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Literature for peptidase S01.213: coagulation factor XIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, V Review, M Mutation, I Inhibitor, R Splicing, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Angiolillo,D.J. and Capodanno,D.
    Uncoupling Thrombosis and Hemostasis by Inhibiting Factor XI
    N Engl J Med392, 400-403. PubMed  Europe PubMed DOI
  2. Connors,J.M.
    Factor XI inhibitors: a new class of anticoagulants
    Blood Adv9, 192-192. PubMed  Europe PubMed DOI
  3. Gibson,C.M., Desai,U.R. and Wesling,M.E.
    Factor XI/XIa inhibitors: a potential solution to anticoagulation dilemmas
    Expert Opin Pharmacother1-12. PubMed  Europe PubMed DOI  V
  4. Srivastava,P., Zhou,A., Fuja,C., Eby,C.S., Baxter,G., Matafonov,A., Fedorov,S., Brown,M., Pettit,M., Tillman,B.F., Gailani,D. and Jacobs,J.W.
    Identification and characterization of factor XI autoantibodies in 2 patients with systemic lupus erythematosus: insights into mechanisms of acquired factor XI deficiency
    Res Pract Thromb Haemost9, 102703-102703. PubMed  Europe PubMed DOI
  5. Wayne,N.B., Schaidle,S.B. and Beavers,C.J.
    Factor XI as a Drug Target for the Prevention and Treatment of Thrombosis
    J Cardiovasc Pharmacol PubMed  Europe PubMed DOI  K
    6. 2024
  6. Ades,M., Simard,C., Vanassche,T., Verhamme,P., Eikelboom,J. and Mavrakanas,T.A.
    Factor XI Inhibitors: Potential Role in End-Stage Kidney Disease
    Semin Nephrol151484-151484. PubMed  Europe PubMed DOI  K  V
  7. Al-Horani,R.A.
    Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases
    Heliyon10, e28017-e28017. PubMed  Europe PubMed DOI  I
  8. Ali,A.E. and Becker,R.C.
    The foundation for investigating factor XI as a target for inhibition in human cardiovascular disease
    J Thromb Thrombolysis57, 1283-1296. PubMed  Europe PubMed DOI  V
  9. Ali,A.E. and Becker,R.C.
    Factor XI: structure, function and therapeutic inhibition
    J Thromb Thrombolysis57, 1315-1328. PubMed  Europe PubMed DOI  K  V
  10. Andreotti,F., Massetti,M. and Montalescot,G.
    Thrombosis, Bleeding, and the Promise of Factor XI(a) Inhibition
    J Am Coll Cardiol83, 679-681. PubMed  Europe PubMed DOI
  11. Bakhtiari,K. and Meijers,J.C.M.
    Reversal of factor XI targeting anticoagulants: an in vitro evaluation
    J Thromb Haemost22, 300-303. PubMed  Europe PubMed DOI
  12. Bar Barroeta,A., Albanese,P., Kadava,T., Jankevics,A., Marquart,J.A., Meijers,J.C.M. and Scheltema,R.A.
    Thrombin activation of the factor XI dimer is a multistaged process for each subunit
    J Thromb Haemost22, 1336-1346. PubMed  Europe PubMed DOI
  13. Barg,A.A., Livnat,T. and Kenet,G.
    Factor XI Deficiency: Phenotypic Age related considerations and Clinical Approach Towards Bleeding Risk Assessment
    Blood143, 1455-1464. PubMed  Europe PubMed DOI  V
  14. Bentounes,N.K., Melicine,S., Martin,A.C., Smadja,D.M. and Gendron,N.
    [New anticoagulants in 2024: Development of factor XI and XIa inhibitors]
    Ann Biol Clin (Paris)82, 9-23. PubMed  Europe PubMed DOI  V  I
  15. Carlin,S., Jakovac,M., Budaj,A. and Eikelboom,J.
    Factor XI inhibition in cardiovascular disease
    Pol Arch Intern Med134, 16799-16799. PubMed  Europe PubMed DOI  V
  16. Cohen,O., Santagata,D. and Ageno,W.
    Novel horizons in anticoagulation: the emerging role of factor XI inhibitors across different settings
    Haematologica109, 3110-3124. PubMed  Europe PubMed DOI  V
  17. Davidson,S. and Gomez,K.
    Laboratory and Molecular Diagnosis of Factor XI Deficiency
    Semin Thromb Hemost PubMed  Europe PubMed DOI
  18. De Vriese,A.S. and Ledo,N.
    Factor XI antagonists: the discovery of the philosopher's stone?
    Clin Kidney J17, sfae106-sfae106. PubMed  Europe PubMed DOI
  19. Demoy,M., Labrousse,J., Grand,F., Moyrand,S., Tuffigo,M., Lamarche,S. and Macchi,L.
    [Factor XI deficiency: actuality and review of the literature]
    Ann Biol Clin (Paris)82, PubMed  Europe PubMed DOI
  20. Gailani,D. and Gruber,A.
    Targeting Factor XI and Factor XIa to Prevent Thrombosis
    Blood143, 1465-1475. PubMed  Europe PubMed DOI  V
  21. Liang,C., Jin,J.Y., Shi,H.H., Li,H.X., Chen,L.L., Zhang,Y.H., Wang,Q., Li,Q.L. and Li,R.M.
    Case Report: Allelic and biallelic variants in coagulation factor XI cause factor XI deficiency
    Front Cardiovasc Med11, 1461899-1461899. PubMed  Europe PubMed DOI
  22. Lira,A.L., Kohs,T.C.L., Moellmer,S.A., Shatzel,J.J., McCarty,O.J.T. and Puy,C.
    Substrates, Cofactors, and Cellular Targets of Coagulation Factor XIa
    Semin Thromb Hemost50, 962-969. PubMed  Europe PubMed DOI  V
  23. Moellmer,S.A., Puy,C. and McCarty,O.J.T.
    Biology of Factor Xl
    Blood143, 1445-1454. PubMed  Europe PubMed DOI  V
  24. Natorska,J., Zabczyk,M., Mastalerz,L. and Undas,A.
    Increased factor XI but not factor XII is associated with enhanced inflammation and impaired fibrin clot properties in patients with eosinophilic granulomatosis with polyangiitis
    Clin Exp Rheumatol42, 822-827. PubMed  Europe PubMed DOI
  25. Nolte,C.H.
    Factor XI inhibitors - Rising stars in anti-thrombotic therapy?
    J Neurol Sci464, 123157-123157. PubMed  Europe PubMed DOI  K  I
  26. Paramo,J.A. and Marcos-Jubilar,M.
    Factor XI inhibitors: A new era in antithrombotic therapy
    Med Clin (Barc)162, 73-76. PubMed  Europe PubMed DOI
  27. Presume,J., Ferreira,J. and Ribeiras,R.
    Factor XI Inhibitors: A New Horizon in Anticoagulation Therapy
    Cardiol Ther13, 1-16. PubMed  Europe PubMed DOI  V
  28. Prisco,D., Canfora,M., Mazzetti,M., Mattioli,I. and Bettiol,A.
    Factor XI Inhibitors: perspectives in primary and secondary prevention of ischemic stroke
    Intern Emerg Med19, 1807-1819. PubMed  Europe PubMed DOI  V
  29. Sammut,M.A., Elamin,N. and Storey,R.F.
    Factor XI and XIa inhibition: a new approach to anticoagulant therapy
    Br J Cardiol31, 018-018. PubMed  Europe PubMed DOI  V
  30. Schuermans,A., Verstraete,A., Lammi,V., Nakanishi,T., Ardissino,M., Van den Eynde,J., Sun,B.B., Georgakis,M.K., Van Weyenbergh,J., Lewandowski,A.J., Raman,B., Ollila,H.M., Burgess,S., Natarajan,P., Honigberg,M.C., Freson,K., Vanassche,T. and Verhamme,P.
    Proteogenomic analyses identify coagulation factor XI as a thromboinflammatory mediator of long COVID
    medRxiv PubMed  Europe PubMed DOI
  31. Sun,F., Wang,W., Li,Z., Li,Y., Guo,W. and Kong,Y.
    Design, expression and biological evaluation of DX-88mut as a novel selective factor XIa inhibitor for antithrombosis
    Bioorg Chem142, 106951-106951. PubMed  Europe PubMed DOI  I
  32. Taskin,B., Kohs,T.C.L., Shatzel,J.J., Puy,C. and McCarty,O.J.T.
    Factor XI as a therapeutic target in neuroinflammatory disease
    Curr Opin Hematol31, 32-38. PubMed  Europe PubMed DOI  V
  33. Wang,Y., Yuan,J., Yan,S., Liu,P., Zheng,Z., Zhang,S., Meng,F., Liu,W., Huang,C. and Wei,Q.
    Design, synthesis and biological evaluation of 6-chloro-quinolin-2-one derivatives as novel FXIa inhibitors
    Bioorg Med Chem Lett99, 129610-129610. PubMed  Europe PubMed DOI  I
    34. 2023
  34. Bentounes,N.K., Melicine,S., Martin,A.C., Smadja,D.M. and Gendron,N.
    Development of new anticoagulant in 2023: Prime time for anti-factor XI and XIa inhibitors
    J Med Vasc48, 69-80. PubMed  Europe PubMed DOI  V
  35. Chan,N.C. and Weitz,J.I.
    New Therapeutic Targets for the Prevention and Treatment of Venous Thromboembolism With a Focus on Factor XI Inhibitors
    Arterioscler Thromb Vasc Biol43, 1755-1763. PubMed  Europe PubMed DOI  V
  36. Elsheikh,S., Tidbury,N. and Lip,G.Y.H.
    A review of emerging factor XI inhibitors
    Expert Opin Emerg Drugs28, 43-53. PubMed  Europe PubMed DOI
  37. Emmerich,J.
    Factor XI-inhibitors the search of the holy graal
    J Med Vasc48, 51-52. PubMed  Europe PubMed DOI
  38. Frunt,R., El Otmani,H., Gibril Kaira,B., de Maat,S. and Maas,C.
    Factor XII Explored with AlphaFold - Opportunities for Selective Drug Development
    Thromb Haemost123, 177-185. PubMed  Europe PubMed DOI
  39. Greco,A., Laudani,C., Spagnolo,M., Agnello,F., Faro,D.C., Finocchiaro,S., Legnazzi,M., Mauro,M.S., Mazzone,P.M., Occhipinti,G., Rochira,C., Scalia,L. and Capodanno,D.
    Pharmacology and Clinical Development of Factor XI Inhibitors
    Circulation147, 897-913. PubMed  Europe PubMed DOI  K
  40. Kreutz,R.P., Ipe,J. and Skaar,T.C.
    Sex specific differences of factor XI and relationship with other coagulation factors
    Thromb Res226, 156-158. PubMed  Europe PubMed DOI
  41. Li,C., Barroeta,A.B., Wong,S.S., Kim,H.J., Pathak,M., Dreveny,I., Meijers,J.C.M. and Emsley,J.
    Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites
    J Thromb Haemost21, 2378-2389. PubMed  Europe PubMed DOI
  42. Lova,A., Pagan,J., de la Morena,G., Vazquez,D.J., Cerezo-Manchado,J.J., Bravo-Perez,C., Minano,A., Tomas,A., Vicente,V., Lozano,M.L., Corral,J. and Morena-Barrio,M.E.
    Congenital factor XI deficiency and risk of heart failure in humans
    J Thromb Haemost21, 2626-2629. PubMed  Europe PubMed DOI
  43. Modrzycka,S., Kolt,S., Adams,T.E., Potoczek,S., Huntington,J.A., Kasperkiewicz,P. and Drag,M.
    Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma
    J Med Chem66, 3785-3797. PubMed  Europe PubMed DOI
  44. Novichikhina,N.P., Shestakov,A.S., Medvedeva,S.M., Lagutina,A.M., Krysin,M.Y., Podoplelova,N.A., Panteleev,M.A., Ilin,I.S., Sulimov,A.V., Tashchilova,A.S., Sulimov,V.B., Geronikaki,A. and Shikhaliev,K.S.
    New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation
    Molecules28, PubMed  Europe PubMed DOI  I
  45. Parunov,L.A., Liang,Y., Lu,Q., Shibeko,A.M., Tucker,E.I., Lee,T.K., Ataullakhanov,F.I., Scott,D.E. and Ovanesov,M.V.
    Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation
    Blood Adv7, 2622-2631. PubMed  Europe PubMed DOI
  46. Piel,I., Engelen,A., Lang,D., Schulz,S.I., Gerisch,M., Brase,C., Janssen,W., Fiebig,L., Heitmeier,S. and Kanefendt,F.
    Metabolism and Disposition of the Novel Oral Factor XIa Inhibitor Asundexian in Rats and in Humans
    Eur J Drug Metab Pharmacokinet48, 411-425. PubMed  Europe PubMed DOI  I
  47. Poenou,G., Heestermans,M., Lafaie,L., Accassat,S., Moulin,N., Rodiere,A., Petit,B., Duvillard,C., Mismetti,P. and Bertoletti,L.
    Inhibition of Factor XI: A New Era in the Treatment of Venous Thromboembolism in Cancer Patients?
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  48. van der Vorst,E.P.C. and Badimon,L.
    The unknown functions of a known protein: the case of coagulation factor XI
    Cardiovasc Res119, e137-e137. PubMed  Europe PubMed DOI
  49. Vedovati,M.C., Becattini,C. and Agnelli,G.
    A new strategy for anticoagulation: The factor XI inhibitors
    Eur J Intern Med116, 8-15. PubMed  Europe PubMed DOI
  50. Vedovati,M.C. and Agnelli,G.
    [A new anticoagulant strategy: the factor XI inhibitors]
    G Ital Cardiol (Rome)24, 454. PubMed  Europe PubMed DOI
  51. Whiteson,H.Z. and Frishman,W.H.
    Factor XI/XIa Inhibitors: A New Approach to Anticoagulation
    Cardiol Rev PubMed  Europe PubMed DOI  V
  52. Xie,Z., Meng,Z., Yang,X., Duan,Y., Wang,Q. and Liao,C.
    Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives
    J Med Chem66, 5332-5363. PubMed  Europe PubMed DOI
  53. Xu,J., Zhao,N., Huang,J., Li,J., Zhao,X., Xiang,Q., Yang,S., Dong,Y., Wang,H., Li,Y., Yang,G. and Cui,Y.
    The Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, an Oral Small Molecule Factor XIa Inhibitor, in Healthy Chinese Volunteers
    Clin Drug Investig43, 435-445. PubMed  Europe PubMed DOI  I
  54. Zhang,X., Lewandowska,M., Aldridge,M., Iglay,K., Wolford,E. and Shapiro,A.
    Global epidemiology of factor XI deficiency: A targeted review of the literature and foundation reports
    Haemophilia29, 423-434. PubMed  Europe PubMed DOI
    55. 2022
  55. Al-Horani,R.A., Parsaeian,E., Mohammad,M. and Mottamal,M.
    Sulfonated non-saccharide molecules and human factor XIa: Enzyme inhibition and computational studies
    Chem Biol Drug Des100, 64-79. PubMed  Europe PubMed DOI  I
  56. Bar Barroeta,A., Marquart,J.A. and Meijers,J.C.M.
    A FRET-based assay for the quantitation of the thrombin-factor XI interaction
    Thromb Res214, 23-28. PubMed  Europe PubMed DOI
  57. Barg,A.A., Levy-Mendelovich,S., Budnik,I., Mandel-Shorer,N., Dardik,R., Avishai,E., Brutman-Barazani,T., Ifrah,A.D., Oren-Malek,L., Yacobovich,J., Gilad,O., Nakav,S., Fruchtman,Y., Revel-Vilk,S., Miskin,H. and Kenet,G.
    Pediatric severe factor XI deficiency: A multicenter study
    Pediatr Blood Cancer69, e29545-e29545. PubMed  Europe PubMed DOI
  58. Cao,Y., Wang,Y., Zhou,Z., Pan,C., Jiang,L., Zhou,Z., Meng,Y., Charugundla,S., Li,T., Allayee,H., Seldin,M.M. and Lusis,A.J.
    Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure
    Science377, 1399-1406. PubMed  Europe PubMed DOI
  59. Heal,S.L., Hardy,L.J., Wilson,C.L., Ali,M., Ariens,R.A.S., Foster,R. and Philippou,H.
    Novel interaction of properdin and coagulation factor XI: Crosstalk between complement and coagulation
    Res Pract Thromb Haemost6, e12715-e12715. PubMed  Europe PubMed DOI
  60. Ito,K., Inoue,Y., Ino,K. and Shiku,H.
    High-Sensitivity Amperometric Dual Immunoassay Using Two Cascade Reactions with Signal Amplification of Redox Cycling in Nanoscale Gap
    Anal Chem94, 16451-16460. PubMed  Europe PubMed DOI
  61. Jiang,S., Jia,Z., Zheng,Y., Zhang,J., Li,Z., Yu,X., Zhang,K., Bai,Y., Guo,W., Kong,Y. and Li,Q.
    Bifunctional fusion protein targeting both FXIIa and FXIa displays potent anticoagulation effects
    Life Sci309, 121021-121021. PubMed  Europe PubMed DOI
  62. Jordan,K.R., Wyatt,C.R., Fallon,M.E., Woltjer,R., Neuwelt,E.A., Cheng,Q., Gailani,D., Lorentz,C., Tucker,E.I., McCarty,O.J.T., Hinds,M.T. and Nguyen,K.P.
    Pharmacological reduction of coagulation factor XI reduces macrophage accumulation and accelerates deep vein thrombosis resolution in a mouse model of venous thrombosis
    J Thromb Haemost20, 2035-2045. PubMed  Europe PubMed DOI
  63. Kubitza,D., Heckmann,M., Distler,J., Koechel,A., Schwers,S. and Kanefendt,F.
    Pharmacokinetics, pharmacodynamics and safety of BAY 2433334, a novel activated factor XI inhibitor, in healthy volunteers: A randomized phase 1 multiple-dose study
    Br J Clin Pharmacol88, 3447-3462. PubMed  Europe PubMed DOI  I
  64. Li,T., Liu,J. and Wu,W.
    Factor XI, a potential target for anticoagulation therapy for venous thromboembolism
    Front Cardiovasc Med9, 975767-975767. PubMed  Europe PubMed DOI  V
  65. Lim,G.B.
    Novel factor XIa inhibitor reduces bleeding compared with apixaban in atrial fibrillation
    Nat Rev Cardiol19, 350-350. PubMed  Europe PubMed DOI
  66. Marshalek,J.P., Yashar,D., Huynh,K. and Tomassetti,S.
    Case of concurrent factor VII and factor XI deficiencies manifesting as spontaneous lower extremity compartment syndrome
    Clin Case Rep10, e05710-e05710. PubMed  Europe PubMed DOI
  67. Mohammed,B.M., Cheng,Q. and Gailani,D.
    A demonstration of factor XI contributing to hemostasis in the absence of factor XII
    Res Pract Thromb Haemost6, e12841-e12841. PubMed  Europe PubMed DOI
  68. Nopp,S., Kraemmer,D. and Ay,C.
    Factor XI Inhibitors for Prevention and Treatment of Venous Thromboembolism: A Review on the Rationale and Update on Current Evidence
    Front Cardiovasc Med9, 903029-903029. PubMed  Europe PubMed DOI  V
  69. Nowotny,B., Thomas,D., Schwers,S., Wiegmann,S., Prange,W., Yassen,A. and Boxnick,S.
    First randomized evaluation of safety, pharmacodynamics, and pharmacokinetics of BAY 1831865, an antibody targeting coagulation factor XI and factor XIa, in healthy men
    J Thromb Haemost20, 1684-1695. PubMed  Europe PubMed DOI
  70. Sharma,M., Molina,C.A., Toyoda,K., Bereczki,D., Kasner,S.E., Lutsep,H.L., Tsivgoulis,G., Ntaios,G., Czlonkowska,A., Shuaib,A., Amarenco,P., Endres,M., Diener,H.C., Gailani,D., Kahl,A., Donovan,M., Perera,V., Li,D. and Hankey,G.J.
    Rationale and design of the AXIOMATIC-SSP phase II trial: Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute Thromboembolic events for Secondary Stroke Prevention
    J Stroke Cerebrovasc Dis31, 106742-106742. PubMed  Europe PubMed DOI  I
  71. Tong,D. and Hill,J.A.
    A coagulation factor moonlights in the heart
    Science377, 1382-1383. PubMed  Europe PubMed DOI
  72. Yao,N., Jia,Z., Tian,Y., Hou,S., Yang,X., Han,J., Duan,Y., Liao,C., Kong,Y. and Xie,Z.
    Targeting the S2 Subsite Enables the Structure-Based Discovery of Novel Highly Selective Factor XIa Inhibitors
    J Med Chem65, 4318-4334. PubMed  Europe PubMed DOI
  73. Yi,B.A., Freedholm,D., Widener,N., Wang,X., Simard,E., Cullen,C., Al-Saady,N.M., Lepor,N.E., Coulter,S., Lovern,M. and Bloomfield,D.
    Pharmacokinetics and pharmacodynamics of Abelacimab (MAA868), a novel dual inhibitor of Factor XI and Factor XIa
    J Thromb Haemost20, 307-315. PubMed  Europe PubMed DOI
    74. 2021
  74. Hayakawa,Y., Tamura,S., Suzuki,N., Odaira,K., Tokoro,M., Kawashima,F., Hayakawa,F., Takagi,A., Katsumi,A., Suzuki,A., Okamoto,S., Kanematsu,T., Matsushita,T. and Kojima,T.
    Essential role of a carboxyl-terminal alpha-helix motif in the secretion of coagulation factor XI
    J Thromb Haemost PubMed  Europe PubMed DOI
  75. Hsu,C., Hutt,E., Bloomfield,D.M., Gailani,D. and Weitz,J.I.
    Factor XI Inhibition to Uncouple Thrombosis From Hemostasis: JACC Review Topic of the Week
    J Am Coll Cardiol78, 625-631. PubMed  Europe PubMed DOI
  76. Kearney,K.J., Butler,J., Posada,O.M., Wilson,C., Heal,S., Ali,M., Hardy,L., Ahnstrom,J., Gailani,D., Foster,R., Hethershaw,E., Longstaff,C. and Philippou,H.
    Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
  77. Lei,Y., Zhang,B., Zhang,Y., Dai,X., Duan,Y., Mao,Q., Gao,J., Yang,Y., Bao,Z., Fu,X., Ping,K., Yan,C., Mou,Y. and Wang,S.
    Design, synthesis and biological evaluation of novel FXIa inhibitors with 2-phenyl-1H-imidazole-5-carboxamide moiety as P1 fragment
    Eur J Med Chem220, 113437-113437. PubMed  Europe PubMed DOI  I
  78. Li,P., Wu,D.R., Yip,H., Sun,D., Zhang,H., Hou,X., Kempson,J. and Mathur,A.
    The effect of water on the large-scale supercritical fluid chromatography purification of two factor XIa active pharmaceutical ingredients
    J Chromatogr A1651, 462318-462318. PubMed  Europe PubMed DOI  I
  79. Thomas,D., Kanefendt,F., Schwers,S., Unger,S., Yassen,A. and Boxnick,S.
    First evaluation of the safety, pharmacokinetics and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor Xia
    J Thromb Haemost PubMed  Europe PubMed DOI  I
  80. Zheng,Y.Z., Ji,X.R., Liu,Y.Y., Jiang,S., Yu,X.Y., Jia,Z.P., Zhao,Y., Zhang,J.Q., Zhang,J.L. and Kong,Y.
    WPK5, a Novel Kunitz-Type Peptide from the Leech Whitmania pigra Inhibiting Factor XIa, and Its Loop-Replaced Mutant to Improve Potency
    Biomedicines9, PubMed  Europe PubMed DOI  I
    81. 2020
  81. Bauduer,F., de la Morena-Barrio,M.E., Salloum-Asfar,S., de la Morena-Barrio,B., Padilla,J., Minano,A., Vicente,V., Carbonell,P., Corral,J. and Esteban,J.
    When genetic and surname analyses meet historical sources: The C56R mutation associated with factor XI deficiency as a marker of human migration during the Spanish Reconquista
    Med Hypotheses141, 109709-109709. PubMed  Europe PubMed DOI  M
  82. Fang,C. and Schmaier,A.H.
    Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems
    Pharmacol Res160, 105096-105096. PubMed  Europe PubMed DOI  V
  83. Gotovac Jercic,K., Blazekovic,A., Hancevic,M., Bilic,E. and Borovecki,F.
    Congenital factor XI deficiency caused by a novel F11 missense variant: a case report
    Croat Med J61, 62-65. PubMed  Europe PubMed  M
  84. Holt,B.A. and Kwong,G.A.
    Protease circuits for processing biological information
    Nat Commun11, 5021-5021. PubMed  Europe PubMed DOI
  85. Leung,P.Y., Li,C.K., Cheng,C.K., Ng,M.H.L. and Chan,N.C.N.
    A novel F11 mutation in a Chinese paediatric patient with severe factor XI deficiency
    Thromb Res190, 89-90. PubMed  Europe PubMed DOI  M
  86. Li,Y.Y., Xu,K., Zhao,M.S., Tong,Y., Su,K.K. and Wang,M.S.
    [Gene analysis of a family with hereditary coagulation factor XI deficiency]
    Zhonghua Xue Ye Xue Za Zhi41, 422-424. PubMed  Europe PubMed DOI
  87. Lin,F., Weng,M.S., Wu,J.R., Fang,S.H. and Yang,L.Y.
    Gene variants in four pedigrees with hereditary coagulation factor XI deficiency and one novel mutation identification
    Blood Coagul Fibrinolysis31, 160-164. PubMed  Europe PubMed DOI  M
  88. Lin,H.Y., Lin,C.Y., Hung,M.H., Kuo,S.F., Lin,J.S. and Shen,M.C.
    Characterization of hereditary factor XI deficiency in Taiwanese patients: identification of three novel and two common mutations
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