$VAR1 = undef;

Summary for peptidase A02.012: retropepsin (human T-cell leukemia virus)

Names
MEROPS Name	retropepsin (human T-cell leukemia virus)
Other names	simian T-cell leukemia virus endopeptidase, human T-cell lymphotropic virus 1 protease, HTLV-1 protease

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily X >> A02.012
Holotype	retropepsin (human T-cell leukemia virus) (human T-cell lymphotropic virus type 1), Uniprot accession P14074 (peptidase unit: 455-564), MERNUM MER0016601
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00033
NC-IUBMB	Not yet included in IUBMB recommendations.
Physiology	Processing of viral polyprotein.
Pharmaceutical relevance	Drug target for human leukemia.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	pta/kqs/VI/LPvf/Vil/qim/ph (based on 15 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	0	0	1
Pro	5	0	0	0	10	0	0	6
Ala	3	0	0	0	0	0	1	2
Val	0	2	8	0	3	10	0	0
Leu	0	0	1	13	0	2	0	2
Ile	0	0	6	0	0	3	3	0
Met	1	0	0	0	0	0	3	0
Phe	0	0	0	0	1	0	0	0
Tyr	0	0	0	1	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	3	0	0	0	0	0	1
Thr	4	1	0	0	0	0	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	3	0	0	0	0	6	0
Asp	0	0	0	0	0	0	1	0
Glu	0	1	0	0	0	0	0	0
Lys	1	5	0	0	0	0	0	0
Arg	1	0	0	0	0	0	0	0
His	0	0	0	0	0	0	0	3