Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.199: complement factor I

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation, I Inhibitor, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Gerogianni,A., Baas,L.M., Sjostrom,D.J., van de Kar,N.C.A.J., Pullen,M., van de Peppel,S.J., Nilsson,P.H. and van den Heuvel,L.P.
    Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE
    Front Immunol14, 1279612-1279612. PubMed  Europe PubMed DOI
  2. Hallam,T.M., Sharp,S.J., Andreadi,A. and Kavanagh,D.
    Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic
    Immunobiology228, 152410-152410. PubMed  Europe PubMed DOI
    3. 2022
  3. Java,A., Nicola,P., Schroeder Molly,C., Zheng,H., Tianxiao,H., Johnna,S. and John,A.
    Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) in Advanced Age-related Macular Degeneration (AMD)
    Hum Mol Genet31, 3683-3693. PubMed  Europe PubMed DOI
    4. 2020
  4. Java,A., Baciu,P., Widjajahakim,R., Sung,Y.J., Yang,J., Kavanagh,D., Atkinson,J. and Seddon,J.
    Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration
    Transl Vis Sci Technol9, 37-37. PubMed  Europe PubMed DOI
  5. Jia,B.B., Jin,C.D. and Li,M.F.
    The trypsin-like serine protease domain of Paralichthys olivaceus complement factor I regulates complement activation and inhibits bacterial growth
    Fish Shellfish Immunol97, 18-26. PubMed  Europe PubMed DOI
  6. Lv,W., Ma,A., Chi,X., Li,Q., Pang,Y. and Su,P.
    A novel complement factor I involving in the complement system immune response from Lampetra morii
    Fish Shellfish Immunol98, 988-994. PubMed  Europe PubMed DOI
  7. Schafer,N., Wolf,H.N., Enzbrenner,A., Schikora,J., Reichenthaler,M., Enzmann,V. and Pauly,D.
    Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells
    Antioxidants (Basel)9, PubMed  Europe PubMed DOI
    8. 2018
  8. Lachmann,P.J., Lay,E. and Seilly,D.J.
    A novel and sensitive functional assay for complement factor I based on the third proteolytic clip of C3b
    J Immunol Methods457, 30-32. PubMed  Europe PubMed DOI  A
  9. Qin,C., Gong,Q., Wen,Z. and Yuan,D.
    Molecular characterization and expression of complement factor I in Pelteobagrus vachellii during Aeromonas hydrophila infection
    Dev Comp Immunol82, 66-71. PubMed  Europe PubMed DOI
    10. 2017
  10. Xue,X., Wu,J., Ricklin,D., Forneris,F., Di Crescenzio,P., Schmidt,C.Q., Granneman,J., Sharp,T.H., Lambris,J.D. and Gros,P.
    Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses
    Nat Struct Mol Biol24, 643-651. PubMed  Europe PubMed DOI  S
    11. 2015
  11. Liszewski,M.K. and Atkinson,J.P.
    Complement regulator CD46: genetic variants and disease associations
    Hum Genomics9, 7-7. PubMed  Europe PubMed DOI
    12. 2014
  12. Ho,D.K., Skurnik,M., Blom,A.M. and Meri,S.
    Yersinia pestis Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b
    Eur J Immunol44, 742-751. PubMed  Europe PubMed DOI
  13. Wang,Y., Chen,B., Ke,Y., Wang,C. and Ye,B.
    Molecular characterization and expression analysis of the complement factor I (CpFI) in the whitespotted bamboo shark (Chiloscyllium plagiosum)
    Fish Shellfish Immunol40, 414-423. PubMed  Europe PubMed DOI
    14. 2013
  14. Haerynck,F., Stordeur,P., Vandewalle,J., Van Coster,R., Bordon,V., De Baets,F., Schelstraete,P., Javaux,C., Bouvry,M.R., Fremeaux-Bacchi,V. and Dehoorne,J.
    Complete factor I deficiency due to dysfunctional factor I with recurrent aseptic meningo-encephalitis
    J Clin Immunol33, 1293-1301. PubMed  Europe PubMed DOI  M
    15. 2012
  15. Momeni,N., Brudin,L., Behnia,F., Nordstrom,B., Yosefi-Oudarji,A., Sivberg,B., Joghataei,M.T. and Persson,B.L.
    High complement factor I activity in the plasma of children with autism spectrum disorders
    Autism Res Treat2012, 868576-868576. PubMed  Europe PubMed DOI
  16. Sim,R.B.
    Complement factor I
    [ISSN:978-0-12-407742-3]3, 2875-2880. DOI
    17. 2011
  17. Nilsson,S.C., Sim,R.B., Lea,S.M., Fremeaux-Bacchi,V. and Blom,A.M.
    Complement factor I in health and disease
    Mol Immunol48, 1611-1620. PubMed  Europe PubMed DOI  V
  18. Nita,I.M., Genel,F., Nilsson,S.C., Smart,J., Truedsson,L., Choo,S. and Blom,A.M.
    Molecular characterization of two novel cases of complete complement inhibitor factor I deficiency
    Mol Immunol48, 1068-1072. PubMed  Europe PubMed DOI  M
  19. Roversi,P., Johnson,S., Caesar,J.J., McLean,F., Leath,K.J., Tsiftsoglou,S.A., Morgan,B.P., Harris,C.L., Sim,R.B. and Lea,S.M.
    Structural basis for complement factor I control and its disease-associated sequence polymorphisms
    Proc Natl Acad Sci U S A108, 12839-12844. PubMed  Europe PubMed DOI  M
    20. 2010
  20. Nilsson,S.C., Kalchishkova,N., Trouw,L.A., Fremeaux-Bacchi,V., Villoutreix,B.O. and Blom,A.M.
    Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I
    Eur J Immunol40, 172-185. PubMed  Europe PubMed DOI  M
    21. 2009
  21. Abernathy,J.W., Lu,J., Liu,H., Kucuktas,H. and Liu,Z.
    Molecular characterization of complement factor I reveals constitutive expression in channel catfish
    Fish Shellfish Immunol27, 529-534. PubMed  Europe PubMed DOI
  22. Nilsson,S.C., Trouw,L.A., Renault,N., Miteva,M.A., Genel,F., Zelazko,M., Marquart,H., Muller,K., Sjoholm,A.G., Truedsson,L., Villoutreix,B.O. and Blom,A.M.
    Genetic, molecular and functional analyses of complement factor I deficiency
    Eur J Immunol39, 310-323. PubMed  Europe PubMed DOI  M
    23. 2008
  23. Kavanagh,D., Richards,A., Noris,M., Hauhart,R., Liszewski,M.K., Karpman,D., Goodship,J.A., Fremeaux-Bacchi,V., Remuzzi,G., Goodship,T.H. and Atkinson,J.P.
    Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome
    Mol Immunol45, 95-105. PubMed  Europe PubMed DOI  M
    24. 2006
  24. Tsiftsoglou,S.A., Arnold,J.N., Roversi,P., Crispin,M.D., Radcliffe,C., Lea,S.M., Dwek,R.A., Rudd,P.M. and Sim,R.B.
    Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides
    Biochim Biophys Acta1764, 1757-1766. PubMed  Europe PubMed DOI
    25. 2005
  25. [YEAR:26-4-2005]Tsiftsoglou,S.A., Willis,A.C., Li,P., Chen,X., Mitchell,D.A., Rao,Z. and Sim,R.B.
    The catalytically active serine protease domain of human complement factor I
    Biochemistry44, 6239-6249. PubMed  Europe PubMed DOI
    26. 2004
  26. Sim,R.B.
    Complement factor I
    [ISSN:0-12-079610-4]2, 1637-1641.  V
  27. Tsiftsoglou,S.A. and Sim,R.B.
    Human complement factor I does not require cofactors for cleavage of synthetic substrates
    J Immunol173, 367-375. PubMed  Europe PubMed  P
    28. 2003
  28. Nakao,M., Hisamatsu,S., Nakahara,M., Kato,Y., Smith,S.L. and Yano,T.
    Molecular cloning of the complement regulatory factor I isotypes from the common carp (Cyprinus carpio)
    Immunogenetics54, 801-806. PubMed  Europe PubMed DOI
    29. 2002
  29. Terado,T., Nonaka,M.I., Nonaka,M. and Kimura,H.
    Conservation of the modular structure of complement factor I through vertebrate evolution
    Dev Comp Immunol26, 403-413. PubMed  Europe PubMed DOI
    30. 2000
  30. Jiang,N. and Molina,H.
    Genomic organization of the serine protease light chain of mouse complement factor I gene
    IUBMB Life49, 109-112. PubMed  Europe PubMed DOI  M
  31. Sim,R.B. and Laich,A.
    Serine proteases of the complement system
    Biochem Soc Trans28, 545-550. PubMed  Europe PubMed
    32. 1998
  32. [YEAR:3-2-1998]Fevig,J.M., Buriak,J., Jr., Cacciola,J., Alexander,R.S., Kettner,C.A., Knabb,R.M., Pruitt,J.R., Weber,P.C. and Wexler,R.R.
    Rational design of boropeptide thrombin inhibitors: beta, beta-dialkyl-phenethylglycine P2 analogs of DuP 714 with greater selectivity over complement factor I and an improved safety profile
    Bioorg Med Chem Lett8, 301-306. PubMed  Europe PubMed DOI  I
    33. 1997
  33. Rupin,A., Mennecier,P., Lila,C., de Nanteuil,G. and Verbeuren,T.J.
    Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor
    Thromb Haemost78, 1221-1227. PubMed  Europe PubMed  I
  34. Soames,C.J. and Sim,R.B.
    Interactions between human complement components factor H, factor I and C3b
    Biochem J326, 553-561. PubMed  Europe PubMed
    35. 1996
  35. Minta,J.O., Wong,M.J., Kozak,C.A., Kunnath-Muglia,L.M. and Goldberger,G.
    cDNA cloning, sequencing and chromosomal assignment of the gene for mouse complement factor I (C3b/C4b inactivator): identification of a species specific divergent segment in factor I
    Mol Immunol33, 101-112. PubMed  Europe PubMed DOI
    36. 1994
  36. Vyse,T.J., Spath,P.J., Davies,K.A., Morley,B.J., Philippe,P., Athanassiou,P., Giles,C.M. and Walport,M.J.
    Hereditary complement factor I deficiency
    QJM87, 385-401. PubMed  Europe PubMed
  37. Vyse,T.J., Bates,G.P., Walport,M.J. and Morley,B.J.
    The organization of the human complement factor I gene (IF): A member of the serine protease gene family
    Genomics24, 90-98. PubMed  Europe PubMed DOI
    38. 1993
  38. Kunnath-Muglia,L.M., Chang,G.H., Sim,R.B., Day,A.J. and Ezekowitz,R.A.
    Characterization of Xenopus laevis complement factor I structure - conservation of modular structure except for an unusual insert not present in human factor I
    Mol Immunol30, 1249-1256. PubMed  Europe PubMed DOI
  39. Perkins,S.J., Smith,K.F. and Sim,R.B.
    Molecular modelling of the domain structure of factor I of human complement by X-ray and neutron solution scattering
    Biochem J295, 101-108. PubMed  Europe PubMed
  40. Sim,R.B., Day,A.J., Moffatt,B.E. and Fontaine,M.
    Complement factor I and cofactors in control of complement system convertase enzymes
    Methods Enzymol223, 13-35. PubMed  Europe PubMed DOI  V
  41. Sim,R.B., Kolble,K., McAleer,M.A., Dominguez,O. and Dee,V.M.
    Genetics and deficiencies of the soluble regulatory proteins of the complement system
    Int Rev Immunol10, 65-86. PubMed  Europe PubMed
    42. 1992
  42. [YEAR:15-10-1992]DiScipio,R.G.
    Ultrastructures and interactions of complement factors H and I
    J Immunol149, 2592-2599. PubMed  Europe PubMed
  43. Kam,C.M., Oglesby,T.J., Pangburn,M.K., Volanakis,J.E. and Powers,J.C.
    Substituted isocoumarins as inhibitors of complement serine proteases
    J Immunol149, 163-168. PubMed  Europe PubMed  I
  44. Masaki,T., Matsumoto,M., Nakanishi,I., Yasuda,R. and Seya,T.
    Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b receptor (CR1, CD35) and membrane cofactor protein (MCP, CD46)
    J Biochem111, 573-578. PubMed  Europe PubMed
    45. 1991
  45. Floret,D., Stamm,D. and Ponard,D.
    Increased susceptibility to infection in children with congenital deficiency of factor I
    Pediatr Infect Dis J10, 615-618. PubMed  Europe PubMed
    46. 1990
  46. [YEAR:1-6-1990]Ekdahl,K.N., Nilsson,U.R. and Nilsson,B.
    Inhibition of factor I by diisopropylfluorophosphate. Evidence of conformational changes in factor I induced by C3b and additional studies on the specificity of factor I
    J Immunol144, 4269-4274. PubMed  Europe PubMed  I
  47. Jepsen,H.H., Teisner,B. and Svehag,S.E.
    Zinc ions inhibit factor I-mediated release of CR1-bound immune complexes and degradation of cell-bound complement factors C3b and C4b
    Scand J Immunol31, 397-403. PubMed  Europe PubMed
  48. Rasmussen,J.M., Teisner,B., Brandt,J., Brandslund,I. and Gry,H.
    Metabolism of C3 and factor B in patients with congenital factor I deficiency
    J Clin Lab Immunol31, 59-67. PubMed  Europe PubMed
  49. Seya,T., Okada,M., Nishino,H. and Atkinson,J.P.
    Regulation of proteolytic activity of complement factor I by pH: C3b/C4b receptor (CR1) and membrane cofactor protein (MCP) have different pH optima for factor I-mediated cleavage of C3b
    J Biochem107, 310-315. PubMed  Europe PubMed
    50. 1989
  50. Shiang,R., Murray,J.C., Morton,C.C., Buetow,K.H., Wasmuth,J.J., Olney,A.H., Sanger,W.G. and Goldberger,G.
    Mapping of the human complement factor I gene to 4q25
    Genomics4, 82-86. PubMed  Europe PubMed  M
    51. 1987
  51. Catterall,C.F., Lyons,A., Sim,R.B., Day,A.J. and Harris,T.J.
    Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones
    Biochem J242, 849-856. PubMed  Europe PubMed
  52. [YEAR:25-7-1987]Goldberger,G., Bruns,G.A., Rits,M., Edge,M.D. and Kwiatkowski,D.J.
    Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4
    J Biol Chem262, 10065-10071. PubMed  Europe PubMed
    53. 1986
  53. Jepsen,H.H., Svehag,S.E., Jensenius,J.C. and Sim,R.B.
    Release of immune complexes bound to erythrocyte complement receptor (CR1), with particular reference to the role of factor I
    Scand J Immunol24, 205-213. PubMed  Europe PubMed
    54. 1985
  54. Seya,T. and Nagasawa,S.
    Limited proteolysis of complement protein C3b by regulatory enzyme C3b inactivator: isolation and characterization of a biologically active fragment, C3d,g
    J Biochem97, 373-382. PubMed  Europe PubMed
    55. 1983
  55. Pangburn,M.K. and Muller-Eberhard,H.J.
    Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I
    Biochemistry22, 178-185. PubMed  Europe PubMed
    56. 1982
  56. [YEAR:9-11-1982]Davis,A.E., III and Harrison,R.A.
    Structural characterization of factor I mediated cleavage of the third component of complement
    Biochemistry21, 5745-5749. PubMed  Europe PubMed
  57. [YEAR:1-4-1982]Hsiung,L., Barclay,A.N., Brandon,M.R., Sim,E. and Porter,R.R.
    Purification of human C3b inactivator by monoclonal-antibody affinity chromatography
    Biochem J203, 293-298. PubMed  Europe PubMed
    58. 1981
  58. Crossley,L.G.
    C3b inactivator and beta1H
    Methods Enzymol80, 112-124. PubMed  Europe PubMed DOI  V
  59. Davis,A.E., III
    The C3b inactivator of the human complement system: homology with serine proteases
    FEBS Lett134, 147-150. PubMed  Europe PubMed DOI
    60. 1979
  60. Law,S.K., Fearon,D.T. and Levine,R.P.
    Action of the C3b-inactivator on the cell-bound C3b
    J Immunol122, 759-765. PubMed  Europe PubMed
    61. 1977
  61. [YEAR:1-7-1977]Pangburn,M.K., Schreiber,R.D. and Muller-Eberhard,H.J.
    Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution
    J Exp Med146, 257-270. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use