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Literature for peptidase C14.004: caspase-7

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Vidak,E., Vizovisek,M., Kavcic,N., Biasizzo,M., Fonovic,M. and Turk,B.
    Apoptotic Caspases-3 and -7 Cleave Extracellular Domains of Membrane-Bound Proteins from MDA-MB-231 Breast Cancer Cells
    Int J Mol Sci26, PubMed  Europe PubMed DOI
    2. 2024
  2. Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
    The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
    Mol Cell84, 170-179. PubMed  Europe PubMed DOI  V
  3. Bertani,F.R., Moghaddam,F.D., Panella,C., Giannitelli,S.M., Peluzzi,V., Gerardino,A., Rainer,A., Roscilli,G., De Ninno,A. and Businaro,L.
    Kinetic Detection of Apoptosis Events Via Caspase 3/7 Activation in a Tumor-Immune Microenvironment on a Chip
    Methods Mol Biol2748, 109-118. PubMed  Europe PubMed DOI
  4. Ge,J., Wang,Y., Li,X., Lu,Q., Yu,H., Liu,H., Ma,K., Deng,X., Luo,Z.Q., Liu,X. and Qiu,J.
    Phosphorylation of caspases by a bacterial kinase inhibits host programmed cell death
    Nat Commun15, 8464-8464. PubMed  Europe PubMed DOI
  5. Purnamasari,Y., Hermawati,E., Mujahidin,D., Happyana,N. and Syah,Y.M.
    Xanthorrhizol derivatives and their biological properties as caspase-7 inhibitors
    Nat Prod Res1-9. PubMed  Europe PubMed DOI
  6. Xu,H., Yuan,Z., Qin,K., Jiang,S. and Sun,L.
    The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation
    elife12, PubMed  Europe PubMed DOI
    7. 2023
  7. Hobbs,K.F., Propp,J., Vance,N.R., Kalenkiewicz,A., Witkin,K.R. and Ashley Spies,M.
    Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power
    Chemistry29, e202300872-e202300872. PubMed  Europe PubMed DOI
  8. Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
    A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
    Mol Neurobiol60, 5805-5837. PubMed  Europe PubMed DOI  V
    9. 2022
  9. Ghazavi,F., Huysentruyt,J., De Coninck,J., Kourula,S., Martens,S., Hassannia,B., Wartewig,T., Divert,T., Roelandt,R., Popper,B., Hiergeist,A., Tougaard,P., Vanden Berghe,T., Joossens,M., Berx,G., Takahashi,N., Wahida,A. and Vandenabeele,P.
    Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state
    Proc Natl Acad Sci U S A119, PubMed  Europe PubMed DOI
  10. Nozaki,K., Maltez,V.I., Rayamajhi,M., Tubbs,A.L., Mitchell,J.E., Lacey,C.A., Harvest,C.K., Li,L., Nash,W.T., Larson,H.N., McGlaughon,B.D., Moorman,N.J., Brown,M.G., Whitmire,J.K. and Miao,E.A.
    Caspase-7 activates ASM to repair gasdermin and perforin pores
    Nature606, 960-967. PubMed  Europe PubMed DOI
  11. Roychowdhury,H. and Romero,P.A.
    Microfluidic deep mutational scanning of the human executioner caspases reveals differences in structure and regulation
    Cell Death Discov8, 7-7. PubMed  Europe PubMed DOI
    12. 2021
  12. Davies,C.W., Stowe,I., Phung,Q.T., Ho,H., Bakalarski,C.E., Gupta,A., Zhang,Y., Lill,J.R., Payandeh,J., Kayagaki,N. and Koerber,J.T.
    Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
  13. Desroches,A. and Denault,J.B.
    Characterization of caspase-7 interaction with RNA
    Biochem J478, 2681-2696. PubMed  Europe PubMed DOI
  14. Maluch,I., Grzymska,J., Snipas,S.J., Salvesen,G.S. and Drag,M.
    Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7
    Biochem J478, 2233-2245. PubMed  Europe PubMed DOI
  15. Ozdemir,A., Ibisoglu,B., Simay Demir,Y.D., Benhur,E., Valipour,F. and Ark,M.
    A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2
    Biochem Biophys Res Commun547, 118-124. PubMed  Europe PubMed DOI
    16. 2020
  16. Chen,X., Chen,D., Huang,L., Chen,X., Zhou,M., Xi,X., Ma,C., Chen,T. and Wang,L.
    Identification and Target-Modification of SL-BBI: A Novel Bowman-Birk Type Trypsin Inhibitor from Sylvirana latouchii
    Biomolecules10, PubMed  Europe PubMed DOI
  17. de Vasconcelos,N.M., Van Opdenbosch,N., Van Gorp,H., Martin-Perez,R., Zecchin,A., Vandenabeele,P. and Lamkanfi,M.
    An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
    Cell Rep32, 107959-107959. PubMed  Europe PubMed DOI
  18. Firoozpour,L., Gao,L., Moghimi,S., Pasalar,P., Davoodi,J., Wang,M.W., Rezaei,Z., Dadgar,A., Yahyavi,H., Amanlou,M. and Foroumadi,A.
    Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors
    J Enzyme Inhib Med Chem35, 1674-1684. PubMed  Europe PubMed DOI  I
  19. Garcia-Arguello,S.F., Lopez-Lorenzo,B., Cornelissen,B. and Smith,G.
    Development of [(18)F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
    Cancers (Basel)12, PubMed  Europe PubMed DOI  V
  20. Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.
    Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets
    Genomics PubMed  Europe PubMed DOI
  21. McKenzie,B.A., Fernandes,J.P., Doan,M.A.L., Schmitt,L.M., Branton,W.G. and Power,C.
    Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis
    J Neuroinflammation17, 253-253. PubMed  Europe PubMed DOI  K
  22. Nerlich,A., von Wunsch Teruel,I., Mieth,M., Honzke,K., Ruckert,J.C., Mitchell,T.J., Suttorp,N., Hippenstiel,S. and Hocke,A.C.
    Reversion of pneumolysin induced executioner caspase activation redirects cells to survival
    J Infect Dis PubMed  Europe PubMed DOI
  23. Razai,A.S., Snipas,S.J., Poreba,M., Fasci,D. and Salvesen,G.S.
    Engineering caspase 7 as an affinity reagent to capture proteolytic products
    FEBS J PubMed  Europe PubMed DOI
  24. Taki,K., Horie,T., Kida,T., Mimura,M., Ikeda,T. and Oku,H.
    Impairment of Autophagy Causes Superoxide Formation and Caspase Activation in 661 W Cells, a Cell Line for Cone Photoreceptors, under Hyperglycemic Conditions
    Int J Mol Sci21, PubMed  Europe PubMed DOI
    25. 2019
  25. Bingol,E.N., Sercinoglu,O. and Ozbek,P.
    How do mutations and allosteric inhibitors modulate caspase-7 activity? A molecular dynamics study
    J Biomol Struct Dyn37, 3456-3466. PubMed  Europe PubMed DOI
  26. Pham,B., Eron,S.J., Hill,M.E., Li,X., Fahie,M.A., Hardy,J.A. and Chen,M.
    A nanopore approach for analysis of caspase-7 activity in cell lysates
    Biophys J117, 844-855. PubMed  Europe PubMed DOI  A
    27. 2018
  27. Akazawa,K., Sugihara,F., Nakamura,T., Mizukami,S. and Kikuchi,K.
    Highly sensitive detection of caspase-3/7 activity in living mice using enzyme-responsive (19)F MRI nanoprobes
    Bioconjug Chem29, 1720-1728. PubMed  Europe PubMed DOI  L
  28. Bi,X., Liu,X., Bi,D. and Sun,Y.
    Identification of caspase-6 and caspase-7 from miiuy croaker and evolution analysis in fish
    Fish Shellfish Immunol83, 406-409. PubMed  Europe PubMed DOI
  29. Pal,A. and Rehemtulla,A.
    Imaging proteolytic activities in mouse models of cancer
    1731, 247-260. PubMed  Europe PubMed DOI  L
    30. 2017
  30. Martini,C., Bedard,M., Lavigne,P. and Denault,J.B.
    Characterization of Hsp90 co-chaperone p23 cleavage by caspase-7 uncovers a peptidase-substrate interaction involving intrinsically disordered regions
    Biochemistry56, 5099-5111. PubMed  Europe PubMed DOI
  31. Vance,N.R., Gakhar,L. and Spies,M.A.
    Allosteric tuning of caspase-7: a fragment-based drug discovery approach
    Angew Chem Int Ed Engl56, 14443-14447. PubMed  Europe PubMed DOI  I
    32. 2016
  32. Baek,H.J., Lee,Y.M., Kim,T.H., Kim,J.Y., Park,E.J., Iwabuchi,K., Mishra,L. and Kim,S.S.
    Caspase-3/7-mediated cleavage of beta2-spectrin is required for acetaminophen-induced liver damage
    Int J Biol Sci12, 172-183. PubMed  Europe PubMed DOI
  33. Hill,M.E., MacPherson,D.J., Wu,P., Julien,O., Wells,J.A. and Hardy,J.A.
    Reprogramming caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition
    ACS Chem Biol11, 1603-1612. PubMed  Europe PubMed DOI
  34. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A113, E2001-E2010. PubMed  Europe PubMed DOI  P
  35. Seaman,J.E., Julien,O., Lee,P.S., Rettenmaier,T.J., Thomsen,N.D. and Wells,J.A.
    Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues
    Cell Death Differ23, 1717-1726. PubMed  Europe PubMed DOI  P
    36. 2015
  36. Guyenet,S.J., Mookerjee,S.S., Lin,A., Custer,S.K., Chen,S.F., Sopher,B.L., La Spada,A.R. and Ellerby,L.M.
    Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction
    Hum Mol Genet24, 3908-3917. PubMed  Europe PubMed DOI  T
  37. Limpachayaporn,P., Schafers,M. and Haufe,G.
    Isatin sulfonamides: potent caspases-3 and -7 inhibitors, and promising PET and SPECT radiotracers for apoptosis imaging
    Future Med Chem7, 1173-1196. PubMed  Europe PubMed DOI  L  I
  38. Udemba,A., Smith,G., Nguyen,Q.D., Kaliszczak,M., Carroll,L., Fortt,R., Fuchter,M.J. and Aboagye,E.O.
    Design, synthesis and initial characterisation of a radiolabelled [(18)F]pyrimidoindolone probe for detecting activated caspase-3/7
    Org Biomol Chem13, 5418-5423. PubMed  Europe PubMed DOI  L
  39. Waldmann,C.M., Hermann,S., Faust,A., Riemann,B., Schober,O., Schafers,M., Haufe,G. and Kopka,K.
    Novel fluorine-18 labeled 5-(1-pyrrolidinylsulfonyl)-7-azaisatin derivatives as potential PET tracers for in vivo imaging of activated caspases in apoptosis
    Bioorg Med Chem23, 5734-5739. PubMed  Europe PubMed DOI  L
  40. Yuan,Y., Sun,H., Ge,S., Wang,M., Zhao,H., Wang,L., An,L., Zhang,J., Zhang,H., Hu,B., Wang,J. and Liang,G.
    Controlled intracellular self-assembly and disassembly of 19F nanoparticles for MR imaging of caspase 3/7 in zebrafish
    ACS Nano9, 761-768. PubMed  Europe PubMed DOI  L
    41. 2014
  41. Adamova,E., Liskova,M., Matalova,E. and Kleparnik,K.
    A miniaturized device for bioluminescence analysis of caspase-3/7 activity in a single apoptotic cell
    Anal Bioanal Chem406, 5389-5394. PubMed  Europe PubMed DOI  L
  42. Flutsch,A., Ackermann,R., Schroeder,T., Lukarska,M., Hausammann,G.J., Weinert,C., Briand,C. and Grutter,M.G.
    Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise
    Biochem J461, 279-290. PubMed  Europe PubMed DOI
  43. Fuchs,J.E., von Grafenstein,S., Huber,R.G., Wallnoefer,H.G. and Liedl,K.R.
    Specificity of a protein-protein interface: local dynamics direct substrate recognition of effector caspases
    Proteins82, 546-555. PubMed  Europe PubMed DOI  P
  44. Li,Z., Pan,Y., Zhong,W., Zhu,Y., Zhao,Y., Li,L., Liu,W., Zhou,H. and Yang,C.
    Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors
    Bioorg Med Chem22, 6735-6745. PubMed  Europe PubMed DOI  I
  45. Ye,D., Shuhendler,A.J., Pandit,P., Brewer,K.D., Tee,S.S., Cui,L., Tikhomirov,G., Rutt,B. and Rao,J.
    Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis
    Chem Sci4, 3845-3852. PubMed  Europe PubMed DOI  L
    46. 2013
  46. Brentnall,M., Rodriguez-Menocal,L., De Guevara,R.L., Cepero,E. and Boise,L.H.
    Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
    BMC Cell Biol14, 32-32. PubMed  Europe PubMed DOI
  47. Choudhury,S., Bhootada,Y., Gorbatyuk,O. and Gorbatyuk,M.
    Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration
    Cell Death Dis4, e528-e528. PubMed  Europe PubMed DOI  K
  48. Galban,S., Jeon,Y.H., Bowman,B.M., Stevenson,J., Sebolt,K.A., Sharkey,L.M., Lafferty,M., Hoff,B.A., Butler,B.L., Wigdal,S.S., Binkowski,B.F., Otto,P., Zimmerman,K., Vidugiris,G., Encell,L.P., Fan,F., Wood,K.V., Galban,C.J., Ross,B.D. and Rehemtulla,A.
    Imaging proteolytic activity in live cells and animal models
    PLoS ONE8, e66248-e66248. PubMed  Europe PubMed DOI  L
  49. Guicciardi,M.E. and Gores,G.J.
    Unshackling caspase-7 for cancer therapy
    J Clin Invest123, 3706-3708. PubMed  Europe PubMed DOI
  50. Kang,H.J., Lee,Y.M., Bae,K.H., Kim,S.J. and Chung,S.J.
    Structural asymmetry of procaspase-7 bound to a specific inhibitor
    Acta Crystallogr Sect D Biol Crystallogr69, 1514-1521. PubMed  Europe PubMed DOI  S  I
  51. Krause-Heuer,A.M., Howell,N.R., Matesic,L., Dhand,G., Young,E.L., Burgess,L., Jiang,C.D., Lengkeek,N.A., Fookes,C.J.R., Pham,T.Q., Sobrio,F., Greguric,I. and Fraser,B.H.
    A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis
    MedChemComm4, 347-352. DOI  L  I
  52. Limpachayaporn,P., Riemann,B., Kopka,K., Schober,O., Schafers,M. and Haufe,G.
    Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7
    Eur J Med Chem64, 562-578. PubMed  Europe PubMed DOI  I
  53. Limpachayaporn,P., Schafers,M., Schober,O., Kopka,K. and Haufe,G.
    Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents
    Bioorg Med Chem21, 2025-2036. PubMed  Europe PubMed DOI  I
  54. Lin,Y.F., Lai,T.C., Chang,C.K., Chen,C.L., Huang,M.S., Yang,C.J., Liu,H.G., Dong,J.J., Chou,Y.A., Teng,K.H., Chen,S.H., Tian,W.T., Jan,Y.H., Hsiao,M. and Liang,P.H.
    Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies
    J Clin Invest123, 3861-3875. PubMed  Europe PubMed DOI
  55. Thomsen,N.D., Koerber,J.T. and Wells,J.A.
    Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
    Proc Natl Acad Sci U S A110, 8477-8482. PubMed  Europe PubMed DOI  S
    56. 2012
  56. Cassidy,S.K., Hagar,J.A., Kanneganti,T.D., Franchi,L., Nunez,G. and O'Riordan,M.X.
    Membrane Damage during Listeria monocytogenes Infection Triggers a Caspase-7 Dependent Cytoprotective Response
    PLoS Pathog8, e1002628-e1002628. PubMed  Europe PubMed DOI
  57. Feldman,T., Kabaleeswaran,V., Jang,S.B., Antczak,C., Djaballah,H., Wu,H. and Jiang,X.
    A class of allosteric caspase inhibitors identified by high-throughput screening
    Mol Cell47, 585-595. PubMed  Europe PubMed DOI  I
  58. Kang,H.J., Lee,Y.M., Jeong,M.S., Kim,M., Bae,K.H., Kim,S.J. and Chung,S.J.
    Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7
    Biosci Rep32, 305-313. PubMed  Europe PubMed DOI
  59. Nguyen,Q.D., Challapalli,A., Smith,G., Fortt,R. and Aboagye,E.O.
    Imaging apoptosis with positron emission tomography: 'Bench to bedside' development of the caspase-3/7 specific radiotracer [(18)F]ICMT-11
    Eur J Cancer48, 432-440. PubMed  Europe PubMed DOI  L
  60. Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
    Human caspases in vitro: expression, purification and kinetic characterization
    Protein Expr Purif84, 236-246. PubMed  Europe PubMed DOI  E
  61. Vanden Berghe,T., Kersse,K. and Vandenabeele,P.
    Caspase-3 and caspase-7
    [ISSN:978-0-12-407743-0]3, 2256-2265. DOI
    62. 2011
  62. Boucher,D., Blais,V., Drag,M. and Denault,J.B.
    Molecular determinants involved in activation of caspase 7
    Biosci Rep31, 283-294. PubMed  Europe PubMed DOI
  63. Burguillos,M.A., Deierborg,T., Kavanagh,E., Persson,A., Hajji,N., Garcia-Quintanilla,A., Cano,J., Brundin,P., Englund,E., Venero,J.L. and Joseph,B.
    Caspase signalling controls microglia activation and neurotoxicity
    Nature472, 319-324. PubMed  Europe PubMed DOI
  64. Edelmann,B., Bertsch,U., Tchikov,V., Winoto-Morbach,S., Perrotta,C., Jakob,M., Adam-Klages,S., Kabelitz,D. and Schutze,S.
    Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes
    EMBO J30, 379-394. PubMed  Europe PubMed DOI  P
  65. Scabini,M., Stellari,F., Cappella,P., Rizzitano,S., Texido,G. and Pesenti,E.
    In vivo imaging of early stage apoptosis by measuring real-time caspase-3/7 activation
    Apoptosis16, 198-207. PubMed  Europe PubMed DOI  L
  66. Soares,J., Lowe,M.M. and Jarstfer,M.B.
    The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate
    Biochemistry50, 9046-9055. PubMed  Europe PubMed DOI  P
  67. Witkowski,W.A. and Hardy,J.A.
    A designed redox-controlled caspase
    Protein Sci20, 1421-1431. PubMed  Europe PubMed DOI
    68. 2010
  68. Gray,D.C., Mahrus,S. and Wells,J.A.
    Activation of specific apoptotic caspases with an engineered small-molecule-activated protease
    Cell142, 637-646. PubMed  Europe PubMed DOI
  69. Lamkanfi,M. and Kanneganti,T.D.
    Caspase-7: a protease involved in apoptosis and inflammation
    Int J Biochem Cell Biol42, 21-24. PubMed  Europe PubMed DOI  T
  70. Lee,Y.M., Kang,H.J., Jang,M., Kim,M., Bae,K.H. and Chung,S.J.
    Large-scale expression in Escherichia coli and efficient purification of precursor and active caspase-7 by introduction of thrombin cleavage sites
    Protein Expr Purif69, 29-33. PubMed  Europe PubMed DOI  E
  71. Miscione,G.P., Calvaresi,M. and Bottoni,A.
    Computational evidence for the catalytic mechanism of caspase-7. A DFT investigation
    J Phys Chem B114, 4637-4645. PubMed  Europe PubMed DOI
    72. 2009
  72. Agniswamy,J., Fang,B. and Weber,I.T.
    Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7
    Apoptosis14, 1135-1144. PubMed  Europe PubMed DOI  S
  73. Akhter,A., Gavrilin,M.A., Frantz,L., Washington,S., Ditty,C., Limoli,D., Day,C., Sarkar,A., Newland,C., Butchar,J., Marsh,C.B., Wewers,M.D., Tridandapani,S., Kanneganti,T.D. and Amer,A.O.
    Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
    PLoS Pathog5, e1000361-e1000361. PubMed  Europe PubMed DOI
  74. Alves,J., Wurdak,H., Garay-Malpartida,H.M., Harris,J.L., Occhiucci,J.M., Belizario,J.E. and Li,J.
    TAF15 and the leukemia-associated fusion protein TAF15-CIZ/NMP4 are cleaved by caspases-3 and -7
    Biochem Biophys Res Commun384, 495-500. PubMed  Europe PubMed DOI  P
  75. Demon,D., Van Damme,P., Vanden Berghe,T., Deceuninck,A., Van Durme,J., Verspurten,J., Helsens,K., Impens,F., Wejda,M., Schymkowitz,J., Rousseau,F., Madder,A., Vandekerckhove,J., Declercq,W., Gevaert,K. and Vandenabeele,P.
    Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity
    Mol Cell Proteomics8, 2700-2714. PubMed  Europe PubMed DOI  P
  76. Gafni,J., Cong,X., Chen,S.F., Gibson,B.W. and Ellerby,L.M.
    Calpain-1 cleaves and activates caspase-7
    J Biol Chem284, 25441-25449. PubMed  Europe PubMed DOI
  77. Hardy,J.A. and Wells,J.A.
    Dissecting an allosteric switch in caspase-7 using chemical and mutational probes
    J Biol Chem284, 26063-26069. PubMed  Europe PubMed DOI
  78. Lee,W.K., Kim,J.S., Kang,H.G., Cha,S.I., Kim,D.S., Hyun,D.S., Kam,S., Kim,C.H., Jung,T.H. and Park,J.Y.
    Polymorphisms in the caspase7 gene and the risk of lung cancer
    Lung Cancer65, 19-24. PubMed  Europe PubMed DOI  M
  79. Podichetty,A.K., Faust,A., Kopka,K., Wagner,S., Schober,O., Schafers,M. and Haufe,G.
    Fluorinated isatin derivatives. Part 1: Synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors
    Bioorg Med Chem17, 2680-2688. PubMed  Europe PubMed DOI  I
  80. Witkowski,W.A. and Hardy,J.A.
    L2' loop is critical for caspase-7 active site formation
    Protein Sci18, 1459-1468. PubMed  Europe PubMed DOI
    81. 2008
  81. Fu,G., Chumanevich,A.A., Agniswamy,J., Fang,B., Harrison,R.W. and Weber,I.T.
    Structural basis for executioner caspase recognition of P5 position in substrates
    Apoptosis13, 1291-1302. PubMed  Europe PubMed DOI  P
  82. Hashimoto,T., Yamauchi,L., Hunter,T., Kikkawa,U. and Kamada,S.
    Possible involvement of caspase-7 in cell cycle progression at mitosis
    Genes Cells13, 609-621. PubMed  Europe PubMed DOI
  83. Jang,M., Park,B.C., Kang,S., Lee,d.H., Cho,S., Lee,S.C., Bae,K.H. and Park,S.G.
    Mining of caspase-7 substrates using a degradomic approach
    Mol Cells26, 152-157. PubMed  Europe PubMed  P
  84. Li,I.T., Pham,E., Chiang,J.J. and Truong,K.
    FRET evidence that an isoform of caspase-7 binds but does not cleave its substrate
    Biochem Biophys Res Commun373, 325-329. PubMed  Europe PubMed DOI
  85. McStay,G.P., Salvesen,G.S. and Green,D.R.
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