$VAR1 = undef;

Summary for peptidase A01.017: endothiapepsin

Names
MEROPS Name	endothiapepsin
Other names	Endothia aspartic proteinase, Suparen

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.017
Holotype	endothiapepsin (Cryphonectria parasitica), Uniprot accession P11838 (peptidase unit: 93-418), MERNUM MER0000928
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00015
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.22
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Biotechnology	Used in cheese making (Awad et al., 1999; Kim et al., 2004).
Physiology	Endothiapepsin probably has a role in nutrition of the organism, Endothia parasitica, a plant pathogen, so is potentially implicated in plant pathology.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/k-/-/Alt/- (based on 11 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	0	1	0	0	0	0	2
Pro	2	0	0	0	0	0	0	1
Ala	0	3	3	0	0	4	5	0
Val	0	1	1	0	1	1	0	0
Leu	0	0	2	1	1	1	2	1
Ile	0	1	0	0	0	0	0	1
Met	0	0	0	0	0	1	0	0
Phe	1	1	0	2	2	0	0	0
Tyr	0	0	0	1	0	1	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	1	0	1	0	0	0	0
Thr	0	0	0	0	0	0	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	1	1	0	0	0	0
Gln	0	0	0	1	1	0	0	0
Asp	0	0	0	0	0	0	0	0
Glu	2	0	1	0	0	1	0	0
Lys	0	0	0	4	0	0	0	0
Arg	0	1	0	0	0	1	0	0
His	0	1	1	0	1	1	0	0