Substrates for peptidase S01.152: chymotrypsin B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Bz-Arg-Val-Trp-NHPhNO2			Bz-Arg-Val-Trp-NHPhNO2	S		Bz	Arg	Val	Trp	NAN	-	-	-	Reseland et al., 1997
Bz-Lys-Val-Tyr-NHPhNO2			Bz-Lys-Val-Tyr-NHPhNO2	S		Bz	Lys	Val	Tyr	NAN	-	-	-	Reseland et al., 1997
C5a anaphylatoxin chemotactic receptor	P21730	9-29	Pro-Asp-Tyr11+Gly-Peptide	N	MS	-	Pro	Asp	Tyr	Gly	His	Tyr	Asp	Jagels et al., 1996
C5a anaphylatoxin chemotactic receptor	P21730	9-29	Peptide-Leu22+Asn-Peptide	N	MS	Thr	Leu	Asp	Leu	Asn	Thr	Pro	Val	Jagels et al., 1996
C5a anaphylatoxin chemotactic receptor	P21730	9-29	Peptide-Tyr14+Asp-Peptide	N	MS	Tyr	Gly	His	Tyr	Asp	Asp	Lys	Asp	Jagels et al., 1996
C5a anaphylatoxin chemotactic receptor	P21730	9-29	Peptide-Leu20+Asp-Peptide	N	MS	Lys	Asp	Thr	Leu	Asp	Leu	Asn	Thr	Jagels et al., 1996
Chymotrypsinogen B	P07338	19-263	Peptide-Phe132+Ser-Peptide	P	NT	Pro	Ala	Gln	Phe	Ser	Glu	Thr	Val	Bódi et al., 2001
Chymotrypsinogen B	P07338	19-263	Peptide-Tyr164+Asn-Peptide	P	NT	Lys	Thr	Lys	Tyr	Asn	Ala	Leu	Lys	Bódi et al., 2001
Chymotrypsinogen B	P07338	19-263	Peptide-Asn165+Ala-Peptide	P	NT	Thr	Lys	Tyr	Asn	Ala	Leu	Lys	Thr	Bódi et al., 2001
Citrate synthase, mitochondrial	O75390	28-466	Peptide-Leu350+Arg-Peptide	P	NT	His	Ala	Val	Leu	Arg	Lys	Thr	Asp	Lill et al., 1984
D-Lys-Val-Phe-NHPhNO2			D-Lys-Val-Phe-NHPhNO2	S		-	Dly	Val	Phe	NAN	-	-	-	Reseland et al., 1997
D-Ser-Leu-Met-NHPhNO2			D-Ser-Leu-Met-NHPhNO2	S		-	Dse	Leu	Met	NAN	-	-	-	Reseland et al., 1997
Glutaryl-Ala-Ala-Pro-Leu-NHPhNO2			Glutaryl-Ala-Ala-Pro-Leu-NHPhNO2	S		Ala	Ala	Pro	Leu	NAN	-	-	-	Reseland et al., 1997
Glutathione S-transferase P	P09211	2-210	Peptide-Tyr50+Gly-Peptide	P	NT	Ser	Cys	Leu	Tyr	Gly	Gln	Leu	Pro	Martini et al., 1993
Heparin cofactor 2	P05546	20-499	Peptide-Leu463+Ser-Peptide	P	NT	Phe	Met	Pro	Leu	Ser	Thr	Gln	Val	Church et al., 1985
leucyl bond			peptide-Leu+peptide	N		-	-	NPe	Leu	CPe	-	-	-	Graf et al., 2004
leukocyte elastase inhibitor	P30740	1-379	peptide-Phe343+Cys-peptide	P		Ile	Ala	Thr	Phe	Cys	Met	Leu	Met	Cooley et al., 2001	20491
OMe-Suc-Arg-Pro-Tyr-NHPhNO2			OMe-Suc-Arg-Pro-Tyr-NHPhNO2	S		Ome	Arg	Pro	Tyr	NAN	-	-	-	Reseland et al., 1997
phenylalanyl bond			peptide-Phe+peptide	N		-	-	NPe	Phe	CPe	-	-	-	Graf et al., 2004
Suc-Ala-Ala-Pro-Phe-NHMec			Suc-Ala-Ala-Pro-Phe+NHMec	S		Ala	Ala	Pro	Phe	AMC	-	-	-	Graf et al., 2004
Suc-Ala-Ala-Pro-Phe-NHPhNO2			Suc-Ala-Ala-Pro-Phe+NHPhNO2	S		Ala	Ala	Pro	Phe	NAN	-	-	-	Graf et al., 2004
Suc-Ala-Ala-Pro-Phe-SBzl			Suc-Ala-Ala-Pro-Phe+SBzl	S		Ala	Ala	Pro	Phe	SBz	-	-	-	Graf et al., 2004
Suc-Ala-Ala-Pro-Trp-NHMec			Suc-Ala-Ala-Pro-Trp+NHMec	S		Ala	Ala	Pro	Trp	AMC	-	-	-	Graf et al., 2004
Suc-Phe-NHPhNO2			Suc-Phe+NHPhNO2	S		-	-	Suc	Phe	NAN	-	-	-	Graf et al., 2004
tryptophanyl bond			peptide-Trp+peptide	N		-	-	NPe	Trp	CPe	-	-	-	Graf et al., 2004
tyrosyl bond			peptide-Tyr+peptide	N		-	-	NPe	Tyr	CPe	-	-	-	Graf et al., 2004