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Literature for peptidase A01.017: endothiapepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Czodrowski,P., Vatheuer,H., Palomino-Hernandez,O., Muller,J., Galonska,P. and Glinca,S.<br>Protonation effects in protein-ligand complexes - a case study of endothiapepsin and pepstatin A with computational and experimental methods<br>ChemMedChem (2025) , e202400953-e202400953. PubMed  Europe PubMed DOI  I
    2. 2024
  2. Schmitz,B., Frieg,B., Homeyer,N., Jessen,G. and Gohlke,H.<br>Extracting binding energies and binding modes from biomolecular simulations of fragment binding to endothiapepsin<br>Arch Pharm (Weinheim) (2024) , e2300612-e2300612. PubMed  Europe PubMed DOI
    3. 2022
  3. Huang,C.Y., Aumonier,S., Engilberge,S., Eris,D., Smith,K.M.L., Leonarski,F., Wojdyla,J.A., Beale,J.H., Buntschu,D., Pauluhn,A., Sharpe,M.E., Metz,A., Olieric,V. and Wang,M.<br>Probing ligand binding of endothiapepsin by `temperature-resolved' macromolecular crystallography<br>Acta Crystallogr D Struct Biol (2022) 78, 964-974. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2021
  4. Beale,J.H. and Marsh,M.E.<br>Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments<br>J Vis Exp (2021) PubMed  Europe PubMed DOI
    5. 2019
  5. Gu,C.X., Zhang,B.L., Bai,W.W., Liu,J., Zhou,W., Ling,Z.Q., Lu,Y., Xu,L. and Wan,Y.J.<br>Characterization of the endothiapepsin-like protein in the entomopathogenic fungus Beauveria bassiana and its virulence effect on the silkworm, Bombyx mori<br>J Invertebr Pathol (2019) , 107277-107277. PubMed  Europe PubMed DOI
    6. 2018
  6. Jumde,V.R., Mondal,M., Gierse,R.M., Unver,M.Y., Magari,F., van Lier,R.C.W., Heine,A., Klebe,G. and Hirsch,A.K.H.<br>Design and synthesis of bioisosteres of acylhydrazones as stable inhibitors of the aspartic protease endothiapepsin<br>ChemMedChem (2018) 13, 2266-2270. PubMed  Europe PubMed DOI  I
    7. 2016
  7. Huschmann,F.U., Linnik,J., Sparta,K., Uhlein,M., Wang,X., Metz,A., Schiebel,J., Heine,A., Klebe,G., Weiss,M.S. and Mueller,U.<br>Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library<br>Acta Crystallogr F Struct Biol Commun (2016) 72, 346-355. PubMed  Europe PubMed DOI
  8. Mondal,M., Radeva,N., Fanlo-Virgos,H., Otto,S., Klebe,G. and Hirsch,A.K.<br>Fragment linking and optimization of inhibitors of the aspartic protease endothiapepsin: fragment-based drug design facilitated by dynamic combinatorial chemistry<br>Angew Chem Int Ed Engl (2016) 55, 9422-9426. PubMed  Europe PubMed DOI  I
  9. Mondal,M., Unver,M.Y., Pal,A., Bakker,M., Berrier,S.P. and Hirsch,A.K.<br>Fragment-based drug design facilitated by protein-templated Click chemistry: fragment linking and optimization of inhibitors of the aspartic protease endothiapepsin<br>Chemistry (2016) 22, 14826-14830. PubMed  Europe PubMed DOI  I
  10. Radeva,N., Krimmer,S.G., Stieler,M., Fu,K., Wang,X., Ehrmann,F.R., Metz,A., Huschmann,F.U., Weiss,M.S., Mueller,U., Schiebel,J., Heine,A. and Klebe,G.<br>Experimental active-site mapping by fragments: hot spots remote from the catalytic center of endothiapepsin<br>J Med Chem (2016) 59, 7561-7575. PubMed  Europe PubMed DOI
  11. Radeva,N., Schiebel,J., Wang,X., Krimmer,S.G., Fu,K., Stieler,M., Ehrmann,F.R., Metz,A., Rickmeyer,T., Betz,M., Winquist,J., Park,A.Y., Huschmann,F.U., Weiss,M.S., Mueller,U., Heine,A. and Klebe,G.<br>Active site mapping of an aspartic protease by multiple fragment crystal structures: versatile warheads to address a catalytic dyad<br>J Med Chem (2016) 59, 9743-9759. PubMed  Europe PubMed DOI  I
    12. 2015
  12. Kuhnert,M., Koster,H., Bartholomaus,R., Park,A.Y., Shahim,A., Heine,A., Steuber,H., Klebe,G. and Diederich,W.E.<br>Tracing binding modes in hit-to-lead optimization: chameleon-like poses of aspartic protease inhibitors<br>Angew Chem Int Ed Engl (2015) 54, 2849-2853. PubMed  Europe PubMed DOI  I
    13. 2014
  13. Guo,J., Cooper,J.B. and Wood,S.P.<br>The structure of endothiapepsin complexed with a Phe-Tyr reduced-bond inhibitor at 1.35 A resolution<br>Acta Crystallogr F Struct Biol Commun (2014) 70, 30-33. PubMed  Europe PubMed DOI  S  I
  14. Mondal,M., Radeva,N., Koster,H., Park,A., Potamitis,C., Zervou,M., Klebe,G. and Hirsch,A.K.<br>Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry<br>Angew Chem Int Ed Engl (2014) 53, 3259-3263. PubMed  Europe PubMed DOI  I
    15. 2012
  15. Bailey,D., Carpenter,E.P., Coker,A., Coker,S., Read,J., Jones,A.T., Erskine,P., Aguilar,C.F., Badasso,M., Toldo,L., Rippmann,F., Sanz-Aparicio,J., Albert,A., Blundell,T.L., Roberts,N.B., Wood,S.P. and Cooper,J.B.<br>An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases<br>Acta Crystallogr D Biol Crystallogr (2012) 68, 541-552. PubMed  Europe PubMed DOI  S
  16. Cooper,J.B.<br>Endothiapepsin<br>[ISSN:978-0-12-407744-7] (2012) 3, 147-150. DOI
    17. 2009
  17. Beveridge,A.J.<br>An ab initio study of the first stage of catalysis in the monomeric aspartic proteinases<br>Theochem (2009) 900, 1-8. DOI
    18. 2008
  18. Coates,L., Tuan,H.F., Tomanicek,S., Kovalevsky,A., Mustyakimov,M., Erskine,P. and Cooper,J.<br>The catalytic mechanism of an aspartic proteinase explored with neutron and X-ray diffraction<br>J Am Chem Soc (2008) 130, 7235-7237. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2007
  19. Tuan,H.F., Erskine,P., Langan,P., Cooper,J. and Coates,L.<br>Preliminary neutron and ultrahigh-resolution X-ray diffraction studies of the aspartic proteinase endothiapepsin cocrystallized with a gem-diol inhibitor<br>Acta Crystallograph Sect F Struct Biol Cryst Commun (2007) 63, 1080-1083. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    20. 2005
  20. Leherte,L., Meurice,N. and Vercauteren,D.P.<br>Influence of conformation on the representation of small flexible molecules at low resolution: alignment of endothiapepsin ligands<br>J Comput Aided Mol Des (2005) 19, 525-549.
    21. 2004
  21. Cooper,J.B.<br>Endothiapepsin<br>[ISSN:0-12-079610-4] (2004) 2, 104-107.  V
  22. Kim,S.Y., Gunasekaran,S. and Olson,N.F.<br>Combined use of chymosin and protease from Cryphonectria parasitica for control of meltability and firmness of cheddar cheese<br>J Dairy Sci (2004) 87, 274-283. PubMed  Europe PubMed DOI
    23. 2003
  23. Coates,L., Erskine,P.T., Mall,S., Williams,P.A., Gill,R.S., Wood,S.P. and Cooper,J.B.<br>The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A<br>Acta Crystallogr D Biol Crystallogr (2003) 59, 978-981. PubMed  Europe PubMed DOI  S  I
  24. Erskine,P.T., Coates,L., Mall,S., Gill,R.S., Wood,S.P., Myles,D.A. and Cooper,J.B.<br>Atomic resolution analysis of the catalytic site of an aspartic proteinase and an unexpected mode of binding by short peptides<br>Protein Sci (2003) 12, 1741-1749. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    25. 2002
  25. [YEAR:17-5-2002]Coates,L., Erskine,P.T., Crump,M.P., Wood,S.P. and Cooper,J.B.<br>Five atomic resolution structures of endothiapepsin inhibitor complexes: implications for the aspartic proteinase mechanism<br>J Mol Biol (17-5-2002) 318, 1405-1415. PubMed  Europe PubMed DOI  I
    26. 2001
  26. [YEAR:6-11-2001]Coates,L., Erskine,P.T., Wood,S.P., Myles,D.A.A. and Cooper,J.B.<br>A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism<br>Biochemistry (6-11-2001) 40, 13149-13157. PubMed  Europe PubMed DOI  I
    27. 2000
  27. [YEAR:1-8-2000]Stultz,C.M. and Karplus,M.<br>Dynamic ligand design and combinatorial optimization: designing inhibitors to endothiapepsin<br>Proteins (1-8-2000) 40, 258-289. PubMed  Europe PubMed DOI  I
    28. 1999
  28. Awad,S., Luthi-Peng,Q.Q. and Puhan,Z.<br>Proteolytic activities of Suparen and Rennilase on buffalo, cow, and goat whole casein and beta-casein<br>J Agric Food Chem (1999) 47, 3632-3639. PubMed  Europe PubMed DOI
    29. 1998
  29. Luque,I., Gomez,J., Semo,N. and Freire,E.<br>Structure-based thermodynamic design of peptide ligands: application to peptide inhibitors of the aspartic protease endothiapepsin<br>Proteins (1998) 30, 74-85. PubMed  Europe PubMed DOI
    30. 1997
  30. Clark,S.J., Templeton,M.D. and Sullivan,P.A.<br>A secreted aspartic proteinase from Glomerella cingulata: Purification of the enzyme and molecular cloning of the cDNA<br>Microbiology (Reading, Engl.) (1997) 143, 1395-1403. PubMed  Europe PubMed
    31. 1996
  31. Beveridge,A.<br>A theoretical study of torsional flexibility in the active site of aspartic proteinases: implications for catalysis<br>Proteins (1996) 24, 322-334. PubMed  Europe PubMed DOI
    32. 1995
  32. Gomez,J. and Freire,E.<br>Thermodynamic mapping of the inhibitor site of the aspartic protease endothiapepsin<br>J Mol Biol (1995) 252, 337-350. PubMed  Europe PubMed DOI  I
  33. Valverde,V., Delmas,P., Kaghad,M., Loison,G. and Jara,P.<br>Secretion and maturation study of endothiapepsin in Saccharomyces cerevisiae. A first step toward improving its substrate specificity<br>J Biol Chem (1995) 270, 15821-15826. PubMed  Europe PubMed DOI  E
    34. 1994
  34. Bailey,D. and Cooper,J.B.<br>A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica<br>Protein Sci (1994) 3, 2129-2143. PubMed  Europe PubMed DOI  PMC  EPMC  I
    35. 1993
  35. Bailey,D., Cooper,J.B., Veerapandian,B., Blundell,T.L., Atrash,B., Jones,D.M. and Szelke,M.<br>X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin<br>Biochem J (1993) 289, 363-371. PubMed  Europe PubMed  PMC  EPMC  S  I
  36. Balbaa,M., Cunningham,A. and Hofmann,T.<br>Secondary substrate binding in aspartic proteinases: contributions of subsites S3 and S'2 to kcat<br>Arch Biochem Biophys (1993) 306, 297-303. PubMed  Europe PubMed DOI  P
  37. [YEAR:30-3-1993]Choi,G.H., Pawlyk,D.M., Rae,B., Shapira,R. and Nuss,D.L.<br>Molecular analysis and overexpression of the gene encoding endothiapepsin, an aspartic protease from Cryphonectria parasitica<br>Gene (30-3-1993) 125, 135-141. PubMed  Europe PubMed DOI
  38. Lunney,E.A., Hamilton,H.W., Hodges,J.C., Kaltenbronn,J.S., Repine,J.T., Badasso,M., Cooper,J.B., Dealwis,C., Wallace,B.A., Lowther,W.T., Dunn,B.M. and Humblet,C.<br>Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors<br>J Med Chem (1993) 36, 3809-3820. PubMed  Europe PubMed DOI  S  I
    39. 1992
  39. Cooper,J., Quail,W., Frazao,C., Foundling,S.I., Blundell,T.L., Humblet,C., Lunney,E.A., Lowther,W.T. and Dunn,B.M.<br>X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors<br>Biochemistry (1992) 31, 8142-8150. PubMed  Europe PubMed  S  I
  40. Sali,A., Veerapandian,B., Cooper,J.B., Moss,D.S., Hofmann,T. and Blundell,T.L.<br>Domain flexibility in aspartic proteinases<br>Proteins (1992) 12, 158-170. PubMed  Europe PubMed DOI  S
  41. Veerapandian,B., Cooper,J.B., Sali,A., Blundell,T.L., Rosati,R.L., Dominy,B.W., Damon,D.B. and Hoover,D.J.<br>Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases<br>Protein Sci (1992) 1, 322-328. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    42. 1989
  42. Sali,A., Veerapandian,B., Cooper,J.B., Foundling,S.I., Hoover,D.J. and Blundell,T.L.<br>High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme<br>EMBO J (1989) 8, 2179-2188. PubMed  Europe PubMed  PMC  EPMC  S  I
    43. 1987
  43. Dunn,B.M., Valler,M.J., Rolph,C.E., Foundling,S.I., Jimenez,M. and Kay,J.<br>The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2<br>Biochim Biophys Acta (1987) 913, 122-130. PubMed  Europe PubMed
  44. [YEAR:28-5-1987]Foundling,S.I., Cooper,J., Watson,F.E., Cleasby,A., Pearl,L.H., Sibanda,B.L., Hemmings,A., Wood,S.P., Blundell,T.L. and Valler,M.J.<br>High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes<br>Nature (28-5-1987) 327, 349-352. PubMed  Europe PubMed DOI  S  I
    45. 1984
  45. [YEAR:20-8-1984]Pearl,L. and Blundell,T.<br>The active site of aspartic proteinases<br>FEBS Lett (20-8-1984) 174, 96-101. PubMed  Europe PubMed  S  I
    46. 1977
  46. Subramanian,E., Swan,I.D., Liu,M., Davies,D.R., Jenkins,J.A., Tickle,I.J. and Blundell,T.L.<br>Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica<br>Proc Natl Acad Sci U S A (1977) 74, 556-559. PubMed  Europe PubMed  PMC  EPMC
    47. 1972
  47. Williams,D.C., Witaker,J.R. and Caldwell,P.V.<br>Hydrolysis of peptide bonds of the oxidized B-chain of insulin by Endothia parasitica protease<br>Arch Biochem Biophys (1972) 149, 52-61. PubMed  Europe PubMed  P
    48. 1970
  48. Whitaker,J.R.<br>Protease of Endothia parasitica<br>Methods Enzymol (1970) 19, 436-445. DOI  V
    49. 1968
  49. Sardinas,J.L.<br>Rennin enzyme of Endothia parasitica<br>Appl Microbiol (1968) 16, 248-255. PubMed  Europe PubMed  PMC  EPMC

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