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Literature for peptidase S01.152: chymotrypsin B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, P Specificity, E Expression, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Demcsak,A., Hegyi,E., Hegyi,P., Rosendahl,J. and Sahin-Toth,M.
    Chymotrypsin B2 (CTRB2) Deletion Variant Induces Endoplasmic Reticulum Stress but does not Increase Risk for Chronic Pancreatitis
    Pancreas (2025) PubMed  Europe PubMed DOI
  2. Morales Granda,N.C., Szabo,A., Koller,Z., Pal,G. and Sahin-Toth,M.
    Engineering mouse chymotrypsin B1 for improved trypsinogen degradation
    Sci Rep (2025) 15, 10201-10201. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Moreau,T., Recoules,E., De Pauw,M., Labas,V. and Rehault-Godbert,S.
    Evidence that the Bowman-Birk inhibitor from Pisum sativum affects intestinal proteolytic activities in chickens
    Poult Sci (2024) 103, 103182-103182. PubMed  Europe PubMed DOI  PMC  EPMC  L
    4. 2021
  4. Jermusyk,A., Zhong,J., Connelly,K.E., Gordon,N., Perera,S., Abdolalizadeh,E., Zhang,T., O'Brien,A., Hoskins,J.W., Collins,I., Eiser,D., Yuan,C., Risch,H.A., Jacobs,E.J., Li,D., Du,M., Stolzenberg-Solomon,R.Z., Klein,A.P., Smith,J.P., Wolpin,B.M., Chanock,S.J., Shi,J., Petersen,G.M., Westlake,C.J. and Amundadottir,L.T.
    A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer
    Am J Hum Genet (2021) 108, 1852-1865. PubMed  Europe PubMed DOI
    5. 2016
  5. Szabo,A., Pilsak,C., Bence,M., Witt,H. and Sahin-Toth,M.
    Complex formation of human proelastases with procarboxypeptidases A1 and A2
    J Biol Chem (2016) 291, 17706-17716. PubMed  Europe PubMed DOI
    6. 2012
  6. Graf,L., Szilagyi,L. and Venekei,I.
    Chymotrypsin
    [ISSN:978-0-12-407742-3] (2012) 3, 2626-2633. DOI
    7. 2010
  7. Zhao,K., Zhao,X., Tu,Y., Miao,Q., Cao,D., Duan,W., Sun,Y., Wang,J., Wei,T. and Yang,F.
    Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid
    Cell Mol Life Sci (2010) 67, 2665-2678. PubMed  Europe PubMed DOI
    8. 2008
  8. Miao,Q., Sun,Y., Wei,T., Zhao,X., Zhao,K., Yan,L., Zhang,X., Shu,H. and Yang,F.
    Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway
    J Biol Chem (2008) 283, 8218-8228. PubMed  Europe PubMed DOI
    9. 2007
  9. Psochiou,E., Sarropoulou,E., Mamuris,Z. and Moutou,K.A.
    Sequence analysis and tissue expression pattern of Sparus aurata chymotrypsinogens and trypsinogen
    Comp Biochem Physiol B Biochem Mol Biol (2007) 147, 367-377. PubMed  Europe PubMed DOI
    10. 2004
  10. Graf,L., Szilagyi,L. and Venekei,I.
    Chymotrypsin
    [ISSN:0-12-079610-4] (2004) 2, 1495-1501.  V
  11. Jelinek,B., Antal,J., Venekei,I. and Graf,L.
    Ala226 to Gly and Ser189 to Asp mutations convert rat chymotrypsin B to a trypsin-like protease
    Protein Eng Des Sel (2004) 17, 127-131. PubMed  Europe PubMed DOI
    12. 2003
  12. [YEAR:29-8-2003]Szabo,E., Venekei,I., Bocskei,Z., Naray-Szabo,G. and Graf,L.
    Three dimensional structures of S189D chymotrypsin and D189S trypsin mutants: the effect of polarity at site 189 on a protease-specific stabilization of the substrate-binding site
    J Mol Biol (29-8-2003) 331, 1121-1130. PubMed  Europe PubMed DOI  S
    13. 2001
  13. Curvers,S., Brixius,P., Klauser,T., Thommes,J., Weuster-Botz,D., Takors,R. and Wandrey,C.
    Human chymotrypsinogen B production with Pichia pastoris by integrated development of fermentation and downstream processing. Part 1. Fermentation
    Biotechnol Prog (2001) 17, 495-502. PubMed  Europe PubMed DOI
  14. Thommes,J., Halfar,M., Gieren,H., Curvers,S., Takors,R., Brunschier,R. and Kula,M.R.
    Human chymotrypsinogen B production from Pichia pastoris by integrated development of fermentation and downstream processing. Part 2. Protein recovery
    Biotechnol Prog (2001) 17, 503-512. PubMed  Europe PubMed DOI
    15. 2000
  15. [YEAR:5-7-2000]Harris,J.L., Backes,B.J., Leonetti,F., Mahrus,S., Ellman,J.A. and Craik,C.S.
    Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
    Proc Natl Acad Sci U S A (5-7-2000) 97, 7754-7759. PubMed  Europe PubMed DOI  PMC  EPMC  P
    16. 1999
  16. [YEAR:6-8-1999]Guyonnet,V., Tluscik,F., Long,P.L., Polanowski,A. and Travis,J.
    Purification and partial characterization of the pancreatic proteolytic enzymes trypsin, chymotrypsin, and elastase from the chicken
    J Chromatogr A (6-8-1999) 852, 217-225. PubMed  Europe PubMed DOI
  17. Hudaky,P., Kaslik,G., Venekei,I. and Graf,L.
    The differential specificity of chymotrypsin A and B is determined by amino acid 226
    Eur J Biochem (1999) 259, 528-533. PubMed  Europe PubMed DOI
    18. 1998
  18. Wang,X.C., Strauss,K.I., Ha,Q.N., Nagula,S., Wolpoe,M.E. and Jacobowitz,D.M.
    Chymotrypsin gene expression in rat peripheral organs
    Cell Tissue Res (1998) 292, 345-354. PubMed  Europe PubMed DOI
    19. 1997
  19. Jiang,Q., Hall,M., Noriega,F.G. and Wells,M.
    cDNA cloning and pattern of expression of an adult, female-specific chymotrypsin from Aedes aegypti midgut
    Insect Biochem Mol Biol (1997) 27, 283-289. PubMed  Europe PubMed DOI
    20. 1996
  20. Venekei,I., Graf,L. and Rutter,W.J.
    Expression of rat chymotrypsinogen in yeast: a study on the structural and functional significance of the chymotrypsinogen propeptide
    FEBS Lett (1996) 379, 139-142. PubMed  Europe PubMed DOI  E
    21. 1995
  21. Raae,A.J., Flengsrud,R. and Sletten,K.
    Chymotrypsin isoenzymes in Atlantic cod; differences in kinetics and substrate specificity
    Comp Biochem Physiol B Biochem Mol Biol (1995) 112, 393-398. PubMed  Europe PubMed DOI
    22. 1989
  22. Tomita,N., Izumoto,Y., Horii,A., Doi,S., Yokouchi,H., Ogawa,M., Mori,T. and Matsubara,K.
    Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA
    Biochem Biophys Res Commun (1989) 158, 569-575. PubMed  Europe PubMed
    23. 1984
  23. Honey,N.K., Sakaguchi,A.Y., Lalley,P.A., Quinto,C., Macdonald,R.J., Craik,C., Bell,G.I., Rutter,W.J. and Naylor,S.L.
    Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse
    Somat Cell Mol Genet (1984) 10, 377-383. PubMed  Europe PubMed
    24. 1970
  24. Wilcox,P.E.
    Chymotrypsinogens - chymotrypsins
    Methods Enzymol (1970) 19, 64-108. DOI  V
    25. 1968
  25. Gratecos,D. and Desnuelle,P.
    On porcine chymotrypsinogen B
    FEBS Lett (1968) 1, 117-118. PubMed  Europe PubMed
    26. 1965
  26. Hartley,B.S., Brown,J.R., Kauffman,D.L. and Smillie,L.B.
    Evolutionary similarities between pancreatic proteolytic enzymes
    Nature (1965) 207, 1157-1159. PubMed  Europe PubMed DOI
    27. 1963
  27. Enenkel,A.G. and Smillie,L.B.
    Specificity of chymotrypsin B toward glucagon
    Biochemistry (1963) 2, 1449-1454. PubMed  Europe PubMed
  28. Enenkel,A.G. and Smillie,L.B.
    Preparation and purity of chymotrypsinogen B
    Biochemistry (1963) 2, 1445-1448. PubMed  Europe PubMed
    29. 1962
  29. Kassell,B. and Laskowski,M., Sr.
    A comparison of the terminal amino acids of chymotrypsinogen B and alpha-chymotrypsinogen
    J Biol Chem (1962) 237, 413-417. PubMed  Europe PubMed
    30. 1961
  30. Kassell,B. and Laskowski,M., Sr.
    The amino acid composition of chymotrypsinogen B
    J Biol Chem (1961) 236, 1996-2000. PubMed  Europe PubMed
    31. 1960
  31. Laskowski,M. and Kassell,B.
    Chromatographic studies with chymotrypsinogen B and chymotrypsin B
    Acta Biochim Pol (1960) 7, 253-260. PubMed  Europe PubMed

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