Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C05.001: adenain

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2018
  1. Ramirez,Y.A., Adler,T.B., Altmann,E., Klemm,T., Tiesmeyer,C., Sauer,F., Kathman,S.G., Statsyuk,A.V., Sotriffer,C. and Kisker,C.
    Structural basis of substrate recognition and covalent inhibition of Cdu1 from Chlamydia trachomatis
    ChemMedChem13, 2014-2023. PubMed  Europe PubMed DOI  I
    2. 2017
  2. Gaba,A., Ayalew,L., Makadiya,N. and Tikoo,S.
    Proteolytic cleavage of bovine adenovirus-3 encoded pVIII
    J Virol91, e00211-17-e00211-17. PubMed  Europe PubMed DOI
    3. 2015
  3. Grosche,P., Sirockin,F., Mac Sweeney,A., Ramage,P., Erbel,P., Melkko,S., Bernardi,A., Hughes,N., Ellis,D., Combrink,K.D., Jarousse,N. and Altmann,E.
    Structure-based design and optimization of potent inhibitors of the adenoviral protease
    Bioorg Med Chem Lett25, 438-443. PubMed  Europe PubMed DOI  I
  4. Makadiya,N., Gaba,A. and Tikoo,S.K.
    Cleavage of bovine adenovirus type 3 non-structural 100K protein by protease is required for nuclear localization in infected cells but is not essential for virus replication
    J Gen Virol96, 2749-2763. PubMed  Europe PubMed DOI
  5. Moyer,C.L., Besser,E.S. and Nemerow,G.R.
    A single maturation cleavage site in adenovirus impacts cell entry and capsid assembly
    J Virol90, 521-532. PubMed  Europe PubMed DOI
    6. 2014
  6. Mac Sweeney,A., Grosche,P., Ellis,D., Combrink,K., Erbel,P., Hughes,N., Sirockin,F., Melkko,S., Bernardi,A., Ramage,P., Jarousse,N. and Altmann,E.
    Discovery and structure-based optimization of adenain inhibitors
    ACS Med Chem Lett5, 937-941. PubMed  Europe PubMed DOI  S  I
  7. Mangel,W.F. and San Martin,C.
    Structure, function and dynamics in adenovirus maturation
    Viruses6, 4536-4570. PubMed  Europe PubMed DOI
  8. Perez-Berna,A.J., Mangel,W.F., McGrath,W.J., Graziano,V., Flint,J. and San Martin,C.
    Processing of the L1 52/55k protein by the adenovirus protease: a new substrate and new insights into virion maturation
    J Virol88, 1513-1524. PubMed  Europe PubMed DOI  P
    9. 2013
  9. Blainey,P.C., Graziano,V., Perez-Berna,A.J., McGrath,W.J., Flint,S.J., San Martin,C., Xie,X.S. and Mangel,W.F.
    Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates
    J Biol Chem288, 2092-2102. PubMed  Europe PubMed DOI
  10. Graziano,V., McGrath,W.J., Suomalainen,M., Greber,U.F., Freimuth,P., Blainey,P.C., Luo,G., Xie,X.S. and Mangel,W.F.
    Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA and to hexon of the precursor to protein VI, pVI, of human adenovirus
    J Biol Chem288, 2059-2067. PubMed  Europe PubMed DOI
  11. Graziano,V., Luo,G., Blainey,P.C., Perez-Berna,A.J., McGrath,W.J., Flint,S.J., San Martin,C., Xie,X.S. and Mangel,W.F.
    Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction
    J Biol Chem288, 2068-2080. PubMed  Europe PubMed DOI
  12. McGrath,W.J., Graziano,V., Zabrocka,K. and Mangel,W.F.
    First generation inhibitors of the adenovirus proteinase
    FEBS Lett587, 2332-2339. PubMed  Europe PubMed DOI  I
    13. 2012
  13. Weber,J.M.
    Adenain, the adenovirus endopeptidase
    [ISSN:978-0-12-407743-0]3, 2355-2358. DOI
    14. 2007
  14. Mangel,W.F. and McGrath,W.J.
    Cofactors of the adenovirus proteinase: measuring equilibrium dissociation constants and stoichiometries of binding
    Methods Mol Med131, 269-280. PubMed  Europe PubMed
  15. Mangel,W.F. and McGrath,W.J.
    Assay for the adenovirus proteinase: purification of the enzyme and synthesis of a fluorogenic substrate
    Methods Mol Med131, 257-267. PubMed  Europe PubMed  A
  16. Weber,J.M.
    Synthesis and assay of recombinant adenovirus protease
    Methods Mol Med131, 251-255. PubMed  Europe PubMed  A  E
    17. 2005
  17. [YEAR:21-6-2005]Bajpayee,N.S., McGrath,W.J. and Mangel,W.F.
    Interaction of the adenovirus proteinase with protein cofactors with high negative charge densities
    Biochemistry44, 8721-8729. PubMed  Europe PubMed DOI
    18. 2004
  18. [YEAR:9-4-2004]Brown,M.T. and Mangel,W.F.
    Interaction of actin and its 11-amino acid C-terminal peptide as cofactors with the adenovirus proteinase
    FEBS Lett563, 213-218. PubMed  Europe PubMed DOI
  19. [YEAR:24-6-2004]Gupta,S., Mangel,W.F., McGrath,W.J., Perek,J.L., Lee,D.W., Takamoto,K. and Chance,M.R.
    DNA binding provides a molecular strap activating the adenovirus proteinase
    Mol Cell Proteomics3, 950-959. PubMed  Europe PubMed DOI
  20. Honkavuori,K.S., Pollard,B.D., Rodriguez,M.S., Hay,R.T. and Kemp,G.D.
    Dual role of the adenovirus pVI C terminus as a nuclear localization signal and activator of the viral protease
    J Gen Virol85, 3367-3376. PubMed  Europe PubMed DOI
  21. Weber,J.M.
    Adenain, the adenovirus endopeptidase
    [ISSN:0-12-079610-4]2, 1337-1339.  V
    22. 2003
  22. Cao,W., Baniecki,M.L., McGrath,W.J., Bao,C., Deming,C.B., Rade,J.J., Lowenstein,C.J. and Mangel,W.F.
    Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo
    FASEB J17, 2345-2346. PubMed  Europe PubMed DOI
  23. Kovacs,G.M., LaPatra,S.E., D'Halluin,J.C. and Benko,M.
    Phylogenetic analysis of the hexon and protease genes of a fish adenovirus isolated from white sturgeon (Acipenser transmontanus) supports the proposal for a new adenovirus genus
    Virus Res98, 27-34. PubMed  Europe PubMed DOI
  24. Mangel,W.F., Baniecki,M.L. and McGrath,W.J.
    Specific interactions of the adenovirus proteinase with the viral DNA, an 11-amino-acid viral peptide, and the cellular protein actin
    Cell Mol Life Sci60, 2347-2355. PubMed  Europe PubMed DOI
  25. [YEAR:30-5-2003]McGrath,W.J., Ding,J., Didwania,A., Sweet,R.M. and Mangel,W.F.
    Crystallographic structure at 1.6-A resolution of the human adenovirus proteinase in a covalent complex with its 11-amino-acid peptide cofactor: insights on a new fold
    Biochim Biophys Acta1648, 1-11. PubMed  Europe PubMed DOI  S
  26. Weber,J.M., Ruzindana-Umunyana,A., Imbeault,L. and Sircar,S.
    Inhibition of adenovirus infection and adenain by green tea catechins
    Antiviral Res58, 167-173. PubMed  Europe PubMed DOI
    27. 2002
  27. Balakirev,M.Y., Jaquinod,M., Haas,A.L. and Chroboczek,J.
    Deubiquitinating function of adenovirus proteinase
    J Virol76, 6323-6331. PubMed  Europe PubMed DOI  I
  28. Baniecki,M.L., McGrath,W.J., Dauter,Z. and Mangel,W.F.
    Adenovirus proteinase: crystallization and preliminary X-ray diffraction studies to atomic resolution
    Acta Crystallogr D Biol Crystallogr58, 1462-1464. PubMed  Europe PubMed DOI  S
  29. [YEAR:29-11-2002]Brown,M.T., McBride,K.M., Baniecki,M.L., Reich,N.C., Marriott,G. and Mangel,W.F.
    Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton
    J Biol Chem277, 46298-46303. PubMed  Europe PubMed DOI
  30. [YEAR:10-5-2002]McGrath,W.J., Aherne,K.S. and Mangel,W.F.
    In the virion, the 11-amino-acid peptide cofactor pVIc is covalently linked to the adenovirus proteinase
    Virology296, 234-240. PubMed  Europe PubMed DOI
  31. Ruzindana-Umunyana,A., Imbeault,L. and Weber,J.M.
    Substrate specificity of adenovirus protease
    Virus Res89, 41-52. PubMed  Europe PubMed DOI  P
  32. Tong,L.
    Viral proteases
    Chem Rev102, 4609-4626. PubMed  Europe PubMed DOI  V
    33. 2001
  33. [YEAR:16-10-2001]Baniecki,M.L., McGrath,W.J., McWhirter,S.M., Li,C., Toledo,D.L., Pellicena,P., Barnard,D.L., Thorn,K.S. and Mangel,W.F.
    Interaction of the human adenovirus proteinase with its 11-amino acid cofactor pVIc
    Biochemistry40, 12349-12356. PubMed  Europe PubMed DOI
  34. Mangel,W.F., McGrath,W.J., Brown,M.T., Baniecki,M.L., Barnard,D.L. and Pang,Y.P.
    A new form of antiviral combination therapy predicted to prevent resistance from arising, and a model system to test it
    Curr Med Chem8, 933-939. PubMed  Europe PubMed
  35. [YEAR:6-11-2001]McGrath,W.J., Baniecki,M.L., Li,C., McWhirter,S.M., Brown,M.T., Toledo,D.L. and Mangel,W.F.
    Human adenovirus proteinase: DNA binding and stimulation of proteinase activity by DNA
    Biochemistry40, 13237-13245. PubMed  Europe PubMed DOI
  36. [YEAR:4-12-2001]McGrath,W.J., Baniecki,M.L., Peters,E., Green,D.T. and Mangel,W.F.
    Roles of two conserved cysteine residues in the activation of human adenovirus proteinase
    Biochemistry40, 14468-14474. PubMed  Europe PubMed DOI
  37. [YEAR:3-8-2001]Pang,Y.P., Xu,K., Kollmeyer,T.M., Perola,E., McGrath,W.J., Green,D.T. and Mangel,W.F.
    Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases
    FEBS Lett502, 93-97. PubMed  Europe PubMed DOI  I
  38. Ruzindana-Umunyana,A. and Weber,J.M.
    Interactions of human lacrimal and salivary cystatins with adenovirus endopeptidase
    Antiviral Res51, 203-214. PubMed  Europe PubMed DOI
    39. 2000
  39. Barbezange,C., Benko,M., Dan,A. and Harrach,B.
    DNA sequencing and phylogenetic analysis of the protease gene of ovine adenovirus 3 suggest that adenoviruses of sheep belong to two different genera
    Virus Res66, 79-85. PubMed  Europe PubMed DOI
  40. Oualikene,W., Lamoureux,L., Weber,J.M. and Massie,B.
    Protease-deleted adenovirus vectors and complementing cell lines: Potential applications of single-round replication mutants for vaccination and gene therapy
    Hum Gene Ther11, 1341-1353. PubMed  Europe PubMed DOI
  41. [YEAR:1-3-2000]Ruzindana-Umunyana,A., Sircar,S., Schick,C., Silverman,G.A. and Weber,J.M.
    Adenovirus endopeptidase hydrolyses human squamous cell carcinoma antigens in vitro but not ex vivo
    Virology268, 141-146. PubMed  Europe PubMed DOI
    42. 1998
  42. Matiz,K., Ursu,K., Harrach,B., Zadori,Z. and Benko,M.
    Sequencing and phylogenetic analysis of the protease gene, and genetic mapping of bovine adenovirus type 10 define its relatedness to other bovine adenoviruses
    Virus Res55, 29-35. PubMed  Europe PubMed DOI
  43. Sircar,S., Ruzindana-Umunyana,A., Neugebauer,W. and Weber,J.M.
    Adenovirus endopeptidase and papain are inhibited by the same agents
    Antiviral Res40, 45-51. PubMed  Europe PubMed DOI  I
    44. 1997
  44. [YEAR:14-11-1997]Babe,L.M. and Craik,C.S.
    Viral proteases: evolution of diverse structural motifs to optimize function
    Cell91, 427-430. PubMed  Europe PubMed
  45. Cabrita,G., Iqbal,M., Reddy,H. and Kemp,G.
    Activation of the adenovirus protease requires sequence elements from both ends of the activating peptide
    J Biol Chem272, 5635-5639. PubMed  Europe PubMed DOI
  46. Mangel,W.F., Toledo,D.L., Ding,J., Sweet,R.M. and McGrath,W.J.
    Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA
    Trends Biochem Sci22, 393-398. PubMed  Europe PubMed DOI
  47. Reubel,G.H. and Studdert,M.J.
    Sequence analysis of equine adenovirus 2 hexon and 23K proteinase genes indicates a phylogenetic origin distinct from equine adenovirus 1
    Virus Res50, 41-56. PubMed  Europe PubMed DOI
    48. 1996
  48. Ding,J., McGrath,W.J., Sweet,R.M. and Mangel,W.F.
    Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor
    EMBO J15, 1778-1783. PubMed  Europe PubMed  S
  49. Diouri,M., Keyvani-Amineh,H., Geoghegan,K.F. and Weber,J.M.
    Cleavage efficiency by adenovirus protease is site-dependent
    J Biol Chem271, 32511-32514. PubMed  Europe PubMed DOI
  50. Greber,U.F., Webster,P., Weber,J. and Helenius,A.
    The role of the adenovirus protease on virus entry into cells
    EMBO J15, 1766-1777. PubMed  Europe PubMed
  51. Mangel,W.F., Toledo,D.L., Brown,M.T., Martin,J.H. and McGrath,W.J.
    Characterization of three components of human adenovirus proteinase activity in vitro
    J Biol Chem271, 536-543. PubMed  Europe PubMed DOI
  52. McGrath,W.J., Ding,J., Sweet,R.M. and Mangel,W.F.
    Preparation and crystallization of a complex between human adenovirus serotype 2 proteinase and its 11-amino-acid cofactor pVIc
    J Struct Biol117, 77-79. PubMed  Europe PubMed DOI
    53. 1995
  53. Cornish,J.A., Murray,H., Kemp,G.D. and Gani,D.
    Inhibitors of the adenovirus type 2 proteinase based on substrate-like tetrapeptide nitriles
    Bioorg Med Chem Lett5, 25-30. DOI  I
  54. Diouri,M., Geoghegan,K.F. and Weber,J.M.
    Functional characterization of the adenovirus proteinase using fluorogenic substrates
    Protein Pept Lett2, 363-370.  A
  55. Keefe,L.J., Ginell,S.L., Westbrook,E.M. and Anderson,C.W.
    Crystallization and preliminary X-ray diffraction studies of the human adenovirus serotype 2 proteinase with peptide cofactor
    Protein Sci4, 1658-1660. PubMed  Europe PubMed DOI  S
  56. Weber,J.M.
    Adenovirus endopeptidase and its role in virus infection
    Curr Top Microbiol Immunol199, 227-235. PubMed  Europe PubMed
    57. 1994
  57. Rancourt,C., Tihanyi,K., Bourbonniere,M. and Weber,J.M.
    Identification of active-site residues of the adenovirus endopeptidase
    Proc Natl Acad Sci U S A91, 844-847. PubMed  Europe PubMed
  58. Weber,J.M. and Tihanyi,K.
    Adenovirus endopeptidases
    Methods Enzymol244, 595-604. PubMed  Europe PubMed DOI  V
  59. Webster,A., Leith,I.R. and Hay,R.T.
    Activation of adenovirus-coded protease and processing of preterminal protein
    J Virol68, 7292-7300. PubMed  Europe PubMed
    60. 1993
  60. Cai,F. and Weber,J.M.
    Organization of the avian adenovirus genome and the structure of its endopeptidase
    Virology196, 358-362. PubMed  Europe PubMed DOI
    61. 1992
  61. Cai,F., Tang,D. and Weber,J.M.
    Primary structure of the murine adenovirus type 1 proteinase
    Biochim Biophys Acta1129, 339-341. PubMed  Europe PubMed DOI
  62. Cai,F. and Weber,J.M.
    Nucleotide and deduced amino acid sequence of the canine adenovirus type 1 proteinase
    Virus Genes6, 307-312. PubMed  Europe PubMed
    63. 1990
  63. Anderson,C.W.
    The proteinase polypeptide of adenovirus serotype 2 virions
    Virology177, 259-272. PubMed  Europe PubMed DOI
  64. Cai,F.X., Tang,D., Hu,S.L. and Weber,J.M.
    Nucleotide and deduced amino acid sequence of the bovine adenovirus type 7 proteinase
    Nucleic Acids Res18, 5567-5567. PubMed  Europe PubMed
    65. 1989
  65. Webster,A., Russell,S., Talbot,P., Russell,W.C. and Kemp,G.D.
    Characterization of the adenovirus proteinase: substrate specificity
    J Gen Virol70, 3225-3234. PubMed  Europe PubMed  P
  66. Webster,A., Russell,W.C. and Kemp,G.D.
    Characterization of the adenovirus proteinase: development and use of a specific peptide assay
    J Gen Virol70, 3215-3223. PubMed  Europe PubMed
    67. 1988
  67. Houde,A. and Weber,J.M.
    Sequence of the human adenovirus type 3 protease
    Nucleic Acids Res16, 11374-11374. PubMed  Europe PubMed  P
  68. Houde,A. and Weber,J.M.
    The primary structure of human adenovirus type 12 protease
    Nucleic Acids Res16, 7195-7195. PubMed  Europe PubMed DOI
  69. Krausslich,H.G. and Wimmer,E.
    Viral proteinases
    Annu Rev Biochem57, 701-754. PubMed  Europe PubMed DOI
    70. 1983
  70. [YEAR:15-6-1983]Yeh-Kai,L., Akusjarvi,G., Alestrom,P., Pettersson,U., Tremblay,M. and Weber,J.
    Genetic identification of an endoproteinase encoded by the adenovirus genome
    J Mol Biol167, 217-222. PubMed  Europe PubMed
    71. 1980
  71. Kruijer,W., van Schaik,F.M. and Sussenbach,J.S.
    Nucleotide sequence analysis of a region of adenovirus 5 DNA encoding a hitherto unidentified gene
    Nucleic Acids Res8, 6033-6042. PubMed  Europe PubMed
    72. 1979
  72. Bhatti,A.R. and Weber,J.
    Protease of adenovirus type 2: partial characterization
    Virology96, 478-485. PubMed  Europe PubMed
    73. 1976
  73. Weber,J.
    Genetic analysis of adenovirus type 2 III. Temperature sensitivity of processing viral proteins
    J Virol17, 462-471. PubMed  Europe PubMed
    74. 1973
  74. Anderson,C.W., Baum,P.R. and Gesteland,R.F.
    Processing of adenovirus 2-induced proteins
    J Virol12, 241-252. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use