Literature for peptidase M01.010: cytosol alanyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: M Mutation, K Knockout, P Specificity, I Inhibitor, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Kobayashi,K., Fujita,K., Kojima,R., Hino,R., Urano,Y. and Sato,M.
    Rapid imaging of pulmonary metastasis from colorectal cancer with a red fluorescence probe targeting puromycin-sensitive aminopeptidase and dipeptidyl peptidase IV
    Sci Rep (2025) 15, 43930-43930. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Zheng,W., Hagino,T., Wang,H., Cheng,H.Y., Koylass,N., Chen,K.H., Wang,H., Mani,S., Mondal,A.K., Twomey,E.C. and Qiu,Z.
    Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  3. Zheng,W., Hagino,T., Wang,H., Cheng,H.Y., Koylass,N., Chen,K.H., Wang,H., Mani,S., Mondal,A.K., Twomey,E.C. and Qiu,Z.
    Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels and regulates cGAMP transport
    Mol Cell (2025) 85, 4621-4632. PubMed  Europe PubMed DOI  PMC  EPMC
  4. 2024
  5. Durkan,A., Koup,A., Bell,S.E. and Lyczak,R.
    Loss of the puromycin-sensitive aminopeptidase, PAM-1, triggers the spindle assembly checkpoint during the first mitotic division in Caenorhabditis elegans
    MicroPubl Biol (2024) 2024 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Feldman,L.E.R., Mohapatra,S., Jones,R.T., Scholtes,M., Tilton,C.B., Orman,M.V., Joshi,M., Deiter,C.S., Broneske,T.P., Qu,F., Gutierrez,C., Ye,H., Clambey,E.T., Parker,S., Mahmoudi,T., Zuiverloon,T., Costello,J.C. and Theodorescu,D.
    Regulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy
    Sci Adv (2024) 10, eadr9364-eadr9364. PubMed  Europe PubMed DOI  PMC  EPMC
  7. 2023
  8. Madabushi,S., Chow,K.M., Song,E.S., Goswami,A., Hersh,L.B. and Rodgers,D.W.
    Structure of puromycin-sensitive aminopeptidase and polyglutamine binding
    PLoS ONE (2023) 18, e0287086-e0287086. PubMed  Europe PubMed DOI  PMC  EPMC
  9. 2021
  10. Benton,D., Jaeger,E.C., Kilner,A., Kimble,A., Lowry,J., Schleicher,E.M., Power,K.M., Uibel,D., Eisele,C., Bowerman,B. and Lyczak,R.
    Interactions between the WEE-1.3 kinase and the PAM-1 aminopeptidase in oocyte maturation and the early C. elegans embryo
    G3 (Bethesda) (2021) PubMed  Europe PubMed DOI
  11. 2020
  12. Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E.
    Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
    Bone Joint Res (2020) 9, 789-797. PubMed  Europe PubMed DOI  PMC  EPMC
  13. 2017
  14. Wu,S., Liu,B., Yuan,Z., Zhang,X., Liu,H., Pang,Q. and Zhao,B.
    Planarian homolog of puromycin-sensitive aminopeptidase DjPsa is required for brain regeneration
    Invert Neurosci (2017) 17, 3-3. PubMed  Europe PubMed DOI
  15. 2015
  16. Aeluri,R., Ganji,R.J., Marapaka,A.K., Pillalamarri,V., Alla,M. and Addlagatta,A.
    Highly functionalized tetrahydropyridines are cytotoxic and selective inhibitors of human puromycin sensitive aminopeptidase
    Eur J Med Chem (2015) 106, 26-33. PubMed  Europe PubMed DOI  I
  17. 2014
  18. Althoff,M.J., Flick,K. and Trzepacz,C.
    Collaboration within the M1 aminopeptidase family promotes reproductive success in Caenorhabditis elegans
    Dev Genes Evol (2014) 224, 137-146. PubMed  Europe PubMed DOI  M
  19. Hitzerd,S.M., Verbrugge,S.E., Ossenkoppele,G., Jansen,G. and Peters,G.J.
    Positioning of aminopeptidase inhibitors in next generation cancer therapy
    Amino Acids (2014) 46, 793-808. PubMed  Europe PubMed DOI  I
  20. Numadate,A., Mita,Y., Matsumoto,Y., Fujii,S. and Hashimoto,Y.
    Development of 2-thioxoquinazoline-4-one derivatives as dual and selective inhibitors of dynamin-related protein 1 (Drp1) and puromycin-sensitive aminopeptidase (PSA)
    Chem Pharm Bull (Tokyo) (2014) 62, 979-988. PubMed  Europe PubMed  I
  21. 2013
  22. Kruppa,A.J., Ott,S., Chandraratna,D.S., Irving,J.A., Page,R.M., Speretta,E., Seto,T., Camargo,L.M., Marciniak,S.J., Lomas,D.A. and Crowther,D.C.
    Suppression of Abeta toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity
    Biochim Biophys Acta (2013) 1832, 2115-2126. PubMed  Europe PubMed DOI
  23. 2012
  24. Barrett,A.J.
    Cytosol alanyl aminopeptidase
    [ISSN:978-0-12-407744-7] (2012) 3, 431-434. DOI
  25. Irigoyen,N., Caston,J.R. and Rodriguez,J.F.
    Host proteolytic activity is necessary for infectious bursal disease virus capsid protein assembly
    J Biol Chem (2012) 287, 24473-24482. PubMed  Europe PubMed DOI
  26. Ren,G., Ma,Z., Hui,M., Kudo,L.C., Hui,K.S. and Karsten,S.L.
    Puromycin-sensitive aminopeptidase is involved in wild-type huntingtin clearance
    Mol Neurodegener (2012) 7 Suppl 1, S5-S5. DOI  PMC  EPMC
  27. 2011
  28. Catalano,A., Poloz,Y. and O'Day,D.H.
    Dictyostelium puromycin-sensitive aminopeptidase A is a nucleoplasmic nucleomorphin-binding protein that relocates to the cytoplasm during mitosis
    Histochem Cell Biol (2011) 136, 677-688. PubMed  Europe PubMed DOI
  29. Chen,S.H., Cao,M.J., Huang,J.Z. and Wu,G.P.
    Identification of a puromycin-sensitive aminopeptidase from zebrafish (Danio rerio)
    Comp Biochem Physiol B Biochem Mol Biol (2011) 159, 10-17. PubMed  Europe PubMed DOI
  30. Kudo,L.C., Parfenova,L., Ren,G., Vi,N., Hui,M., Ma,Z., Lau,K., Gray,M., Bardag-Gorce,F., Wiedau-Pazos,M., Hui,K.S. and Karsten,S.L.
    Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice
    Hum Mol Genet (2011) 20, 1820-1833. PubMed  Europe PubMed DOI
  31. Ren,G., Ma,Z., Hui,M., Kudo,L.C., Hui,K.S. and Karsten,S.L.
    Cu, Zn-Superoxide dismutase 1 (SOD1) is a novel target of puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis
    Mol Neurodegener (2011) 6, 29-29. PubMed  Europe PubMed DOI
  32. 2010
  33. Chow,K.M., Guan,H. and Hersh,L.B.
    Aminopeptidases do not directly degrade tau protein
    Mol Neurodegener (2010) 5, 48-48. PubMed  Europe PubMed DOI  E
  34. Fortin,S.M., Marshall,S.L., Jaeger,E.C., Greene,P.E., Brady,L.K., Isaac,R.E., Schrandt,J.C., Brooks,D.R. and Lyczak,R.
    The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos
    Dev Biol (2010) 344, 992-1000. PubMed  Europe PubMed DOI
  35. Menzies,F.M., Hourez,R., Imarisio,S., Raspe,M., Sadiq,O., Chandraratna,D., O'Kane,C., Rock,K.L., Reits,E., Goldberg,A.L. and Rubinsztein,D.C.
    Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy
    Hum Mol Genet (2010) 19, 4573-4586. PubMed  Europe PubMed DOI  P  U
  36. Tehler,U., Nelson,C.H., Peterson,L.W., Provoda,C.J., Hilfinger,J.M., Lee,K.D., McKenna,C.E. and Amidon,G.L.
    Puromycin-sensitive aminopeptidase: an antiviral prodrug activating enzyme
    Antiviral Res (2010) 85, 482-489. PubMed  Europe PubMed DOI
  37. 2009
  38. Kim,E., Kwak,H. and Ahn,K.
    Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner
    J Immunol (2009) 183, 7379-7387. PubMed  Europe PubMed DOI  K
  39. Yanagi,K., Tanaka,T., Kato,K., Sadik,G., Morihara,T., Kudo,T. and Takeda,M.
    Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau
    Psychogeriatrics (2009) 9, 157-166. PubMed  Europe PubMed DOI
  40. 2008
  41. Towne,C.F., York,I.A., Neijssen,J., Karow,M.L., Murphy,A.J., Valenzuela,D.M., Yancopoulos,G.D., Neefjes,J.J. and Rock,K.L.
    Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections
    J Immunol (2008) 180, 1704-1712. PubMed  Europe PubMed  K
  42. 2007
  43. Bhutani,N., Venkatraman,P. and Goldberg,A.L.
    Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation
    EMBO J (2007) 26, 1385-1396. PubMed  Europe PubMed DOI  PMC  EPMC
  44. 2006
  45. Karsten,S.L., Sang,T.K., Gehman,L.T., Chatterjee,S., Liu,J., Lawless,G.M., Sengupta,S., Berry,R.W., Pomakian,J., Oh,H.S., Schulz,C., Hui,K.S., Wiedau-Pazos,M., Vinters,H.V., Binder,L.I., Geschwind,D.H. and Jackson,G.R.
    A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
    Neuron (2006) 51, 549-560. PubMed  Europe PubMed DOI
  46. Lyczak,R., Zweier,L., Group,T., Murrow,M.A., Snyder,C., Kulovitz,L., Beatty,A., Smith,K. and Bowerman,B.
    The puromycin-sensitive aminopeptidase PAM-1 is required for meiotic exit and anteroposterior polarity in the one-cell Caenorhabditis elegans embryo
    Development (2006) 133, 4281-4292. PubMed  Europe PubMed DOI  K
  47. [YEAR:19-12-2006]Sengupta,S., Horowitz,P.M., Karsten,S.L., Jackson,G.R., Geschwind,D.H., Fu,Y., Berry,R.W. and Binder,L.I.
    Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro
    Biochemistry (19-12-2006) 45, 15111-15119. PubMed  Europe PubMed DOI  U
  48. 2004
  49. Dando,P.M. and Barrett,A.J.
    Aminopeptidase PS
    [ISSN:0-12-079610-4] (2004) 2, 313-316.  V
  50. [YEAR:3-10-2004]Thielitz,A., Bukowska,A., Wolke,C., Vetter,R., Lendeckel,U., Wrenger,S., Hashimoto,Y., Ansorge,S., Gollnick,H. and Reinhold,D.
    Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation
    Biochem Biophys Res Commun (3-10-2004) 321, 795-801. PubMed  Europe PubMed DOI  I
  51. 2003
  52. [YEAR:31-10-2003]Brooks,D.R., Hooper,N.M. and Isaac,R.E.
    The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction
    J Biol Chem (31-10-2003) 278, 42795-42801. PubMed  Europe PubMed DOI  K  P  I
  53. Bukowska,A., Tadje,J., Arndt,M., Wolke,C., Kahne,T., Bartsch,J., Faust,J., Neubert,K., Hashimoto,Y. and Lendeckel,U.
    Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets
    Biol Chem (2003) 384, 657-665. PubMed  Europe PubMed DOI  I
  54. [YEAR:6-1-2003]Kakuta,H., Koiso,Y., Nagasawa,K. and Hashimoto,Y.
    Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells
    Bioorg Med Chem Lett (6-1-2003) 13, 83-86. PubMed  Europe PubMed DOI  I
  55. Kakuta,H., Tanatani,A., Nagasawa,K. and Hashimoto,Y.
    Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton
    Chem Pharm Bull (Tokyo) (2003) 51, 1273-1282. PubMed  Europe PubMed DOI  I
  56. [YEAR:1-7-2003]Ma,Z., Daquin,A., Yao,J., Rodgers,D., Thompson,M.W. and Hersh,L.B.
    Proteolytic cleavage of the puromycin-sensitive aminopeptidase generates a substrate binding domain
    Arch Biochem Biophys (1-7-2003) 415, 80-86. PubMed  Europe PubMed DOI
  57. [YEAR:15-5-2003]Thompson,M.W., Govindaswami,M. and Hersh,L.B.
    Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein
    Arch Biochem Biophys (15-5-2003) 413, 236-242. PubMed  Europe PubMed DOI
  58. Thompson,M.W. and Hersh,L.B.
    Analysis of conserved residues of the human puromycin-sensitive aminopeptidase
    Peptides (2003) 24, 1359-1365. PubMed  Europe PubMed DOI  I
  59. 2002
  60. Goldberg,A.L., Cascio,P., Saric,T. and Rock,K.L.
    The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides
    Mol Immunol (2002) 39, 147-164. PubMed  Europe PubMed DOI
  61. [YEAR:15-10-2002]Levy,F., Burri,L., Morel,S., Peitrequin,A.L., Levy,N., Bachi,A., Hellman,U., Van den Eynde,B.J. and Servis,C.
    The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases
    J Immunol (15-10-2002) 169, 4161-4171. PubMed  Europe PubMed
  62. Yamamoto,M., Chikuma,T., Yajima,R., Hirano,H., Yamamoto,Y., Nishi,K., Ohkubo,I. and Kato,T.
    Axonal transport of puromycin-sensitive aminopeptidase in rat sciatic nerves
    Neurosci Res (2002) 42, 133-140. PubMed  Europe PubMed DOI
  63. 2001
  64. Bauer,W.O., Nanda,I., Beck,G., Schmid,M. and Jakob,F.
    Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21
    Cytogenet Cell Genet (2001) 92, 221-224. PubMed  Europe PubMed  M
  65. Kakuta,H., Koiso,Y., Takahashi,H., Nagasawa,K. and Hashimoto,Y.
    Novel specific puromycin-sensitive aminopeptidase inhibitors: 3-(2,6-diethylphenyl)-2,4(1H, 3H)-quinazolinedione and N-(2,6-diethylphenyl)-2-amino-4H-3,1-benzoxazin-4-one
    Heterocycles (2001) 55, 1433-1438.  I
  66. Komoda,M., Kakuta,H., Takahashi,H., Fujimoto,Y., Kadoya,S., Kato,F. and Hashimoto,Y.
    Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study
    Bioorg Med Chem (2001) 9, 121-131. PubMed  Europe PubMed DOI  I
  67. Osada,T., Watanabe,G., Kondo,S., Toyoda,M., Sakaki,Y. and Takeuchi,T.
    Male reproductive defects caused by puromycin-sensitive aminopeptidase deficiency in mice
    Mol Endocrinol (2001) 15, 960-971. PubMed  Europe PubMed DOI  K
  68. Osada,T., Watanabe,G., Sakaki,Y. and Takeuchi,T.
    Puromycin-sensitive aminopeptidase is essential for the maternal recognition of pregnancy in mice
    Mol Endocrinol (2001) 15, 882-893. PubMed  Europe PubMed DOI  K
  69. Schulz,C., Perezgasga,L. and Fuller,M.T.
    Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases
    Dev Genes Evol (2001) 211, 581-588. PubMed  Europe PubMed DOI  K
  70. 2000
  71. Stoltze,L., Schirle,M., Schwarz,G., Schroter,C., Thompson,M.W., Hersh,L.B., Kalbacher,H., Stevanovic,S., Rammensee,H.G. and Schild,H.
    Two new proteases in the MHC class I processing pathway
    Nat Immunol (2000) 1, 413-418. PubMed  Europe PubMed DOI
  72. Takahashi,H., Komoda,M., Kakuta,H. and Hashimoto,Y.
    [Preparation of novel specific aminopeptidase inhibitors with a cyclic imide skeleton]
    Yakugaku Zasshi (2000) 120, 909-921. PubMed  Europe PubMed  I
  73. [YEAR:11-9-2000]Yamamoto,Y., Li,Y.H., Ushiyama,I., Nishimura,A., Ohkubo,I. and Nishi,K.
    Puromycin-sensitive alanyl aminopeptidase from human liver cytosol: purification and characterization
    Forensic Sci Int (11-9-2000) 113, 143-146. PubMed  Europe PubMed DOI  P  I
  74. 1999
  75. [YEAR:1-11-1999]de Gandarias,J.M., Irazusta,J., Gil,J., Fernandez,D., Varona,A. and Casis,L.
    Ontogeny of puromycin-sensitive and insensitive aminopeptidase activities in several subcellular fractions of the rat brain
    Brain Res Bull (1-11-1999) 50, 283-290. PubMed  Europe PubMed DOI
  76. [YEAR:7-8-1999]Huber,A.B., Brosamle,C., Mechler,H. and Huber,G.
    Metalloprotease MP100: a synaptic protease in rat brain
    Brain Res (7-8-1999) 837, 193-202. PubMed  Europe PubMed DOI
  77. Huber,G., Thompson,A., Gruninger,F., Mechler,H., Hochstrasser,R., Hauri,H.P. and Malherbe,P.
    cDNA cloning and molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate?
    J Neurochem (1999) 72, 1215-1223. PubMed  Europe PubMed DOI  E
  78. [YEAR:15-7-1999]Osada,T., Ikegami,S., Takiguchi-Hayashi,K., Yamazaki,Y., Katoh-Fukui,Y., Higashinakagawa,T., Sakaki,Y. and Takeuchi,T.
    Increased anxiety and impaired pain response in puromycin-sensitive aminopeptidase gene-deficient mice obtained by a mouse gene-trap method
    J Neurosci (15-7-1999) 19, 6068-6078. PubMed  Europe PubMed  M
  79. [YEAR:15-3-1999]Osada,T., Sakaki,Y. and Takeuchi,T.
    Puromycin-sensitive aminopeptidase gene (Psa) maps to mouse chromosome 11
    Genomics (15-3-1999) 56, 361-362. PubMed  Europe PubMed DOI
  80. [YEAR:10-5-1999]Thompson,M.W., Tobler,A., Fontana,A. and Hersh,L.B.
    Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase
    Biochem Biophys Res Commun (10-5-1999) 258, 234-240. PubMed  Europe PubMed DOI
  81. 1998
  82. Yamamoto,Y., Li,Y.H., Huang,K., Ohkubo,I. and Nishi,K.
    Isolation and characterization of an alanyl aminopeptidase from rat liver cytosol as a puromycin-sensitive enkephalin-degrading aminopeptidase
    Biol Chem (1998) 379, 711-719. PubMed  Europe PubMed  I
  83. 1997
  84. Dando,P.M., Young,N.E. and Barrett,A.J.
    Aminopeptidase PS: a widely distributed cytosolic peptidase
    [ISSN:ISBN 90 5199 322 6 (IOS Press)] (1997) , 88-95.
  85. de Gandarias,J.M., Irazusta,J., Gil,J., Gallego,M., Casis,O. and Casis,L.
    Subcellular analysis of Tyr-aminopeptidase activities in the developing rat cerebellum
    Brain Res Dev Brain Res (1997) 99, 66-71. PubMed  Europe PubMed DOI
  86. Tobler,A.R., Constam,D.B., Schmitt-Graff,A., Malipiero,U., Schlapbach,R. and Fontana,A.
    Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons
    J Neurochem (1997) 68, 889-897. PubMed  Europe PubMed
  87. 1996
  88. Flores,M., Aristoy,M.C. and Toldra,F.
    HPLC purification and characterization of soluble alanyl aminopeptidase from porcine skeletal muscle
    J Agric Food Chem (1996) 44, 2578-2583.
  89. 1995
  90. Constam,D.B., Tobler,A.R., Rensing-Ehl,A., Kemler,I., Hersh,L.B. and Fontana,A.
    Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization
    J Biol Chem (1995) 270, 26931-26939. PubMed  Europe PubMed DOI
  91. Hussain,M.A., Mersinger,L., Maurin,M.B. and Kettner,C.
    In situ characterization of nasal leucine enkephalin degrading aminopeptidase. Susceptibility of the nasal enzyme to boronic acids and phosphorus-containing peptide and amino acid isosteres
    Int J Pharm (1995) 117, 181-188.  I
  92. Itoh,C. and Nagamatsu,A.
    An aminopeptidase activity from porcine kidney that hydrolyzes oxytocin and vasopressin: Purification and partial characterization
    Biochim Biophys Acta (1995) 1243, 203-208. PubMed  Europe PubMed DOI
  93. Safavi,A. and Hersh,L.B.
    Degradation of dynorphin-related peptides by the puromycin-sensitive aminopeptidase and aminopeptidase M
    J Neurochem (1995) 65, 389-395. PubMed  Europe PubMed
  94. 1994
  95. [YEAR:1-3-1994]Murray,H., Turner,A.J. and Kenny,A.J.
    The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13)
    Biochem J (1-3-1994) 298, 353-360. PubMed  Europe PubMed  PMC  EPMC  I
  96. Smyth,M. and O'Cuinn,G.
    Alanine aminopeptidase of guinea-pig brain: a broad specificity cytoplasmic enzyme capable of hydrolysing short and intermediate length peptides
    Int J Biochem (1994) 26, 1287-1297. PubMed  Europe PubMed DOI
  97. 1993
  98. Belhacene,N., Mari,B., Rossi,B. and Auberger,P.
    Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation
    Eur J Immunol (1993) 23, 1948-1955. PubMed  Europe PubMed DOI  I
  99. Hui,K.S., Saito,M., Hui,M., Lajtha,A., Yamamoto,K. and Osawa,T.
    Two cytosolic puromycin-sensitive aminopeptidase isozymes in chicken brain: molecular homology to brain-specific 14-3-3 protein
    Neurochem Int (1993) 22, 445-453. PubMed  Europe PubMed DOI
  100. Hui,M.P., Lajtha,A. and Hui,K.S.
    A new soluble brain-specific protein: identification and partial purification
    Brain Res (1993) 606, 36-43. PubMed  Europe PubMed DOI
  101. 1992
  102. Gillespie,T.J., Konings,P.N., Merrill,B.J. and Davis,T.P.
    A specific enzyme assay for aminopeptidase M in rat brain
    Life Sci (1992) 51, 2097-2106. PubMed  Europe PubMed DOI  I
  103. Hiroi,Y., Endo,Y. and Natori,Y.
    Purification and properties of an aminopeptidase from rat-liver cytosol
    Arch Biochem Biophys (1992) 294, 440-445. PubMed  Europe PubMed DOI
  104. [YEAR:30-4-1992]Mantle,D.
    Comparison of soluble aminopeptidases in human cerebral cortex, skeletal muscle and kidney tissues
    Clin Chim Acta (30-4-1992) 207, 107-118. PubMed  Europe PubMed DOI
  105. Nishimura,T., Kato,Y., Rhyu,M.R., Okitani,A. and Kato,H.
    Purification and properties of aminopeptidase C from porcine skeletal muscle
    Comp Biochem Physiol B (1992) 102, 129-135. PubMed  Europe PubMed DOI
  106. Ocain,T.D. and Rich,D.H.
    alpha-Keto amide inhibitors of aminopeptidases
    J Med Chem (1992) 35, 451-456. PubMed  Europe PubMed  I
  107. 1991
  108. Akasaki,K. and Tsuji,H.
    An enkephalin-degrading aminopeptidase from rat brain catalyzes the hydrolysis of a neuropeptide, kyotorphin (L-Tyr-L-Arg)
    Chem Pharm Bull (Tokyo) (1991) 39, 1883-1885. PubMed  Europe PubMed
  109. De Souza,A.N.C., Bruno,J.A. and Carvalho,K.M.
    An enkephalin degrading aminopeptidase of human brain preserved during the vertebrate phylogeny
    Comp Biochem Physiol C (1991) 99, 363-367. PubMed  Europe PubMed DOI
  110. Nishimura,T., Kato,Y., Okitani,A. and Kato,H.
    Purification and properties of aminopeptidase C from chicken skeletal muscle
    Agric Biol Chem (1991) 55, 1771-1778. PubMed  Europe PubMed
  111. 1990
  112. Dyer,S.H., Slaughter,C.A., Orth,K., Moomaw,C.R. and Hersh,L.B.
    Comparison of the soluble and membrane-bound forms of the puromycin-sensitive enkephalin-degrading aminopeptidases from rat
    J Neurochem (1990) 54, 547-554. PubMed  Europe PubMed DOI
  113. Johnson,G.D. and Hersh,L.B.
    Studies on the subsite specificity of the rat brain puromycin- sensitive aminopeptidase
    Arch Biochem Biophys (1990) 276, 305-309. PubMed  Europe PubMed DOI
  114. Sherekar,S.V., Gore,M.S. and Ninjoor,V.
    Aminopeptidase from the skeletal muscle of fresh water fish Tilapia mossambica
    Indian J Biochem Biophys (1990) 27, 316-323. PubMed  Europe PubMed
  115. 1989
  116. Gibson,A.M., McDermott,J.R., Lauffart,B. and Mantle,D.
    Specificity of action of human brain alanyl aminopeptidase on Leu-enkephalin and dynorphin-related peptides
    Neuropeptides (1989) 13, 259-262. PubMed  Europe PubMed
  117. 1988
  118. McLellan,S., Dyer,S.H., Rodriguez,G. and Hersh,L.B.
    Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases
    J Neurochem (1988) 51, 1552-1559. PubMed  Europe PubMed
  119. 1987
  120. Watanabe,Y., Kumagai,Y., Shimamori,Y. and Fujimoto,Y.
    Purification and characterization of thiol aminopeptidase from the cytosolic fraction of human placenta
    Biochem Med Metab Biol (1987) 37, 235-245. PubMed  Europe PubMed
  121. 1986
  122. McDonald,J.K. and Barrett,A.J.
    Mammalian Proteases: a Glossary and Bibliography. Volume 2: Exopeptidases
    [ISSN:ISBN 0-12-079502-7] (1986)
  123. Sharma,K.K. and Ortwerth,B.J.
    Isolation and characterization of a new aminopeptidase from bovine lens
    J Biol Chem (1986) 261, 4295-4301. PubMed  Europe PubMed
  124. 1985
  125. Hui,K.S., Hui,M.P., Ling,N. and Lajtha,A.
    Proctolin: a potent inhibitor of aminoenkephalinase
    Life Sci (1985) 36, 2309-2315. PubMed  Europe PubMed DOI  I
  126. 1983
  127. Imamura,T., Kawata,S., Ninomiya,K. and Makisumi,S.
    Porcine liver aminopeptidase. Further characterization of its sulfhydryl groups
    J Biochem (1983) 94, 267-273. PubMed  Europe PubMed
  128. Mantle,D., Hardy,M.F., Lauffart,B., McDermott,J.R., Smith,A.I. and Pennington,R.J.
    Purification and characterization of the major aminopeptidase from human skeletal muscle
    Biochem J (1983) 211, 567-573. PubMed  Europe PubMed  PMC  EPMC
  129. 1982
  130. Coletti-Previero,M.A., Crastes de Paulet,A., Mattras,H. and Previero,A.
    Amino acid hydroxamates as inhibitors of the human enkephalin-degrading aminopeptidase
    Biochem Biophys Res Commun (1982) 107, 465-469. PubMed  Europe PubMed  I
  131. Hersh,L.B.
    Degradation of enkephalins: the search for an enkephalinase
    Mol Cell Biochem (1982) 47, 35-43. PubMed  Europe PubMed
  132. Hui,K.S., Graf,L. and Lajtha,A.
    Beta-endorphin inhibits Met-enkephalin breakdown by a brain aminopeptidase: structure-activity relationships
    Biochem Biophys Res Commun (1982) 105, 1482-1487. PubMed  Europe PubMed
  133. 1981
  134. Hersh,L.B.
    Solubilization and characterization of two rat brain membrane-bound aminopeptidases active on Met-enkephalin
    Biochemistry (1981) 20, 2345-2350. PubMed  Europe PubMed
  135. Hersh,L.B. and McKelvy,J.F.
    An aminopeptidase from bovine brain which catalyzes the hydrolysis of enkephalin
    J Neurochem (1981) 36, 171-178. PubMed  Europe PubMed
  136. [YEAR:19-3-1981]Sidorowicz,W., Zownir,O. and Behal,F.J.
    Action of human pancreas alanine aminopeptidase on biologically active peptides: kinin converting activity
    Clin Chim Acta (19-3-1981) 111, 69-79. PubMed  Europe PubMed DOI  P
  137. 1980
  138. McClellan,J.B., Jr. and Garner,C.W.
    Purification and properties of human intestine alanine aminopeptidase
    Biochim Biophys Acta (1980) 613, 160-167. PubMed  Europe PubMed
  139. Sidorowicz,W., Hsia,W.C., Maslej-Zownir,O. and Behal,F.J.
    Multiple molecular forms of human alanine aminopeptidase: immunochemical properties
    Clin Chim Acta (1980) 107, 245-256. PubMed  Europe PubMed DOI
  140. 1979
  141. Schnebli,H.P., Phillipps,M.A. and Barclay,R.K.
    Isolation and characterization of an enkephalin-degrading aminopeptidase from human brain
    Biochim Biophys Acta (1979) 569, 89-98. PubMed  Europe PubMed
  142. 1978
  143. Hayashi,M.
    Monkey brain arylamidase. II. Further characterization and studies on mode of hydrolysis of physiologically active peptides
    J Biochem (1978) 84, 1363-1372. PubMed  Europe PubMed
  144. 1977
  145. Garner,C.W. and Behal,F.J.
    Hydrophobic binding sites of human liver alanine aminopeptidase
    Arch Biochem Biophys (1977) 182, 667-673. PubMed  Europe PubMed
  146. Garner,C.W. and Behal,F.J.
    Fluorescence of human liver alanine aminopeptidase
    Physiol Chem Phys (1977) 9, 47-54. PubMed  Europe PubMed
  147. Hayashi,M. and Oshima,K.
    Purification and characterization of arylamidase from monkey brain
    J Biochem (1977) 81, 631-639. PubMed  Europe PubMed
  148. [YEAR:1-11-1977]Hiwada,K. and Kokubu,T.
    Comparison of soluble and membrane-bound neutral arylamidases from renal cell carcinoma
    Clin Chim Acta (1-11-1977) 80, 395-401. PubMed  Europe PubMed
  149. 1975
  150. [YEAR:18-11-1975]Garner,C.W. and Behal,F.J.
    Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups
    Biochemistry (18-11-1975) 14, 5084-5088. PubMed  Europe PubMed
  151. [YEAR:15-7-1975]Garner,C.W. and Behal,F.J.
    Human liver alanine aminopeptidase. Inhibition by amino acids
    Biochemistry (15-7-1975) 14, 3208-3212. PubMed  Europe PubMed
  152. 1974
  153. [YEAR:30-7-1974]Garner,C.W., Jr. and Behal,F.J.
    Human liver aminopeptidase. Role of metal ions in mechanism of action
    Biochemistry (30-7-1974) 13, 3227-3233. PubMed  Europe PubMed
  154. 1969
  155. Brecher,A.S. and Suszkiw,J.B.
    Brain arylamidase. Purfication and characterization of the soluble bovine enzyme
    Biochem J (1969) 112, 335-342. PubMed  Europe PubMed  PMC  EPMC
  156. 1968
  157. Behal,F.J. and Little,G.H.
    Arylamidase of human duodenum
    Clin Chim Acta (1968) 21, 347-355. PubMed  Europe PubMed
  158. Peters,J.E., Rehfeld,N., Beier,L. and Haschen,R.J.
    [Immunological characterization of alanine aminopeptidase isoenzymes]
    Clin Chim Acta (1968) 19, 277-286. PubMed  Europe PubMed
  159. 1966
  160. [YEAR:25-8-1966]Ellis,S. and Perry,M.
    Pituitary arylamidases and peptidases
    J Biol Chem (25-8-1966) 241, 3679-3686. PubMed  Europe PubMed  I
  161. 1964
  162. Ellis,S. and Perry,M.
    Inhibition of thiol-activated aminopeptidase by puromycin
    Biochem Biophys Res Commun (1964) 15, 502-505.  I
  163. 1963
  164. Ellis,S.
    A thiol-activated aminopeptidase of the pituitary
    Biochem Biophys Res Commun (1963) 12, 452-456. PubMed  Europe PubMed