Literature for peptidase C01.073: peptidase 1 (mite)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Han,F., Yang,S.M., Xue,J., Xie,W., Liao,Y., Cheng,Q., Zhou,D., Ren,C. and Cui,Y. A digital ELISA for multiplexed detection of allergen-specific IgE against Der p 1, Der p 2, and Der p 23 Bioeng Transl Med (2025) 10, e70068-e70068. PubMed Europe PubMed DOI PMC EPMC
Zhang,J., Chen,J., Ng,W.H., Saberi-Movahed,A.S., Rathore,Z., Sayed,N., George,K., Sequeira,D., Garrod,D. and Robinson,C. Catalytic Site Inhibitors of Group 1 Allergens Prevent Toll-like Receptor (TLR)4- and TLR1/2-Dependent Innate Responses in Keratinocytes and Airway Epithelial Cells Exposed to House Dust Mite Allergenic Extract ACS Pharmacol Transl Sci (2025) 8, 3546-3567. PubMed Europe PubMed DOI PMC EPMC

2024

Aggarwal,P. and Senthilkumaran,S. Dust Mite Allergy (2024) PubMed Europe PubMed

2021

Ogi,K., Ramezanpour,M., Liu,S., Ferdoush Tuli,J., Bennett,C., Suzuki,M., Fujieda,S., Psaltis,A.J., Wormald,P.J. and Vreugde,S. Der p 1 Disrupts the Epithelial Barrier and Induces IL-6 Production in Patients With House Dust Mite Allergic Rhinitis Front Allergy (2021) 2, 692049-692049. PubMed Europe PubMed DOI PMC EPMC

2020

Cai,X.J., Huang,L.H., Zhu,Y.K. and Huang,Y.J. LncRNA OIP5AS1 aggravates house dust miteinduced inflammatory responses in human bronchial epithelial cells via the miR1433p/HMGB1 axis Mol Med Rep (2020) 22, 4509-4518. PubMed Europe PubMed DOI PMC EPMC K
Lazaro-Gorines,R., Lopez-Rodriguez,J.C., Benede,S., Gonzalez,M., Mayorga,C., Vogel,L., Martinez-Del-Pozo,A., Lacadena,J. and Villalba,M. Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy Sci Rep (2020) 10, 12255-12255. PubMed Europe PubMed DOI PMC EPMC
Zhang,R., Trower,J. and Wu,T. Degradation of bacterial permeability family member A1 (BPIFA1) by house dust mite (HDM) cysteine protease cabrogates immune modulator function Int J Biol Macromol (2020) 164, 4031- PubMed Europe PubMed DOI PMC EPMC

2019

Zhang,J. and Robinson,C. Novel method for the purification of house dust mite allergen Der p 1 and its use in structure-based chemical design of novel inhibitors Methods Mol Biol (2019) 2020, 185-205. PubMed Europe PubMed DOI I

2018

Chevigne,A. and Jacquet,A. Emerging roles of the protease allergen Der p 1 in house dust mite-induced airway inflammation J Allergy Clin Immunol (2018) 142, 398-400. PubMed Europe PubMed DOI V
Cui,Y., Yu,L., Teng,F., Wang,N., Zhou,Y., Zhang,C. and Yang,L. Expression of recombinant allergen, Der f 1, Der f 2 and Der f 4 using baculovirus-insect cell systems Arch Med Sci (2018) 14, 1348-1354. PubMed Europe PubMed DOI PMC EPMC E
Zhang,J., Chen,J., Zuo,J., Newton,G.K., Stewart,M.R., Perrior,T.R., Garrod,D.R. and Robinson,C. Allergen delivery inhibitors: characterisation of potent and selective inhibitors of Der p 1 and their attenuation of airway responses to house dust mite allergens Int J Mol Sci (2018) 19 PubMed Europe PubMed DOI I

2017

Chevigne,A., Campizi,V., Szpakowska,M., Bourry,D., Dumez,M.E., Martins,J.C., Matagne,A., Galleni,M. and Jacquet,A. The Lys-Asp-Tyr triad within the mite allergen Der p 1 propeptide is a critical structural element for the pH-dependent initiation of the protease maturation Int J Mol Sci (2017) 18 PubMed Europe PubMed DOI PMC EPMC
Glesner,J., Vailes,L.D., Schlachter,C., Mank,N., Minor,W., Osinski,T., Chruszcz,M., Chapman,M.D. and Pomes,A. Antigenic determinants of Der p 1: specificity and cross-reactivity associated with IgE antibody recognition J Immunol (2017) 198, 1334-1344. PubMed Europe PubMed DOI
Jacquet,A., Campisi,V., Szpakowska,M., Dumez,M.E., Galleni,M. and Chevigne,A. Profiling the extended cleavage specificity of the house dust mite protease allergens Der p 1, Der p 3 and Der p 6 for the prediction of new cell surface protein substrates Int J Mol Sci (2017) 18 PubMed Europe PubMed DOI P
Oida,K., Einhorn,L., Herrmann,I., Panakova,L., Resch,Y., Vrtala,S., Hofstetter,G., Tanaka,A., Matsuda,H. and Jensen-Jarolim,E. Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH World Allergy Organ J (2017) 10, 23-23. PubMed Europe PubMed DOI PMC EPMC
Randall,T.A., London,R.E., Fitzgerald,M.C. and Mueller,G.A. Proteases of Dermatophagoides pteronyssinus Int J Mol Sci (2017) 18 PubMed Europe PubMed DOI
Reddy,V.B. and Lerner,E.A. Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation J Biol Chem (2017) 292, 17399-17406. PubMed Europe PubMed DOI

2015

Ling,C., Zhang,J., Chen,H., Zou,Z., Lai,H., Zhang,J., Lin,D. and Tao,A. Expression and refolding of mite allergen pro-Der f1 from inclusion bodies in Escherichia coli Protein Expr Purif (2015) 109, 93-98. PubMed Europe PubMed DOI E
Osinski,T., Pomes,A., Majorek,K.A., Glesner,J., Offermann,L.R., Vailes,L.D., Chapman,M.D., Minor,W. and Chruszcz,M. Structural analysis of Der p 1-antibody complexes and comparison with complexes of proteins or peptides with monoclonal antibodies J Immunol (2015) 195, 307-316. PubMed Europe PubMed DOI S
Yi,M.H., Kim,H.P., Jeong,K.Y., Kim,C.R., Kim,T.Y. and Yong,T.S. House dust mite allergen Der f 1 induces IL-8 in human basophilic cells via ROS-ERK and p38 signal pathways Cytokine (2015) 75, 356-364. PubMed Europe PubMed DOI

2014

Dumez,M.E., Herman,J., Campizi,V., Galleni,M., Jacquet,A. and Chevigne,A. Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet Front Immunol (2014) 5, 138-138. PubMed Europe PubMed DOI PMC EPMC
Herman,J., Thelen,N., Smargiasso,N., Mailleux,A.C., Luxen,A., Cloes,M., de Pauw,E., Chevigne,A., Galleni,M. and Dumez,M.E. Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus Biochim Biophys Acta (2014) 1840, 1117-1124. PubMed Europe PubMed DOI
Jiang,Y.X., Yin,K., Jin,W.J., Wu,L.Y. and Li,C.P. [Experimental study on the Der f 1 mRNA molecules derived from Dermatophagoides farinae for specific immunotherapy on murine model of asthma] Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2014) 32, 268-273. PubMed Europe PubMed
Liu,Z., Jiang,Y. and Li,C. Design of a ProDer f 1 vaccine delivered by the MHC class II pathway of antigen presentation and analysis of the effectiveness for specific immunotherapy Int J Clin Exp Pathol (2014) 7, 4636-4644. PubMed Europe PubMed PMC EPMC
Newton,G.K., Perrior,T.R., Jenkins,K., Major,M.R., Key,R.E., Stewart,M.R., Firth-Clark,S., Lloyd,S.M., Zhang,J., Francis-Newton,N.J., Richardson,J.P., Chen,J., Lai,P., Garrod,D.R. and Robinson,C. The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma J Med Chem (2014) 57, 9447-9462. PubMed Europe PubMed DOI T I
Shafique,R.H., Klimov,P.B., Inam,M., Chaudhary,F.R. and OConnor,B.M. Group 1 allergen genes in two species of house dust mites, Dermatophagoides farinae and D. pteronyssinus (Acari: Pyroglyphidae): direct sequencing, characterization and polymorphism PLoS ONE (2014) 9, e114636-e114636. PubMed Europe PubMed DOI PMC EPMC

2013

Kamijo,S., Takeda,H., Tokura,T., Suzuki,M., Inui,K., Hara,M., Matsuda,H., Matsuda,A., Oboki,K., Ohno,T., Saito,H., Nakae,S., Sudo,K., Suto,H., Ichikawa,S., Ogawa,H., Okumura,K. and Takai,T. IL-33-Mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation J Immunol (2013) 190, 4489-4499. PubMed Europe PubMed DOI
Liao,Y.W., Wu,X.M., Jia,J., Wu,X.L., Tao,H. and Wang,H.Y. Proteolytic antigens interfere with endosome/lysosome fusion in epithelial cells Biochem Cell Biol (2013) 91, 449-454. PubMed Europe PubMed DOI
Serrano-Luna,J., Pina-Vazquez,C., Reyes-Lopez,M., Ortiz-Estrada,G. and de la Garza,M. Proteases from Entamoeba spp. and pathogenic free-living amoebae as virulence factors J Trop Med (2013) 2013, 890603-890603. PubMed Europe PubMed DOI PMC EPMC V
Warmbold,C., Uliczka,K., Rus,F., Suck,R., Petersen,A., Silverman,N., Ulmer,A.J., Heine,H. and Roeder,T. Dermatophagoides pteronyssinus major allergen 1 activates the innate immune response of the fruit fly Drosophila melanogaster J Immunol (2013) 190, 366-371. PubMed Europe PubMed DOI

2012

Marconi,G., Albertini,E., Mari,A., Palazzo,P., Porceddu,A., Raggi,L., Bolis,L., Lancioni,H., Palomba,A., Lucentini,L., Lanfaloni,L., Marcucci,F., Falcinelli,M. and Panara,F. In planta expression of a mature Der p 1 allergen isolated from an Italian strain of Dermatophagoides pteronyssinus Transgenic Res (2012) 21, 523-535. PubMed Europe PubMed DOI E
Prester,L., Kovacic,J. and Macan,J. Comparison of buffers for extraction of mite allergen der p 1 from dust Arh Hig Rada Toksikol (2012) 63, 293-300. PubMed Europe PubMed DOI
Takai,T. Mite endopeptidase 1 [ISSN:978-0-12-407743-0] (2012) 3, 1957-1963. DOI

2011

Bessot,J.C. and Pauli,G. Mite allergens: an overview Eur Ann Allergy Clin Immunol (2011) 43, 141-156. PubMed Europe PubMed
Dai,Y.C., Chuang,W.J., Chua,K.Y., Shieh,C.C. and Wang,J.Y. Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: insight into therapeutic potential J Mol Med (Berl) (2011) 89, 701-712. PubMed Europe PubMed DOI
Fukunaga,M., Gon,Y., Nunomura,S., Inoue,T., Yoshioka,M., Hashimoto,S. and Ra,C. Protease-mediated house dust mite allergen-induced reactive oxygen species production by neutrophils Int Arch Allergy Immunol (2011) 155 Suppl 1, 104-109. PubMed Europe PubMed DOI
Jacquet,A. Interactions of airway epithelium with protease allergens in the allergic response Clin Exp Allergy (2011) 41, 305-311. PubMed Europe PubMed DOI

2010

Chevigne,A., Dumez,M.E., Dumoulin,M., Matagne,A., Jacquet,A. and Galleni,M. Comparative study of mature and zymogen mite cysteine protease stability and pH unfolding Biochim Biophys Acta (2010) 1800, 937-945. PubMed Europe PubMed DOI
Kondoh,M., Fukada,K., Shimada,T., Kitamura,Y., Yasueda,H. and Enomoto,T. [Highly sensitive enzyme-linked immunosorbent assay for the quantification of allergens from Dermatophagoides, DER p 1 and DER f 1] Arerugi (2010) 59, 109-116. PubMed Europe PubMed
Pulsawat,P., Piboonpocanun,S., Sirivichayakul,S., Buranapraditkun,S., Jacquet,A., Shimada,M., Okuda,K. and Ruxrungtham,K. Production and immunogenicity of hypoallergenic codon-optimized DNA vaccine encoding mature Der p 1 allergen J Investig Allergol Clin Immunol (2010) 20, 582-590. PubMed Europe PubMed

2009

Burtin,D., Chabre,H., Olagnier,B., Didierlaurent,A., Couret,M.N., Comeau,D., Wambre,E., Laparra,H., Van Overtvelt,L., Montandon,F., Batard,T., Jonval,V., Lorphelin,A., Merle,C., Berrouet,C., Parry,L., Gomord,V., Van Ree,R. and Moingeon,P. Production of native and modified recombinant Der p 1 molecules in tobacco plants Clin Exp Allergy (2009) 39, 760-770. PubMed Europe PubMed DOI E
Chruszcz,M., Chapman,M.D., Vailes,L.D., Stura,E.A., Saint-Remy,J.M., Minor,W. and Pomes,A. Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding J Mol Biol (2009) 386, 520-530. PubMed Europe PubMed DOI PMC EPMC S
Nakamura,Y., Miyata,M., Shimokawa,N., Ohnuma,Y., Katoh,R., Ogawa,H., Okumura,K. and Nakao,A. House dust mite allergen Der f 1 can induce the activation of latent TGF-beta via its protease activity FEBS Lett (2009) 583, 2088-2092. PubMed Europe PubMed DOI
Takai,T., Kato,T., Hatanaka,H., Inui,K., Nakazawa,T., Ichikawa,S., Mitsuishi,K., Ogawa,H. and Okumura,K. Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand J Immunol (2009) 183, 7958-7965. PubMed Europe PubMed DOI
Zhang,J., Saint-Remy,J.M., Garrod,D.R. and Robinson,C. Comparative enzymology of native and recombinant house dust mite allergen Der p 1 Allergy (2009) 64, 469-477. PubMed Europe PubMed DOI I

2008

Cui,Y., Zhou,P., Peng,J., Peng,M., Zhou,Y., Lin,Y. and Liu,L. Cloning, sequence analysis, and expression of cDNA coding for the major house dust mite allergen, Der f 1, in Escherichia coli Braz J Med Biol Res (2008) 41, 380-388. PubMed Europe PubMed E
Dumez,M.E., Teller,N., Mercier,F., Tanaka,T., Vandenberghe,I., Vandenbranden,M., Devreese,B., Luxen,A., Frere,J.M., Matagne,A., Jacquet,A., Galleni,M. and Chevigne,A. Activation mechanism of recombinant Der p 3 allergen zymogen: contribution of cysteine protease Der p 1 and effect of propeptide glycosylation J Biol Chem (2008) 283, 30606-30617. PubMed Europe PubMed DOI PMC EPMC
Ogawa,T., Takai,T., Kato,T., Kikuchi,Y., Niyonsaba,F., Ikeda,S., Okumura,K. and Ogawa,H. Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1 Int Arch Allergy Immunol (2008) 146, 27-35. PubMed Europe PubMed DOI

2007

Chapman,M.D., Wunschmann,S. and Pomes,A. Proteases as th2 adjuvants Curr Allergy Asthma Rep (2007) 7, 363-367. PubMed Europe PubMed DOI
Chevigne,A., Barumandzadeh,R., Groslambert,S., Cloes,B., Dehareng,D., Filee,P., Marx,J.C., Frere,J.M., Matagne,A., Jacquet,A. and Galleni,M. Relationship between propeptide pH unfolding and inhibitory ability during proDer p 1 activation mechanism J Mol Biol (2007) 374, 170-185. PubMed Europe PubMed DOI
Deb,R., Shakib,F., Reid,K. and Clark,H. Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D J Biol Chem (2007) 282, 36808-36819. PubMed Europe PubMed DOI
Furmonaviciene,R., Ghaemmaghami,A.M., Boyd,S.E., Jones,N.S., Bailey,K., Willis,A.C., Sewell,H.F., Mitchell,D.A. and Shakib,F. The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses Clin Exp Allergy (2007) 37, 231-242. PubMed Europe PubMed DOI P
Meng,J.F., McFall,C. and Rosenwasser,L.J. Polymorphism R62W results in resistance of CD23 to enzymatic cleavage in cultured cells Genes Immun (2007) 8, 215-223. PubMed Europe PubMed DOI
Nisbet,A.J., MacKellar,A., McLean,K., Brennan,G.P. and Huntley,J.F. Eukaryotic expression of recombinant Pso o 1, an allergen from Psoroptes ovis, and its localization in the mite Parasitology (2007) 134, 83-89. PubMed Europe PubMed DOI E
Zhang,J., Hamilton,J.M., Garrod,D.R. and Robinson,C. Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases Allergy (2007) 62, 1302-1309. PubMed Europe PubMed DOI

2006

[YEAR:17-11-2006]Adam,E., Hansen,K.K., Astudillo,O.F., Coulon,L., Bex,F., Duhant,X., Jaumotte,E., Hollenberg,M.D. and Jacquet,A. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism J Biol Chem (17-11-2006) 281, 6910-6923. PubMed Europe PubMed DOI
de Halleux,S., Stura,E., VanderElst,L., Carlier,V., Jacquemin,M. and Saint-Remy,J.M. Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen J Allergy Clin Immunol (2006) 117, 571-576. PubMed Europe PubMed DOI S
Kauffman,H.F., Tamm,M., Timmerman,J.A. and Borger,P. House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms Clin Mol Allergy (2006) 4, 5-5. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-8-2006]Kikuchi,Y., Takai,T., Kuhara,T., Ota,M., Kato,T., Hatanaka,H., Ichikawa,S., Tokura,T., Akiba,H., Mitsuishi,K., Ikeda,S., Okumura,K. and Ogawa,H. Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses J Immunol (1-8-2006) 177, 1609-1617. PubMed Europe PubMed
[YEAR:28-9-2006]Nakamura,T., Hirasawa,Y., Takai,T., Mitsuishi,K., Okuda,M., Kato,T., Okumura,K., Ikeda,S. and Ogawa,H. Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite major allergen Der f 1 J Invest Dermatol (28-9-2006) 126, 2719-2723. PubMed Europe PubMed DOI
[YEAR:26-1-2006]Takai,T., Mizuuchi,E., Kikuchi,Y., Nagamune,T., Okumura,K. and Ogawa,H. Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation Int Arch Allergy Immunol (26-1-2006) 139, 181-187. PubMed Europe PubMed DOI

2005

Grunstein,M.M., Veler,H., Shan,X., Larson,J., Grunstein,J.S. and Chuang,S. Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle J Allergy Clin Immunol (2005) 116, 94-101. PubMed Europe PubMed DOI
Kato,T., Takai,T., Mitsuishi,K., Okumura,K. and Ogawa,H. Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases J Allergy Clin Immunol (2005) 116, 169-176. PubMed Europe PubMed DOI
[YEAR:15-9-2005]Meno,K., Thorsted,P.B., Ipsen,H., Kristensen,O., Larsen,J.N., Spangfort,M.D., Gajhede,M. and Lund,K. The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen J Immunol (15-9-2005) 175, 3835-3845. PubMed Europe PubMed S
Pichavant,M., Charbonnier,A.S., Taront,S., Brichet,A., Wallaert,B., Pestel,J., Tonnel,A.B. and Gosset,P. Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment J Allergy Clin Immunol (2005) 115, 771-778. PubMed Europe PubMed DOI
[YEAR:25-3-2005]Takai,T., Kato,T., Sakata,Y., Yasueda,H., Izuhara,K., Okumura,K. and Ogawa,H. Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity Biochem Biophys Res Commun (25-3-2005) 328, 944-952. PubMed Europe PubMed DOI
Takai,T., Kato,T., Yasueda,H., Okumura,K. and Ogawa,H. Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: major conformational IgE epitopes blocked by prodomains J Allergy Clin Immunol (2005) 115, 555-563. PubMed Europe PubMed DOI E
[YEAR:9-6-2005]Takai,T., Kato,T., Ota,M., Yasueda,H., Kuhara,T., Okumura,K. and Ogawa,H. Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice Int Arch Allergy Immunol (9-6-2005) 137, 194-200. PubMed Europe PubMed DOI E

2004

Harris,J., Mason,D.E., Li,J., Burdick,K.W., Backes,B.J., Chen,T., Shipway,A., Van Heeke,G., Gough,L., Ghaemmaghami,A., Shakib,F., Debaene,F. and Winssinger,N. Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays Chem Biol (2004) 11, 1361-1372. PubMed Europe PubMed DOI
Meighan,P. and Pirzad,R. Mite endopeptidase 1 [ISSN:0-12-079610-4] (2004) 2, 1187-1189. V
[YEAR:20-11-2004]Sakata,Y., Arima,K., Takai,T., Sakurai,W., Masumoto,K., Yuyama,N., Suminami,Y., Kishi,F., Yamashita,T., Kato,T., Ogawa,H., Fujimoto,K., Matsuo,Y., Sugita,Y. and Izuhara,K. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1 J Biol Chem (20-11-2004) 279, 5081-5087. PubMed Europe PubMed DOI

2003

Cheong,N., Soon,S.C., Ramos,J.D., Kuo,I.C., Kolatkar,P.R., Lee,B.W., Chua,K.Y. and Kolortkar,P.R. Lack of human IgE cross-reactivity between mite allergens Blo t 1 and Der p 1 Allergy (2003) 58, 912-920. PubMed Europe PubMed DOI
Gough,L., Campbell,E., Bayley,D., Van Heeke,G. and Shakib,F. Proteolytic activity of the house dust mite allergen Der p 1 enhances allergenicity in a mouse inhalation model Clin Exp Allergy (2003) 33, 1159-1163. PubMed Europe PubMed DOI

2002

[YEAR:15-10-2002]Asokananthan,N., Graham,P.T., Stewart,D.J., Bakker,A.J., Eidne,K.A., Thompson,P.J. and Stewart,G.A. House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: The cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1 J Immunol (15-10-2002) 169, 4572-4578. PubMed Europe PubMed
Ghaemmaghami,A.M. and Shakib,F. Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells Clin Exp Allergy (2002) 32, 728-732. PubMed Europe PubMed DOI
Ghaemmaghami,A.M., Gough,L., Sewell,H.F. and Shakib,F. The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level Clin Exp Allergy (2002) 32, 1468-1475. PubMed Europe PubMed DOI
Jacquet,A., Magi,M., Petry,H. and Bollen,A. High-level expression of recombinant house dust mite allergen Der p 1 in Pichia pastoris Clin Exp Allergy (2002) 32, 1048-1053. PubMed Europe PubMed DOI E
Lee,A.J., Machell,J., Van Den Broek,A.H., Nisbet,A.J., Miller,H.R., Isaac,R.E. and Huntley,J.F. Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens Parasite Immunol (2002) 24, 413-422. PubMed Europe PubMed DOI
[YEAR:6-11-2002]Takai,T., Mineki,R., Nakazawa,T., Takaoka,M., Yasueda,H., Murayama,K., Okumura,K. and Ogawa,H. Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity FEBS Lett (6-11-2002) 531, 265-272. PubMed Europe PubMed DOI
van Oort,E., de Heer,P.G., van Leeuwen,W.A., Derksen,N.I., Muller,M., Huveneers,S., Aalberse,R.C. and Van Ree,R. Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite Eur J Biochem (2002) 269, 671-679. PubMed Europe PubMed DOI

2001

Ghaemmaghami,A.M., Robins,A., Gough,L., Sewell,H.F. and Shakib,F. Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-gamma Eur J Immunol (2001) 31, 1211-1216. PubMed Europe PubMed DOI
Gough,L., Sewell,H.F. and Shakib,F. The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen Clin Exp Allergy (2001) 31, 1594-1598. PubMed Europe PubMed DOI
Takahashi,K., Takai,T., Yasuhara,T., Yokota,T. and Okumura,Y. Effects of site-directed mutagenesis in the cysteine residues and the N-glycosylation motif in recombinant Der f 1 on secretion and protease activity Int Arch Allergy Immunol (2001) 124, 454-460. PubMed Europe PubMed DOI
Wan,H., Winton,H.L., Soeller,C., Taylor,G.W., Gruenert,D.C., Thompson,P.J., Cannell,M.B., Stewart,G.A., Garrod,D.R. and Robinson,C. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus Clin Exp Allergy (2001) 31, 279-294. PubMed Europe PubMed DOI
Yasuhara,T., Takai,T., Yuuki,T., Okudaira,H. and Okumura,Y. Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding Clin Exp Allergy (2001) 31, 116-124. PubMed Europe PubMed DOI E

2000

Best,E.A., Stedman,K.E., Bozic,C.M., Hunter,S.W., Vailes,L., Chapman,M.D., McCall,C.A. and McDermott,M.J. A recombinant group 1 house dust mite allergen, rDer f 1, with biological activities similar to those of the native allergen Protein Expr Purif (2000) 20, 462-471. PubMed Europe PubMed DOI E
John,R.J., Rusznak,C., Ramjee,M., Lamont,A.G., Abrahamson,M. and Hewitt,E.L. Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide-based inhibitor Clin Exp Allergy (2000) 30, 784-793. PubMed Europe PubMed DOI I
Pernas,M., Sanchez-Ramos,I., Sanchez-Monge,R., Lombardero,M., Arteaga,C., Castanera,P. and Salcedo,G. Der p 1 and Der f 1, the highly related and major allergens from house dust mites, are differentially affected by a plant cystatin Clin Exp Allergy (2000) 30, 972-978. PubMed Europe PubMed DOI
Shakib,F. and Gough,L. The proteolytic activity of Der p 1 selectively enhances IgE synthesis: a link between allergenicity and cysteine protease activity Clin Exp Allergy (2000) 30, 751-752. PubMed Europe PubMed DOI
Takahashi,K., Takai,T., Yasuhara,T., Yuuki,T., Ohtake,Y., Yokota,T. and Okumura,Y. Production of enzymatically and immunologically active Der f 1 in Escherichia coli Int Arch Allergy Immunol (2000) 122, 108-114. PubMed Europe PubMed E

1999

[YEAR:20-12-1999]Gough,L., Schulz,O., Sewell,H.F. and Shakib,F. The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response J Exp Med (20-12-1999) 190, 1897-1902. PubMed Europe PubMed DOI PMC EPMC
Wan,H., Winton,H.L., Soeller,C., Tovey,E.R., Gruenert,D.C., Thompson,P.J., Stewart,G.A., Taylor,G.W., Garrod,D.R., Cannell,M.B. and Robinson,C. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions J Clin Invest (1999) 104, 123-133. PubMed Europe PubMed DOI PMC EPMC

1998

[YEAR:5-5-1998]Billson,J., Clark,J., Conway,S.P., Hart,T., Johnson,T., Langston,S.P., Ramjee,M., Quibell,M. and Scott,R.K. The design and synthesis of inhibitors of the cysteinyl protease, Der p I Bioorg Med Chem Lett (5-5-1998) 8, 993-998. PubMed Europe PubMed DOI I
[YEAR:1-10-1998]King,C., Brennan,S., Thompson,P.J. and Stewart,G.A. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium J Immunol (1-10-1998) 161, 3645-3651. PubMed Europe PubMed
Schulz,O., Sewell,H.F. and Shakib,F. A sensitive fluorescent assay for measuring the cysteine protease activity of Der p 1, a major allergen from the dust mite Dermatophagoides pteronyssinus Mol Pathol (1998) 51, 222-224. PubMed Europe PubMed PMC EPMC A
Shakib,F., Schulz,O. and Sewell,H. A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicity Immunol Today (1998) 19, 313-316. PubMed Europe PubMed DOI
Thomas,W.R. and Smith,W. House-dust-mite allergens Allergy (1998) 53, 821-832. PubMed Europe PubMed V
Winton,H.L., Wan,H., Cannell,M.B., Thompson,P.J., Garrod,D.R., Stewart,G.A. and Robinson,C. Class specific inhibition of house dust mite proteinases which cleave cell adhesion, induce cell death and which increase the permeability of lung epithelium Br J Pharmacol (1998) 124, 1048-1059. PubMed Europe PubMed DOI PMC EPMC

1997

Schulz,O., Sutton,B.J., Beavil,R.L., Shi,J., Sewell,H.F., Gould,H.J., Laing,P. and Shakib,F. Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23 Eur J Immunol (1997) 27, 584-588. PubMed Europe PubMed DOI
Shoji,H., Shibuya,I., Hirai,M., Horiuchi,H. and Takagi,M. Production of recombinant Der f I with the native IgE-binding activity using a baculovirus expression system Biosci Biotechnol Biochem (1997) 61, 1668-1673. PubMed Europe PubMed

1996

[YEAR:5-4-1996]Kalsheker,N.A., Deam,S., Chambers,L., Sreedharan,S., Brocklehurst,K. and Lomas,D.A. The house dust mite allergen Der p1 catalytically inactivates alpha 1-antitrypsin by specific reactive centre loop cleavage: a mechanism that promotes airway inflammation and asthma Biochem Biophys Res Commun (5-4-1996) 221, 59-61. PubMed Europe PubMed DOI

1995

Herbert,C.A., King,C.M., Ring,P.C., Holgate,S.T., Stewart,G.A., Thompson,P.J. and Robinson,C. Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1 Am J Respir Cell Mol Biol (1995) 12, 369-378. PubMed Europe PubMed DOI

1993

Chua,K.Y., Kehal,P.K. and Thomas,W.R. Sequence polymorphisms of cDNA clones encoding the mite allergen Der p I Int Arch Allergy Immunol (1993) 101, 364-368. PubMed Europe PubMed

1992

Kent,N.A., Hill,M.R., Keen,J.N., Holland,P.W. and Hart,B.J. Molecular characterisation of group I allergen Eur m I from house dust mite Euroglyphus maynei Int Arch Allergy Immunol (1992) 99, 150-152. PubMed Europe PubMed

1991

Ando,T., Ino,Y., Haida,M., Honma,R., Maeda,H., Yamakawa,H., Iwaki,M. and Okudaira,H. Isolation of cysteine protease in the crude mite extract, Dermatophagoides farinae Int Arch Allergy Appl Immunol (1991) 96, 199-205. PubMed Europe PubMed
Dilworth,R.J., Chua,K.Y. and Thomas,W.R. Sequence analysis of cDNA coding for a major house dust mite allergen, Der f I Clin Exp Allergy (1991) 21, 25-32. PubMed Europe PubMed
Stewart,G.A., Lake,F.R. and Thompson,P.J. Faecally derived hydrolytic enzymes from Dermatophagoides pteronyssinus: physicochemical characterisation of potential allergens Int Arch Allergy Appl Immunol (1991) 95, 248-256. PubMed Europe PubMed
Thomas,B., Heap,P. and Carswell,F. Ultrastructural localization of the allergen Der p I in the gut of the house dust mite Dermatophagoides pteronyssinus Int Arch Allergy Appl Immunol (1991) 94, 365-367. PubMed Europe PubMed

1990

Herbert,C.A., Holgate,S.T., Robinson,C., Thompson,P.J. and Stewart,G.A. Effect of mite allergen on permeability of bronchial mucosa Lancet (1990) 336, 1132-1132. PubMed Europe PubMed

1989

Ino,Y., Ando,T., Haida,M., Nakamura,K., Iwaki,M., Okudaira,H. and Miyamoto,T. Characterization of the proteases in the crude mite extract Int Arch Allergy Appl Immunol (1989) 89, 321-326. PubMed Europe PubMed
Stewart,G.A., Thompson,P.J. and Simpson,R.J. Protease antigens from house dust mite Lancet (1989) 2, 154-155. PubMed Europe PubMed

1988

[YEAR:1-1-1988]Chua,K.Y., Stewart,G.A., Thomas,W.R., Simpson,R.J., Dilworth,R.J., Plozza,T.M. and Turner,K.J. Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases J Exp Med (1-1-1988) 167, 175-182. PubMed Europe PubMed PMC EPMC
Lind,P., Hansen,O.C. and Horn,N. The binding of mouse hybridoma and human IgE antibodies to the major fecal allergen, Der p I, of Dermatophagoides pteronyssinus. Relative binding site location and species specificity studied by solid-phase inhibition assays with radiolabeled antigen J Immunol (1988) 140, 4256-4262. PubMed Europe PubMed
Thomas,W.R., Stewart,G.A., Simpson,R.J., Chua,K.Y., Plozza,T.M., Dilworth,R.J., Nisbet,A. and Turner,K.J. Cloning and expression of DNA coding for the major house dust mite allergen Der p 1 in Escherichia coli Int Arch Allergy Appl Immunol (1988) 85, 127-129. PubMed Europe PubMed

1986

Heymann,P.W., Chapman,M.D. and Platts-Mills,T.A. Antigen Der f I from the dust mite Dermatophagoides farinae: structural comparison with Der p I from Dermatophagoides pteronyssinus and epitope specificity of murine IgG and human IgE antibodies J Immunol (1986) 137, 2841-2847. PubMed Europe PubMed
Yasueda,H., Mita,H., Yui,Y. and Shida,T. Isolation and characterization of two allergens from Dermatophagoides farinae Int Arch Allergy Appl Immunol (1986) 81, 214-223. PubMed Europe PubMed

1967

Voorhorst,R., Spieksma,F.T.M., Vanekamp,M.J., Leupen,M.J. and Lyklema,A.W. The house dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house dust allergen J Allergy (1967) 39, 325-328.