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Literature for peptidase A01.017: endothiapepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Czodrowski,P., Vatheuer,H., Palomino-Hernandez,O., Muller,J., Galonska,P. and Glinca,S.
    Protonation effects in protein-ligand complexes - a case study of endothiapepsin and pepstatin A with computational and experimental methods
    ChemMedCheme202400953-e202400953. PubMed  Europe PubMed DOI  I
    2. 2024
  2. Schmitz,B., Frieg,B., Homeyer,N., Jessen,G. and Gohlke,H.
    Extracting binding energies and binding modes from biomolecular simulations of fragment binding to endothiapepsin
    Arch Pharm (Weinheim)e2300612-e2300612. PubMed  Europe PubMed DOI
    3. 2022
  3. Huang,C.Y., Aumonier,S., Engilberge,S., Eris,D., Smith,K.M.L., Leonarski,F., Wojdyla,J.A., Beale,J.H., Buntschu,D., Pauluhn,A., Sharpe,M.E., Metz,A., Olieric,V. and Wang,M.
    Probing ligand binding of endothiapepsin by `temperature-resolved' macromolecular crystallography
    Acta Crystallogr D Struct Biol78, 964-974. PubMed  Europe PubMed DOI
    4. 2021
  4. Beale,J.H. and Marsh,M.E.
    Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments
    J Vis Exp PubMed  Europe PubMed DOI
    5. 2019
  5. Gu,C.X., Zhang,B.L., Bai,W.W., Liu,J., Zhou,W., Ling,Z.Q., Lu,Y., Xu,L. and Wan,Y.J.
    Characterization of the endothiapepsin-like protein in the entomopathogenic fungus Beauveria bassiana and its virulence effect on the silkworm, Bombyx mori
    J Invertebr Pathol107277-107277. PubMed  Europe PubMed DOI
    6. 2018
  6. Jumde,V.R., Mondal,M., Gierse,R.M., Unver,M.Y., Magari,F., van Lier,R.C.W., Heine,A., Klebe,G. and Hirsch,A.K.H.
    Design and synthesis of bioisosteres of acylhydrazones as stable inhibitors of the aspartic protease endothiapepsin
    ChemMedChem13, 2266-2270. PubMed  Europe PubMed DOI  I
    7. 2016
  7. Huschmann,F.U., Linnik,J., Sparta,K., Uhlein,M., Wang,X., Metz,A., Schiebel,J., Heine,A., Klebe,G., Weiss,M.S. and Mueller,U.
    Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library
    Acta Crystallogr F Struct Biol Commun72, 346-355. PubMed  Europe PubMed DOI
  8. Mondal,M., Radeva,N., Fanlo-Virgos,H., Otto,S., Klebe,G. and Hirsch,A.K.
    Fragment linking and optimization of inhibitors of the aspartic protease endothiapepsin: fragment-based drug design facilitated by dynamic combinatorial chemistry
    Angew Chem Int Ed Engl55, 9422-9426. PubMed  Europe PubMed DOI  I
  9. Mondal,M., Unver,M.Y., Pal,A., Bakker,M., Berrier,S.P. and Hirsch,A.K.
    Fragment-based drug design facilitated by protein-templated Click chemistry: fragment linking and optimization of inhibitors of the aspartic protease endothiapepsin
    Chemistry22, 14826-14830. PubMed  Europe PubMed DOI  I
  10. Radeva,N., Schiebel,J., Wang,X., Krimmer,S.G., Fu,K., Stieler,M., Ehrmann,F.R., Metz,A., Rickmeyer,T., Betz,M., Winquist,J., Park,A.Y., Huschmann,F.U., Weiss,M.S., Mueller,U., Heine,A. and Klebe,G.
    Active site mapping of an aspartic protease by multiple fragment crystal structures: versatile warheads to address a catalytic dyad
    J Med Chem59, 9743-9759. PubMed  Europe PubMed DOI  I
  11. Radeva,N., Krimmer,S.G., Stieler,M., Fu,K., Wang,X., Ehrmann,F.R., Metz,A., Huschmann,F.U., Weiss,M.S., Mueller,U., Schiebel,J., Heine,A. and Klebe,G.
    Experimental active-site mapping by fragments: hot spots remote from the catalytic center of endothiapepsin
    J Med Chem59, 7561-7575. PubMed  Europe PubMed DOI
    12. 2015
  12. Kuhnert,M., Koster,H., Bartholomaus,R., Park,A.Y., Shahim,A., Heine,A., Steuber,H., Klebe,G. and Diederich,W.E.
    Tracing binding modes in hit-to-lead optimization: chameleon-like poses of aspartic protease inhibitors
    Angew Chem Int Ed Engl54, 2849-2853. PubMed  Europe PubMed DOI  I
    13. 2014
  13. Guo,J., Cooper,J.B. and Wood,S.P.
    The structure of endothiapepsin complexed with a Phe-Tyr reduced-bond inhibitor at 1.35 A resolution
    Acta Crystallogr F Struct Biol Commun70, 30-33. PubMed  Europe PubMed DOI  S  I
  14. Mondal,M., Radeva,N., Koster,H., Park,A., Potamitis,C., Zervou,M., Klebe,G. and Hirsch,A.K.
    Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry
    Angew Chem Int Ed Engl53, 3259-3263. PubMed  Europe PubMed DOI  I
    15. 2012
  15. Bailey,D., Carpenter,E.P., Coker,A., Coker,S., Read,J., Jones,A.T., Erskine,P., Aguilar,C.F., Badasso,M., Toldo,L., Rippmann,F., Sanz-Aparicio,J., Albert,A., Blundell,T.L., Roberts,N.B., Wood,S.P. and Cooper,J.B.
    An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases
    Acta Crystallogr D Biol Crystallogr68, 541-552. PubMed  Europe PubMed DOI  S
  16. Cooper,J.B.
    Endothiapepsin
    [ISSN:978-0-12-407744-7]3, 147-150. DOI
    17. 2009
  17. Beveridge,A.J.
    An ab initio study of the first stage of catalysis in the monomeric aspartic proteinases
    Theochem900, 1-8. DOI
    18. 2008
  18. Coates,L., Tuan,H.F., Tomanicek,S., Kovalevsky,A., Mustyakimov,M., Erskine,P. and Cooper,J.
    The catalytic mechanism of an aspartic proteinase explored with neutron and X-ray diffraction
    J Am Chem Soc130, 7235-7237. PubMed  Europe PubMed DOI
    19. 2007
  19. Tuan,H.F., Erskine,P., Langan,P., Cooper,J. and Coates,L.
    Preliminary neutron and ultrahigh-resolution X-ray diffraction studies of the aspartic proteinase endothiapepsin cocrystallized with a gem-diol inhibitor
    Acta Crystallograph Sect F Struct Biol Cryst Commun63, 1080-1083. PubMed  Europe PubMed DOI  S  I
    20. 2005
  20. Leherte,L., Meurice,N. and Vercauteren,D.P.
    Influence of conformation on the representation of small flexible molecules at low resolution: alignment of endothiapepsin ligands
    J Comput Aided Mol Des19, 525-549.
    21. 2004
  21. Cooper,J.B.
    Endothiapepsin
    [ISSN:0-12-079610-4]2, 104-107.  V
  22. Kim,S.Y., Gunasekaran,S. and Olson,N.F.
    Combined use of chymosin and protease from Cryphonectria parasitica for control of meltability and firmness of cheddar cheese
    J Dairy Sci87, 274-283. PubMed  Europe PubMed DOI
    23. 2003
  23. Coates,L., Erskine,P.T., Mall,S., Williams,P.A., Gill,R.S., Wood,S.P. and Cooper,J.B.
    The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A
    Acta Crystallogr D Biol Crystallogr59, 978-981. PubMed  Europe PubMed DOI  S  I
  24. Erskine,P.T., Coates,L., Mall,S., Gill,R.S., Wood,S.P., Myles,D.A. and Cooper,J.B.
    Atomic resolution analysis of the catalytic site of an aspartic proteinase and an unexpected mode of binding by short peptides
    Protein Sci12, 1741-1749. PubMed  Europe PubMed DOI  S  I
    25. 2002
  25. [YEAR:17-5-2002]Coates,L., Erskine,P.T., Crump,M.P., Wood,S.P. and Cooper,J.B.
    Five atomic resolution structures of endothiapepsin inhibitor complexes: implications for the aspartic proteinase mechanism
    J Mol Biol318, 1405-1415. PubMed  Europe PubMed DOI  I
    26. 2001
  26. [YEAR:6-11-2001]Coates,L., Erskine,P.T., Wood,S.P., Myles,D.A.A. and Cooper,J.B.
    A neutron Laue diffraction study of endothiapepsin: implications for the aspartic proteinase mechanism
    Biochemistry40, 13149-13157. PubMed  Europe PubMed DOI  I
    27. 2000
  27. [YEAR:1-8-2000]Stultz,C.M. and Karplus,M.
    Dynamic ligand design and combinatorial optimization: designing inhibitors to endothiapepsin
    Proteins40, 258-289. PubMed  Europe PubMed DOI  I
    28. 1999
  28. Awad,S., Luthi-Peng,Q.Q. and Puhan,Z.
    Proteolytic activities of Suparen and Rennilase on buffalo, cow, and goat whole casein and beta-casein
    J Agric Food Chem47, 3632-3639. PubMed  Europe PubMed DOI
    29. 1998
  29. Luque,I., Gomez,J., Semo,N. and Freire,E.
    Structure-based thermodynamic design of peptide ligands: application to peptide inhibitors of the aspartic protease endothiapepsin
    Proteins30, 74-85. PubMed  Europe PubMed DOI
    30. 1997
  30. Clark,S.J., Templeton,M.D. and Sullivan,P.A.
    A secreted aspartic proteinase from Glomerella cingulata: Purification of the enzyme and molecular cloning of the cDNA
    Microbiology (Reading, Engl )143, 1395-1403. PubMed  Europe PubMed
    31. 1996
  31. Beveridge,A.
    A theoretical study of torsional flexibility in the active site of aspartic proteinases: implications for catalysis
    Proteins24, 322-334. PubMed  Europe PubMed DOI
    32. 1995
  32. Gomez,J. and Freire,E.
    Thermodynamic mapping of the inhibitor site of the aspartic protease endothiapepsin
    J Mol Biol252, 337-350. PubMed  Europe PubMed DOI  I
  33. Valverde,V., Delmas,P., Kaghad,M., Loison,G. and Jara,P.
    Secretion and maturation study of endothiapepsin in Saccharomyces cerevisiae. A first step toward improving its substrate specificity
    J Biol Chem270, 15821-15826. PubMed  Europe PubMed DOI  E
    34. 1994
  34. Bailey,D. and Cooper,J.B.
    A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica
    Protein Sci3, 2129-2143. PubMed  Europe PubMed DOI  I
    35. 1993
  35. Bailey,D., Cooper,J.B., Veerapandian,B., Blundell,T.L., Atrash,B., Jones,D.M. and Szelke,M.
    X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin
    Biochem J289, 363-371. PubMed  Europe PubMed  S  I
  36. Balbaa,M., Cunningham,A. and Hofmann,T.
    Secondary substrate binding in aspartic proteinases: contributions of subsites S3 and S'2 to kcat
    Arch Biochem Biophys306, 297-303. PubMed  Europe PubMed DOI  P
  37. [YEAR:30-3-1993]Choi,G.H., Pawlyk,D.M., Rae,B., Shapira,R. and Nuss,D.L.
    Molecular analysis and overexpression of the gene encoding endothiapepsin, an aspartic protease from Cryphonectria parasitica
    Gene125, 135-141. PubMed  Europe PubMed DOI
  38. Lunney,E.A., Hamilton,H.W., Hodges,J.C., Kaltenbronn,J.S., Repine,J.T., Badasso,M., Cooper,J.B., Dealwis,C., Wallace,B.A., Lowther,W.T., Dunn,B.M. and Humblet,C.
    Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors
    J Med Chem36, 3809-3820. PubMed  Europe PubMed DOI  S  I
    39. 1992
  39. Cooper,J., Quail,W., Frazao,C., Foundling,S.I., Blundell,T.L., Humblet,C., Lunney,E.A., Lowther,W.T. and Dunn,B.M.
    X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors
    Biochemistry31, 8142-8150. PubMed  Europe PubMed  S  I
  40. Sali,A., Veerapandian,B., Cooper,J.B., Moss,D.S., Hofmann,T. and Blundell,T.L.
    Domain flexibility in aspartic proteinases
    Proteins12, 158-170. PubMed  Europe PubMed DOI  S
  41. Veerapandian,B., Cooper,J.B., Sali,A., Blundell,T.L., Rosati,R.L., Dominy,B.W., Damon,D.B. and Hoover,D.J.
    Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases
    Protein Sci1, 322-328. PubMed  Europe PubMed DOI  S  I
    42. 1989
  42. Sali,A., Veerapandian,B., Cooper,J.B., Foundling,S.I., Hoover,D.J. and Blundell,T.L.
    High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme
    EMBO J8, 2179-2188. PubMed  Europe PubMed  S  I
    43. 1987
  43. Dunn,B.M., Valler,M.J., Rolph,C.E., Foundling,S.I., Jimenez,M. and Kay,J.
    The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2
    Biochim Biophys Acta913, 122-130. PubMed  Europe PubMed
  44. [YEAR:28-5-1987]Foundling,S.I., Cooper,J., Watson,F.E., Cleasby,A., Pearl,L.H., Sibanda,B.L., Hemmings,A., Wood,S.P., Blundell,T.L. and Valler,M.J.
    High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes
    Nature327, 349-352. PubMed  Europe PubMed DOI  S  I
    45. 1984
  45. [YEAR:20-8-1984]Pearl,L. and Blundell,T.
    The active site of aspartic proteinases
    FEBS Lett174, 96-101. PubMed  Europe PubMed  S  I
    46. 1977
  46. Subramanian,E., Swan,I.D., Liu,M., Davies,D.R., Jenkins,J.A., Tickle,I.J. and Blundell,T.L.
    Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica
    Proc Natl Acad Sci U S A74, 556-559. PubMed  Europe PubMed
    47. 1972
  47. Williams,D.C., Witaker,J.R. and Caldwell,P.V.
    Hydrolysis of peptide bonds of the oxidized B-chain of insulin by Endothia parasitica protease
    Arch Biochem Biophys149, 52-61. PubMed  Europe PubMed  P
    48. 1970
  48. Whitaker,J.R.
    Protease of Endothia parasitica
    Methods Enzymol19, 436-445. DOI  V
    49. 1968
  49. Sardinas,J.L.
    Rennin enzyme of Endothia parasitica
    Appl Microbiol16, 248-255. PubMed  Europe PubMed

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