$VAR1 = undef;

Summary for peptidase C05.001: adenain

Names
MEROPS Name	adenain
Other names	adenovirus endopeptidase, L3, p23

Domain architecture

MEROPS Classification
Classification	Clan CE >> Subclan (none) >> Family C5 >> Subfamily (none) >> C05.001
Holotype	adenain (human adenovirus type 2), Uniprot accession P03252 (peptidase unit: 1-204), MERNUM MER0000802
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00089
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.39
Enzymology	BRENDA database
Proteolytic events	CutDB database (15 cleavages)
Physiology	Cleaves scaffold and other proteins in adenoviral capsid maturation.
Pharmaceutical relevance	Potential drug target for antiviral therapy.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	lmi/-/G/Ggai/-/-/- (based on 26 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	23	14	11	1	1	1
Pro	1	1	0	1	0	0	2	0
Ala	0	3	0	0	4	1	0	1
Val	2	3	0	0	1	4	1	3
Leu	10	1	0	3	0	3	1	1
Ile	5	0	0	1	3	0	0	0
Met	7	0	0	0	1	0	0	0
Phe	0	1	0	0	1	3	1	2
Tyr	0	0	0	0	0	0	1	0
Trp	0	1	0	0	0	1	0	3
Ser	0	4	3	0	1	1	2	4
Thr	0	1	0	0	0	0	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	1	0	1	1	0	2	0
Gln	1	0	0	0	0	0	3	0
Asp	0	0	0	1	0	0	0	1
Glu	0	1	0	0	0	1	0	1
Lys	0	1	0	0	0	2	3	0
Arg	0	1	0	2	0	3	1	3
His	0	0	0	0	0	0	1	0