$VAR1 = undef;

Summary for peptidase C04.001: nuclear-inclusion-a peptidase (plum pox virus)

Names
MEROPS Name	nuclear-inclusion-a peptidase (plum pox virus)
Other names	48/49 kDa protease, protease nuclear inclusion a (NIa), Japanese yam virus NIa protease, plum pox virus NIa protease, potato virus A NIa protease, turnip mosaic virus NIa protease, VPg-protease

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C4 >> Subfamily (none) >> C04.001
Holotype	nuclear-inclusion-a peptidase (plum pox virus), Uniprot accession P13529 (peptidase unit: 2049-2293), MERNUM MER0001785
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00087
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.44
Enzymology	BRENDA database
Proteolytic events	CutDB database (2 cleavages)
Biotechnology	Has found applications in protein expression vectors, conferring self-cleaving activity on the products.
Physiology	Polyprotein processing in the viral replication.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	V/yvh/H/Qsagt/l/-/- (based on 21 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	3	3	1	0
Pro	0	0	1	0	0	0	2	1
Ala	0	0	0	1	6	3	0	0
Val	17	5	0	0	0	1	2	3
Leu	2	0	0	0	0	7	0	1
Ile	0	0	0	0	0	0	1	0
Met	0	0	0	0	0	0	0	1
Phe	0	0	2	0	0	1	1	1
Tyr	0	9	0	0	0	0	0	0
Trp	0	0	0	0	1	1	0	0
Ser	1	0	0	1	7	2	1	3
Thr	0	0	0	1	3	0	3	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	1	0	0	1	2	0
Gln	0	1	1	18	0	0	1	1
Asp	0	0	0	0	0	1	1	2
Glu	0	0	0	0	0	0	1	1
Lys	1	1	0	0	1	0	0	1
Arg	0	2	0	0	0	0	0	1
His	0	3	16	0	0	0	0	0