Literature for peptidase S01.213: coagulation factor XIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, V Review, M Mutation, I Inhibitor, R Splicing, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Campanella,F., Barreca,F., Giubilato,S., Alagna,G., Taverna,G., Giamundo,D.M., Ibrahim,A., Sabouret,P., Amico,F. and Ando,G. Targeting Factor XI for Safer Anticoagulation: Emerging Data and Future Directions Am J Cardiovasc Drugs (2026) PubMed Europe PubMed DOI K
Gabrielsen,A., Ueckert,S., Nilsson,C., Egnell,A.C., Fu,J., Wikstrom,J., Svedlund,S., Friend,R., Zhang,H., Liang,Z., Gao,S. and Gan,L.M. RNA interference therapy targeting coagulation factor XI - a first-in-human trial of RBD4059 Blood Adv (2026) PubMed Europe PubMed DOI
Zhuang,X., Yang,H., Zhou,F., Li,R., Zhao,X., Zou,M. and Li,Q. Development of selective NBD-based fluorescent probes for in vitro detection of factor XIa and Thrombus imaging Bioorg Chem (2026) 171, 109571-109571. PubMed Europe PubMed DOI

2025

Angiolillo,D.J. and Capodanno,D. Uncoupling Thrombosis and Hemostasis by Inhibiting Factor XI N Engl J Med (2025) 392, 400-403. PubMed Europe PubMed DOI
Connors,J.M. Factor XI inhibitors: a new class of anticoagulants Blood Adv (2025) 9, 192-192. PubMed Europe PubMed DOI
Gibson,C.M., Desai,U.R. and Wesling,M.E. Factor XI/XIa inhibitors: a potential solution to anticoagulation dilemmas Expert Opin Pharmacother (2025) , 1-12. PubMed Europe PubMed DOI V
Lopez-Lera,A., Corvillo,F., Gonzalez-Sanchez,L., Melgosa,M. and Sanchez-Corral,P. Relevance of the interactions between the complement and contact coagulation systems on renal pathology Nefrologia (Engl Ed) (2025) , 501347-501347. PubMed Europe PubMed DOI
Mackman,N., Sachetto,A.T.A. and Grover,S.P. A central role of factor XI in a baboon model of Staphylococcus aureus sepsis J Thromb Haemost (2025) 23, 3075-3078. PubMed Europe PubMed DOI
Mauriello,A., Maratea,A.C., Fonderico,C., Quagliariello,V., Maurea,F. and Maurea,N. Factor XI and Cancer: Physiopathological Linkage and Clinical Perspectives J Clin Med (2025) 14 PubMed Europe PubMed DOI PMC EPMC
Satpathy,C., Mishra,T.K. and Jha,A.K. Factor XI and XII inhibitors-Dawn of a new era Indian Heart J (2025) PubMed Europe PubMed DOI V
Srivastava,P., Zhou,A., Fuja,C., Eby,C.S., Baxter,G., Matafonov,A., Fedorov,S., Brown,M., Pettit,M., Tillman,B.F., Gailani,D. and Jacobs,J.W. Identification and characterization of factor XI autoantibodies in 2 patients with systemic lupus erythematosus: insights into mechanisms of acquired factor XI deficiency Res Pract Thromb Haemost (2025) 9, 102703-102703. PubMed Europe PubMed DOI PMC EPMC
Wayne,N.B., Schaidle,S.B. and Beavers,C.J. Factor XI as a Drug Target for the Prevention and Treatment of Thrombosis J Cardiovasc Pharmacol (2025) PubMed Europe PubMed DOI K

2024

Ades,M., Simard,C., Vanassche,T., Verhamme,P., Eikelboom,J. and Mavrakanas,T.A. Factor XI Inhibitors: Potential Role in End-Stage Kidney Disease Semin Nephrol (2024) , 151484-151484. PubMed Europe PubMed DOI K V
Al-Horani,R.A. Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases Heliyon (2024) 10, e28017-e28017. PubMed Europe PubMed DOI PMC EPMC I
Ali,A.E. and Becker,R.C. The foundation for investigating factor XI as a target for inhibition in human cardiovascular disease J Thromb Thrombolysis (2024) 57, 1283-1296. PubMed Europe PubMed DOI V
Ali,A.E. and Becker,R.C. Factor XI: structure, function and therapeutic inhibition J Thromb Thrombolysis (2024) 57, 1315-1328. PubMed Europe PubMed DOI K V
Andreotti,F., Massetti,M. and Montalescot,G. Thrombosis, Bleeding, and the Promise of Factor XI(a) Inhibition J Am Coll Cardiol (2024) 83, 679-681. PubMed Europe PubMed DOI
Bakhtiari,K. and Meijers,J.C.M. Reversal of factor XI targeting anticoagulants: an in vitro evaluation J Thromb Haemost (2024) 22, 300-303. PubMed Europe PubMed DOI
Bar Barroeta,A., Albanese,P., Kadava,T., Jankevics,A., Marquart,J.A., Meijers,J.C.M. and Scheltema,R.A. Thrombin activation of the factor XI dimer is a multistaged process for each subunit J Thromb Haemost (2024) 22, 1336-1346. PubMed Europe PubMed DOI
Barg,A.A., Livnat,T. and Kenet,G. Factor XI Deficiency: Phenotypic Age related considerations and Clinical Approach Towards Bleeding Risk Assessment Blood (2024) 143, 1455-1464. PubMed Europe PubMed DOI V
Bentounes,N.K., Melicine,S., Martin,A.C., Smadja,D.M. and Gendron,N. [New anticoagulants in 2024: Development of factor XI and XIa inhibitors] Ann Biol Clin (Paris) (2024) 82, 9-23. PubMed Europe PubMed DOI V I
Carlin,S., Jakovac,M., Budaj,A. and Eikelboom,J. Factor XI inhibition in cardiovascular disease Pol Arch Intern Med (2024) 134, 16799-16799. PubMed Europe PubMed DOI V
Cohen,O., Santagata,D. and Ageno,W. Novel horizons in anticoagulation: the emerging role of factor XI inhibitors across different settings Haematologica (2024) 109, 3110-3124. PubMed Europe PubMed DOI V
Davidson,S. and Gomez,K. Laboratory and Molecular Diagnosis of Factor XI Deficiency Semin Thromb Hemost (2024) PubMed Europe PubMed DOI
De Vriese,A.S. and Ledo,N. Factor XI antagonists: the discovery of the philosopher's stone? Clin Kidney J (2024) 17, sfae106-sfae106. PubMed Europe PubMed DOI PMC EPMC
Demoy,M., Labrousse,J., Grand,F., Moyrand,S., Tuffigo,M., Lamarche,S. and Macchi,L. [Factor XI deficiency: actuality and review of the literature] Ann Biol Clin (Paris) (2024) 82 PubMed Europe PubMed DOI
Gailani,D. and Gruber,A. Targeting Factor XI and Factor XIa to Prevent Thrombosis Blood (2024) 143, 1465-1475. PubMed Europe PubMed DOI V
Liang,C., Jin,J.Y., Shi,H.H., Li,H.X., Chen,L.L., Zhang,Y.H., Wang,Q., Li,Q.L. and Li,R.M. Case Report: Allelic and biallelic variants in coagulation factor XI cause factor XI deficiency Front Cardiovasc Med (2024) 11, 1461899-1461899. PubMed Europe PubMed DOI PMC EPMC
Lira,A.L., Kohs,T.C.L., Moellmer,S.A., Shatzel,J.J., McCarty,O.J.T. and Puy,C. Substrates, Cofactors, and Cellular Targets of Coagulation Factor XIa Semin Thromb Hemost (2024) 50, 962-969. PubMed Europe PubMed DOI V
Moellmer,S.A., Puy,C. and McCarty,O.J.T. Biology of Factor Xl Blood (2024) 143, 1445-1454. PubMed Europe PubMed DOI V
Natorska,J., Zabczyk,M., Mastalerz,L. and Undas,A. Increased factor XI but not factor XII is associated with enhanced inflammation and impaired fibrin clot properties in patients with eosinophilic granulomatosis with polyangiitis Clin Exp Rheumatol (2024) 42, 822-827. PubMed Europe PubMed DOI
Nolte,C.H. Factor XI inhibitors - Rising stars in anti-thrombotic therapy? J Neurol Sci (2024) 464, 123157-123157. PubMed Europe PubMed DOI K I
Paramo,J.A. and Marcos-Jubilar,M. Factor XI inhibitors: A new era in antithrombotic therapy Med Clin (Barc) (2024) 162, 73-76. PubMed Europe PubMed DOI
Presume,J., Ferreira,J. and Ribeiras,R. Factor XI Inhibitors: A New Horizon in Anticoagulation Therapy Cardiol Ther (2024) 13, 1-16. PubMed Europe PubMed DOI PMC EPMC V
Prisco,D., Canfora,M., Mazzetti,M., Mattioli,I. and Bettiol,A. Factor XI Inhibitors: perspectives in primary and secondary prevention of ischemic stroke Intern Emerg Med (2024) 19, 1807-1819. PubMed Europe PubMed DOI V
Sammut,M.A., Elamin,N. and Storey,R.F. Factor XI and XIa inhibition: a new approach to anticoagulant therapy Br J Cardiol (2024) 31, 018-018. PubMed Europe PubMed DOI PMC EPMC V
Schuermans,A., Verstraete,A., Lammi,V., Nakanishi,T., Ardissino,M., Van den Eynde,J., Sun,B.B., Georgakis,M.K., Van Weyenbergh,J., Lewandowski,A.J., Raman,B., Ollila,H.M., Burgess,S., Natarajan,P., Honigberg,M.C., Freson,K., Vanassche,T. and Verhamme,P. Proteogenomic analyses identify coagulation factor XI as a thromboinflammatory mediator of long COVID medRxiv (2024) PubMed Europe PubMed DOI PMC EPMC
Sun,F., Wang,W., Li,Z., Li,Y., Guo,W. and Kong,Y. Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis Bioorg Chem (2024) 142, 106951-106951. PubMed Europe PubMed DOI I
Taskin,B., Kohs,T.C.L., Shatzel,J.J., Puy,C. and McCarty,O.J.T. Factor XI as a therapeutic target in neuroinflammatory disease Curr Opin Hematol (2024) 31, 32-38. PubMed Europe PubMed DOI V
Wang,Y., Yuan,J., Yan,S., Liu,P., Zheng,Z., Zhang,S., Meng,F., Liu,W., Huang,C. and Wei,Q. Design, synthesis and biological evaluation of 6-chloro-quinolin-2-one derivatives as novel FXIa inhibitors Bioorg Med Chem Lett (2024) 99, 129610-129610. PubMed Europe PubMed DOI I

2023

Bentounes,N.K., Melicine,S., Martin,A.C., Smadja,D.M. and Gendron,N. Development of new anticoagulant in 2023: Prime time for anti-factor XI and XIa inhibitors J Med Vasc (2023) 48, 69-80. PubMed Europe PubMed DOI V
Chan,N.C. and Weitz,J.I. New Therapeutic Targets for the Prevention and Treatment of Venous Thromboembolism With a Focus on Factor XI Inhibitors Arterioscler Thromb Vasc Biol (2023) 43, 1755-1763. PubMed Europe PubMed DOI V
De Caterina,R., Prisco,D. and Eikelboom,J.W. Factor XI inhibitors: cardiovascular perspectives Eur Heart J (2023) 44, 280-292. PubMed Europe PubMed DOI K V
Elsheikh,S., Tidbury,N. and Lip,G.Y.H. A review of emerging factor XI inhibitors Expert Opin Emerg Drugs (2023) 28, 43-53. PubMed Europe PubMed DOI
Emmerich,J. Factor XI-inhibitors the search of the holy graal J Med Vasc (2023) 48, 51-52. PubMed Europe PubMed DOI
Frunt,R., El Otmani,H., Gibril Kaira,B., de Maat,S. and Maas,C. Factor XII Explored with AlphaFold - Opportunities for Selective Drug Development Thromb Haemost (2023) 123, 177-185. PubMed Europe PubMed DOI
Greco,A., Laudani,C., Spagnolo,M., Agnello,F., Faro,D.C., Finocchiaro,S., Legnazzi,M., Mauro,M.S., Mazzone,P.M., Occhipinti,G., Rochira,C., Scalia,L. and Capodanno,D. Pharmacology and Clinical Development of Factor XI Inhibitors Circulation (2023) 147, 897-913. PubMed Europe PubMed DOI K
Kreutz,R.P., Ipe,J. and Skaar,T.C. Sex specific differences of factor XI and relationship with other coagulation factors Thromb Res (2023) 226, 156-158. PubMed Europe PubMed DOI
Li,C., Barroeta,A.B., Wong,S.S., Kim,H.J., Pathak,M., Dreveny,I., Meijers,J.C.M. and Emsley,J. Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites J Thromb Haemost (2023) 21, 2378-2389. PubMed Europe PubMed DOI
Lova,A., Pagan,J., de la Morena,G., Vazquez,D.J., Cerezo-Manchado,J.J., Bravo-Perez,C., Minano,A., Tomas,A., Vicente,V., Lozano,M.L., Corral,J. and Morena-Barrio,M.E. Congenital factor XI deficiency and risk of heart failure in humans J Thromb Haemost (2023) 21, 2626-2629. PubMed Europe PubMed DOI
Modrzycka,S., Kolt,S., Adams,T.E., Potoczek,S., Huntington,J.A., Kasperkiewicz,P. and Drag,M. Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma J Med Chem (2023) 66, 3785-3797. PubMed Europe PubMed DOI PMC EPMC
Novichikhina,N.P., Shestakov,A.S., Medvedeva,S.M., Lagutina,A.M., Krysin,M.Y., Podoplelova,N.A., Panteleev,M.A., Ilin,I.S., Sulimov,A.V., Tashchilova,A.S., Sulimov,V.B., Geronikaki,A. and Shikhaliev,K.S. New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation Molecules (2023) 28 PubMed Europe PubMed DOI PMC EPMC I
Parunov,L.A., Liang,Y., Lu,Q., Shibeko,A.M., Tucker,E.I., Lee,T.K., Ataullakhanov,F.I., Scott,D.E. and Ovanesov,M.V. Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation Blood Adv (2023) 7, 2622-2631. PubMed Europe PubMed DOI
Piel,I., Engelen,A., Lang,D., Schulz,S.I., Gerisch,M., Brase,C., Janssen,W., Fiebig,L., Heitmeier,S. and Kanefendt,F. Metabolism and Disposition of the Novel Oral Factor XIa Inhibitor Asundexian in Rats and in Humans Eur J Drug Metab Pharmacokinet (2023) 48, 411-425. PubMed Europe PubMed DOI PMC EPMC I
Poenou,G., Heestermans,M., Lafaie,L., Accassat,S., Moulin,N., Rodiere,A., Petit,B., Duvillard,C., Mismetti,P. and Bertoletti,L. Inhibition of Factor XI: A New Era in the Treatment of Venous Thromboembolism in Cancer Patients? Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
van der Vorst,E.P.C. and Badimon,L. The unknown functions of a known protein: the case of coagulation factor XI Cardiovasc Res (2023) 119, e137-e137. PubMed Europe PubMed DOI
Vedovati,M.C., Becattini,C. and Agnelli,G. A new strategy for anticoagulation: The factor XI inhibitors Eur J Intern Med (2023) 116, 8-15. PubMed Europe PubMed DOI
Vedovati,M.C. and Agnelli,G. [A new anticoagulant strategy: the factor XI inhibitors] G Ital Cardiol (Rome) (2023) 24454. PubMed Europe PubMed DOI
Whiteson,H.Z. and Frishman,W.H. Factor XI/XIa Inhibitors: A New Approach to Anticoagulation Cardiol Rev (2023) PubMed Europe PubMed DOI V
Xie,Z., Meng,Z., Yang,X., Duan,Y., Wang,Q. and Liao,C. Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives J Med Chem (2023) 66, 5332-5363. PubMed Europe PubMed DOI
Xu,J., Zhao,N., Huang,J., Li,J., Zhao,X., Xiang,Q., Yang,S., Dong,Y., Wang,H., Li,Y., Yang,G. and Cui,Y. The Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, an Oral Small Molecule Factor XIa Inhibitor, in Healthy Chinese Volunteers Clin Drug Investig (2023) 43, 435-445. PubMed Europe PubMed DOI I
Zhang,X., Lewandowska,M., Aldridge,M., Iglay,K., Wolford,E. and Shapiro,A. Global epidemiology of factor XI deficiency: A targeted review of the literature and foundation reports Haemophilia (2023) 29, 423-434. PubMed Europe PubMed DOI

2022

Al-Horani,R.A., Parsaeian,E., Mohammad,M. and Mottamal,M. Sulfonated non-saccharide molecules and human factor XIa: Enzyme inhibition and computational studies Chem Biol Drug Des (2022) 100, 64-79. PubMed Europe PubMed DOI I
Bar Barroeta,A., Marquart,J.A. and Meijers,J.C.M. A FRET-based assay for the quantitation of the thrombin-factor XI interaction Thromb Res (2022) 214, 23-28. PubMed Europe PubMed DOI
Barg,A.A., Levy-Mendelovich,S., Budnik,I., Mandel-Shorer,N., Dardik,R., Avishai,E., Brutman-Barazani,T., Ifrah,A.D., Oren-Malek,L., Yacobovich,J., Gilad,O., Nakav,S., Fruchtman,Y., Revel-Vilk,S., Miskin,H. and Kenet,G. Pediatric severe factor XI deficiency: A multicenter study Pediatr Blood Cancer (2022) 69, e29545-e29545. PubMed Europe PubMed DOI
Cao,Y., Wang,Y., Zhou,Z., Pan,C., Jiang,L., Zhou,Z., Meng,Y., Charugundla,S., Li,T., Allayee,H., Seldin,M.M. and Lusis,A.J. Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure Science (2022) 377, 1399-1406. PubMed Europe PubMed DOI PMC EPMC
Heal,S.L., Hardy,L.J., Wilson,C.L., Ali,M., Ariens,R.A.S., Foster,R. and Philippou,H. Novel interaction of properdin and coagulation factor XI: Crosstalk between complement and coagulation Res Pract Thromb Haemost (2022) 6, e12715-e12715. PubMed Europe PubMed DOI PMC EPMC
Ito,K., Inoue,Y., Ino,K. and Shiku,H. High-Sensitivity Amperometric Dual Immunoassay Using Two Cascade Reactions with Signal Amplification of Redox Cycling in Nanoscale Gap Anal Chem (2022) 94, 16451-16460. PubMed Europe PubMed DOI
Jiang,S., Jia,Z., Zheng,Y., Zhang,J., Li,Z., Yu,X., Zhang,K., Bai,Y., Guo,W., Kong,Y. and Li,Q. Bifunctional fusion protein targeting both FXIIa and FXIa displays potent anticoagulation effects Life Sci (2022) 309, 121021-121021. PubMed Europe PubMed DOI
Jordan,K.R., Wyatt,C.R., Fallon,M.E., Woltjer,R., Neuwelt,E.A., Cheng,Q., Gailani,D., Lorentz,C., Tucker,E.I., McCarty,O.J.T., Hinds,M.T. and Nguyen,K.P. Pharmacological reduction of coagulation factor XI reduces macrophage accumulation and accelerates deep vein thrombosis resolution in a mouse model of venous thrombosis J Thromb Haemost (2022) 20, 2035-2045. PubMed Europe PubMed DOI
Kubitza,D., Heckmann,M., Distler,J., Koechel,A., Schwers,S. and Kanefendt,F. Pharmacokinetics, pharmacodynamics and safety of BAY 2433334, a novel activated factor XI inhibitor, in healthy volunteers: A randomized phase 1 multiple-dose study Br J Clin Pharmacol (2022) 88, 3447-3462. PubMed Europe PubMed DOI I
Li,T., Liu,J. and Wu,W. Factor XI, a potential target for anticoagulation therapy for venous thromboembolism Front Cardiovasc Med (2022) 9, 975767-975767. PubMed Europe PubMed DOI PMC EPMC V
Lim,G.B. Novel factor XIa inhibitor reduces bleeding compared with apixaban in atrial fibrillation Nat Rev Cardiol (2022) 19, 350-350. PubMed Europe PubMed DOI
Marshalek,J.P., Yashar,D., Huynh,K. and Tomassetti,S. Case of concurrent factor VII and factor XI deficiencies manifesting as spontaneous lower extremity compartment syndrome Clin Case Rep (2022) 10, e05710-e05710. PubMed Europe PubMed DOI PMC EPMC
Mohammed,B.M., Cheng,Q. and Gailani,D. A demonstration of factor XI contributing to hemostasis in the absence of factor XII Res Pract Thromb Haemost (2022) 6, e12841-e12841. PubMed Europe PubMed DOI PMC EPMC
Nopp,S., Kraemmer,D. and Ay,C. Factor XI Inhibitors for Prevention and Treatment of Venous Thromboembolism: A Review on the Rationale and Update on Current Evidence Front Cardiovasc Med (2022) 9, 903029-903029. PubMed Europe PubMed DOI PMC EPMC V
Nowotny,B., Thomas,D., Schwers,S., Wiegmann,S., Prange,W., Yassen,A. and Boxnick,S. First randomized evaluation of safety, pharmacodynamics, and pharmacokinetics of BAY 1831865, an antibody targeting coagulation factor XI and factor XIa, in healthy men J Thromb Haemost (2022) 20, 1684-1695. PubMed Europe PubMed DOI PMC EPMC
Sharma,M., Molina,C.A., Toyoda,K., Bereczki,D., Kasner,S.E., Lutsep,H.L., Tsivgoulis,G., Ntaios,G., Czlonkowska,A., Shuaib,A., Amarenco,P., Endres,M., Diener,H.C., Gailani,D., Kahl,A., Donovan,M., Perera,V., Li,D. and Hankey,G.J. Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for Secondary Stroke Prevention J Stroke Cerebrovasc Dis (2022) 31, 106742-106742. PubMed Europe PubMed DOI PMC EPMC I
Tong,D. and Hill,J.A. A coagulation factor moonlights in the heart Science (2022) 377, 1382-1383. PubMed Europe PubMed DOI
Yao,N., Jia,Z., Tian,Y., Hou,S., Yang,X., Han,J., Duan,Y., Liao,C., Kong,Y. and Xie,Z. Targeting the S2 Subsite Enables the Structure-Based Discovery of Novel Highly Selective Factor XIa Inhibitors J Med Chem (2022) 65, 4318-4334. PubMed Europe PubMed DOI
Yi,B.A., Freedholm,D., Widener,N., Wang,X., Simard,E., Cullen,C., Al-Saady,N.M., Lepor,N.E., Coulter,S., Lovern,M. and Bloomfield,D. Pharmacokinetics and pharmacodynamics of Abelacimab (MAA868), a novel dual inhibitor of Factor XI and Factor XIa J Thromb Haemost (2022) 20, 307-315. PubMed Europe PubMed DOI

2021

Hayakawa,Y., Tamura,S., Suzuki,N., Odaira,K., Tokoro,M., Kawashima,F., Hayakawa,F., Takagi,A., Katsumi,A., Suzuki,A., Okamoto,S., Kanematsu,T., Matsushita,T. and Kojima,T. Essential role of a carboxyl-terminal alpha-helix motif in the secretion of coagulation factor XI J Thromb Haemost (2021) PubMed Europe PubMed DOI
Hsu,C., Hutt,E., Bloomfield,D.M., Gailani,D. and Weitz,J.I. Factor XI Inhibition to Uncouple Thrombosis From Hemostasis: JACC Review Topic of the Week J Am Coll Cardiol (2021) 78, 625-631. PubMed Europe PubMed DOI
Kearney,K.J., Butler,J., Posada,O.M., Wilson,C., Heal,S., Ali,M., Hardy,L., Ahnstrom,J., Gailani,D., Foster,R., Hethershaw,E., Longstaff,C. and Philippou,H. Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI
Lei,Y., Zhang,B., Zhang,Y., Dai,X., Duan,Y., Mao,Q., Gao,J., Yang,Y., Bao,Z., Fu,X., Ping,K., Yan,C., Mou,Y. and Wang,S. Design, synthesis and biological evaluation of novel FXIa inhibitors with 2-phenyl-1H-imidazole-5-carboxamide moiety as P1 fragment Eur J Med Chem (2021) 220, 113437-113437. PubMed Europe PubMed DOI I
Li,P., Wu,D.R., Yip,H., Sun,D., Zhang,H., Hou,X., Kempson,J. and Mathur,A. The effect of water on the large-scale supercritical fluid chromatography purification of two factor XIa active pharmaceutical ingredients J Chromatogr A (2021) 1651, 462318-462318. PubMed Europe PubMed DOI I
Thomas,D., Kanefendt,F., Schwers,S., Unger,S., Yassen,A. and Boxnick,S. First evaluation of the safety, pharmacokinetics and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor Xia J Thromb Haemost (2021) PubMed Europe PubMed DOI I
Zheng,Y.Z., Ji,X.R., Liu,Y.Y., Jiang,S., Yu,X.Y., Jia,Z.P., Zhao,Y., Zhang,J.Q., Zhang,J.L. and Kong,Y. WPK5, a Novel Kunitz-Type Peptide from the Leech Whitmania pigra Inhibiting Factor XIa, and Its Loop-Replaced Mutant to Improve Potency Biomedicines (2021) 9 PubMed Europe PubMed DOI PMC EPMC I

2020

Bauduer,F., de la Morena-Barrio,M.E., Salloum-Asfar,S., de la Morena-Barrio,B., Padilla,J., Minano,A., Vicente,V., Carbonell,P., Corral,J. and Esteban,J. When genetic and surname analyses meet historical sources: The C56R mutation associated with factor XI deficiency as a marker of human migration during the Spanish Reconquista Med Hypotheses (2020) 141, 109709-109709. PubMed Europe PubMed DOI M
Fang,C. and Schmaier,A.H. Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems Pharmacol Res (2020) 160, 105096-105096. PubMed Europe PubMed DOI PMC EPMC V
Gotovac Jercic,K., Blazekovic,A., Hancevic,M., Bilic,E. and Borovecki,F. Congenital factor XI deficiency caused by a novel F11 missense variant: a case report Croat Med J (2020) 61, 62-65. PubMed Europe PubMed M
Holt,B.A. and Kwong,G.A. Protease circuits for processing biological information Nat Commun (2020) 11, 5021-5021. PubMed Europe PubMed DOI PMC EPMC
Leung,P.Y., Li,C.K., Cheng,C.K., Ng,M.H.L. and Chan,N.C.N. A novel F11 mutation in a Chinese paediatric patient with severe factor XI deficiency Thromb Res (2020) 190, 89-90. PubMed Europe PubMed DOI M
Li,Y.Y., Xu,K., Zhao,M.S., Tong,Y., Su,K.K. and Wang,M.S. [Gene analysis of a family with hereditary coagulation factor XI deficiency] Zhonghua Xue Ye Xue Za Zhi (2020) 41, 422-424. PubMed Europe PubMed DOI PMC EPMC
Lin,F., Weng,M.S., Wu,J.R., Fang,S.H. and Yang,L.Y. Gene variants in four pedigrees with hereditary coagulation factor XI deficiency and one novel mutation identification Blood Coagul Fibrinolysis (2020) 31, 160-164. PubMed Europe PubMed DOI M
Lin,H.Y., Lin,C.Y., Hung,M.H., Kuo,S.F., Lin,J.S. and Shen,M.C. Characterization of hereditary factor XI deficiency in Taiwanese patients: identification of three novel and two common mutations Int J Hematol (2020) PubMed Europe PubMed DOI M
Lorthiois,E., Roache,J., Barnes-Seeman,D., Altmann,E., Hassiepen,U., Turner,G., Duvadie,R., Hornak,V., Karki,R.G., Schiering,N., Weihofen,W.A., Perruccio,F., Calhoun,A., Fazal,T., Dedic,D., Durand,C., Dussauge,S., Fettis,K., Tritsch,F., Dentel,C., Druet,A., Liu,D., Kirman,L., Lachal,J., Namoto,K., Bevan,D., Mo,R., Monnet,G., Muller,L., Zessis,R., Huang,X., Lindsley,L., Currie,T., Chiu,Y.H., Fridrich,C., Delgado,P., Wang,S., Hollis-Symynkywicz,M., Berghausen,J., Williams,E., Liu,H., Liang,G., Kim,H., Hoffmann,P., Hein,A., Ramage,P., D'arcy,A., Harlfinger,S., Renatus,M., Ruedisser,S., Feldman,D., Elliott,J., Sedrani,R., Maibaum,J. and Adams,C.M. Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach J Med Chem (2020) PubMed Europe PubMed DOI
Mrinalini, Koh,C.Y., Li,A.W.L., Bendre,R., Chan,M.Y.Y., Kini,R.M., Benson,M. and Bhattacharya,S. Characterization of a novel inhibitor of coagulation factor XIa identified from salivary gland transcripts of the lone star tick, Amblyomma americanum Toxicon (2020) 177 Suppl 1, S44-S44. PubMed Europe PubMed DOI
Ponczek,M.B., Shamanaev,A., LaPlace,A., Dickeson,S.K., Srivastava,P., Sun,M.F., Gruber,A., Kastrup,C., Emsley,J. and Gailani,D. The evolution of factor XI and the kallikrein-kinin system Blood Adv (2020) 4, 6135-6147. PubMed Europe PubMed DOI PMC EPMC
Rohmann,J.L., Huo,S., Sperber,P.S., Piper,S.K., Rosendaal,F.R., Heuschmann,P.U., Endres,M., Liman,T.G. and Siegerink,B. Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke J Thromb Haemost (2020) PubMed Europe PubMed DOI
Srivastava,P. and Gailani,D. The rebirth of the contact pathway: a new therapeutic target Curr Opin Hematol (2020) 27, 311-319. PubMed Europe PubMed DOI

2019

Bar Barroeta,A., Van Galen,J., Stroo,I., Marquart,J.A., Meijer,A.B. and Meijers,J.C.M. Hydrogen-deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa J Thromb Haemost (2019) 17, 2047-2055. PubMed Europe PubMed DOI
Chan,N.C. and Weitz,J.I. AB023, a novel antibody that binds factor XI and blocks its activation by factor XIIa Arterioscler Thromb Vasc Biol (2019) 39, 533-535. PubMed Europe PubMed DOI
Gailani,D. and Emsley,J. Toward a better understanding of factor XI activation J Thromb Haemost (2019) 17, 2016-2018. PubMed Europe PubMed DOI
Li,C., Voos,K.M., Pathak,M., Hall,G., McCrae,K.R., Dreveny,I., Li,R. and Emsley,J. Plasma Kallikrein Structure Reveals Apple Domain Disc Rotated Conformation Compared to Factor XI J Thromb Haemost (2019) 17, 759-770. PubMed Europe PubMed DOI S
Lorentz,C.U., Verbout,N.G., Wallisch,M., Hagen,M.W., Shatzel,J.J., Olson,S.R., Puy,C., Hinds,M.T., McCarty,O.J.T., Gailani,D., Gruber,A. and Tucker,E.I. Contact activation inhibitor and factor XI antibody, AB023, produces safe, dose-dependent anticoagulation in a phase 1 first-in-human trial Arterioscler Thromb Vasc Biol (2019) 39, 799-809. PubMed Europe PubMed DOI
Schaefer,M., Buchmueller,A., Dittmer,F., Strassburger,J. and Wilmen,A. Allosteric inhibition as a new mode of action for BAY 1213790, a neutralizing antibody targeting the activated form of coagulation factor XI J Mol Biol (2019) 431, 4817-4833. PubMed Europe PubMed DOI
Szekely,O., Borgi,M. and Lip,G.Y.H. Factor XI inhibition fulfilling the optimal expectations for ideal anticoagulation Expert Opin Emerg Drugs (2019) 24, 55-61. PubMed Europe PubMed DOI I
Wang,Y., Wang,Q., Zhang,Y., Ma,P. and Ding,H. A case of a severe factor XI deficiency in a Chinese woman with heavy menorrhagia Blood Coagul Fibrinolysis (2019) 30, 75-79. PubMed Europe PubMed DOI M

2018

Al-Horani,R.A. and Afosah,D.K. Recent advances in the discovery and development of factor XI/XIa inhibitors Med Res Rev (2018) 38, 1974-2023. PubMed Europe PubMed DOI I
Duong,H.Q. and Sieburth,S.M. Asymmetric synthesis of silanediol inhibitors for the serine protease coagulation cascade enzyme FXIa J Org Chem (2018) 83, 5398-5409. PubMed Europe PubMed DOI I
Ely,L.K., Lolicato,M., David,T., Lowe,K., Kim,Y.C., Samuel,D., Bessette,P., Garcia,J.L., Mikita,T., Minor DL Jr. and Coughlin,S.R. Structural basis for activity and specificity of an anticoagulant anti-FXIa monoclonal antibody and a reversal agent Structure (2018) 26, 187-198. PubMed Europe PubMed DOI S
Hu,Z., Wang,C., Han,W., Rossi,K.A., Bozarth,J.M., Wu,Y., Sheriff,S., Myers JE Jr, Luettgen,J.M., Seiffert,D.A., Wexler,R.R. and Quan,M.L. Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors Bioorg Med Chem Lett (2018) 28, 987-992. PubMed Europe PubMed DOI I
Ramesh,K., Lama,D., Tan,K.W., Nguyen,V.S., Chew,F.T., Verma,C.S. and Mok,Y.K. Homologous lympho-epithelial Kazal-type inhibitor domains delay blood coagulation by inhibiting factor X and XI with differential specificity Structure (2018) 26, 1178-1186. PubMed Europe PubMed DOI
Shu,K., Xu,K., Li,F., Chen,T., Liu,J., Jin,S., Guo,J., Zhang,Z. and Jiang,M. [Identification of compound heterozygous mutations p.Gly400Val and p.Arg532Ter of the F11 gene in a Chinese patient with hereditary factor XI deficiency] Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2018) 35, 522-526. PubMed Europe PubMed DOI M
Stroo,I., Marquart,J.A., Bakhtiari,K., Plug,T., Meijer,A.B. and Meijers,J.C.M. Chemical footprinting reveals conformational changes following activation of factor XI Thromb Haemost (2018) 118, 340-350. PubMed Europe PubMed DOI
Su,K., Cai,X., Xia,W., Jin,Y., Yang,L. and Wang,M. A novel mutation (Tyr503Cys) in a severe factor XI deficiency Blood Coagul Fibrinolysis (2018) 29, 338-343. PubMed Europe PubMed DOI M

2017

Corte,J.R., Fang,T., Osuna,H., Pinto,D.J., Rossi,K.A., Myers JE Jr, Sheriff,S., Lou,Z., Zheng,J.J., Harper,T.W., Bozarth,J.M., Wu,Y., Luettgen,J.M., Seiffert,D.A., Decicco,C.P., Wexler,R.R. and Quan,M.L. Structure-based design of macrocyclic factor XIa inhibitors: discovery of the macrocyclic amide linker J Med Chem (2017) 60, 1060-1075. PubMed Europe PubMed DOI I
Corte,J.R., Yang,W., Fang,T., Wang,Y., Osuna,H., Lai,A., Ewing,W.R., Rossi,K.A., Myers JE Jr, Sheriff,S., Lou,Z., Zheng,J.J., Harper,T.W., Bozarth,J.M., Wu,Y., Luettgen,J.M., Seiffert,D.A., Quan,M.L., Wexler,R.R. and Lam,P.Y.S. Macrocyclic inhibitors of factor XIa: discovery of alkyl-substituted macrocyclic amide linkers with improved potency Bioorg Med Chem Lett (2017) 27, 3833-3839. PubMed Europe PubMed DOI I
Donkor,D.A., Bhakta,V., Eltringham-Smith,L.J., Stafford,A.R., Weitz,J.I. and Sheffield,W.P. Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa Sci Rep (2017) 7, 2102-2102. PubMed Europe PubMed DOI PMC EPMC I
Garland,K.S., Reitsma,S.E., Shirai,T., Zilberman-Rudenko,J., Tucker,E.I., Gailani,D., Gruber,A., McCarty,O.J.T. and Puy,C. Removal of the C-terminal domains of ADAMTS13 by activated coagulation factor XI induces platelet adhesion on endothelial cells under flow conditions Front Med (Lausanne) (2017) 4, 232-232. PubMed Europe PubMed DOI PMC EPMC
Mohammed,B.M., Matafonov,A., Ivanov,I., Sun,M.F., Cheng,Q., Dickeson,S.K., Li,C., Sun,D., Verhamme,I.M., Emsley,J. and Gailani,D. An update on factor XI structure and function Thromb Res (2017) 161, 94-105. PubMed Europe PubMed DOI V
Pinto,D.J.P., Orwat,M.J., Smith LM 2nd, Quan,M.L., Lam,P.Y.S., Rossi,K.A., Apedo,A., Bozarth,J.M., Wu,Y., Zheng,J.J., Xin,B., Toussaint,N., Stetsko,P., Gudmundsson,O., Maxwell,B., Crain,E.J., Wong,P.C., Lou,Z., Harper,T.W., Chacko,S.A., Myers JE Jr, Sheriff,S., Zhang,H., Hou,X., Mathur,A., Seiffert,D.A., Wexler,R.R., Luettgen,J.M. and Ewing,W.R. Discovery of a parenteral small molecule coagulation factor XIa inhibitor clinical candidate (BMS-962212) J Med Chem (2017) 60, 9703-9723. PubMed Europe PubMed DOI
Wang,C., Corte,J.R., Rossi,K.A., Bozarth,J.M., Wu,Y., Sheriff,S., Myers JE Jr, Luettgen,J.M., Seiffert,D.A., Wexler,R.R. and Quan,M.L. Macrocyclic factor XIa inhibitors Bioorg Med Chem Lett (2017) 27, 4056-4060. PubMed Europe PubMed DOI I
Woodruff,R.S., Ivanov,I., Verhamme,I.M., Sun,M.F., Gailani,D. and Sullenger,B.A. Generation and characterization of aptamers targeting factor XIa Thromb Res (2017) 156, 134-141. PubMed Europe PubMed DOI I

2016

David,T., Kim,Y.C., Ely,L.K., Rondon,I., Gao,H., O'Brien,P., Bolt,M.W., Coyle,A.J., Garcia,J.L., Flounders,E.A., Mikita,T. and Coughlin,S.R. Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis Sci Transl Med (2016) 8, 353ra112-353ra. PubMed Europe PubMed DOI
Gailani,D. and Gruber,A. Factor XI as a therapeutic target Arterioscler Thromb Vasc Biol (2016) 36, 1316-1322. PubMed Europe PubMed DOI T
Ponczek,M.B. The susceptibility of plasma coagulation factor XI to nitration and peroxynitrite action Int J Biol Macromol (2016) 91, 589-597. PubMed Europe PubMed DOI
Puy,C., Rigg,R.A. and McCarty,O.J. The hemostatic role of factor XI Thromb Res (2016) 141 Suppl 2, S8-S8. PubMed Europe PubMed DOI
Shao,Y., Cao,Y., Lu,Y., Dai,J., Ding,Q., Wang,X., Xi,X. and Wang,H. Clinical manifestations and mutation spectrum of 57 subjects with congenital factor XI deficiency in China Blood Cells Mol Dis (2016) 58, 29-34. PubMed Europe PubMed DOI M
Smith LM 2nd, Orwat,M.J., Hu,Z., Han,W., Wang,C., Rossi,K.A., Gilligan,P.J., Pabbisetty,K.B., Osuna,H., Corte,J.R., Rendina,A.R., Luettgen,J.M., Wong,P.C., Narayanan,R., Harper,T.W., Bozarth,J.M., Crain,E.J., Wei,A., Ramamurthy,V., Morin,P.E., Xin,B., Zheng,J., Seiffert,D.A., Quan,M.L., Lam,P.Y., Wexler,R.R. and Pinto,D.J. Novel phenylalanine derived diamides as factor XIa inhibitors Bioorg Med Chem Lett (2016) 26, 472-478. PubMed Europe PubMed DOI I
Wong,S.S., Ostergaard,S., Hall,G., Li,C., Williams,P.M., Stennicke,H. and Emsley,J. A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain Blood (2016) 127, 2915-2923. PubMed Europe PubMed DOI
Zucker,M., Seligsohn,U., Yeheskel,A. and Mor-Cohen,R. An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase J Thromb Haemost (2016) 14, 2202-2211. PubMed Europe PubMed DOI

2015

Bauduer,F., de Raucourt,E., Boyer-Neumann,C., Trossaert,M., Beurrier,P., Faradji,A., Peynet,J., Borg,J.Y., Chamouni,P., Chatelanaz,C., Henriet,C., Bridey,F. and Goudemand,J. Factor XI replacement for inherited factor XI deficiency in routine clinical practice: results of the HEMOLEVEN prospective 3-year postmarketing study Haemophilia (2015) 21, 481-489. PubMed Europe PubMed DOI U
Buller,H.R., Bethune,C., Bhanot,S., Gailani,D., Monia,B.P., Raskob,G.E., Segers,A., Verhamme,P. and Weitz,J.I. Factor XI antisense oligonucleotide for prevention of venous thrombosis N Engl J Med (2015) 372, 232-240. PubMed Europe PubMed DOI K
Corte,J.R., Fang,T., Hangeland,J.J., Friends,T.J., Rendina,A.R., Luettgen,J.M., Bozarth,J.M., Barbera,F.A., Rossi,K.A., Wei,A., Ramamurthy,V., Morin,P.E., Seiffert,D.A., Wexler,R.R. and Quan,M.L. Pyridine and pyridinone-based factor XIa inhibitors Bioorg Med Chem Lett (2015) 25, 925-930. PubMed Europe PubMed DOI I
Duarte,J.H. Anticoagulation therapy: reducing factor XI with antisense oligonucleotides superior to endoxaparin for postoperative venous thromboembolism Nat Rev Cardiol (2015) 12, 66-66. PubMed Europe PubMed DOI K
Fjellstrom,O., Akkaya,S., Beisel,H.G., Eriksson,P.O., Erixon,K., Gustafsson,D., Jurva,U., Kang,D., Karis,D., Knecht,W., Nerme,V., Nilsson,I., Olsson,T., Redzic,A., Roth,R., Sandmark,J., Tigerstrom,A. and Oster,L. Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design PLoS ONE (2015) 10, e0113705-e0113705. PubMed Europe PubMed DOI I
Gupta,E., Finn,L., Johns,G., Pruthi,R.K. and Roy,V. Correction of factor XI deficiency by liver transplantation Blood Coagul Fibrinolysis (2015) 26, 961-963. PubMed Europe PubMed DOI
Hu,Z., Wong,P.C., Gilligan,P.J., Han,W., Pabbisetty,K.B., Bozarth,J.M., Crain,E.J., Harper,T., Luettgen,J.M., Myers JE Jr, Ramamurthy,V., Rossi,K.A., Sheriff,S., Watson,C.A., Wei,A., Zheng,J.J., Seiffert,D.A., Wexler,R.R. and Quan,M.L. Discovery of a potent parenterally administered factor XIa inhibitor with hydroxyquinolin-2(1H)-one as the P2' moiety ACS Med Chem Lett (2015) 6, 590-595. PubMed Europe PubMed DOI PMC EPMC I
Keskin,E.Y., Gursel,T., Kaya,Z., Dai,L., Kocak,U., Yenicesu,I., Belen,F.B. and Mitchell,M. Molecular basis and bleeding manifestations of factor XI deficiency in 11 Turkish families Blood Coagul Fibrinolysis (2015) 26, 63-68. PubMed Europe PubMed DOI M
Lippi,G., Harenberg,J., Mattiuzzi,C. and Favaloro,E.J. Next generation antithrombotic therapy: focus on antisense therapy against coagulation factor XI Semin Thromb Hemost (2015) 41, 255-262. PubMed Europe PubMed DOI K
Liu,H., Wang,H.F., Tang,L., Yang,Y., Wang,Q.Y., Zeng,W., Wu,Y.Y., Cheng,Z.P., Hu,B., Guo,T. and Hu,Y. Genetic analysis in Factor XI deficient patients from central China: Identification of one novel and seven recurrent mutations Gene (2015) 561, 101-106. PubMed Europe PubMed DOI M
Mulder,R., Croles,F.N., Lukens,M.V., Meijer,K. and Mulder,A.B. A novel c.290G>A mutation in the factor 11 gene in a Dutch caucasian family with a factor XI deficiency Thromb Res (2015) 135, 767-769. PubMed Europe PubMed DOI M
Pinto,D.J., Smallheer,J.M., Corte,J.R., Austin,E.J., Wang,C., Fang,T., Smith,L.M.2., Rossi,K.A., Rendina,A.R., Bozarth,J.M., Zhang,G., Wei,A., Ramamurthy,V., Sheriff,S., Myers,J.E., Jr., Morin,P.E., Luettgen,J.M., Seiffert,D.A., Quan,M.L. and Wexler,R.R. Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties Bioorg Med Chem Lett (2015) 25, 1635-1642. PubMed Europe PubMed DOI I
Puy,C., Tucker,E.I., Matafonov,A., Cheng,Q., Zientek,K.D., Gailani,D., Gruber,A. and McCarty,O.J. Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor Blood (2015) 125, 1488-1496. PubMed Europe PubMed DOI

2014

Chen,Z., Seiffert,D. and Hawes,B. Inhibition of factor XI activity as a promising antithrombotic strategy Drug Discov Today (2014) 19, 1435-1439. PubMed Europe PubMed DOI I
Choi,S.J., Kim,J., Lee,K.A., Choi,J.R. and Yoo,J. Cys482Trp missense mutation in the coagulation factor XI gene (F11) in a Korean patient with factor XI deficiency Ann Lab Med (2014) 34, 332-335. PubMed Europe PubMed DOI PMC EPMC M
Gailani,D., Geng,Y., Verhamme,I., Sun,M.F., Bajaj,S.P., Messer,A. and Emsley,J. The mechanism underlying activation of factor IX by factor XIa Thromb Res (2014) 133 Suppl 1, S48-S51. PubMed Europe PubMed DOI PMC EPMC
Girolami,A., Sambado,L., Peroni,E., Santarossa,L. and Lombardi,A.M. A family with factor-XI deficiency due to a compound heterozygosis between Gln 47 Pro (new mutation) in exon 3 and Leu 619 Pro in exon 15 Blood Coagul Fibrinolysis (2014) 25, 191-195. PubMed Europe PubMed DOI M
Hangeland,J.J., Friends,T.J., Rossi,K.A., Smallheer,J.M., Wang,C., Sun,Z., Corte,J.R., Fang,T., Wong,P.C., Rendina,A.R., Barbera,F.A., Bozarth,J.M., Luettgen,J.M., Watson,C.A., Zhang,G., Wei,A., Ramamurthy,V., Morin,P.E., Bisacchi,G.S., Subramaniam,S., Arunachalam,P., Mathur,A., Seiffert,D.A., Wexler,R.R. and Quan,M.L. Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity J Med Chem (2014) 57, 9915-9932. PubMed Europe PubMed DOI S I
Windyga,J., Lissitchkov,T., Stasyshyn,O., Mamonov,V., Ghandehari,H., Chapman,M., Fritsch,S., Wong,W.Y., Pavlova,B.G. and Abbuehl,B.E. Efficacy and safety of a recombinant factor IX (Bax326) in previously treated patients with severe or moderately severe haemophilia B undergoing surgical or other invasive procedures: a prospective, open-label, uncontrolled, multicentre, phase III study Haemophilia (2014) 20, 651-658. PubMed Europe PubMed DOI U

2013

Castaman,G., Giacomelli,S.H., Tagliaferri,A. and Rodeghiero,F. A novel heterozygous missense mutation (His127Arg) in a family with inherited cross-reacting material positive factor XI deficiency Blood Coagul Fibrinolysis (2013) 24, 670-672. PubMed Europe PubMed DOI M
Crosby,J.R., Marzec,U., Revenko,A.S., Zhao,C., Gao,D., Matafonov,A., Gailani,D., Macleod,A.R., Tucker,E.I., Gruber,A., Hanson,S.R. and Monia,B.P. Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates Arterioscler Thromb Vasc Biol (2013) 33, 1670-1678. PubMed Europe PubMed DOI K
Duga,S. and Salomon,O. Congenital factor XI deficiency: an update Semin Thromb Hemost (2013) 39, 621-631. PubMed Europe PubMed DOI M
Geng,Y., Verhamme,I.M., Smith,S.B., Sun,M.F., Matafonov,A., Cheng,Q., Smith,S.A., Morrissey,J.H. and Gailani,D. The dimeric structure of factor XI and zymogen activation Blood (2013) 121, 3962-3969. PubMed Europe PubMed DOI
Geng,Y., Verhamme,I.M., Sun,M.F., Bajaj,S.P., Emsley,J. and Gailani,D. Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa J Thromb Haemost (2013) 11, 1374-1384. PubMed Europe PubMed DOI M
Matafonov,A., Cheng,Q., Geng,Y., Verhamme,I.M., Umunakwe,O., Tucker,E.I., Sun,M.F., Serebrov,V., Gruber,A. and Gailani,D. Evidence for factorIX-independent roles for factorXIa in blood coagulation J Thromb Haemost (2013) 11, 2118-2127. PubMed Europe PubMed DOI K
Morrissey,J.H. Targeting factor XI to prevent thrombosis Arterioscler Thromb Vasc Biol (2013) 33, 1454-1455. PubMed Europe PubMed DOI T
Mulder,R., Wiewel-Verschueren,S., Meijer,K. and Mulder,A.B. Identification of a novel factor XI gene mutational event in a Dutch Caucasian family with inherited factor XI deficiency Thromb Haemost (2013) 109, 1183-1185. PubMed Europe PubMed DOI M
Peretz,H., Salomon,O., Mor-Cohen,R., Usher,S., Zucker,M., Zivelin,A. and Seligsohn,U. Type I mutation in the F11 gene is a third ancestral mutation which causes factor XI deficiency in Ashkenazi Jews J Thromb Haemost (2013) 11, 724-730. PubMed Europe PubMed DOI M

2012

Fradera,X., Kazemier,B., Carswell,E., Cooke,A., Oubrie,A., Hamilton,W., Dempster,M., Krapp,S., Nagel,S. and Jestel,A. High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 68, 404-408. PubMed Europe PubMed DOI PMC EPMC S
Girolami,A., Scarparo,P., Bonamigo,E., Santarossa,L., Cristiani,A., Moro,S. and Lombardi,A.M. A cluster of factor XI-deficient patients due to a new mutation (Ile 436 Lys) in Northeastern Italy Eur J Haematol (2012) 88, 229-236. PubMed Europe PubMed DOI M
Luo,D., Szaba,F.M., Kummer,L.W., Johnson,L.L., Tucker,E.I., Gruber,A., Gailani,D. and Smiley,S.T. Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis Infect Immun (2012) 80, 91-99. PubMed Europe PubMed DOI K
Marcinkiewicz,M.M., Sinha,D. and Walsh,P.N. Productive recognition of factor IX by factor XIa exosites requires disulfide linkage between heavy and light chains of factor XIa J Biol Chem (2012) 287, 6187-6195. PubMed Europe PubMed DOI
Tirefort,Y., Uhr,M.R., Neerman-Arbez,M. and de Moerloose,P. Identification of a novel F11 missense mutation (Ile463Ser) in a family with congenital factor XI deficiency Blood Coagul Fibrinolysis (2012) 23, 251-252. PubMed Europe PubMed DOI M
Tucker,E.I., Verbout,N.G., Leung,P.Y., Hurst,S., McCarty,O.J., Gailani,D. and Gruber,A. Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis Blood (2012) 119, 4762-4768. PubMed Europe PubMed DOI
Walsh,P.N. Coagulation factor XIa [ISSN:978-0-12-407742-3] (2012) 3, 2892-2898. DOI
Wu,W., Li,H., Navaneetham,D., Reichenbach,Z.W., Tuma,R.F. and Walsh,P.N. The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis Blood (2012) 120, 671-677. PubMed Europe PubMed DOI
Younis,H.S., Crosby,J., Huh,J.I., Lee,H.S., Rime,S., Monia,B. and Henry,S.P. Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys Blood (2012) 119, 2401-2408. PubMed Europe PubMed DOI K

2011

Berber,E. Molecular characterization of FXI deficiency Clin Appl Thromb Hemost (2011) 17, 27-32. PubMed Europe PubMed DOI M V
Choi,S.H., Smith,S.A. and Morrissey,J.H. Polyphosphate is a cofactor for the activation of factor XI by thrombin Blood (2011) 118, 6963-6970. PubMed Europe PubMed DOI
Dai,L., Rangarajan,S. and Mitchell,M. Three dominant-negative mutations in factor XI-deficient patients Haemophilia (2011) 17, e919-e922. PubMed Europe PubMed DOI M
Gailani,D. A cofactor for factor XI activation Blood (2011) 118, 6730-6731. PubMed Europe PubMed DOI
Lee,J.H., Cho,H.S., Hyun,M.S., Kim,H.Y. and Kim,H.J. A novel missense mutation Asp506Gly in exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency Korean J Lab Med (2011) 31, 290-293. PubMed Europe PubMed DOI PMC EPMC M
Santoro,R., Prejano,S. and Iannaccaro,P. Factor XI deficiency: a description of 34 cases and literature review Blood Coagul Fibrinolysis (2011) 22, 431-435. PubMed Europe PubMed DOI M V
Su,Y.C., Miller,T.N., Navaneetham,D., Schoonmaker,R.T., Sinha,D. and Walsh,P.N. The role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2 J Biol Chem (2011) 286, 31904-31914. PubMed Europe PubMed DOI
Ye,X., Feng,Y., Ding,Q., Dai,J. and Wang,X. Genetic analysis of a pedigree with combined factor XII and factor XI deficiency Blood Coagul Fibrinolysis (2011) 22, 118-122. PubMed Europe PubMed DOI M
Zucker,M., Rosenberg,N., Peretz,H., Green,D., Bauduer,F., Zivelin,A. and Seligsohn,U. Point mutations regarded as missense mutations cause splicing defects in the factor XI gene J Thromb Haemost (2011) 9, 1977-1984. PubMed Europe PubMed DOI M

2010

Emsley,J., McEwan,P.A. and Gailani,D. Structure and function of factor XI Blood (2010) 115, 2569-2577. PubMed Europe PubMed DOI V
Lowenberg,E.C., Meijers,J.C., Monia,B.P. and Levi,M. Coagulation factor XI as a novel target for antithrombotic treatment J Thromb Haemost (2010) 8, 2349-2357. PubMed Europe PubMed DOI V T
Rugeri,L., Quelin,F., Chatard,B., DE Mazancourt,P., Negrier,C. and Dargaud,Y. Thrombin generation in patients with factor XI deficiency and clinical bleeding risk Haemophilia (2010) 16, 771-777. PubMed Europe PubMed DOI M
Zhang,H., Lowenberg,E.C., Crosby,J.R., Macleod,A.R., Zhao,C., Gao,D., Black,C., Revenko,A.S., Meijers,J.C., Stroes,E.S., Levi,M. and Monia,B.P. Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk Blood (2010) 116, 4684-4692. PubMed Europe PubMed DOI

2009

Agah,S. and Bajaj,S.P. Role of magnesium in factor XIa catalyzed activation of factor IX: calcium binding to factor IX under physiologic magnesium J Thromb Haemost (2009) 7, 1426-1428. PubMed Europe PubMed DOI
Duga,S. and Salomon,O. Factor XI deficiency Semin Thromb Hemost (2009) 35, 416-425. PubMed Europe PubMed DOI M
Gailani,D. and Smith,S.B. Structural and functional features of factor XI J Thromb Haemost (2009) 7 Suppl 1, 75-78. PubMed Europe PubMed DOI V
Kravtsov,D.V., Matafonov,A., Tucker,E.I., Sun,M.F., Walsh,P.N., Gruber,A. and Gailani,D. Factor XI contributes to thrombin generation in the absence of factor XII Blood (2009) 114, 452-458. PubMed Europe PubMed DOI PMC EPMC
Renne,T., Oschatz,C., Seifert,S., Muller,F., Antovic,J., Karlman,M. and Benz,P.M. Factor XI deficiency in animal models J Thromb Haemost (2009) 7 Suppl 1, 79-83. PubMed Europe PubMed DOI
Saunders,R.E., Shiltagh,N., Gomez,K., Mellars,G., Cooper,C., Perry,D.J., Tuddenham,E.G. and Perkins,S.J. Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency Thromb Haemost (2009) 102, 287-301. PubMed Europe PubMed DOI M
Seligsohn,U. Factor XI deficiency in humans J Thromb Haemost (2009) 7 Suppl 1, 84-87. PubMed Europe PubMed DOI M
Spena,S., Asselta,R., Caccia,S., Rimoldi,V., Giacomelli,S.H., Tagliaferri,A., Peyvandi,F., Castaman,G. and Duga,S. Analysis of the structural effects of four novel and a previously known mutations causing factor XI deficiency Thromb Haemost (2009) 102, 603-606. PubMed Europe PubMed DOI M
Wang,J., Wang,X., Dai,J., Ding,Q., Fu,Q., Wang,H., Shen,L. and Li,D. A case of factor XI deficiency caused by compound heterozygous F11 gene mutation Haemophilia (2009) 15, 603-606. PubMed Europe PubMed DOI M
Yang,L., Sun,M.F., Gailani,D. and Rezaie,A.R. Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor Biochemistry (2009) 48, 1517-1524. PubMed Europe PubMed DOI PMC EPMC
Zucker,M., Zivelin,A., Landau,M., Rosenberg,N. and Seligsohn,U. Three residues at the interface of factor XI (FXI) monomers augment covalent dimerization of FXI J Thromb Haemost (2009) 7, 970-975. PubMed Europe PubMed DOI

2008

Buchanan,M.S., Carroll,A.R., Wessling,D., Jobling,M., Avery,V.M., Davis,R.A., Feng,Y., Xue,Y., Oster,L., Fex,T., Deinum,J., Hooper,J.N. and Quinn,R.J. Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa J Med Chem (2008) 51, 3583-3587. PubMed Europe PubMed DOI I
Schmidt,A.E., Sun,M.F., Ogawa,T., Bajaj,S.P. and Gailani,D. Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa Biochemistry (2008) 47, 1326-1335. PubMed Europe PubMed DOI
Smith,S.B., Verhamme,I.M., Sun,M.F., Bock,P.E. and Gailani,D. Characterization of novel forms of coagulation factor XIa: independence of factor XIa subunits in factor IX activation J Biol Chem (2008) 283, 6696-6705. PubMed Europe PubMed DOI PMC EPMC
Smith,S.B. and Gailani,D. Update on the physiology and pathology of factor IX activation by factor XIa Expert Rev Hematol (2008) 1, 87-98. PubMed Europe PubMed DOI PMC EPMC
Tucker,E.I., Gailani,D., Hurst,S., Cheng,Q., Hanson,S.R. and Gruber,A. Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis J Infect Dis (2008) 198, 271-274. PubMed Europe PubMed DOI PMC EPMC K
Wu,W., Sinha,D., Shikov,S., Yip,C.K., Walz,T., Billings,P.C., Lear,J.D. and Walsh,P.N. Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa J Biol Chem (2008) 283, 18655-18664. PubMed Europe PubMed DOI PMC EPMC

2007

Bozzao,C., Rimoldi,V., Asselta,R., Landau,M., Ghiotto,R., Tenchini,M.L., De Cristofaro,R., Castaman,G. and Duga,S. A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency FEBS J (2007) 274, 6128-6138. PubMed Europe PubMed DOI M
Gailani,D., Schmidt,A., Sun,M.F., Bolton-Maggs,P.H. and Bajaj,S.P. A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect J Thromb Haemost (2007) 5, 781-787. PubMed Europe PubMed DOI M
Pedicord,D.L., Seiffert,D. and Blat,Y. Feedback activation of factor XI by thrombin does not occur in plasma Proc Natl Acad Sci U S A (2007) 104, 12855-12860. PubMed Europe PubMed DOI PMC EPMC
Samuel,D., Cheng,H., Riley,P.W., Canutescu,A.A., Nagaswami,C., Weisel,J.W., Bu,Z., Walsh,P.N. and Roder,H. Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation Proc Natl Acad Sci U S A (2007) 104, 15693-15698. PubMed Europe PubMed DOI PMC EPMC

2006

Deng,H., Bannister,T.D., Jin,L., Babine,R.E., Quinn,J., Nagafuji,P., Celatka,C.A., Lin,J., Lazarova,T.I., Rynkiewicz,M.J., Bibbins,F., Pandey,P., Gorga,J., Meyers,H.V., Abdel-Meguid,S.S. and Strickler,J.E. Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine Bioorg Med Chem Lett (2006) 16, 3049-3054. PubMed Europe PubMed DOI S I
Dossenbach-Glaninger,A. and Hopmeier,P. Coagulation factor XI gene analysis in three factor XI deficient Austrian patients Eur J Haematol (2006) 76, 317-321. PubMed Europe PubMed DOI
Lazarova,T.I., Jin,L., Rynkiewicz,M., Gorga,J.C., Bibbins,F., Meyers,H.V., Babine,R. and Strickler,J. Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa Bioorg Med Chem Lett (2006) 16, 5022-5027. PubMed Europe PubMed DOI S I
[YEAR:28-12-2006]Lin,J., Deng,H., Jin,L., Pandey,P., Quinn,J., Cantin,S., Rynkiewicz,M.J., Gorga,J.C., Bibbins,F., Celatka,C.A., Nagafuji,P., Bannister,T.D., Meyers,H.V., Babine,R.E., Hayward,N.J., Weaver,D., Benjamin,H., Stassen,F., Abdel-Meguid,S.S. and Strickler,J.E. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants J Med Chem (28-12-2006) 49, 7781-7791. PubMed Europe PubMed DOI T I
[YEAR:9-6-2006]Neuenschwander,P.F., Williamson,S.R., Nalian,A. and Baker-Deadmond,K.J. Heparin modulates the 99-loop of factor IXa: effects on reactivity with isolated Kunitz-type inhibitor domains J Biol Chem (9-6-2006) 281, 23066-23074. PubMed Europe PubMed DOI PMC EPMC
[YEAR:14-5-2006]Papagrigoriou,E., McEwan,P.A., Walsh,P.N. and Emsley,J. Crystal structure of the factor XI zymogen reveals a pathway for transactivation Nat Struct Mol Biol (14-5-2006) 13, 557-558. PubMed Europe PubMed DOI S

2005

Bezak,A., Kaczanowski,R., Dossenbach-Glaninger,A., Kucharczyk,K., Lubitz,W. and Hopmeier,P. Detection of single nucleotide polymorphisms in coagulation factor XI deficient patients by multitemperature single-strand conformation polymorphism analysis J Clin Lab Anal (2005) 19, 233-240. PubMed Europe PubMed DOI M
Dossenbach-Glaninger,A. and Hopmeier,P. Coagulation factor XI: a database of mutations and polymorphisms associated with factor XI deficiency Blood Coagul Fibrinolysis (2005) 16, 231-238. PubMed Europe PubMed
[YEAR:15-11-2005]Jin,L., Pandey,P., Babine,R.E., Gorga,J.C., Seidl,K.J., Gelfand,E., Weaver,D.T., Abdel-Meguid,S.S. and Strickler,J.E. Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions J Biol Chem (15-11-2005) 280, 4704-4712. PubMed Europe PubMed DOI S
Jin,L., Pandey,P., Babine,R.E., Weaver,D.T., Abdel-Meguid,S.S. and Strickler,J.E. Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors Acta Crystallogr D Biol Crystallogr (2005) 61, 1418-1425. PubMed Europe PubMed DOI S I
Kravtsov,D.V., Monahan,P.E. and Gailani,D. A classification system for cross-reactive material-negative factor XI deficiency Blood (2005) 105, 4671-4673. PubMed Europe PubMed DOI PMC EPMC M
McVey,J.H., Lal,K., Imanaka,Y., Kemball-Cook,G., Bolton-Maggs,P.H. and Tuddenham,E.G. Characterisation of blood coagulation factor XI T475I Thromb Haemost (2005) 93, 1082-1088. PubMed Europe PubMed DOI
[YEAR:6-8-2005]Navaneetham,D., Jin,L., Pandey,P., Strickler,J.E., Babine,R.E., Abdel-Meguid,S.S. and Walsh,P.N. Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2 J Biol Chem (6-8-2005) 280, 36165-36175. PubMed Europe PubMed DOI S
O'Connell,N.M., Saunders,R.E., Lee,C.A., Perry,D.J. and Perkins,S.J. Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling J Thromb Haemost (2005) 3, 127-138. PubMed Europe PubMed DOI M
[YEAR:13-4-2005]Ogawa,T., Verhamme,I.M., Sun,M.F., Bock,P.E. and Gailani,D. Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX J Biol Chem (13-4-2005) 280, 23523-23530. PubMed Europe PubMed DOI PMC EPMC I
Saunders,R.E., O'Connell,N.M., Lee,C.A., Perry,D.J. and Perkins,S.J. Factor XI deficiency database: an interactive web database of mutations, phenotypes, and structural analysis tools Hum Mutat (2005) 26, 192-198. PubMed Europe PubMed DOI V

2004

[YEAR:21-9-2004]Pedicord,D.L., Seiffert,D. and Blat,Y. Substrate-dependent modulation of the mechanism of factor XIa inhibition Biochemistry (21-9-2004) 43, 11883-11888. PubMed Europe PubMed DOI
[YEAR:16-4-2004]Schmidt,A.E., Ogawa,T., Gailani,D. and Bajaj,S.P. Structural role of Gly193 in serine proteases: investigations of Gly555Glu (Gly193 in chymotrypsin) mutant of blood coagulation factor XI J Biol Chem (16-4-2004) 279, 29485-29492. PubMed Europe PubMed DOI
Walsh,P.N. Coagulation factor XIa [ISSN:0-12-079610-4] (2004) 2, 1651-1655. V
Zadra,G., Asselta,R., Malcovati,M., Santagostino,E., Peyvandi,F., Mannucci,P.M., Tenchini,M.L. and Duga,S. Molecular genetic analysis of severe coagulation factor XI deficiency in six Italian patients Haematologica (2004) 89, 1332-1340. PubMed Europe PubMed M
Zivelin,A., Ogawa,T., Bulvik,S., Landau,M., Toomey,J.R., Lane,J., Seligsohn,U. and Gailani,D. Severe factor XI deficiency caused by a Gly555 to Glu mutation (factor XI-Glu555): a cross-reactive material positive variant defective in factor IX activation J Thromb Haemost (2004) 2, 1782-1789. PubMed Europe PubMed DOI

2003

[YEAR:2-10-2003]Yun,T.H., Baglia,F.A., Myles,T., Navaneetham,D., Lopez,J.A., Walsh,P.N. and Leung,L.L. Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively J Biol Chem (2-10-2003) 278, 48112-48119. PubMed Europe PubMed DOI

2002

[YEAR:15-2-2002]Renne,T., Gailani,D., Meijers,J.C. and Muller-Esterl,W. Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein J Biol Chem (15-2-2002) 277, 4892-4899. PubMed Europe PubMed DOI

2001

[YEAR:2-3-2001]Dorfman,R. and Walsh,P.N. Noncovalent interactions of the apple 4 domain that mediate coagulation factor XI homodimerization J Biol Chem (2-3-2001) 276, 6429-6438. PubMed Europe PubMed DOI
Shariat-Madar,Z., Mahdi,F. and Schmaier,A.H. Factor XI assembly and activation on human umbilical vein endothelial cells in culture Thromb Haemost (2001) 85, 544-551. PubMed Europe PubMed
Walsh,P.N. Roles of platelets and factor XI in the initiation of blood coagulation by thrombin Thromb Haemost (2001) 86, 75-82. PubMed Europe PubMed

2000

[YEAR:13-10-2000]Baglia,F.A., Badellino,K.O., Ho,D.H., Dasari,V.R. and Walsh,P.N. A binding site for the kringle II domain of prothrombin in the apple 1 domain of factor XI J Biol Chem (13-10-2000) 275, 31954-31962. PubMed Europe PubMed DOI
[YEAR:1-12-2000]Knauer,D.J., Majumdar,D., Fong,P.C. and Knauer,M.F. SERPIN regulation of factor XIa. The novel observation that protease nexin 1 in the presence of heparin is a more potent inhibitor of factor XIa than C1 inhibitor J Biol Chem (1-12-2000) 275, 37340-37346. PubMed Europe PubMed DOI

1998

[YEAR:26-6-1998]Ho,D.H., Badellino,K., Baglia,F.A. and Walsh,P.N. A binding site for heparin in the apple 3 domain of factor XI J Biol Chem (26-6-1998) 273, 16382-16390. PubMed Europe PubMed DOI
[YEAR:29-5-1998]Hsu,T.C., Shore,S.K., Seshsmma,T., Bagasra,O. and Walsh,P.N. Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene J Biol Chem (29-5-1998) 273, 13787-13793. PubMed Europe PubMed DOI R

1997

Butenas,S., DiLorenzo,M.E. and Mann,K.G. Ultrasensitive fluorogenic substrates for serine proteases Thromb Haemost (1997) 78, 1193-1201. PubMed Europe PubMed A
Gailani,D., Sun,M.F. and Sun,Y. A comparison of murine and human factor XI Blood (1997) 90, 1055-1064. PubMed Europe PubMed
Scandura,J.M., Zhang,Y., Van Nostrand,W.E. and Walsh,P.N. Progress curve analysis of the kinetics with which blood coagulation factor XIa is inhibited by protease nexin-2 Biochemistry (1997) 36, 412-420. PubMed Europe PubMed DOI
von dem Borne,P.A., Mosnier,L.O., Tans,G., Meijers,J.C. and Bouma,B.N. Factor XI activation by meizothrombin: stimulation by phospholipid vesicles containing both phosphatidylserine and phosphatidylethanolamine Thromb Haemost (1997) 78, 834-839. PubMed Europe PubMed
Zhang,Y., Scandura,J.M., Van Nostrand,W.E. and Walsh,P.N. The mechanism by which heparin promotes the inhibition of coagulation factor XIa by protease nexin-2 J Biol Chem (1997) 272, 26139-26144. PubMed Europe PubMed DOI

1996

[YEAR:16-2-1996]Baglia,F.A. and Walsh,P.N. A binding site for thrombin in the apple 1 domain of factor XI J Biol Chem (16-2-1996) 271, 3652-3658. PubMed Europe PubMed DOI
[YEAR:15-11-1996]Sun,Y. and Gailani,D. Identification of a factor IX binding site on the third apple domain of activated factor XI J Biol Chem (15-11-1996) 271, 29023-29028. PubMed Europe PubMed DOI

1995

Baglia,F.A., Seaman,F.S. and Walsh,P.N. The Apple 1 and Apple 4 domains of factor XI act synergistically to promote the surface-mediated activation of factor XI by factor XIIa Blood (1995) 85, 2078-2083. PubMed Europe PubMed
[YEAR:24-3-1995]Baglia,F.A., Jameson,B.A. and Walsh,P.N. Identification and characterization of a binding site for platelets in the Apple 3 domain of coagulation factor XI J Biol Chem (24-3-1995) 270, 6734-6740. PubMed Europe PubMed DOI
Briseid,K., Hoem,N.O., Johannesen,S. and Haug,K. Amidolytic assay of factor XI in human plasma - significance of kallikrein for the activity measured Thromb Res (1995) 78, 239-250. PubMed Europe PubMed DOI A

1994

Bristol,J.A., Freedman,S.J., Furie,B.C. and Furie,B. Profactor IX: the propeptide inhibits binding to membrane surfaces and activation by factor XIa Biochemistry (1994) 33, 14136-14143. PubMed Europe PubMed DOI
Mashiko,H. and Takahashi,H. Factor XI: purification from porcine plasma by affinity chromatography and some properties of factor XI and activated factor XI Biol Chem Hoppe Seyler (1994) 375, 481-484. PubMed Europe PubMed
[YEAR:15-12-1994]Seaman,F.S., Baglia,F.A., Gurr,J.A., Jameson,B.A. and Walsh,P.N. Binding of high-molecular-mass kininogen to the Apple 1 domain of factor XI is mediated in part by Val64 and Ile77 Biochem J (15-12-1994) 304, 715-721. PubMed Europe PubMed PMC EPMC

1993

Walsh,P.N., Baglia,F.A. and Jameson,B.A. Factor XI: structure-function relationships utilizing monoclonal antibodies protein modification, computational chemistry, and rational synthetic peptide design Methods Enzymol (1993) 222, 65-96. PubMed Europe PubMed DOI V

1992

Walsh,P.N. Factor XI: a renaissance Semin Hematol (1992) 29, 189-201. PubMed Europe PubMed

1991

[YEAR:23-8-1991]Gailani,D. and Broze,G.J., Jr. Factor XI activation in a revised model of blood coagulation Science (23-8-1991) 253, 909-912. PubMed Europe PubMed
[YEAR:25-4-1991]Naito,K. and Fujikawa,K. Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces J Biol Chem (25-4-1991) 266, 7353-7358. PubMed Europe PubMed

1989

Asakai,R., Chung,D.W., Ratnoff,O.D. and Davie,E.W. Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations Proc Natl Acad Sci U S A (1989) 86, 7667-7671. PubMed Europe PubMed PMC EPMC

1986

Fujikawa,K., Chung,D.W., Hendrickson,L.E. and Davie,E.W. Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein Biochemistry (1986) 25, 2417-2424. PubMed Europe PubMed

1985

Ragni,M.V., Sinha,D., Seaman,F., Lewis,J.H., Spero,J.A. and Walsh,P.N. Comparison of bleeding tendency, factor XI coagulant activity, and factor XI antigen in 25 factor XI-deficient kindreds Blood (1985) 65, 719-724. PubMed Europe PubMed

1984

Cho,K., Tanaka,T., Cook,R.R., Kisiel,W., Fujikawa,K., Kurachi,K. and Powers,J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates Biochemistry (1984) 23, 644-650. PubMed Europe PubMed
Scott,C.F., Sinha,D., Seaman,F.S., Walsh,P.N. and Colman,R.W. Amidolytic assay of human factor XI in plasma: comparison with a coagulant assay and a new rapid radioimmunoassay Blood (1984) 63, 42-50. PubMed Europe PubMed

1981

Kurachi,K. and Davie,E.W. Human factor XI (plasma thromboplastin antecedent) Methods Enzymol (1981) 80, 211-220. DOI V
McRae,B.J., Kurachi,K., Heimark,R.L., Fujikawa,K., Davie,E.W. and Powers,J.C. Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates Biochemistry (1981) 20, 7196-7206. PubMed Europe PubMed

1980

Jackson,C.M. and Nemerson,Y. Blood coagulation Annu Rev Biochem (1980) 49, 765-811. PubMed Europe PubMed DOI

1979

Saito,H., Goldsmith,G.H., Moroi,M. and Aoki,N. Inhibitory spectrum of alpha2-plasmin inhibitor Proc Natl Acad Sci U S A (1979) 76, 2013-2017. PubMed Europe PubMed PMC EPMC

1977

Kurachi,K. and Davie,E.W. Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor) Biochemistry (1977) 16, 5831-5839. PubMed Europe PubMed

1976

Koide,T., Kato,H. and Davie,E.W. Bovine factor XI (plasma thromboplastin antecedent) Methods Enzymol (1976) 45, 65-73. PubMed Europe PubMed DOI V

1975

Enfield,D.L., Ericsson,L.H., Walsh,K.A., Neurath,H. and Titani,K. Bovine factor X1 (Stuart factor). Primary structure of the light chain Proc Natl Acad Sci U S A (1975) 72, 16-19. PubMed Europe PubMed PMC EPMC
Titani,K., Fujikawa,K., Enfield,D.L., Ericsson,L.H., Walsh,K.A. and Neurath,H. Bovine factor X1 (Stuart factor): amino-acid sequence of heavy chain Proc Natl Acad Sci U S A (1975) 72, 3082-3086. PubMed Europe PubMed PMC EPMC

1972

Forbes,C.D. and Ratnoff,O.D. Studies on plasma thromboplastin antecedent (factor XI), PTA deficiency and inhibition of PTA by plasma: pharmacologic inhibitors and specific antiserum J Lab Clin Med (1972) 79, 113-127. PubMed Europe PubMed

1970

Forbes,C.D., Pensky,J. and Ratnoff,O.D. Inhibition of activated Hageman factor and activated plasma thromboplastin antecedent by purified serum C1 inactivator J Lab Clin Med (1970) 76, 809-815. PubMed Europe PubMed

1969

Kociba,G.J., Ratnoff,O.D., Loeb,W.F., Wall,R.L. and Heider,L.E. Bovine plasma thromboplastin antecedent (factor XI) deficiency J Lab Clin Med (1969) 74, 37-41. PubMed Europe PubMed K

1965

Leiba,H., Ramot,B. and Many,A. Heredity and coagulation studies in ten families with factor XI (plasma thromboplastin antecedent) deficiency Br J Haematol (1965) 11, 654-665. PubMed Europe PubMed M

1962

Ratnoff,O.D. and Davie,E.W. The activation of Christmas Factor (Factor IX) by activated plasma thromboplastin antecedent (activated Factor XII) Biochemistry (1962) 1, 677-685.

1961

Rapaport,S.I., Proctor,R.R., Patch,M.J. and Yettra,M. The mode of inheritance of PTA deficiency: evidence for the existence of major PTA deficiency and minor PTA deficiency Blood (1961) 18, 149-165. PubMed Europe PubMed M

1955

Rosenthal,R.L., Dreskin,O.H. and Rosenthal,N. Plasma thromboplastin antecedent (PTA) deficiency; clinical, coagulation, therapeutic and hereditary aspects of a new hemophilia-like disease Blood (1955) 10, 120-131. PubMed Europe PubMed M