$VAR1 = undef;

Summary for peptidase C14.004: caspase-7

Names
MEROPS Name	caspase-7
Other names	caspase 7, ICE-LAP3, Mch3, CMH-1

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.004
Holotype	caspase-7 (Homo sapiens), Uniprot accession P55210 (peptidase unit: 62-336), MERNUM MER0002705
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00101
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.60
Enzymology	BRENDA database
Proteolytic events	CutDB database (53 cleavages)
Activity status	human: active (Nicholson & Thornberry, 2004) mouse: active (by similarity) (Lee et al., 2001)
Physiology	One of the "executioner" caspases in mammalian cell apoptosis.
Pharmaceutical relevance	A non-peptidic inhibitor of caspase-3 and caspase-7 was effective in reducing cardiac ischemic injury in a rabbit model (Chapman et al., 2002).
Pathways	KEGG	Alzheimer's disease
	KEGG	Apoptosis
	KEGG	Legionellosis
	KEGG	Non-alcoholic fatty liver disease (NAFLD)
	KEGG	Pertussis
	KEGG	TNF signaling pathway
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Caspase_7
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	d/-/-/Dg/-/-/- (based on 502 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	20	14	22	2	200	48	39	28
Pro	20	4	63	1	3	36	30	30
Ala	37	42	27	3	56	45	39	47
Val	27	38	96	3	14	30	53	35
Leu	13	42	68	1	42	40	51	41
Ile	9	15	26	0	7	18	18	43
Met	15	9	14	0	6	5	12	6
Phe	12	13	13	0	22	17	10	14
Tyr	4	7	9	2	15	9	12	10
Trp	3	5	6	0	3	3	3	5
Ser	46	43	16	3	56	47	38	35
Thr	28	22	56	0	10	24	21	34
Cys	5	7	6	1	4	0	5	11
Asn	5	14	3	6	19	20	11	9
Gln	11	28	12	1	1	29	18	23
Asp	140	37	4	448	11	18	23	24
Glu	68	119	9	27	7	34	37	41
Lys	9	20	21	2	6	53	47	32
Arg	4	11	26	2	9	16	25	23
His	9	4	2	0	9	8	8	9

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Homo sapiens	recombinant	D	-	-	D	G	-	-	-	DxxDGxxx	Abz-Tyr(NO2)	Stennicke et al., 2000
Homo sapiens	recombinant	D	E/V	V/I	D	-	-	-	-	DEVD	AMC	Thornberry et al., 1997