Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C01.073: peptidase 1 (mite)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Han,F., Yang,S.M., Xue,J., Xie,W., Liao,Y., Cheng,Q., Zhou,D., Ren,C. and Cui,Y.
    A digital ELISA for multiplexed detection of allergen-specific IgE against Der p 1, Der p 2, and Der p 23
    Bioeng Transl Med (2025) 10, e70068-e70068. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Zhang,J., Chen,J., Ng,W.H., Saberi-Movahed,A.S., Rathore,Z., Sayed,N., George,K., Sequeira,D., Garrod,D. and Robinson,C.
    Catalytic Site Inhibitors of Group 1 Allergens Prevent Toll-like Receptor (TLR)4- and TLR1/2-Dependent Innate Responses in Keratinocytes and Airway Epithelial Cells Exposed to House Dust Mite Allergenic Extract
    ACS Pharmacol Transl Sci (2025) 8, 3546-3567. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Aggarwal,P. and Senthilkumaran,S.
    Dust Mite Allergy
     (2024) PubMed  Europe PubMed
    4. 2021
  4. Ogi,K., Ramezanpour,M., Liu,S., Ferdoush Tuli,J., Bennett,C., Suzuki,M., Fujieda,S., Psaltis,A.J., Wormald,P.J. and Vreugde,S.
    Der p 1 Disrupts the Epithelial Barrier and Induces IL-6 Production in Patients With House Dust Mite Allergic Rhinitis
    Front Allergy (2021) 2, 692049-692049. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2020
  5. Cai,X.J., Huang,L.H., Zhu,Y.K. and Huang,Y.J.
    LncRNA OIP5AS1 aggravates house dust miteinduced inflammatory responses in human bronchial epithelial cells via the miR1433p/HMGB1 axis
    Mol Med Rep (2020) 22, 4509-4518. PubMed  Europe PubMed DOI  PMC  EPMC  K
  6. Lazaro-Gorines,R., Lopez-Rodriguez,J.C., Benede,S., Gonzalez,M., Mayorga,C., Vogel,L., Martinez-Del-Pozo,A., Lacadena,J. and Villalba,M.
    Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy
    Sci Rep (2020) 10, 12255-12255. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Zhang,R., Trower,J. and Wu,T.
    Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease cabrogates immune modulator function
    Int J Biol Macromol (2020) 164, 4031- PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2019
  8. Zhang,J. and Robinson,C.
    Novel method for the purification of house dust mite allergen Der p 1 and its use in structure-based chemical design of novel inhibitors
    Methods Mol Biol (2019) 2020, 185-205. PubMed  Europe PubMed DOI  I
    9. 2018
  9. Chevigne,A. and Jacquet,A.
    Emerging roles of the protease allergen Der p 1 in house dust mite-induced airway inflammation
    J Allergy Clin Immunol (2018) 142, 398-400. PubMed  Europe PubMed DOI  V
  10. Cui,Y., Yu,L., Teng,F., Wang,N., Zhou,Y., Zhang,C. and Yang,L.
    Expression of recombinant allergen, Der f 1, Der f 2 and Der f 4 using baculovirus-insect cell systems
    Arch Med Sci (2018) 14, 1348-1354. PubMed  Europe PubMed DOI  PMC  EPMC  E
  11. Zhang,J., Chen,J., Zuo,J., Newton,G.K., Stewart,M.R., Perrior,T.R., Garrod,D.R. and Robinson,C.
    Allergen delivery inhibitors: characterisation of potent and selective inhibitors of Der p 1 and their attenuation of airway responses to house dust mite allergens
    Int J Mol Sci (2018) 19 PubMed  Europe PubMed DOI  I
    12. 2017
  12. Chevigne,A., Campizi,V., Szpakowska,M., Bourry,D., Dumez,M.E., Martins,J.C., Matagne,A., Galleni,M. and Jacquet,A.
    The Lys-Asp-Tyr triad within the mite allergen Der p 1 propeptide is a critical structural element for the pH-dependent initiation of the protease maturation
    Int J Mol Sci (2017) 18 PubMed  Europe PubMed DOI  PMC  EPMC
  13. Glesner,J., Vailes,L.D., Schlachter,C., Mank,N., Minor,W., Osinski,T., Chruszcz,M., Chapman,M.D. and Pomes,A.
    Antigenic determinants of Der p 1: specificity and cross-reactivity associated with IgE antibody recognition
    J Immunol (2017) 198, 1334-1344. PubMed  Europe PubMed DOI
  14. Jacquet,A., Campisi,V., Szpakowska,M., Dumez,M.E., Galleni,M. and Chevigne,A.
    Profiling the extended cleavage specificity of the house dust mite protease allergens Der p 1, Der p 3 and Der p 6 for the prediction of new cell surface protein substrates
    Int J Mol Sci (2017) 18 PubMed  Europe PubMed DOI  P
  15. Oida,K., Einhorn,L., Herrmann,I., Panakova,L., Resch,Y., Vrtala,S., Hofstetter,G., Tanaka,A., Matsuda,H. and Jensen-Jarolim,E.
    Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH
    World Allergy Organ J (2017) 10, 23-23. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Randall,T.A., London,R.E., Fitzgerald,M.C. and Mueller,G.A.
    Proteases of Dermatophagoides pteronyssinus
    Int J Mol Sci (2017) 18 PubMed  Europe PubMed DOI
  17. Reddy,V.B. and Lerner,E.A.
    Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation
    J Biol Chem (2017) 292, 17399-17406. PubMed  Europe PubMed DOI
    18. 2015
  18. Ling,C., Zhang,J., Chen,H., Zou,Z., Lai,H., Zhang,J., Lin,D. and Tao,A.
    Expression and refolding of mite allergen pro-Der f1 from inclusion bodies in Escherichia coli
    Protein Expr Purif (2015) 109, 93-98. PubMed  Europe PubMed DOI  E
  19. Osinski,T., Pomes,A., Majorek,K.A., Glesner,J., Offermann,L.R., Vailes,L.D., Chapman,M.D., Minor,W. and Chruszcz,M.
    Structural analysis of Der p 1-antibody complexes and comparison with complexes of proteins or peptides with monoclonal antibodies
    J Immunol (2015) 195, 307-316. PubMed  Europe PubMed DOI  S
  20. Yi,M.H., Kim,H.P., Jeong,K.Y., Kim,C.R., Kim,T.Y. and Yong,T.S.
    House dust mite allergen Der f 1 induces IL-8 in human basophilic cells via ROS-ERK and p38 signal pathways
    Cytokine (2015) 75, 356-364. PubMed  Europe PubMed DOI
    21. 2014
  21. Dumez,M.E., Herman,J., Campizi,V., Galleni,M., Jacquet,A. and Chevigne,A.
    Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet
    Front Immunol (2014) 5, 138-138. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Herman,J., Thelen,N., Smargiasso,N., Mailleux,A.C., Luxen,A., Cloes,M., de Pauw,E., Chevigne,A., Galleni,M. and Dumez,M.E.
    Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus
    Biochim Biophys Acta (2014) 1840, 1117-1124. PubMed  Europe PubMed DOI
  23. Jiang,Y.X., Yin,K., Jin,W.J., Wu,L.Y. and Li,C.P.
    [Experimental study on the Der f 1 mRNA molecules derived from Dermatophagoides farinae for specific immunotherapy on murine model of asthma]
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2014) 32, 268-273. PubMed  Europe PubMed
  24. Liu,Z., Jiang,Y. and Li,C.
    Design of a ProDer f 1 vaccine delivered by the MHC class II pathway of antigen presentation and analysis of the effectiveness for specific immunotherapy
    Int J Clin Exp Pathol (2014) 7, 4636-4644. PubMed  Europe PubMed  PMC  EPMC
  25. Newton,G.K., Perrior,T.R., Jenkins,K., Major,M.R., Key,R.E., Stewart,M.R., Firth-Clark,S., Lloyd,S.M., Zhang,J., Francis-Newton,N.J., Richardson,J.P., Chen,J., Lai,P., Garrod,D.R. and Robinson,C.
    The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma
    J Med Chem (2014) 57, 9447-9462. PubMed  Europe PubMed DOI  T  I
  26. Shafique,R.H., Klimov,P.B., Inam,M., Chaudhary,F.R. and OConnor,B.M.
    Group 1 allergen genes in two species of house dust mites, Dermatophagoides farinae and D. pteronyssinus (Acari: Pyroglyphidae): direct sequencing, characterization and polymorphism
    PLoS ONE (2014) 9, e114636-e114636. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2013
  27. Kamijo,S., Takeda,H., Tokura,T., Suzuki,M., Inui,K., Hara,M., Matsuda,H., Matsuda,A., Oboki,K., Ohno,T., Saito,H., Nakae,S., Sudo,K., Suto,H., Ichikawa,S., Ogawa,H., Okumura,K. and Takai,T.
    IL-33-Mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation
    J Immunol (2013) 190, 4489-4499. PubMed  Europe PubMed DOI
  28. Liao,Y.W., Wu,X.M., Jia,J., Wu,X.L., Tao,H. and Wang,H.Y.
    Proteolytic antigens interfere with endosome/lysosome fusion in epithelial cells
    Biochem Cell Biol (2013) 91, 449-454. PubMed  Europe PubMed DOI
  29. Serrano-Luna,J., Pina-Vazquez,C., Reyes-Lopez,M., Ortiz-Estrada,G. and de la Garza,M.
    Proteases from Entamoeba spp. and pathogenic free-living amoebae as virulence factors
    J Trop Med (2013) 2013, 890603-890603. PubMed  Europe PubMed DOI  PMC  EPMC  V
  30. Warmbold,C., Uliczka,K., Rus,F., Suck,R., Petersen,A., Silverman,N., Ulmer,A.J., Heine,H. and Roeder,T.
    Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster
    J Immunol (2013) 190, 366-371. PubMed  Europe PubMed DOI
    31. 2012
  31. Marconi,G., Albertini,E., Mari,A., Palazzo,P., Porceddu,A., Raggi,L., Bolis,L., Lancioni,H., Palomba,A., Lucentini,L., Lanfaloni,L., Marcucci,F., Falcinelli,M. and Panara,F.
    In planta expression of a mature Der p 1 allergen isolated from an Italian strain of Dermatophagoides pteronyssinus
    Transgenic Res (2012) 21, 523-535. PubMed  Europe PubMed DOI  E
  32. Prester,L., Kovacic,J. and Macan,J.
    Comparison of buffers for extraction of mite allergen der p 1 from dust
    Arh Hig Rada Toksikol (2012) 63, 293-300. PubMed  Europe PubMed DOI
  33. Takai,T.
    Mite endopeptidase 1
    [ISSN:978-0-12-407743-0] (2012) 3, 1957-1963. DOI
    34. 2011
  34. Bessot,J.C. and Pauli,G.
    Mite allergens: an overview
    Eur Ann Allergy Clin Immunol (2011) 43, 141-156. PubMed  Europe PubMed
  35. Dai,Y.C., Chuang,W.J., Chua,K.Y., Shieh,C.C. and Wang,J.Y.
    Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: insight into therapeutic potential
    J Mol Med (Berl) (2011) 89, 701-712. PubMed  Europe PubMed DOI
  36. Fukunaga,M., Gon,Y., Nunomura,S., Inoue,T., Yoshioka,M., Hashimoto,S. and Ra,C.
    Protease-mediated house dust mite allergen-induced reactive oxygen species production by neutrophils
    Int Arch Allergy Immunol (2011) 155 Suppl 1, 104-109. PubMed  Europe PubMed DOI
  37. Jacquet,A.
    Interactions of airway epithelium with protease allergens in the allergic response
    Clin Exp Allergy (2011) 41, 305-311. PubMed  Europe PubMed DOI
    38. 2010
  38. Chevigne,A., Dumez,M.E., Dumoulin,M., Matagne,A., Jacquet,A. and Galleni,M.
    Comparative study of mature and zymogen mite cysteine protease stability and pH unfolding
    Biochim Biophys Acta (2010) 1800, 937-945. PubMed  Europe PubMed DOI
  39. Kondoh,M., Fukada,K., Shimada,T., Kitamura,Y., Yasueda,H. and Enomoto,T.
    [Highly sensitive enzyme-linked immunosorbent assay for the quantification of allergens from Dermatophagoides, DER p 1 and DER f 1]
    Arerugi (2010) 59, 109-116. PubMed  Europe PubMed
  40. Pulsawat,P., Piboonpocanun,S., Sirivichayakul,S., Buranapraditkun,S., Jacquet,A., Shimada,M., Okuda,K. and Ruxrungtham,K.
    Production and immunogenicity of hypoallergenic codon-optimized DNA vaccine encoding mature Der p 1 allergen
    J Investig Allergol Clin Immunol (2010) 20, 582-590. PubMed  Europe PubMed
    41. 2009
  41. Burtin,D., Chabre,H., Olagnier,B., Didierlaurent,A., Couret,M.N., Comeau,D., Wambre,E., Laparra,H., Van Overtvelt,L., Montandon,F., Batard,T., Jonval,V., Lorphelin,A., Merle,C., Berrouet,C., Parry,L., Gomord,V., Van Ree,R. and Moingeon,P.
    Production of native and modified recombinant Der p 1 molecules in tobacco plants
    Clin Exp Allergy (2009) 39, 760-770. PubMed  Europe PubMed DOI  E
  42. Chruszcz,M., Chapman,M.D., Vailes,L.D., Stura,E.A., Saint-Remy,J.M., Minor,W. and Pomes,A.
    Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding
    J Mol Biol (2009) 386, 520-530. PubMed  Europe PubMed DOI  PMC  EPMC  S
  43. Nakamura,Y., Miyata,M., Shimokawa,N., Ohnuma,Y., Katoh,R., Ogawa,H., Okumura,K. and Nakao,A.
    House dust mite allergen Der f 1 can induce the activation of latent TGF-beta via its protease activity
    FEBS Lett (2009) 583, 2088-2092. PubMed  Europe PubMed DOI
  44. Takai,T., Kato,T., Hatanaka,H., Inui,K., Nakazawa,T., Ichikawa,S., Mitsuishi,K., Ogawa,H. and Okumura,K.
    Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand
    J Immunol (2009) 183, 7958-7965. PubMed  Europe PubMed DOI
  45. Zhang,J., Saint-Remy,J.M., Garrod,D.R. and Robinson,C.
    Comparative enzymology of native and recombinant house dust mite allergen Der p 1
    Allergy (2009) 64, 469-477. PubMed  Europe PubMed DOI  I
    46. 2008
  46. Cui,Y., Zhou,P., Peng,J., Peng,M., Zhou,Y., Lin,Y. and Liu,L.
    Cloning, sequence analysis, and expression of cDNA coding for the major house dust mite allergen, Der f 1, in Escherichia coli
    Braz J Med Biol Res (2008) 41, 380-388. PubMed  Europe PubMed  E
  47. Dumez,M.E., Teller,N., Mercier,F., Tanaka,T., Vandenberghe,I., Vandenbranden,M., Devreese,B., Luxen,A., Frere,J.M., Matagne,A., Jacquet,A., Galleni,M. and Chevigne,A.
    Activation mechanism of recombinant Der p 3 allergen zymogen: contribution of cysteine protease Der p 1 and effect of propeptide glycosylation
    J Biol Chem (2008) 283, 30606-30617. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Ogawa,T., Takai,T., Kato,T., Kikuchi,Y., Niyonsaba,F., Ikeda,S., Okumura,K. and Ogawa,H.
    Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1
    Int Arch Allergy Immunol (2008) 146, 27-35. PubMed  Europe PubMed DOI
    49. 2007
  49. Chapman,M.D., Wunschmann,S. and Pomes,A.
    Proteases as th2 adjuvants
    Curr Allergy Asthma Rep (2007) 7, 363-367. PubMed  Europe PubMed DOI
  50. Chevigne,A., Barumandzadeh,R., Groslambert,S., Cloes,B., Dehareng,D., Filee,P., Marx,J.C., Frere,J.M., Matagne,A., Jacquet,A. and Galleni,M.
    Relationship between propeptide pH unfolding and inhibitory ability during proDer p 1 activation mechanism
    J Mol Biol (2007) 374, 170-185. PubMed  Europe PubMed DOI
  51. Deb,R., Shakib,F., Reid,K. and Clark,H.
    Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D
    J Biol Chem (2007) 282, 36808-36819. PubMed  Europe PubMed DOI
  52. Furmonaviciene,R., Ghaemmaghami,A.M., Boyd,S.E., Jones,N.S., Bailey,K., Willis,A.C., Sewell,H.F., Mitchell,D.A. and Shakib,F.
    The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses
    Clin Exp Allergy (2007) 37, 231-242. PubMed  Europe PubMed DOI  P
  53. Meng,J.F., McFall,C. and Rosenwasser,L.J.
    Polymorphism R62W results in resistance of CD23 to enzymatic cleavage in cultured cells
    Genes Immun (2007) 8, 215-223. PubMed  Europe PubMed DOI
  54. Nisbet,A.J., MacKellar,A., McLean,K., Brennan,G.P. and Huntley,J.F.
    Eukaryotic expression of recombinant Pso o 1, an allergen from Psoroptes ovis, and its localization in the mite
    Parasitology (2007) 134, 83-89. PubMed  Europe PubMed DOI  E
  55. Zhang,J., Hamilton,J.M., Garrod,D.R. and Robinson,C.
    Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases
    Allergy (2007) 62, 1302-1309. PubMed  Europe PubMed DOI
    56. 2006
  56. [YEAR:17-11-2006]Adam,E., Hansen,K.K., Astudillo,O.F., Coulon,L., Bex,F., Duhant,X., Jaumotte,E., Hollenberg,M.D. and Jacquet,A.
    The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism
    J Biol Chem (17-11-2006) 281, 6910-6923. PubMed  Europe PubMed DOI
  57. de Halleux,S., Stura,E., VanderElst,L., Carlier,V., Jacquemin,M. and Saint-Remy,J.M.
    Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen
    J Allergy Clin Immunol (2006) 117, 571-576. PubMed  Europe PubMed DOI  S
  58. Kauffman,H.F., Tamm,M., Timmerman,J.A. and Borger,P.
    House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms
    Clin Mol Allergy (2006) 4, 5-5. PubMed  Europe PubMed DOI  PMC  EPMC
  59. [YEAR:1-8-2006]Kikuchi,Y., Takai,T., Kuhara,T., Ota,M., Kato,T., Hatanaka,H., Ichikawa,S., Tokura,T., Akiba,H., Mitsuishi,K., Ikeda,S., Okumura,K. and Ogawa,H.
    Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses
    J Immunol (1-8-2006) 177, 1609-1617. PubMed  Europe PubMed
  60. [YEAR:28-9-2006]Nakamura,T., Hirasawa,Y., Takai,T., Mitsuishi,K., Okuda,M., Kato,T., Okumura,K., Ikeda,S. and Ogawa,H.
    Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite major allergen Der f 1
    J Invest Dermatol (28-9-2006) 126, 2719-2723. PubMed  Europe PubMed DOI
  61. [YEAR:26-1-2006]Takai,T., Mizuuchi,E., Kikuchi,Y., Nagamune,T., Okumura,K. and Ogawa,H.
    Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation
    Int Arch Allergy Immunol (26-1-2006) 139, 181-187. PubMed  Europe PubMed DOI
    62. 2005
  62. Grunstein,M.M., Veler,H., Shan,X., Larson,J., Grunstein,J.S. and Chuang,S.
    Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle
    J Allergy Clin Immunol (2005) 116, 94-101. PubMed  Europe PubMed DOI
  63. Kato,T., Takai,T., Mitsuishi,K., Okumura,K. and Ogawa,H.
    Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases
    J Allergy Clin Immunol (2005) 116, 169-176. PubMed  Europe PubMed DOI
  64. [YEAR:15-9-2005]Meno,K., Thorsted,P.B., Ipsen,H., Kristensen,O., Larsen,J.N., Spangfort,M.D., Gajhede,M. and Lund,K.
    The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen
    J Immunol (15-9-2005) 175, 3835-3845. PubMed  Europe PubMed  S
  65. Pichavant,M., Charbonnier,A.S., Taront,S., Brichet,A., Wallaert,B., Pestel,J., Tonnel,A.B. and Gosset,P.
    Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment
    J Allergy Clin Immunol (2005) 115, 771-778. PubMed  Europe PubMed DOI
  66. [YEAR:25-3-2005]Takai,T., Kato,T., Sakata,Y., Yasueda,H., Izuhara,K., Okumura,K. and Ogawa,H.
    Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity
    Biochem Biophys Res Commun (25-3-2005) 328, 944-952. PubMed  Europe PubMed DOI
  67. Takai,T., Kato,T., Yasueda,H., Okumura,K. and Ogawa,H.
    Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: major conformational IgE epitopes blocked by prodomains
    J Allergy Clin Immunol (2005) 115, 555-563. PubMed  Europe PubMed DOI  E
  68. [YEAR:9-6-2005]Takai,T., Kato,T., Ota,M., Yasueda,H., Kuhara,T., Okumura,K. and Ogawa,H.
    Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice
    Int Arch Allergy Immunol (9-6-2005) 137, 194-200. PubMed  Europe PubMed DOI  E
    69. 2004
  69. Harris,J., Mason,D.E., Li,J., Burdick,K.W., Backes,B.J., Chen,T., Shipway,A., Van Heeke,G., Gough,L., Ghaemmaghami,A., Shakib,F., Debaene,F. and Winssinger,N.
    Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays
    Chem Biol (2004) 11, 1361-1372. PubMed  Europe PubMed DOI
  70. Meighan,P. and Pirzad,R.
    Mite endopeptidase 1
    [ISSN:0-12-079610-4] (2004) 2, 1187-1189.  V
  71. [YEAR:20-11-2004]Sakata,Y., Arima,K., Takai,T., Sakurai,W., Masumoto,K., Yuyama,N., Suminami,Y., Kishi,F., Yamashita,T., Kato,T., Ogawa,H., Fujimoto,K., Matsuo,Y., Sugita,Y. and Izuhara,K.
    The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1
    J Biol Chem (20-11-2004) 279, 5081-5087. PubMed  Europe PubMed DOI
    72. 2003
  72. Cheong,N., Soon,S.C., Ramos,J.D., Kuo,I.C., Kolatkar,P.R., Lee,B.W., Chua,K.Y. and Kolortkar,P.R.
    Lack of human IgE cross-reactivity between mite allergens Blo t 1 and Der p 1
    Allergy (2003) 58, 912-920. PubMed  Europe PubMed DOI
  73. Gough,L., Campbell,E., Bayley,D., Van Heeke,G. and Shakib,F.
    Proteolytic activity of the house dust mite allergen Der p 1 enhances allergenicity in a mouse inhalation model
    Clin Exp Allergy (2003) 33, 1159-1163. PubMed  Europe PubMed DOI
    74. 2002
  74. [YEAR:15-10-2002]Asokananthan,N., Graham,P.T., Stewart,D.J., Bakker,A.J., Eidne,K.A., Thompson,P.J. and Stewart,G.A.
    House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: The cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1
    J Immunol (15-10-2002) 169, 4572-4578. PubMed  Europe PubMed
  75. Ghaemmaghami,A.M. and Shakib,F.
    Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells
    Clin Exp Allergy (2002) 32, 728-732. PubMed  Europe PubMed DOI
  76. Ghaemmaghami,A.M., Gough,L., Sewell,H.F. and Shakib,F.
    The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level
    Clin Exp Allergy (2002) 32, 1468-1475. PubMed  Europe PubMed DOI
  77. Jacquet,A., Magi,M., Petry,H. and Bollen,A.
    High-level expression of recombinant house dust mite allergen Der p 1 in Pichia pastoris
    Clin Exp Allergy (2002) 32, 1048-1053. PubMed  Europe PubMed DOI  E
  78. Lee,A.J., Machell,J., Van Den Broek,A.H., Nisbet,A.J., Miller,H.R., Isaac,R.E. and Huntley,J.F.
    Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens
    Parasite Immunol (2002) 24, 413-422. PubMed  Europe PubMed DOI
  79. [YEAR:6-11-2002]Takai,T., Mineki,R., Nakazawa,T., Takaoka,M., Yasueda,H., Murayama,K., Okumura,K. and Ogawa,H.
    Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity
    FEBS Lett (6-11-2002) 531, 265-272. PubMed  Europe PubMed DOI
  80. van Oort,E., de Heer,P.G., van Leeuwen,W.A., Derksen,N.I., Muller,M., Huveneers,S., Aalberse,R.C. and Van Ree,R.
    Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite
    Eur J Biochem (2002) 269, 671-679. PubMed  Europe PubMed DOI
    81. 2001
  81. Ghaemmaghami,A.M., Robins,A., Gough,L., Sewell,H.F. and Shakib,F.
    Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-gamma
    Eur J Immunol (2001) 31, 1211-1216. PubMed  Europe PubMed DOI
  82. Gough,L., Sewell,H.F. and Shakib,F.
    The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen
    Clin Exp Allergy (2001) 31, 1594-1598. PubMed  Europe PubMed DOI
  83. Takahashi,K., Takai,T., Yasuhara,T., Yokota,T. and Okumura,Y.
    Effects of site-directed mutagenesis in the cysteine residues and the N-glycosylation motif in recombinant Der f 1 on secretion and protease activity
    Int Arch Allergy Immunol (2001) 124, 454-460. PubMed  Europe PubMed DOI
  84. Wan,H., Winton,H.L., Soeller,C., Taylor,G.W., Gruenert,D.C., Thompson,P.J., Cannell,M.B., Stewart,G.A., Garrod,D.R. and Robinson,C.
    The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus
    Clin Exp Allergy (2001) 31, 279-294. PubMed  Europe PubMed DOI
  85. Yasuhara,T., Takai,T., Yuuki,T., Okudaira,H. and Okumura,Y.
    Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding
    Clin Exp Allergy (2001) 31, 116-124. PubMed  Europe PubMed DOI  E
    86. 2000
  86. Best,E.A., Stedman,K.E., Bozic,C.M., Hunter,S.W., Vailes,L., Chapman,M.D., McCall,C.A. and McDermott,M.J.
    A recombinant group 1 house dust mite allergen, rDer f 1, with biological activities similar to those of the native allergen
    Protein Expr Purif (2000) 20, 462-471. PubMed  Europe PubMed DOI  E
  87. John,R.J., Rusznak,C., Ramjee,M., Lamont,A.G., Abrahamson,M. and Hewitt,E.L.
    Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide-based inhibitor
    Clin Exp Allergy (2000) 30, 784-793. PubMed  Europe PubMed DOI  I
  88. Pernas,M., Sanchez-Ramos,I., Sanchez-Monge,R., Lombardero,M., Arteaga,C., Castanera,P. and Salcedo,G.
    Der p 1 and Der f 1, the highly related and major allergens from house dust mites, are differentially affected by a plant cystatin
    Clin Exp Allergy (2000) 30, 972-978. PubMed  Europe PubMed DOI
  89. Shakib,F. and Gough,L.
    The proteolytic activity of Der p 1 selectively enhances IgE synthesis: a link between allergenicity and cysteine protease activity
    Clin Exp Allergy (2000) 30, 751-752. PubMed  Europe PubMed DOI
  90. Takahashi,K., Takai,T., Yasuhara,T., Yuuki,T., Ohtake,Y., Yokota,T. and Okumura,Y.
    Production of enzymatically and immunologically active Der f 1 in Escherichia coli
    Int Arch Allergy Immunol (2000) 122, 108-114. PubMed  Europe PubMed  E
    91. 1999
  91. [YEAR:20-12-1999]Gough,L., Schulz,O., Sewell,H.F. and Shakib,F.
    The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response
    J Exp Med (20-12-1999) 190, 1897-1902. PubMed  Europe PubMed DOI  PMC  EPMC
  92. Wan,H., Winton,H.L., Soeller,C., Tovey,E.R., Gruenert,D.C., Thompson,P.J., Stewart,G.A., Taylor,G.W., Garrod,D.R., Cannell,M.B. and Robinson,C.
    Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions
    J Clin Invest (1999) 104, 123-133. PubMed  Europe PubMed DOI  PMC  EPMC
    93. 1998
  93. [YEAR:5-5-1998]Billson,J., Clark,J., Conway,S.P., Hart,T., Johnson,T., Langston,S.P., Ramjee,M., Quibell,M. and Scott,R.K.
    The design and synthesis of inhibitors of the cysteinyl protease, Der p I
    Bioorg Med Chem Lett (5-5-1998) 8, 993-998. PubMed  Europe PubMed DOI  I
  94. [YEAR:1-10-1998]King,C., Brennan,S., Thompson,P.J. and Stewart,G.A.
    Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium
    J Immunol (1-10-1998) 161, 3645-3651. PubMed  Europe PubMed
  95. Schulz,O., Sewell,H.F. and Shakib,F.
    A sensitive fluorescent assay for measuring the cysteine protease activity of Der p 1, a major allergen from the dust mite Dermatophagoides pteronyssinus
    Mol Pathol (1998) 51, 222-224. PubMed  Europe PubMed  PMC  EPMC  A
  96. Shakib,F., Schulz,O. and Sewell,H.
    A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicity
    Immunol Today (1998) 19, 313-316. PubMed  Europe PubMed DOI
  97. Thomas,W.R. and Smith,W.
    House-dust-mite allergens
    Allergy (1998) 53, 821-832. PubMed  Europe PubMed  V
  98. Winton,H.L., Wan,H., Cannell,M.B., Thompson,P.J., Garrod,D.R., Stewart,G.A. and Robinson,C.
    Class specific inhibition of house dust mite proteinases which cleave cell adhesion, induce cell death and which increase the permeability of lung epithelium
    Br J Pharmacol (1998) 124, 1048-1059. PubMed  Europe PubMed DOI  PMC  EPMC
    99. 1997
  99. Schulz,O., Sutton,B.J., Beavil,R.L., Shi,J., Sewell,H.F., Gould,H.J., Laing,P. and Shakib,F.
    Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23
    Eur J Immunol (1997) 27, 584-588. PubMed  Europe PubMed DOI
  100. Shoji,H., Shibuya,I., Hirai,M., Horiuchi,H. and Takagi,M.
    Production of recombinant Der f I with the native IgE-binding activity using a baculovirus expression system
    Biosci Biotechnol Biochem (1997) 61, 1668-1673. PubMed  Europe PubMed
    101. 1996
  101. [YEAR:5-4-1996]Kalsheker,N.A., Deam,S., Chambers,L., Sreedharan,S., Brocklehurst,K. and Lomas,D.A.
    The house dust mite allergen Der p1 catalytically inactivates alpha 1-antitrypsin by specific reactive centre loop cleavage: a mechanism that promotes airway inflammation and asthma
    Biochem Biophys Res Commun (5-4-1996) 221, 59-61. PubMed  Europe PubMed DOI
    102. 1995
  102. Herbert,C.A., King,C.M., Ring,P.C., Holgate,S.T., Stewart,G.A., Thompson,P.J. and Robinson,C.
    Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1
    Am J Respir Cell Mol Biol (1995) 12, 369-378. PubMed  Europe PubMed DOI
    103. 1993
  103. Chua,K.Y., Kehal,P.K. and Thomas,W.R.
    Sequence polymorphisms of cDNA clones encoding the mite allergen Der p I
    Int Arch Allergy Immunol (1993) 101, 364-368. PubMed  Europe PubMed
    104. 1992
  104. Kent,N.A., Hill,M.R., Keen,J.N., Holland,P.W. and Hart,B.J.
    Molecular characterisation of group I allergen Eur m I from house dust mite Euroglyphus maynei
    Int Arch Allergy Immunol (1992) 99, 150-152. PubMed  Europe PubMed
    105. 1991
  105. Ando,T., Ino,Y., Haida,M., Honma,R., Maeda,H., Yamakawa,H., Iwaki,M. and Okudaira,H.
    Isolation of cysteine protease in the crude mite extract, Dermatophagoides farinae
    Int Arch Allergy Appl Immunol (1991) 96, 199-205. PubMed  Europe PubMed
  106. Dilworth,R.J., Chua,K.Y. and Thomas,W.R.
    Sequence analysis of cDNA coding for a major house dust mite allergen, Der f I
    Clin Exp Allergy (1991) 21, 25-32. PubMed  Europe PubMed
  107. Stewart,G.A., Lake,F.R. and Thompson,P.J.
    Faecally derived hydrolytic enzymes from Dermatophagoides pteronyssinus: physicochemical characterisation of potential allergens
    Int Arch Allergy Appl Immunol (1991) 95, 248-256. PubMed  Europe PubMed
  108. Thomas,B., Heap,P. and Carswell,F.
    Ultrastructural localization of the allergen Der p I in the gut of the house dust mite Dermatophagoides pteronyssinus
    Int Arch Allergy Appl Immunol (1991) 94, 365-367. PubMed  Europe PubMed
    109. 1990
  109. Herbert,C.A., Holgate,S.T., Robinson,C., Thompson,P.J. and Stewart,G.A.
    Effect of mite allergen on permeability of bronchial mucosa
    Lancet (1990) 336, 1132-1132. PubMed  Europe PubMed
    110. 1989
  110. Ino,Y., Ando,T., Haida,M., Nakamura,K., Iwaki,M., Okudaira,H. and Miyamoto,T.
    Characterization of the proteases in the crude mite extract
    Int Arch Allergy Appl Immunol (1989) 89, 321-326. PubMed  Europe PubMed
  111. Stewart,G.A., Thompson,P.J. and Simpson,R.J.
    Protease antigens from house dust mite
    Lancet (1989) 2, 154-155. PubMed  Europe PubMed
    112. 1988
  112. [YEAR:1-1-1988]Chua,K.Y., Stewart,G.A., Thomas,W.R., Simpson,R.J., Dilworth,R.J., Plozza,T.M. and Turner,K.J.
    Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases
    J Exp Med (1-1-1988) 167, 175-182. PubMed  Europe PubMed  PMC  EPMC
  113. Lind,P., Hansen,O.C. and Horn,N.
    The binding of mouse hybridoma and human IgE antibodies to the major fecal allergen, Der p I, of Dermatophagoides pteronyssinus. Relative binding site location and species specificity studied by solid-phase inhibition assays with radiolabeled antigen
    J Immunol (1988) 140, 4256-4262. PubMed  Europe PubMed
  114. Thomas,W.R., Stewart,G.A., Simpson,R.J., Chua,K.Y., Plozza,T.M., Dilworth,R.J., Nisbet,A. and Turner,K.J.
    Cloning and expression of DNA coding for the major house dust mite allergen Der p 1 in Escherichia coli
    Int Arch Allergy Appl Immunol (1988) 85, 127-129. PubMed  Europe PubMed
    115. 1986
  115. Heymann,P.W., Chapman,M.D. and Platts-Mills,T.A.
    Antigen Der f I from the dust mite Dermatophagoides farinae: structural comparison with Der p I from Dermatophagoides pteronyssinus and epitope specificity of murine IgG and human IgE antibodies
    J Immunol (1986) 137, 2841-2847. PubMed  Europe PubMed
  116. Yasueda,H., Mita,H., Yui,Y. and Shida,T.
    Isolation and characterization of two allergens from Dermatophagoides farinae
    Int Arch Allergy Appl Immunol (1986) 81, 214-223. PubMed  Europe PubMed
    117. 1967
  117. Voorhorst,R., Spieksma,F.T.M., Vanekamp,M.J., Leupen,M.J. and Lyklema,A.W.
    The house dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house dust allergen
    J Allergy (1967) 39, 325-328.

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use