$VAR1 = undef;

Summary for peptidase A02.011: human endogenous retrovirus K retropepsin

Names
MEROPS Name	human endogenous retrovirus K retropepsin
Other names	human endogenous retrovirus K10 endopeptidase, HERV K10 endopeptidase

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.011
Holotype	human endogenous retrovirus K retropepsin (Homo sapiens), Uniprot accession P63127 (peptidase unit: 5-106), MERNUM MER0000968
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00032
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.50
Enzymology	BRENDA database
Pharmaceutical relevance	Activities of endogenous retroviruses in the brain may be relevant to schizophrenia (Yolken et al., 2000). Inhibitors of human endogenous retrovirus K retropepsin have been described (Kuhelj et al., 2001).
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/veia/fgyallv/va/-/- (based on 100 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	7	2	22	2	6	2	7
Pro	7	0	0	0	2	0	1	4
Ala	8	4	14	12	8	23	8	12
Val	5	9	24	0	19	30	12	7
Leu	8	16	1	12	20	1	18	20
Ile	9	11	17	0	13	9	11	3
Met	2	5	0	3	4	0	0	1
Phe	3	10	0	22	9	2	4	0
Tyr	8	4	0	19	3	0	0	3
Trp	2	2	0	4	7	0	2	1
Ser	7	4	2	0	0	4	9	6
Thr	4	3	3	0	4	9	7	6
Cys	1	4	0	0	0	2	1	1
Asn	6	6	4	1	0	4	1	3
Gln	4	5	1	0	0	0	5	5
Asp	7	2	11	5	2	4	3	10
Glu	6	6	21	0	5	6	14	6
Lys	3	0	0	0	0	0	0	2
Arg	2	1	0	0	0	0	1	0
His	5	1	0	0	0	0	1	2

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
	5		ENSG00000184379