Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.199: complement factor I

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Gerogianni,A., Baas,L.M., Sjostrom,D.J., van de Kar,N.C.A.J., Pullen,M., van de Peppel,S.J., Nilsson,P.H. and van den Heuvel,L.P.<br>Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE<br>Front Immunol (2023) 14, 1279612-1279612. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Hallam,T.M., Sharp,S.J., Andreadi,A. and Kavanagh,D.<br>Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic<br>Immunobiology (2023) 228, 152410-152410. PubMed  Europe PubMed DOI
    3. 2022
  3. Java,A., Nicola,P., Schroeder Molly,C., Zheng,H., Tianxiao,H., Johnna,S. and John,A.<br>Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) in Advanced Age-related Macular Degeneration (AMD)<br>Hum Mol Genet (2022) 31, 3683-3693. PubMed  Europe PubMed DOI
    4. 2020
  4. Java,A., Baciu,P., Widjajahakim,R., Sung,Y.J., Yang,J., Kavanagh,D., Atkinson,J. and Seddon,J.<br>Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration<br>Transl Vis Sci Technol (2020) 9, 37-37. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Jia,B.B., Jin,C.D. and Li,M.F.<br>The trypsin-like serine protease domain of Paralichthys olivaceus complement factor I regulates complement activation and inhibits bacterial growth<br>Fish Shellfish Immunol (2020) 97, 18-26. PubMed  Europe PubMed DOI
  6. Lv,W., Ma,A., Chi,X., Li,Q., Pang,Y. and Su,P.<br>A novel complement factor I involving in the complement system immune response from Lampetra morii<br>Fish Shellfish Immunol (2020) 98, 988-994. PubMed  Europe PubMed DOI
  7. Schafer,N., Wolf,H.N., Enzbrenner,A., Schikora,J., Reichenthaler,M., Enzmann,V. and Pauly,D.<br>Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells<br>Antioxidants (Basel) (2020) 9 PubMed  Europe PubMed DOI
    8. 2018
  8. Lachmann,P.J., Lay,E. and Seilly,D.J.<br>A novel and sensitive functional assay for complement factor I based on the third proteolytic clip of C3b<br>J Immunol Methods (2018) 457, 30-32. PubMed  Europe PubMed DOI  A
  9. Qin,C., Gong,Q., Wen,Z. and Yuan,D.<br>Molecular characterization and expression of complement factor I in Pelteobagrus vachellii during Aeromonas hydrophila infection<br>Dev Comp Immunol (2018) 82, 66-71. PubMed  Europe PubMed DOI
    10. 2017
  10. Xue,X., Wu,J., Ricklin,D., Forneris,F., Di Crescenzio,P., Schmidt,C.Q., Granneman,J., Sharp,T.H., Lambris,J.D. and Gros,P.<br>Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses<br>Nat Struct Mol Biol (2017) 24, 643-651. PubMed  Europe PubMed DOI  S
    11. 2015
  11. Liszewski,M.K. and Atkinson,J.P.<br>Complement regulator CD46: genetic variants and disease associations<br>Hum Genomics (2015) 9, 7-7. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2014
  12. Ho,D.K., Skurnik,M., Blom,A.M. and Meri,S.<br>Yersinia pestis Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b<br>Eur J Immunol (2014) 44, 742-751. PubMed  Europe PubMed DOI
  13. Wang,Y., Chen,B., Ke,Y., Wang,C. and Ye,B.<br>Molecular characterization and expression analysis of the complement factor I (CpFI) in the whitespotted bamboo shark (Chiloscyllium plagiosum)<br>Fish Shellfish Immunol (2014) 40, 414-423. PubMed  Europe PubMed DOI
    14. 2013
  14. Haerynck,F., Stordeur,P., Vandewalle,J., Van Coster,R., Bordon,V., De Baets,F., Schelstraete,P., Javaux,C., Bouvry,M.R., Fremeaux-Bacchi,V. and Dehoorne,J.<br>Complete factor I deficiency due to dysfunctional factor I with recurrent aseptic meningo-encephalitis<br>J Clin Immunol (2013) 33, 1293-1301. PubMed  Europe PubMed DOI  M
    15. 2012
  15. Momeni,N., Brudin,L., Behnia,F., Nordstrom,B., Yosefi-Oudarji,A., Sivberg,B., Joghataei,M.T. and Persson,B.L.<br>High complement factor I activity in the plasma of children with autism spectrum disorders<br>Autism Res Treat (2012) 2012, 868576-868576. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Sim,R.B.<br>Complement factor I<br>[ISSN:978-0-12-407742-3] (2012) 3, 2875-2880. DOI
    17. 2011
  17. Nilsson,S.C., Sim,R.B., Lea,S.M., Fremeaux-Bacchi,V. and Blom,A.M.<br>Complement factor I in health and disease<br>Mol Immunol (2011) 48, 1611-1620. PubMed  Europe PubMed DOI  V
  18. Nita,I.M., Genel,F., Nilsson,S.C., Smart,J., Truedsson,L., Choo,S. and Blom,A.M.<br>Molecular characterization of two novel cases of complete complement inhibitor factor I deficiency<br>Mol Immunol (2011) 48, 1068-1072. PubMed  Europe PubMed DOI  M
  19. Roversi,P., Johnson,S., Caesar,J.J., McLean,F., Leath,K.J., Tsiftsoglou,S.A., Morgan,B.P., Harris,C.L., Sim,R.B. and Lea,S.M.<br>Structural basis for complement factor I control and its disease-associated sequence polymorphisms<br>Proc Natl Acad Sci U S A (2011) 108, 12839-12844. PubMed  Europe PubMed DOI  PMC  EPMC  M
    20. 2010
  20. Nilsson,S.C., Kalchishkova,N., Trouw,L.A., Fremeaux-Bacchi,V., Villoutreix,B.O. and Blom,A.M.<br>Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I<br>Eur J Immunol (2010) 40, 172-185. PubMed  Europe PubMed DOI  M
    21. 2009
  21. Abernathy,J.W., Lu,J., Liu,H., Kucuktas,H. and Liu,Z.<br>Molecular characterization of complement factor I reveals constitutive expression in channel catfish<br>Fish Shellfish Immunol (2009) 27, 529-534. PubMed  Europe PubMed DOI
  22. Nilsson,S.C., Trouw,L.A., Renault,N., Miteva,M.A., Genel,F., Zelazko,M., Marquart,H., Muller,K., Sjoholm,A.G., Truedsson,L., Villoutreix,B.O. and Blom,A.M.<br>Genetic, molecular and functional analyses of complement factor I deficiency<br>Eur J Immunol (2009) 39, 310-323. PubMed  Europe PubMed DOI  M
    23. 2008
  23. Kavanagh,D., Richards,A., Noris,M., Hauhart,R., Liszewski,M.K., Karpman,D., Goodship,J.A., Fremeaux-Bacchi,V., Remuzzi,G., Goodship,T.H. and Atkinson,J.P.<br>Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome<br>Mol Immunol (2008) 45, 95-105. PubMed  Europe PubMed DOI  M
    24. 2006
  24. Tsiftsoglou,S.A., Arnold,J.N., Roversi,P., Crispin,M.D., Radcliffe,C., Lea,S.M., Dwek,R.A., Rudd,P.M. and Sim,R.B.<br>Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides<br>Biochim Biophys Acta (2006) 1764, 1757-1766. PubMed  Europe PubMed DOI
    25. 2005
  25. [YEAR:26-4-2005]Tsiftsoglou,S.A., Willis,A.C., Li,P., Chen,X., Mitchell,D.A., Rao,Z. and Sim,R.B.<br>The catalytically active serine protease domain of human complement factor I<br>Biochemistry (26-4-2005) 44, 6239-6249. PubMed  Europe PubMed DOI
    26. 2004
  26. Sim,R.B.<br>Complement factor I<br>[ISSN:0-12-079610-4] (2004) 2, 1637-1641.  V
  27. Tsiftsoglou,S.A. and Sim,R.B.<br>Human complement factor I does not require cofactors for cleavage of synthetic substrates<br>J Immunol (2004) 173, 367-375. PubMed  Europe PubMed  P
    28. 2003
  28. Nakao,M., Hisamatsu,S., Nakahara,M., Kato,Y., Smith,S.L. and Yano,T.<br>Molecular cloning of the complement regulatory factor I isotypes from the common carp (Cyprinus carpio)<br>Immunogenetics (2003) 54, 801-806. PubMed  Europe PubMed DOI
    29. 2002
  29. Terado,T., Nonaka,M.I., Nonaka,M. and Kimura,H.<br>Conservation of the modular structure of complement factor I through vertebrate evolution<br>Dev Comp Immunol (2002) 26, 403-413. PubMed  Europe PubMed DOI
    30. 2000
  30. Jiang,N. and Molina,H.<br>Genomic organization of the serine protease light chain of mouse complement factor I gene<br>IUBMB Life (2000) 49, 109-112. PubMed  Europe PubMed DOI  M
  31. Sim,R.B. and Laich,A.<br>Serine proteases of the complement system<br>Biochem Soc Trans (2000) 28, 545-550. PubMed  Europe PubMed
    32. 1998
  32. [YEAR:3-2-1998]Fevig,J.M., Buriak,J., Jr., Cacciola,J., Alexander,R.S., Kettner,C.A., Knabb,R.M., Pruitt,J.R., Weber,P.C. and Wexler,R.R.<br>Rational design of boropeptide thrombin inhibitors: beta, beta-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile<br>Bioorg Med Chem Lett (3-2-1998) 8, 301-306. PubMed  Europe PubMed DOI  I
    33. 1997
  33. Rupin,A., Mennecier,P., Lila,C., de Nanteuil,G. and Verbeuren,T.J.<br>Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor<br>Thromb Haemost (1997) 78, 1221-1227. PubMed  Europe PubMed  I
  34. Soames,C.J. and Sim,R.B.<br>Interactions between human complement components factor H, factor I and C3b<br>Biochem J (1997) 326, 553-561. PubMed  Europe PubMed  PMC  EPMC
    35. 1996
  35. Minta,J.O., Wong,M.J., Kozak,C.A., Kunnath-Muglia,L.M. and Goldberger,G.<br>cDNA cloning, sequencing and chromosomal assignment of the gene for mouse complement factor I (C3b/C4b inactivator): identification of a species specific divergent segment in factor I<br>Mol Immunol (1996) 33, 101-112. PubMed  Europe PubMed DOI
    36. 1994
  36. Vyse,T.J., Bates,G.P., Walport,M.J. and Morley,B.J.<br>The organization of the human complement factor I gene (IF): A member of the serine protease gene family<br>Genomics (1994) 24, 90-98. PubMed  Europe PubMed DOI
  37. Vyse,T.J., Spath,P.J., Davies,K.A., Morley,B.J., Philippe,P., Athanassiou,P., Giles,C.M. and Walport,M.J.<br>Hereditary complement factor I deficiency<br>QJM (1994) 87, 385-401. PubMed  Europe PubMed
    38. 1993
  38. Kunnath-Muglia,L.M., Chang,G.H., Sim,R.B., Day,A.J. and Ezekowitz,R.A.<br>Characterization of Xenopus laevis complement factor I structure - conservation of modular structure except for an unusual insert not present in human factor I<br>Mol Immunol (1993) 30, 1249-1256. PubMed  Europe PubMed DOI
  39. Perkins,S.J., Smith,K.F. and Sim,R.B.<br>Molecular modelling of the domain structure of factor I of human complement by X-ray and neutron solution scattering<br>Biochem J (1993) 295, 101-108. PubMed  Europe PubMed  PMC  EPMC
  40. Sim,R.B., Kolble,K., McAleer,M.A., Dominguez,O. and Dee,V.M.<br>Genetics and deficiencies of the soluble regulatory proteins of the complement system<br>Int Rev Immunol (1993) 10, 65-86. PubMed  Europe PubMed
  41. Sim,R.B., Day,A.J., Moffatt,B.E. and Fontaine,M.<br>Complement factor I and cofactors in control of complement system convertase enzymes<br>Methods Enzymol (1993) 223, 13-35. PubMed  Europe PubMed DOI  V
    42. 1992
  42. [YEAR:15-10-1992]DiScipio,R.G.<br>Ultrastructures and interactions of complement factors H and I<br>J Immunol (15-10-1992) 149, 2592-2599. PubMed  Europe PubMed
  43. Kam,C.M., Oglesby,T.J., Pangburn,M.K., Volanakis,J.E. and Powers,J.C.<br>Substituted isocoumarins as inhibitors of complement serine proteases<br>J Immunol (1992) 149, 163-168. PubMed  Europe PubMed  I
  44. Masaki,T., Matsumoto,M., Nakanishi,I., Yasuda,R. and Seya,T.<br>Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46)<br>J Biochem (1992) 111, 573-578. PubMed  Europe PubMed
    45. 1991
  45. Floret,D., Stamm,D. and Ponard,D.<br>Increased susceptibility to infection in children with congenital deficiency of factor I<br>Pediatr Infect Dis J (1991) 10, 615-618. PubMed  Europe PubMed
    46. 1990
  46. [YEAR:1-6-1990]Ekdahl,K.N., Nilsson,U.R. and Nilsson,B.<br>Inhibition of factor I by diisopropylfluorophosphate. Evidence of conformational changes in factor I induced by C3b and additional studies on the specificity of factor I<br>J Immunol (1-6-1990) 144, 4269-4274. PubMed  Europe PubMed  I
  47. Jepsen,H.H., Teisner,B. and Svehag,S.E.<br>Zinc ions inhibit factor I-mediated release of CR1-bound immune complexes and degradation of cell-bound complement factors C3b and C4b<br>Scand J Immunol (1990) 31, 397-403. PubMed  Europe PubMed
  48. Rasmussen,J.M., Teisner,B., Brandt,J., Brandslund,I. and Gry,H.<br>Metabolism of C3 and factor B in patients with congenital factor I deficiency<br>J Clin Lab Immunol (1990) 31, 59-67. PubMed  Europe PubMed
  49. Seya,T., Okada,M., Nishino,H. and Atkinson,J.P.<br>Regulation of proteolytic activity of complement factor I by pH: C3b/C4b receptor (CR1) and membrane cofactor protein (MCP) have different pH optima for factor I-mediated cleavage of C3b<br>J Biochem (1990) 107, 310-315. PubMed  Europe PubMed
    50. 1989
  50. Shiang,R., Murray,J.C., Morton,C.C., Buetow,K.H., Wasmuth,J.J., Olney,A.H., Sanger,W.G. and Goldberger,G.<br>Mapping of the human complement factor I gene to 4q25<br>Genomics (1989) 4, 82-86. PubMed  Europe PubMed  M
    51. 1987
  51. Catterall,C.F., Lyons,A., Sim,R.B., Day,A.J. and Harris,T.J.<br>Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones<br>Biochem J (1987) 242, 849-856. PubMed  Europe PubMed  PMC  EPMC
  52. [YEAR:25-7-1987]Goldberger,G., Bruns,G.A., Rits,M., Edge,M.D. and Kwiatkowski,D.J.<br>Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4<br>J Biol Chem (25-7-1987) 262, 10065-10071. PubMed  Europe PubMed
    53. 1986
  53. Jepsen,H.H., Svehag,S.E., Jensenius,J.C. and Sim,R.B.<br>Release of immune complexes bound to erythrocyte complement receptor (CR1), with particular reference to the role of factor I<br>Scand J Immunol (1986) 24, 205-213. PubMed  Europe PubMed
    54. 1985
  54. Seya,T. and Nagasawa,S.<br>Limited proteolysis of complement protein C3b by regulatory enzyme C3b inactivator: isolation and characterization of a biologically active fragment, C3d,g<br>J Biochem (1985) 97, 373-382. PubMed  Europe PubMed
    55. 1983
  55. Pangburn,M.K. and Muller-Eberhard,H.J.<br>Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I<br>Biochemistry (1983) 22, 178-185. PubMed  Europe PubMed
    56. 1982
  56. [YEAR:9-11-1982]Davis,A.E., III and Harrison,R.A.<br>Structural characterization of factor I mediated cleavage of the third component of complement<br>Biochemistry (9-11-1982) 21, 5745-5749. PubMed  Europe PubMed
  57. [YEAR:1-4-1982]Hsiung,L., Barclay,A.N., Brandon,M.R., Sim,E. and Porter,R.R.<br>Purification of human C3b inactivator by monoclonal-antibody affinity chromatography<br>Biochem J (1-4-1982) 203, 293-298. PubMed  Europe PubMed  PMC  EPMC
    58. 1981
  58. Crossley,L.G.<br>C3b inactivator and beta1H<br>Methods Enzymol (1981) 80, 112-124. PubMed  Europe PubMed DOI  V
  59. Davis,A.E., III<br>The C3b inactivator of the human complement system: homology with serine proteases<br>FEBS Lett (1981) 134, 147-150. PubMed  Europe PubMed DOI
    60. 1979
  60. Law,S.K., Fearon,D.T. and Levine,R.P.<br>Action of the C3b-inactivator on the cell-bound C3b<br>J Immunol (1979) 122, 759-765. PubMed  Europe PubMed
    61. 1977
  61. [YEAR:1-7-1977]Pangburn,M.K., Schreiber,R.D. and Muller-Eberhard,H.J.<br>Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution<br>J Exp Med (1-7-1977) 146, 257-270. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use