Substrates for peptidase A02.012: retropepsin (human T-cell leukemia virus)

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Asp-Lys-Glu-Leu-Tyr-Pro-Leu-Thr-Ser-Leu Lys-Glu-Leu-Tyr+Pro-Leu-Thr-Ser S NT Lys Glu Leu Tyr Pro Leu Thr Ser Louis et al., 1999
Asp-Pro-Ala-Ser-Ile-Leu-Pro-Val-Ile-Pro Ala-Ser-Ile-Leu+Pro-Val-Ile-Pro S NT Ala Ser Ile Leu Pro Val Ile Pro Louis et al., 1999
gag-Pro polyprotein P10274 2-651 peptide-Leu130+Pro-peptide P NT Pro Gln Val Leu Pro Val Met His
gag-Pro polyprotein P10274 2-651 peptide-Leu449+Pro-peptide P NT Ala Ser Ile Leu Pro Val Ile Pro
gag-Pro polyprotein P10274 2-651 peptide-Leu574+Pro-peptide P NT Pro Val Ile Leu Pro Ile Gln Ala
human T-cell leukemia virus gag-pol polyprotein Gag/retropepsin cleavage peptide Pro-Ala-Ser-Ile-Leu+Pro-Val-Ile-Leu-Pro P Ala Ser Ile Leu Pro Val Ile Leu Daenke, 2004
human T-cell leukemia virus gag-pol polyprotein p19/p24 cleavage peptide P03345 127-134 Pro-Gln-Val-Leu+Pro-Val-Met-His P Pro Gln Val Leu Pro Val Met His Daenke, 2004
human T-cell leukemia virus gag-pol polyprotein p24/p15 cleavage peptide P10274 2-651 Lys-Thr-Lys-Val-Leu+Val-Val-Gln-Pro-Lys P Thr Lys Val Leu Val Val Gln Pro Daenke, 2004
human T-cell leukemia virus Protease P14074 450-574 Peptide-Leu489+Pro-Peptide P NT Met Thr Val Leu Pro Ile Ala Leu Louis et al., 1999
human T-cell leukemia virus Protease peptide P14074 340-349 Thr-Lys-Val-Leu+Val-Val-Gln-Pro P NT Thr Lys Val Leu Val Val Gln Pro Louis et al., 1999
human T-cell leukemia virus Protease peptide P14074 126-135 Pro-Gln-Val-leu+Pro-Val-Met-His P NT Pro Gln Val Leu Pro Val Met His Louis et al., 1999
Ile-Arg-Lys-Ile-Leu-Phe-Leu-Asp-Gly Arg-Lys-Ile-Leu+Phe-Leu-Asp-Gly S NT Arg Lys Ile Leu Phe Leu Asp Gly Louis et al., 1999
Lys-Gly-Pro-Pro-Val-Ile-Leu-Pro-Ile-Gln-Ala-Pro Pro-Val-Ile-Leu+Pro-Ile-Gln-Ala S NT Pro Val Ile Leu Pro Ile Gln Ala Louis et al., 1999
Lys-Thr-Lys-Val-Leu-NPh-Val-Gln-Pro-Lys Thr-Lys-Val-Leu+NPh-Val-Gln-Pro S Thr Lys Val Leu NPh Val Gln Pro Louis et al., 1999
Lys-Thr-Lys-Val-NPh-Val-Val-Gln-Pro-Lys Thr-Lys-Val-NPh+Val-Val-Gln-Pro S Thr Lys Val NPh Val Val Gln Pro Louis et al., 1999