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Literature for peptidase C14.005: caspase-6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Deng,Y., Yu,L., Lai,W., Xiao,S. and Zhang,W.
    Knocking down macrophages Caspase-6 through HMGB1 coordinates macrophage trophoblast crosstalk to suppress ferroptosis and alleviate preeclampsia
    Int Immunopharmacol140, 112859-112859. PubMed  Europe PubMed DOI
    2. 2023
  2. Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
    A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
    Mol Neurobiol60, 5805-5837. PubMed  Europe PubMed DOI  V
    3. 2022
  3. Chu,H., Hou,Y., Yang,D., Wen,L., Shuai,H., Yoon,C., Shi,J., Chai,Y., Yuen,T.T., Hu,B., Li,C., Zhao,X., Wang,Y., Huang,X., Lee,K.S., Luo,C., Cai,J.P., Poon,V.K., Chan,C.C., Zhang,A.J., Yuan,S., Sit,K.Y., Foo,D.C., Au,W.K., Wong,K.K., Zhou,J., Kok,K.H., Jin,D.Y., Chan,J.F. and Yuen,K.Y.
    Coronaviruses exploit a host cysteine-aspartic protease for replication
    Nature609, 785-792. PubMed  Europe PubMed DOI
  4. Hung,M.C., Wang,W.P. and Chi,Y.H.
    AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer
    Cell Biosci12, 122-122. PubMed  Europe PubMed DOI
    5. 2021
  5. Kim,Y.H., Hwang,J.S., Yoon,I.N., Lee,J.H., Lee,J., Park,K.C., Seok,H. and Kim,H.
    The insect peptide CopA3 blocks programmed cell death by directly binding caspases and inhibiting their proteolytic activation
    Biochem Biophys Res Commun547, 82-88. PubMed  Europe PubMed DOI
  6. Soni,I.V. and Hardy,J.A.
    Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence
    Biochemistry60, 2824-2835. PubMed  Europe PubMed DOI
  7. Zheng,M., Karki,R., Kancharana,B., Berns,H., Pruett-Miller,S.M. and Kanneganti,T.D.
    Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections
    J Biol Chem297, 101379-101379. PubMed  Europe PubMed DOI
  8. Zhu,Y., Zhou,J., Niu,P., Chen,H. and Shi,D.
    Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor
    Naunyn Schmiedebergs Arch Pharmacol394, 809-817. PubMed  Europe PubMed DOI  I
    9. 2020
  9. Angel,A., Volkman,R., Royal,T.G. and Offen,D.
    Caspase-6 knockout in the 5xFAD model of Alzheimer's disease reveals favorable outcome on memory and neurological hallmarks
    Int J Mol Sci21, PubMed  Europe PubMed DOI  K
  10. Corrigan,T.S., Lotti Diaz,L.M., Border,S.E., Ratigan,S.C., Kasper,K.Q., Sojka,D., Fajtova,P., Caffrey,C.R., Salvesen,G.S., McElroy,C.A., Hadad,C.M. and Dogan Ekici,O.
    Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
    J Enzyme Inhib Med Chem35, 1387-1402. PubMed  Europe PubMed DOI  I
  11. Cui,W., Li,Y., Wang,Z., Song,C., Yu,Y., Wang,G., Li,J., Wang,C. and Zhang,L.
    Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity via netrin-1 in postoperative pain following orthopedic surgery for tibial fracture in mice
    Pain PubMed  Europe PubMed DOI  K
  12. Islam,M.I., Hossain,M.S. and Park,I.S.
    Differential involvement of caspase-6 in amyloid-beta-induced fragmentation of lamin A and B
    Biochem Biophys Rep24, 100839-100839. PubMed  Europe PubMed DOI
  13. Kumi,R.O., Agoni,C., Issahaku,A.R., Olotu,F.A. and Soliman,M.E.S.
    'Polymorphism-aided' Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment
    Cell Biochem Biophys78, 291-299. PubMed  Europe PubMed DOI
  14. Skotte,N.H., Pouladi,M.A., Ehrnhoefer,D.E., Huynh,K., Qiu,X., Nielsen,S.M.B., Nielsen,T.T., Norremolle,A. and Hayden,M.R.
    Compromised IGF signaling causes caspase-6 activation in Huntington disease
    Exp Neurol332, 113396-113396. PubMed  Europe PubMed DOI
  15. Zheng,M. and Kanneganti,T.D.
    Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense
    J Cell Immunol2, 341-347. PubMed  Europe PubMed DOI
    16. 2019
  16. Chen,Y.J., Liu,Y.C., Liu,Y.W., Lee,Y.B., Huang,H.C., Chen,Y.Y., Shih,Y.H., Lee,Y.C., Cheng,C.F. and Meng,T.C.
    Nitrite protects neurons against hypoxic damage through S-nitrosylation of caspase-6
    Antioxid Redox Signal31, 109-126. PubMed  Europe PubMed DOI
  17. Ehrnhoefer,D.E., Skotte,N.H., Reinshagen,J., Qiu,X., Windshugel,B., Jaishankar,P., Ladha,S., Petina,O., Khankischpur,M., Nguyen,Y.T.N., Caron,N.S., Razeto,A., Meyer Zu Rheda,M., Deng,Y., Huynh,K.T., Wittig,I., Gribbon,P., Renslo,A.R., Geffken,D., Gul,S. and Hayden,M.R.
    Activation of caspase-6 is promoted by a mutant huntingtin fragment and blocked by an allosteric inhibitor compound
    Cell Chem Biol26, 1295-1305. PubMed  Europe PubMed DOI
  18. MacPherson,D.J., Mills,C.L., Ondrechen,M.J. and Hardy,J.A.
    Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis
    J Biol Chem294, 71-88. PubMed  Europe PubMed DOI
  19. Martin,D.D.O., Schmidt,M.E., Nguyen,Y.T., Lazic,N. and Hayden,M.R.
    Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance
    FASEB J33, 3190-3197. PubMed  Europe PubMed DOI
  20. Tubeleviciute-Aydin,A., Beautrait,A., Lynham,J., Sharma,G., Gorelik,A., Deny,L.J., Soya,N., Lukacs,G.L., Nagar,B., Marinier,A. and LeBlanc,A.C.
    Identification of allosteric inhibitors against active caspase-6
    Sci Rep9, 5504-5504. PubMed  Europe PubMed DOI  I
  21. Zhou,L., Flores,J., Noel,A., Beauchet,O., Sjostrom,P.J. and LeBlanc,A.C.
    Methylene blue inhibits caspase-6 activity, and reverses caspase-6-induced cognitive impairment and neuroinflammation in aged mice
    Acta Neuropathol Commun7, 210-210. PubMed  Europe PubMed DOI  I
    22. 2018
  22. Bi,X., Liu,X., Bi,D. and Sun,Y.
    Identification of caspase-6 and caspase-7 from miiuy croaker and evolution analysis in fish
    Fish Shellfish Immunol83, 406-409. PubMed  Europe PubMed DOI
  23. Ladha,S., Qiu,X., Casal,L., Caron,N.S., Ehrnhoefer,D.E. and Hayden,M.R.
    Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli
    Cell Death Discov4, 40-40. PubMed  Europe PubMed DOI  K
  24. Tubeleviciute-Aydin,A., Zhou,L., Sharma,G., Soni,I.V., Savinov,S.N., Hardy,J.A. and LeBlanc,A.C.
    Rare human caspase-6-R65W and caspase-6-G66R variants identify a novel regulatory region of caspase-6 activity
    Sci Rep8, 4428-4428. PubMed  Europe PubMed DOI  M
  25. Victor,K.G., Heffron,D.S., Sokolowski,J.D., Majumder,U., LeBlanc,A. and Mandell,J.W.
    Proteomic identification of synaptic caspase substrates
    Synapse72, PubMed  Europe PubMed DOI  P
    26. 2017
  26. Dagbay,K.B., Hill,M.E., Barrett,E. and Hardy,J.A.
    Tumor-associated mutations in caspase-6 negatively impact catalytic efficiency
    Biochemistry56, 4568-4577. PubMed  Europe PubMed DOI  M
  27. Dagbay,K.B., Bolik-Coulon,N., Savinov,S.N. and Hardy,J.A.
    Caspase-6 undergoes a distinct helix-strand interconversion upon substrate binding
    J Biol Chem292, 4885-4897. PubMed  Europe PubMed DOI
  28. Pakavathkumar,P., Noel,A., Lecrux,C., Tubeleviciute-Aydin,A., Hamel,E., Ahlfors,J.E. and LeBlanc,A.C.
    Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in caspase-6-overexpressing mice
    Mol Neurodegener12, 22-22. PubMed  Europe PubMed DOI  I
  29. Skotte,N.H., Sanders,S.S., Singaraja,R.R., Ehrnhoefer,D.E., Vaid,K., Qiu,X., Kannan,S., Verma,C. and Hayden,M.R.
    Palmitoylation of caspase-6 by HIP14 regulates its activation
    Cell Death Differ24, 433-444. PubMed  Europe PubMed DOI
  30. Suita,H., Shinomiya,T. and Nagahara,Y.
    Caspase-6 induces 7A6 antigen localization to mitochondria during FAS-induced apoptosis of Jurkat cells
    Anticancer Res37, 1697-1704. PubMed  Europe PubMed DOI  I
  31. Woo,V., Cheng,C., Duraikannu,A., Chandrasekhar,A., Purdy,K., Martinez,J.A. and Zochodne,D.W.
    Caspase-6 is a dispensable enabler of adult mammalian axonal degeneration
    Neuroscience371, 242-253. PubMed  Europe PubMed DOI
    32. 2016
  32. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A113, E2001-E2010. PubMed  Europe PubMed DOI  P
    33. 2015
  33. Aharony,I., Ehrnhoefer,D.E., Shruster,A., Qiu,X., Franciosi,S., Hayden,M.R. and Offen,D.
    A huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits
    Hum Mol Genet24, 2604-2614. PubMed  Europe PubMed DOI  I
  34. Wang,X.J., Cao,Q., Zhang,Y. and Su,X.D.
    Activation and regulation of caspase-6 and its role in neurodegenerative diseases
    Annu Rev Pharmacol Toxicol55, 553-572. PubMed  Europe PubMed DOI
    35. 2014
  35. Berta,T., Park,C.K., Xu,Z.Z., Xie,R.G., Liu,T., Lu,N., Liu,Y.C. and Ji,R.R.
    Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion
    J Clin Invest124, 1173-1186. PubMed  Europe PubMed DOI
  36. Flygare,J.A. and Arkin,M.R.
    Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases
    Curr Top Med Chem14, 319-325. PubMed  Europe PubMed DOI  I
  37. Lee,P.Y., Cho,J.H., Chi,S.W., Bae,K.-H., Cho,S., Park,B.C., Kim,J.-H. and Park,S.G.
    Expression of the pro-domain-deleted active form of caspase-6 in Escherichia coli
    J Microbiol Biotechnol24, 719-723. PubMed  Europe PubMed DOI  E
  38. Murray,J., Giannetti,A.M., Steffek,M., Gibbons,P., Hearn,B.R., Cohen,F., Tam,C., Pozniak,C., Bravo,B., Lewcock,J., Jaishankar,P., Ly,C.Q., Zhao,X., Tang,Y., Chugha,P., Arkin,M.R., Flygare,J. and Renslo,A.R.
    Tailoring small molecules for an allosteric site on procaspase-6
    ChemMedChem9, 73-77. PubMed  Europe PubMed DOI  I
    39. 2013
  39. Chen,M.H., Hagemann,T.L., Quinlan,R.A., Messing,A. and Perng,M.D.
    Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation
    ASN Neuro5, e00125-e00125. PubMed  Europe PubMed DOI  P
  40. Cho,J.H., Lee,P.Y., Son,W.-C., Chi,S.-W., Park,B.C., Kim,J.-H. and Park,S.G.
    Identification of the novel substrates for caspase-6 in apoptosis using proteomic approaches
    BMB Rep46, 588-593. PubMed  Europe PubMed DOI  P
  41. LeBlanc,A.C.
    Caspase-6 as a novel early target in the treatment of Alzheimer's disease
    Eur J Neurosci37, 2005-2018. PubMed  Europe PubMed DOI  T
  42. Murray,J. and Renslo,A.R.
    Modulating caspase activity: beyond the active site
    Curr Opin Struct Biol23, 812-819. PubMed  Europe PubMed DOI  I
  43. van Raam,B.J., Ehrnhoefer,D.E., Hayden,M.R. and Salvesen,G.S.
    Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6
    Cell Death Differ20, 86-96. PubMed  Europe PubMed DOI
    44. 2012
  44. Cao,Q., Wang,X.J., Liu,C.W., Liu,D.F., Li,L.F., Gao,Y.Q. and Su,X.D.
    Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays
    J Biol Chem287, 15371-15379. PubMed  Europe PubMed DOI  S
  45. Gafni,J., Papanikolaou,T., DeGiacomo,F., Holcomb,J., Chen,S., Menalled,L., Kudwa,A., Fitzpatrick,J., Miller,S., Ramboz,S., Tuunanen,P.I., Lehtimaki,K.K., Yang,X.W., Park,L., Kwak,S., Howland,D., Park,H. and Ellerby,L.M.
    Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment
    J Neurosci32, 7454-7465. PubMed  Europe PubMed DOI
  46. Heise,C.E., Murray,J., Augustyn,K.E., Bravo,B., Chugha,P., Cohen,F., Giannetti,A.M., Gibbons,P., Hannoush,R.N., Hearn,B.R., Jaishankar,P., Ly,C.Q., Shah,K., Stanger,K., Steffek,M., Tang,Y., Zhao,X., Lewcock,J.W., Renslo,A.R., Flygare,J. and Arkin,M.R.
    Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6
    PLoS ONE7, e50864-e50864. PubMed  Europe PubMed DOI  S  I
  47. Mintzer,R., Ramaswamy,S., Shah,K., Hannoush,R.N., Pozniak,C.D., Cohen,F., Zhao,X., Plise,E., Lewcock,J.W. and Heise,C.E.
    A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C
    PLoS ONE7, e30376-e30376. PubMed  Europe PubMed DOI
  48. Morse,R.J. and Renatus,M.
    Caspase-6
    [ISSN:978-0-12-407743-0]3, 2270-2274. DOI
  49. Renatus,M. and Farady,C.J.
    Phosphorylation meets proteolysis
    Structure20, 570-571. PubMed  Europe PubMed DOI
  50. Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
    Human caspases in vitro: expression, purification and kinetic characterization
    Protein Expr Purif84, 236-246. PubMed  Europe PubMed DOI  E
  51. Stanger,K., Steffek,M., Zhou,L., Pozniak,C.D., Quan,C., Franke,Y., Tom,J., Tam,C., Krylova,I., Elliott,J.M., Lewcock,J.W., Zhang,Y., Murray,J. and Hannoush,R.N.
    Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
    Nat Chem Biol8, 655-660. PubMed  Europe PubMed DOI  I
  52. Velazquez-Delgado,E.M. and Hardy,J.A.
    Phosphorylation regulates assembly of the caspase-6 substrate-binding groove
    Structure20, 742-751. PubMed  Europe PubMed DOI
  53. Velazquez-Delgado,E.M. and Hardy,J.A.
    Zinc-mediated allosteric inhibition of caspase-6
    J Biol Chem287, 36000-36011. PubMed  Europe PubMed DOI
    54. 2011
  54. Ehrnhoefer,D.E., Skotte,N.H., Savill,J., Nguyen,Y.T., Ladha,S., Cao,L.P., Dullaghan,E. and Hayden,M.R.
    A quantitative method for the specific assessment of caspase-6 activity in cell culture
    PLoS ONE6, e27680-e27680. PubMed  Europe PubMed DOI  A
  55. Graham,R.K., Ehrnhoefer,D.E. and Hayden,M.R.
    Caspase-6 and neurodegeneration
    Trends Neurosci34, 646-656. PubMed  Europe PubMed DOI
  56. Kobayashi,H., Nolan,A., Naveed,B., Hoshino,Y., Segal,L.N., Fujita,Y., Rom,W.N. and Weiden,M.D.
    Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M
    J Immunol186, 403-410. PubMed  Europe PubMed DOI
  57. Muller,I., Lamers,M.B., Ritchie,A.J., Dominguez,C., Munoz-Sanjuan,I. and Kiselyov,A.
    Structure of human caspase-6 in complex with Z-VAD-FMK: new peptide binding mode observed for the non-canonical caspase conformation
    Bioorg Med Chem Lett21, 5244-5247. PubMed  Europe PubMed DOI  I
  58. Muller,I., Lamers,M.B., Ritchie,A.J., Park,H., Dominguez,C., Munoz-Sanjuan,I., Maillard,M. and Kiselyov,A.
    A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme
    J Mol Biol410, 307-315. PubMed  Europe PubMed DOI  S
  59. Soares,J., Lowe,M.M. and Jarstfer,M.B.
    The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate
    Biochemistry50, 9046-9055. PubMed  Europe PubMed DOI  P
  60. Vaidya,S. and Hardy,J.A.
    Caspase-6 latent state stability relies on helical propensity
    Biochemistry50, 3282-3287. PubMed  Europe PubMed DOI
  61. Vaidya,S., Velazquez-Delgado,E.M., Abbruzzese,G. and Hardy,J.A.
    Substrate-induced conformational changes occur in all cleaved forms of caspase-6
    J Mol Biol406, 75-91. PubMed  Europe PubMed DOI
    62. 2010
  62. Arnault,E., Doussau,M., Pesty,A., Lefevre,B. and Courtot,A.M.
    Review: lamin a/c, caspase-6, and chromatin configuration during meiosis resumption in the mouse oocyte
    Reprod Sci17, 102-115. PubMed  Europe PubMed DOI
  63. Giaime,E., Sunyach,C., Druon,C., Scarzello,S., Robert,G., Grosso,S., Auberger,P., Goldberg,M.S., Shen,J., Heutink,P., Pouyssegur,J., Pages,G., Checler,F. and Alves da Costa,C.
    Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6
    Cell Death Differ17, 158-169. PubMed  Europe PubMed DOI
  64. Halawani,D., Tessier,S., Anzellotti,D., Bennett,D.A., Latterich,M. and LeBlanc,A.C.
    Identification of caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation
    J Neurosci30, 6132-6142. PubMed  Europe PubMed DOI
  65. Lee,A.W., Champagne,N., Wang,X., Su,X.D., Goodyer,C. and LeBlanc,A.C.
    Alternatively spliced caspase-6b isoform inhibits the activation of caspase-6a
    J Biol Chem285, 31974-31984. PubMed  Europe PubMed DOI  R
  66. Leong,S.M., Tan,B.X., Bte Ahmad,B., Yan,T., Chee,L.Y., Ang,S.T., Tay,K.G., Koh,L.P., Yeoh,A.E., Koay,E.S., Mok,Y.K. and Lim,T.M.
    Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition
    Blood116, 3286-3296. PubMed  Europe PubMed DOI
  67. Wang,X.J., Cao,Q., Liu,X., Wang,K.T., Mi,W., Zhang,Y., Li,L.F., LeBlanc,A.C. and Su,X.D.
    Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation
    EMBO Rep11, 841-847. PubMed  Europe PubMed DOI  S
    68. 2009
  68. Baumgartner,R., Meder,G., Briand,C., Decock,A., D'arcy,A., Hassiepen,U., Morse,R. and Renatus,M.
    The crystal structure of caspase-6, a selective effector of axonal degeneration
    Biochem J423, 429-439. PubMed  Europe PubMed DOI  S
  69. Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V.
    Evaluation of recombinant caspase specificity by competitive substrates
    Anal Biochem394, 68-74. PubMed  Europe PubMed DOI  A  P
  70. Chan,Y.W., Chen,Y. and Poon,R.Y.
    Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe
    Oncogene28, 170-183. PubMed  Europe PubMed DOI  P
  71. Chu,W., Rothfuss,J., Chu,Y., Zhou,D. and Mach,R.H.
    Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6
    J Med Chem52, 2188-2191. PubMed  Europe PubMed DOI  I
  72. Wolan,D.W., Zorn,J.A., Gray,D.C. and Wells,J.A.
    Small-molecule activators of a proenzyme
    Science326, 853-858. PubMed  Europe PubMed DOI
    73. 2008
  73. Fu,G., Chumanevich,A.A., Agniswamy,J., Fang,B., Harrison,R.W. and Weber,I.T.
    Structural basis for executioner caspase recognition of P5 position in substrates
    Apoptosis13, 1291-1302. PubMed  Europe PubMed DOI  P
  74. Klaiman,G., Petzke,T.L., Hammond,J. and LeBlanc,A.C.
    Targets of caspase-6 activity in human neurons and Alzheimer disease
    Mol Cell Proteomics7, 1541-1555. PubMed  Europe PubMed DOI
  75. McStay,G.P., Salvesen,G.S. and Green,D.R.
    Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways
    Cell Death Differ15, 322-331. PubMed  Europe PubMed DOI  P
  76. Pereira,N.A. and Song,Z.
    Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
    Biochem Biophys Res Commun377, 873-877. PubMed  Europe PubMed DOI  P  I
  77. Watanabe,C., Shu,G.L., Zheng,T.S., Flavell,R.A. and Clark,E.A.
    Caspase 6 regulates B cell activation and differentiation into plasma cells
    J Immunol181, 6810-6819. PubMed  Europe PubMed
    78. 2007
  78. Albrecht,S., Bourdeau,M., Bennett,D., Mufson,E.J., Bhattacharjee,M. and LeBlanc,A.C.
    Activation of caspase-6 in aging and mild cognitive impairment
    Am J Pathol170, 1200-1209. PubMed  Europe PubMed DOI
  79. Garner,E., Martinon,F., Tschopp,J., Beard,P. and Raj,K.
    Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6
    Cancer Res67, 7631-7637. PubMed  Europe PubMed DOI
    80. 2006
  80. [YEAR:21-9-2006]Ekici,O.D., Li,Z.Z., Campbell,A.J., James,K.E., Asgian,J.L., Mikolajczyk,J., Salvesen,G.S., Ganesan,R., Jelakovic,S., Grutter,M.G. and Powers,J.C.
    Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10
    J Med Chem49, 5728-5749. PubMed  Europe PubMed DOI  I
  81. [YEAR:16-6-2006]Graham,R.K., Deng,Y., Slow,E.J., Haigh,B., Bissada,N., Lu,G., Pearson,J., Shehadeh,J., Bertram,L., Murphy,Z., Warby,S.C., Doty,C.N., Roy,S., Wellington,C.L., Leavitt,B.R., Raymond,L.A., Nicholson,D.W. and Hayden,M.R.
    Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
    Cell125, 1179-1191. PubMed  Europe PubMed DOI  P
  82. [YEAR:18-11-2006]Loegering,D.A., Ruchaud,S., Earnshaw,W.C. and Kaufmann,S.H.
    Evaluation of the role of caspase-6 in anticancer drug-induced apoptosis
    Cell Death Differ13, 346-347. PubMed  Europe PubMed DOI
  83. [YEAR:8-5-2006]Wu,X., Simone,J., Hewgill,D., Siegel,R., Lipsky,P.E. and He,L.
    Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe
    Cytometry A69, 477-486. PubMed  Europe PubMed DOI  I
    84. 2005
  84. Kalinin,A.E., Kalinin,A.E., Aho,M., Uitto,J. and Aho,S.
    Breaking the connection: caspase 6 disconnects intermediate filament-binding domain of periplakin from its actin-binding N-terminal region
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