamin A and B Biochem Biophys Rep (2020) 24, 100839-100839. PubMed Europe PubMed DOI PMC EPMC
Kumi,R.O., Agoni,C., Issahaku,A.R., Olotu,F.A. and Soliman,M.E.S. 'Polymorphism-aided' Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment Cell Biochem Biophys (2020) 78, 291-299. PubMed Europe PubMed DOI
Skotte,N.H., Pouladi,M.A., Ehrnhoefer,D.E., Huynh,K., Qiu,X., Nielsen,S.M.B., Nielsen,T.T., Norremolle,A. and Hayden,M.R. Compromised IGF signaling causes caspase-6 activation in Huntington disease Exp Neurol (2020) 332, 113396-113396. PubMed Europe PubMed DOI
Zheng,M. and Kanneganti,T.D. Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense J Cell Immunol (2020) 2, 341-347. PubMed Europe PubMed DOI PMC EPMC

2019

Chen,Y.J., Liu,Y.C., Liu,Y.W., Lee,Y.B., Huang,H.C., Chen,Y.Y., Shih,Y.H., Lee,Y.C., Cheng,C.F. and Meng,T.C. Nitrite protects neurons against hypoxic damage through S-nitrosylation of caspase-6 Antioxid Redox Signal (2019) 31, 109-126. PubMed Europe PubMed DOI
Ehrnhoefer,D.E., Skotte,N.H., Reinshagen,J., Qiu,X., Windshugel,B., Jaishankar,P., Ladha,S., Petina,O., Khankischpur,M., Nguyen,Y.T.N., Caron,N.S., Razeto,A., Meyer Zu Rheda,M., Deng,Y., Huynh,K.T., Wittig,I., Gribbon,P., Renslo,A.R., Geffken,D., Gul,S. and Hayden,M.R. Activation of caspase-6 is promoted by a mutant huntingtin fragment and blocked by an allosteric inhibitor compound Cell Chem Biol (2019) 26, 1295-1305. PubMed Europe PubMed DOI
MacPherson,D.J., Mills,C.L., Ondrechen,M.J. and Hardy,J.A. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis J Biol Chem (2019) 294, 71-88. PubMed Europe PubMed DOI
Martin,D.D.O., Schmidt,M.E., Nguyen,Y.T., Lazic,N. and Hayden,M.R. Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance FASEB J (2019) 33, 3190-3197. PubMed Europe PubMed DOI
Tubeleviciute-Aydin,A., Beautrait,A., Lynham,J., Sharma,G., Gorelik,A., Deny,L.J., Soya,N., Lukacs,G.L., Nagar,B., Marinier,A. and LeBlanc,A.C. Identification of allosteric inhibitors against active caspase-6 Sci Rep (2019) 9, 5504-5504. PubMed Europe PubMed DOI PMC EPMC I
Zhou,L., Flores,J., Noel,A., Beauchet,O., Sjostrom,P.J. and LeBlanc,A.C. Methylene blue inhibits caspase-6 activity, and reverses caspase-6-induced cognitive impairment and neuroinflammation in aged mice Acta Neuropathol Commun (2019) 7, 210-210. PubMed Europe PubMed DOI I

2018

Bi,X., Liu,X., Bi,D. and Sun,Y. Identification of caspase-6 and caspase-7 from miiuy croaker and evolution analysis in fish Fish Shellfish Immunol (2018) 83, 406-409. PubMed Europe PubMed DOI
Ladha,S., Qiu,X., Casal,L., Caron,N.S., Ehrnhoefer,D.E. and Hayden,M.R. Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli Cell Death Discov (2018) 4, 40-40. PubMed Europe PubMed DOI PMC EPMC K
Tubeleviciute-Aydin,A., Zhou,L., Sharma,G., Soni,I.V., Savinov,S.N., Hardy,J.A. and LeBlanc,A.C. Rare human caspase-6-R65W and caspase-6-G66R variants identify a novel regulatory region of caspase-6 activity Sci Rep (2018) 8, 4428-4428. PubMed Europe PubMed DOI PMC EPMC M
Victor,K.G., Heffron,D.S., Sokolowski,J.D., Majumder,U., LeBlanc,A. and Mandell,J.W. Proteomic identification of synaptic caspase substrates Synapse (2018) 72 PubMed Europe PubMed DOI P

2017

Dagbay,K.B., Bolik-Coulon,N., Savinov,S.N. and Hardy,J.A. Caspase-6 undergoes a distinct helix-strand interconversion upon substrate binding J Biol Chem (2017) 292, 4885-4897. PubMed Europe PubMed DOI
Dagbay,K.B., Hill,M.E., Barrett,E. and Hardy,J.A. Tumor-associated mutations in caspase-6 negatively impact catalytic efficiency Biochemistry (2017) 56, 4568-4577. PubMed Europe PubMed DOI M
Pakavathkumar,P., Noel,A., Lecrux,C., Tubeleviciute-Aydin,A., Hamel,E., Ahlfors,J.E. and LeBlanc,A.C. Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in caspase-6-overexpressing mice Mol Neurodegener (2017) 12, 22-22. PubMed Europe PubMed DOI PMC EPMC I
Skotte,N.H., Sanders,S.S., Singaraja,R.R., Ehrnhoefer,D.E., Vaid,K., Qiu,X., Kannan,S., Verma,C. and Hayden,M.R. Palmitoylation of caspase-6 by HIP14 regulates its activation Cell Death Differ (2017) 24, 433-444. PubMed Europe PubMed DOI
Suita,H., Shinomiya,T. and Nagahara,Y. Caspase-6 induces 7A6 antigen localization to mitochondria during FAS-induced apoptosis of Jurkat cells Anticancer Res (2017) 37, 1697-1704. PubMed Europe PubMed DOI I
Woo,V., Cheng,C., Duraikannu,A., Chandrasekhar,A., Purdy,K., Martinez,J.A. and Zochodne,D.W. Caspase-6 is a dispensable enabler of adult mammalian axonal degeneration Neuroscience (2017) 371, 242-253. PubMed Europe PubMed DOI

2016

Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles Proc Natl Acad Sci U S A (2016) 113, E2001-E2010. PubMed Europe PubMed DOI P

2015

Aharony,I., Ehrnhoefer,D.E., Shruster,A., Qiu,X., Franciosi,S., Hayden,M.R. and Offen,D. A huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits Hum Mol Genet (2015) 24, 2604-2614. PubMed Europe PubMed DOI I
Wang,X.J., Cao,Q., Zhang,Y. and Su,X.D. Activation and regulation of caspase-6 and its role in neurodegenerative diseases Annu Rev Pharmacol Toxicol (2015) 55, 553-572. PubMed Europe PubMed DOI

2014

Berta,T., Park,C.K., Xu,Z.Z., Xie,R.G., Liu,T., Lu,N., Liu,Y.C. and Ji,R.R. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion J Clin Invest (2014) 124, 1173-1186. PubMed Europe PubMed DOI
Flygare,J.A. and Arkin,M.R. Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases Curr Top Med Chem (2014) 14, 319-325. PubMed Europe PubMed DOI I
Lee,P.Y., Cho,J.H., Chi,S.W., Bae,K.-H., Cho,S., Park,B.C., Kim,J.-H. and Park,S.G. Expression of the pro-domain-deleted active form of caspase-6 in Escherichia coli J Microbiol Biotechnol (2014) 24, 719-723. PubMed Europe PubMed DOI E
Murray,J., Giannetti,A.M., Steffek,M., Gibbons,P., Hearn,B.R., Cohen,F., Tam,C., Pozniak,C., Bravo,B., Lewcock,J., Jaishankar,P., Ly,C.Q., Zhao,X., Tang,Y., Chugha,P., Arkin,M.R., Flygare,J. and Renslo,A.R. Tailoring small molecules for an allosteric site on procaspase-6 ChemMedChem (2014) 9, 73-77. PubMed Europe PubMed DOI I

2013

Chen,M.H., Hagemann,T.L., Quinlan,R.A., Messing,A. and Perng,M.D. Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation ASN Neuro (2013) 5, e00125-e00125. PubMed Europe PubMed DOI P
Cho,J.H., Lee,P.Y., Son,W.-C., Chi,S.-W., Park,B.C., Kim,J.-H. and Park,S.G. Identification of the novel substrates for caspase-6 in apoptosis using proteomic approaches BMB Rep (2013) 46, 588-593. PubMed Europe PubMed DOI P
LeBlanc,A.C. Caspase-6 as a novel early target in the treatment of Alzheimer's disease Eur J Neurosci (2013) 37, 2005-2018. PubMed Europe PubMed DOI T
Murray,J. and Renslo,A.R. Modulating caspase activity: beyond the active site Curr Opin Struct Biol (2013) 23, 812-819. PubMed Europe PubMed DOI I
van Raam,B.J., Ehrnhoefer,D.E., Hayden,M.R. and Salvesen,G.S. Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6 Cell Death Differ (2013) 20, 86-96. PubMed Europe PubMed DOI

2012

Cao,Q., Wang,X.J., Liu,C.W., Liu,D.F., Li,L.F., Gao,Y.Q. and Su,X.D. Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J Biol Chem (2012) 287, 15371-15379. PubMed Europe PubMed DOI S
Gafni,J., Papanikolaou,T., DeGiacomo,F., Holcomb,J., Chen,S., Menalled,L., Kudwa,A., Fitzpatrick,J., Miller,S., Ramboz,S., Tuunanen,P.I., Lehtimaki,K.K., Yang,X.W., Park,L., Kwak,S., Howland,D., Park,H. and Ellerby,L.M. Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment J Neurosci (2012) 32, 7454-7465. PubMed Europe PubMed DOI
Heise,C.E., Murray,J., Augustyn,K.E., Bravo,B., Chugha,P., Cohen,F., Giannetti,A.M., Gibbons,P., Hannoush,R.N., Hearn,B.R., Jaishankar,P., Ly,C.Q., Shah,K., Stanger,K., Steffek,M., Tang,Y., Zhao,X., Lewcock,J.W., Renslo,A.R., Flygare,J. and Arkin,M.R. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6 PLoS ONE (2012) 7, e50864-e50864. PubMed Europe PubMed DOI PMC EPMC S I
Mintzer,R., Ramaswamy,S., Shah,K., Hannoush,R.N., Pozniak,C.D., Cohen,F., Zhao,X., Plise,E., Lewcock,J.W. and Heise,C.E. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C PLoS ONE (2012) 7, e30376-e30376. PubMed Europe PubMed DOI PMC EPMC
Morse,R.J. and Renatus,M. Caspase-6 [ISSN:978-0-12-407743-0] (2012) 3, 2270-2274. DOI
Renatus,M. and Farady,C.J. Phosphorylation meets proteolysis Structure (2012) 20, 570-571. PubMed Europe PubMed DOI
Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G. Human caspases in vitro: expression, purification and kinetic characterization Protein Expr Purif (2012) 84, 236-246. PubMed Europe PubMed DOI E
Stanger,K., Steffek,M., Zhou,L., Pozniak,C.D., Quan,C., Franke,Y., Tom,J., Tam,C., Krylova,I., Elliott,J.M., Lewcock,J.W., Zhang,Y., Murray,J. and Hannoush,R.N. Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization Nat Chem Biol (2012) 8, 655-660. PubMed Europe PubMed DOI I
Velazquez-Delgado,E.M. and Hardy,J.A. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove Structure (2012) 20, 742-751. PubMed Europe PubMed DOI
Velazquez-Delgado,E.M. and Hardy,J.A. Zinc-mediated allosteric inhibition of caspase-6 J Biol Chem (2012) 287, 36000-36011. PubMed Europe PubMed DOI

2011

Ehrnhoefer,D.E., Skotte,N.H., Savill,J., Nguyen,Y.T., Ladha,S., Cao,L.P., Dullaghan,E. and Hayden,M.R. A quantitative method for the specific assessment of caspase-6 activity in cell culture PLoS ONE (2011) 6, e27680-e27680. PubMed Europe PubMed DOI PMC EPMC A
Graham,R.K., Ehrnhoefer,D.E. and Hayden,M.R. Caspase-6 and neurodegeneration Trends Neurosci (2011) 34, 646-656. PubMed Europe PubMed DOI
Kobayashi,H., Nolan,A., Naveed,B., Hoshino,Y., Segal,L.N., Fujita,Y., Rom,W.N. and Weiden,M.D. Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M J Immunol (2011) 186, 403-410. PubMed Europe PubMed DOI PMC EPMC
Muller,I., Lamers,M.B., Ritchie,A.J., Park,H., Dominguez,C., Munoz-Sanjuan,I., Maillard,M. and Kiselyov,A. A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme J Mol Biol (2011) 410, 307-315. PubMed Europe PubMed DOI S
Muller,I., Lamers,M.B., Ritchie,A.J., Dominguez,C., Munoz-Sanjuan,I. and Kiselyov,A. Structure of human caspase-6 in complex with Z-VAD-FMK: new peptide binding mode observed for the non-canonical caspase conformation Bioorg Med Chem Lett (2011) 21, 5244-5247. PubMed Europe PubMed DOI I
Soares,J., Lowe,M.M. and Jarstfer,M.B. The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate Biochemistry (2011) 50, 9046-9055. PubMed Europe PubMed DOI P
Vaidya,S., Velazquez-Delgado,E.M., Abbruzzese,G. and Hardy,J.A. Substrate-induced conformational changes occur in all cleaved forms of caspase-6 J Mol Biol (2011) 406, 75-91. PubMed Europe PubMed DOI
Vaidya,S. and Hardy,J.A. Caspase-6 latent state stability relies on helical propensity Biochemistry (2011) 50, 3282-3287. PubMed Europe PubMed DOI

2010

Arnault,E., Doussau,M., Pesty,A., Lefevre,B. and Courtot,A.M. Review: lamin a/c, caspase-6, and chromatin configuration during meiosis resumption in the mouse oocyte Reprod Sci (2010) 17, 102-115. PubMed Europe PubMed DOI
Giaime,E., Sunyach,C., Druon,C., Scarzello,S., Robert,G., Grosso,S., Auberger,P., Goldberg,M.S., Shen,J., Heutink,P., Pouyssegur,J., Pages,G., Checler,F. and Alves da Costa,C. Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6 Cell Death Differ (2010) 17, 158-169. PubMed Europe PubMed DOI
Halawani,D., Tessier,S., Anzellotti,D., Bennett,D.A., Latterich,M. and LeBlanc,A.C. Identification of caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation J Neurosci (2010) 30, 6132-6142. PubMed Europe PubMed DOI PMC EPMC
Lee,A.W., Champagne,N., Wang,X., Su,X.D., Goodyer,C. and LeBlanc,A.C. Alternatively spliced caspase-6b isoform inhibits the activation of caspase-6a J Biol Chem (2010) 285, 31974-31984. PubMed Europe PubMed DOI R
Leong,S.M., Tan,B.X., Bte Ahmad,B., Yan,T., Chee,L.Y., Ang,S.T., Tay,K.G., Koh,L.P., Yeoh,A.E., Koay,E.S., Mok,Y.K. and Lim,T.M. Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition Blood (2010) 116, 3286-3296. PubMed Europe PubMed DOI
Wang,X.J., Cao,Q., Liu,X., Wang,K.T., Mi,W., Zhang,Y., Li,L.F., LeBlanc,A.C. and Su,X.D. Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation EMBO Rep (2010) 11, 841-847. PubMed Europe PubMed DOI S

2009

Baumgartner,R., Meder,G., Briand,C., Decock,A., D'arcy,A., Hassiepen,U., Morse,R. and Renatus,M. The crystal structure of caspase-6, a selective effector of axonal degeneration Biochem J (2009) 423, 429-439. PubMed Europe PubMed DOI S
Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V. Evaluation of recombinant caspase specificity by competitive substrates Anal Biochem (2009) 394, 68-74. PubMed Europe PubMed DOI A P
Chan,Y.W., Chen,Y. and Poon,R.Y. Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe Oncogene (2009) 28, 170-183. PubMed Europe PubMed DOI P
Chu,W., Rothfuss,J., Chu,Y., Zhou,D. and Mach,R.H. Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6 J Med Chem (2009) 52, 2188-2191. PubMed Europe PubMed DOI I
Wolan,D.W., Zorn,J.A., Gray,D.C. and Wells,J.A. Small-molecule activators of a proenzyme Science (2009) 326, 853-858. PubMed Europe PubMed DOI

2008

Fu,G., Chumanevich,A.A., Agniswamy,J., Fang,B., Harrison,R.W. and Weber,I.T. Structural basis for executioner caspase recognition of P5 position in substrates Apoptosis (2008) 13, 1291-1302. PubMed Europe PubMed DOI P
Klaiman,G., Petzke,T.L., Hammond,J. and LeBlanc,A.C. Targets of caspase-6 activity in human neurons and Alzheimer disease Mol Cell Proteomics (2008) 7, 1541-1555. PubMed Europe PubMed DOI PMC EPMC
McStay,G.P., Salvesen,G.S. and Green,D.R. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways Cell Death Differ (2008) 15, 322-331. PubMed Europe PubMed DOI P
Pereira,N.A. and Song,Z. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity Biochem Biophys Res Commun (2008) 377, 873-877. PubMed Europe PubMed DOI P I
Watanabe,C., Shu,G.L., Zheng,T.S., Flavell,R.A. and Clark,E.A. Caspase 6 regulates B cell activation and differentiation into plasma cells J Immunol (2008) 181, 6810-6819. PubMed Europe PubMed PMC EPMC

2007

Albrecht,S., Bourdeau,M., Bennett,D., Mufson,E.J., Bhattacharjee,M. and LeBlanc,A.C. Activation of caspase-6 in aging and mild cognitive impairment Am J Pathol (2007) 170, 1200-1209. PubMed Europe PubMed DOI PMC EPMC
Garner,E., Martinon,F., Tschopp,J., Beard,P. and Raj,K. Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6 Cancer Res (2007) 67, 7631-7637. PubMed Europe PubMed DOI

2006

[YEAR:21-9-2006]Ekici,O.D., Li,Z.Z., Campbell,A.J., James,K.E., Asgian,J.L., Mikolajczyk,J., Salvesen,G.S., Ganesan,R., Jelakovic,S., Grutter,M.G. and Powers,J.C. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10 J Med Chem (21-9-2006) 49, 5728-5749. PubMed Europe PubMed DOI I
[YEAR:16-6-2006]Graham,R.K., Deng,Y., Slow,E.J., Haigh,B., Bissada,N., Lu,G., Pearson,J., Shehadeh,J., Bertram,L., Murphy,Z., Warby,S.C., Doty,C.N., Roy,S., Wellington,C.L., Leavitt,B.R., Raymond,L.A., Nicholson,D.W. and Hayden,M.R. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin Cell (16-6-2006) 125, 1179-1191. PubMed Europe PubMed DOI P
[YEAR:18-11-2006]Loegering,D.A., Ruchaud,S., Earnshaw,W.C. and Kaufmann,S.H. Evaluation of the role of caspase-6 in anticancer drug-induced apoptosis Cell Death Differ (18-11-2006) 13, 346-347. PubMed Europe PubMed DOI
[YEAR:8-5-2006]Wu,X., Simone,J., Hewgill,D., Siegel,R., Lipsky,P.E. and He,L. Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe Cytometry A (8-5-2006) 69, 477-486. PubMed Europe PubMed DOI I

2005

Kalinin,A.E., Kalinin,A.E., Aho,M., Uitto,J. and Aho,S. Breaking the connection: caspase 6 disconnects intermediate filament-binding domain of periplakin from its actin-binding N-terminal region J Invest Dermatol (2005) 124, 46-55. PubMed Europe PubMed DOI

2004

Horowitz,P.M., Patterson,K.R., Guillozet-Bongaarts,A.L., Reynolds,M.R., Carroll,C.A., Weintraub,S.T., Bennett,D.A., Cryns,V.L., Berry,R.W. and Binder,L.I. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease J Neurosci (2004) 24, 7895-7902. PubMed Europe PubMed DOI

2002

Cowling,V. and Downward,J. Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain Cell Death Differ (2002) 9, 1046-1056. PubMed Europe PubMed DOI
[YEAR:15-6-2002]Kang,B.H., Ko,E., Kwon,O.K. and Choi,K.Y. The structure of procaspase 6 is similar to that of active mature caspase 6 Biochem J (15-6-2002) 364, 629-634. PubMed Europe PubMed DOI PMC EPMC

2001

[YEAR:1-8-2001]Komata,T., Kondo,Y., Kanzawa,T., Hirohata,S., Koga,S., Sumiyoshi,H., Srinivasula,S.M., Barna,B.P., Germano,I.M., Takakura,M., Inoue,M., Alnemri,E.S., Shay,J.W., Kyo,S. and Kondo,S. Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter Cancer Res (1-8-2001) 61, 5796-5802. PubMed Europe PubMed
Nyormoi,O., Wang,Z., Doan,D., Ruiz,M., McConkey,D. and Bar-Eli,M. Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells Mol Cell Biol (2001) 21, 4856-4867. PubMed Europe PubMed DOI PMC EPMC

2000

[YEAR:1-9-2000]Stennicke,H.R., Renatus,M., Meldal,M. and Salvesen,G.S. Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8 Biochem J (1-9-2000) 350, 563-568. PubMed Europe PubMed DOI PMC EPMC A P
Wellington,C.L., Leavitt,B.R. and Hayden,M.R. Huntington disease: new insights on the role of huntingtin cleavage J Neural Transm Suppl (2000) 2000, 1-17. PubMed Europe PubMed P
Wellington,C.L., Singaraja,R., Ellerby,L., Savill,J., Roy,S., Leavitt,B., Cattaneo,E., Hackam,A., Sharp,A., Thornberry,N., Nicholson,D.W., Bredesen,D.E. and Hayden,M.R. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells J Biol Chem (2000) 275, 19831-19838. PubMed Europe PubMed DOI

1999

Garcia-Calvo,M., Peterson,E.P., Rasper,D.M., Vaillancourt,J.P., Zamboni,R., Nicholson,D.W. and Thornberry,N.A. Purification and catalytic properties of human caspase family members Cell Death Differ (1999) 6, 362-369. PubMed Europe PubMed DOI
LeBlanc,A., Liu,H., Goodyer,C., Bergeron,C. and Hammond,J. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease J Biol Chem (1999) 274, 23426-23436. PubMed Europe PubMed DOI

1997

[YEAR:10-10-1997]Stennicke,H.R. and Salvesen,G.S. Biochemical characteristics of caspases-3, -6, -7, and -8 J Biol Chem (10-10-1997) 272, 25719-25723. PubMed Europe PubMed DOI
[YEAR:11-4-1997]Talanian,R.V., Quinlan,C., Trautz,S., Hackett,M.C., Mankovich,J.A., Banach,D., Ghayur,T., Brady,K.D. and Wong,W.W. Substrate specificities of caspase family proteases J Biol Chem (11-4-1997) 272, 9677-9682. PubMed Europe PubMed DOI P
Van de Craen,M., Vandenabeele,P., Declercq,W., van den Brande,I., Van Loo,G., Molemans,F., Schotte,P., van Criekinge,W., Beyaert,R. and Fiers,W. Characterization of seven murine caspase family members FEBS Lett (1997) 403, 61-69. PubMed Europe PubMed DOI

1996

Bullrich,F., Fernandes-Alnemri,T., Litwack,G., Alnemri,E.S. and Croce,C.M. Chromosomal mapping of cell death proteases CPP32, MCH2, and MCH3 Genomics (1996) 36, 362-365. PubMed Europe PubMed DOI
Fernandes-Alnemri,T., Armstrong,R.C., Krebs,J., Srinivasula,S.M., Wang,L., Bullrich,F., Fritz,L.C., Trapani,J.A., Tomaselli,K.J., Litwack,G. and Alnemri,E.S. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains Proc Natl Acad Sci U S A (1996) 93, 7464-7469. PubMed Europe PubMed DOI PMC EPMC I
Lippke,J.A., Gu,Y., Sarnecki,C., Caron,P.R. and Su,M.S. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32 J Biol Chem (1996) 271, 1825-1828. PubMed Europe PubMed
Takahashi,A., Alnemri,E.S., Lazebnik,Y.A., Fernandes-Alnemri,T., Litwack,G., Moir,R.D., Goldman,R.D., Poirier,G.G., Kaufmann,S.H. and Earnshaw,W.C. Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis Proc Natl Acad Sci U S A (1996) 93, 8395-8400. PubMed Europe PubMed PMC EPMC

1995

Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family Cancer Res (1995) 55, 2737-2742. PubMed Europe PubMed