Literature for peptidase C01.034: cathepsin S

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Bentley,D., Mannino,M., Manchester,M., Teixeira,P.C., Reis,B., Boyce,M. and Nagel,S.
A randomized, double-blind, placebo-controlled, multiple dose, parallel study to investigate the effects of a cathepsin S inhibitor in celiac disease
Clin Transl Sci18, e13901-e13901. PubMed Europe PubMed DOI I
Geetha,D., Hameeda,B.A.A., Jose,D., Kuriakose,N. and Skaria,T.
Novel Insights Into the Dynamic Conformational Transitions and Active Site Plasticity of Human Immunoregulatory Cathepsin S
Proteins PubMed Europe PubMed DOI

2024

Deng,T., Lu,X., Jia,X., Du,J., Wang,L., Cao,B., Yang,M., Yin,Y. and Liu,F.
Cathepsins and cancer risk: a Mendelian randomization study
Front Endocrinol (Lausanne)15, 1428433-1428433. PubMed Europe PubMed DOI
Domain,R., Seren,S., Jerke,U., Makridakis,M., Chen,K.J., Zoidakis,J., Rhimi,M., Zhang,X., Bonvent,T., Croix,C., Gonzalez,L., Li,D., Basso,J., Paget,C., Viaud-Massuard,M.C., Lalmanach,G., Shi,G.P., Aghdassi,A., Vlahou,A., McDonald,P.P., Couillin,I., Williams,R., Kettritz,R. and Korkmaz,B.
Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a novel, alternative protease driving the activation of neutrophil serine proteases)
Biochem Pharmacol229, 116114-116114. PubMed Europe PubMed DOI
Estur,F., Murigneux,E., David,A., Magnen,M., Saidi,A., Lalmanach,G. and Lecaille,F.
Short-term exposure to cigarette smoke upregulates cathepsin S and alters expression of tight junction ZO-1
Biochimie226, 34- PubMed Europe PubMed DOI
Meta,M., Zimmer,C., Fuchs,N., Zecher,M.J., Lahu,A. and Schirmeister,T.
Structural Modifications of Covalent Cathepsin S Inhibitors: Impact on Affinity, Selectivity, and Permeability
ACS Med Chem Lett15, 837-844. PubMed Europe PubMed DOI
Xu,B., Mountford,S.J., Thompson,P.E. and Edgington-Mitchell,L.E.
Expanding the Library of Covalent Cysteine Cathepsin Probes Featuring Sulfoxonium Ylide Electrophiles
ACS Omega9, 43940-43947. PubMed Europe PubMed DOI
Yu,P.W., Kao,G., Dai,Z., Nasertorabi,F. and Zhang,Y.
Rational design of humanized antibody inhibitors for cathepsin S
Arch Biochem Biophys751, 109849-109849. PubMed Europe PubMed DOI
Zhang,Y., Yang,L., Gan,Y., Zhao,C., Zhou,C., Chen,J., Yin,Y., Xia,S., Yang,H., Bao,X., Zhang,M., Xu,Y. and Li,J.
Benzydamine attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting cathepsin s
Int Immunopharmacol146, 113824-113824. PubMed Europe PubMed DOI I

2023

Abdoli,M., Krasniqi,V., Bonardi,A., Gutschow,M., Supuran,C.T. and Zalubovskis,R.
4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors
Bioorg Chem139, 106725-106725. PubMed Europe PubMed DOI I
Fuchs,N., Meta,M., Lantzberg,B., Bros,M., Ling Kuan,S., Weil,T. and Schirmeister,T.
Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible alpha-Fluorovinylsulfones and alpha-Sulfonates as Potential Immunomodulators in Cancer
ChemMedChem18, e202300160-e202300160. PubMed Europe PubMed DOI I
Huang,H., Zhang,Y., Xu,X., Liu,Y., Zhao,J., Ma,L., Lei,J., Ge,W., Li,N., Ma,E., Li,Y. and Yuan,L.
Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells
Bioorg Med Chem Lett80, 129087-129087. PubMed Europe PubMed DOI I
Kotsiliti,E.
Cathepsin S in liver fibrogenesis
Nat Rev Gastroenterol Hepatol20, 631-631. PubMed Europe PubMed DOI
Quinn,J.P., Ethier,E.C., Novielli,A., Malone,A., Ramirez,C.E., Salloum,L., Trombetta,B.A., Kivisakk,P., Bremang,M., Selzer,S., Fournier,M., Das,S., Xing,Y., Arnold,S.E. and Carlyle,B.C.
Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease
J Am Soc Mass Spectrom34, 649-667. PubMed Europe PubMed DOI
Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D.
Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
Commun Biol6, 450-450. PubMed Europe PubMed DOI
Zuo,T., Xie,Q., Liu,J., Yang,J., Shi,J., Kong,D., Wang,Y., Zhang,Z., Gao,H., Zeng,D.B., Wang,X., Tao,P., Wei,W., Wang,J., Li,Y., Long,Q., Li,C., Chang,L., Ning,H., Li,Y., Cui,C., Ge,X., Wu,J., Li,G., Hong,X., Yang,X., Dai,E., He,F., Wu,J., Ruan,Y., Lu,S. and Xu,P.
Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis
Gastroenterology165, 746-761. PubMed Europe PubMed DOI

2022

Bigot,P., Chesseron,S., Saidi,A., Sizaret,D., Parent,C., Petit-Court, Courty,Y., Lecaille,F. and Lalmanach,G.
Cleavage of Occludin by Cigarette Smoke-Elicited Cathepsin S Increases Permeability of Lung Epithelial Cells
Antioxidants (Basel)12, PubMed Europe PubMed DOI
Novinec,M., Bembic,P., Jankovic,M., Kisilak,M., Kljun,J. and Turel,I.
Kinetic Characterization of Cerium and Gallium Ions as Inhibitors of Cysteine Cathepsins L, K, and S
Int J Mol Sci23, PubMed Europe PubMed DOI
Sullivan,G.P., Davidovich,P., Munoz-Wolf,N., Ward,R.W., Hernandez Santana,Y.E., Clancy,D.M., Gorman,A., Najda,Z., Turk,B., Walsh,P.T., Lavelle,E.C. and Martin,S.J.
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
Sci Immunol7, eade5728-eade5728. PubMed Europe PubMed DOI
Zhang,Q., Lu,X., Gao,L., Tao,S., Ge,Y., Cui,D., Zhu,R., Lu,W., Wang,J. and Jiang,S.
In Vitro and In Vivo Antigen Presentation and Diagnosis Development of Recombinant Overlapping Peptides Corresponding to Mtb ESAT-6/CFP-10
Front Immunol13, 872676-872676. PubMed Europe PubMed DOI

2021

Bollavaram,K., Leeman,T.H., Lee,M.W., Kulkarni,A., Upshaw,S.G., Yang,J., Song,H. and Platt,M.O.
Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V
Protein Sci PubMed Europe PubMed DOI
Falkowski,P., Mrozek,P., Lukaszewski,Z., Oldak,L. and Gorodkiewicz,E.
An Immunosensor for the Determination of Cathepsin S in Blood Plasma by Array SPRi-A Comparison of Analytical Properties of Silver-Gold and Pure Gold Chips
Biosensors (Basel)11, PubMed Europe PubMed DOI
Fu,R., Edman,M.C. and Hamm-Alvarez,S.F.
Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells
Int J Mol Sci22, PubMed Europe PubMed DOI
Gorican,T., Ciber,L., Petek,N., Svete,J. and Novinec,M.
Synthesis and kinetic characterization of hyperbolic inhibitors of human cathepsins K and S based on a succinimide scaffold
Bioorg Chem115, 105213-105213. PubMed Europe PubMed DOI
Oldak,L., Sankiewicz,A., Zelazowska-Rutkowska,B., Cylwik,B., Lukaszewski,Z., Skoczylas,M. and Gorodkiewicz,E.
Two SPRi biosensors for the determination of cathepsin S in blood plasma
Talanta225, 121900-121900. PubMed Europe PubMed DOI I
Soond,S.M., Savvateeva,L.V., Makarov,V.A., Gorokhovets,N.V., Townsend,P.A. and Zamyatnin,A.A., Jr.
Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis
Pharmaceutics13, PubMed Europe PubMed DOI
Wei,L., Shao,N., Peng,Y. and Zhou,P.
Inhibition of Cathepsin S Restores TGF-beta-induced Epithelial-to-mesenchymal Transition and Tight Junction Turnover in Glioblastoma Cells
J Cancer12, 1592-1603. PubMed Europe PubMed DOI
Zhao,J., Yang,Y. and Wu,Y.
The Clinical Significance and Potential Role of Cathepsin S in IgA Nephropathy
Front Pediatr9, 631473-631473. PubMed Europe PubMed DOI

2020

Cathepsin S protease mediates T-cell response in non-Hodgkin lymphoma
Cancer Discov10, 761-761. PubMed Europe PubMed DOI
Ahmad,S., Bhagwati,S., Kumar,S., Banerjee,D. and Siddiqi,M.I.
Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors
J Mol Graph Model96, 107512-107512. PubMed Europe PubMed DOI I
Andrault,P.M., Panwar,P. and Bromme,D.
Characterization of cathepsin S exosites that govern its elastolytic activity
Biochem J477, 227-242. PubMed Europe PubMed DOI
Brown,R., Nath,S., Lora,A., Samaha,G., Elgamal,Z., Kaiser,R., Taggart,C., Weldon,S. and Geraghty,P.
Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics
Respir Res21, 111-111. PubMed Europe PubMed DOI
Chang,Z., Zhao,G., Zhao,Y., Lu,H., Xiong,W., Liang,W., Sun,J., Wang,H., Zhu,T., Rom,O., Guo,Y., Fan,Y., Chang,L., Yang,B., Garcia-Barrio,M.T., Lin,J.D., Chen,Y.E. and Zhang,J.
BAF60a Deficiency in Vascular Smooth Muscle Cells Prevents Abdominal Aortic Aneurysm by Reducing Inflammation and ECM (Extracellular Matrix) Degradation
Arterioscler Thromb Vasc BiolATVBAHA120314955-ATVBAHA120314955. PubMed Europe PubMed DOI K
Cianni,L., Rocho,F.D.R., Rosini,F., Bonatto,V., Ribeiro,J.F.R., Lameira,J., Leitao,A., Shamim,A. and Montanari,C.A.
Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases
Bioorg Chem101, 104039-104039. PubMed Europe PubMed DOI I
da Costa,A.C., Santa-Cruz,F., Mattos,L.A.R., Rego Aquino,M.A., Martins,C.R., Bandeira Ferraz,A.A. and Figueiredo,J.L.
Cathepsin S as a target in gastric cancer
Mol Clin Oncol12, 99-103. PubMed Europe PubMed DOI V
Dheilly,E., Battistello,E., Katanayeva,N., Sungalee,S., Michaux,J., Duns,G., Wehrle,S., Sordet-Dessimoz,J., Mina,M., Racle,J., Farinha,P., Coukos,G., Gfeller,D., Mottok,A., Kridel,R., Correia,B.E., Steidl,C., Bassani-Sternberg,M., Ciriello,G., Zoete,V. and Oricchio,E.
Cathepsin S regulates antigen processing and T cell activity in non-Hodgkin lymphoma
Cancer Cell37, 674-689. PubMed Europe PubMed DOI
Eckert WA 3rd, Wiener,J.J.M., Cai,H., Ameriks,M.K., Zhu,J., Ngo,K., Nguyen,S., Fung-Leung,W.P., Thurmond,R.L., Grice,C., Edwards,J.P., Chaplan,S.R., Karlsson,L. and Sun,S.
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse
Eur J Pharmacol173171-173171. PubMed Europe PubMed DOI K
Fei,M., Zhang,L., Wang,H., Zhu,Y., Niu,W., Tang,T. and Han,Y.
Inhibition of Cathepsin S Induces Mitochondrial Apoptosis in Glioblastoma Cell Lines Through Mitochondrial Stress and Autophagosome Accumulation
Front Oncol10, 516746-516746. PubMed Europe PubMed DOI
Flynn,C.M., Garbers,Y., Dusterhoft,S., Wichert,R., Lokau,J., Lehmann,C.H.K., Dudziak,D., Schroder,B., Becker-Pauly,C., Rose-John,S., Aparicio-Siegmund,S. and Garbers,C.
Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
Sci Rep10, 21612-21612. PubMed Europe PubMed DOI
Fu,Q., Zhao,S., Yang,N., Tian,M., Cai,X., Zhang,L., Hu,J., Cao,M., Xue,T. and Li,C.
Genome-wide identification, expression signature and immune functional analysis of two cathepsin S (CTSS) genes in turbot (Scophthalmus maximus L.)
Fish Shellfish Immunol102, 243-256. PubMed Europe PubMed DOI
Karimkhanloo,H., Keenan,S.N., Sun,E.W., Wattchow,D.A., Keating,D.J., Montgomery,M.K. and Watt,M.J.
Circulating cathepsin S improves glycemic control in mice
J Endocrinol PubMed Europe PubMed DOI
Lai,C.H., Chang,J.Y., Wang,K.C., Lee,F.T., Wu,H.L. and Cheng,T.L.
Pharmacological inhibition of cathepsin S suppresses abdominal aortic aneurysm in mice
Eur J Vasc Endovasc Surg PubMed Europe PubMed DOI U I
Lemke,C., Cianni,L., Feldmann,C., Gilberg,E., Yin,J., Dos Reis Rocho,F., De Vita,D., Bartz,U., Bajorath,J., Montanari,C.A. and Gutschow,M.
N-Sulfonyl dipeptide nitriles as inhibitors of human cathepsin S: In silico design, synthesis and biochemical characterization
Bioorg Med Chem Lett30, 127420-127420. PubMed Europe PubMed DOI I
Lyu,W., Jia,B., Liu,W. and Guo,Q.
[Cathepsin S (CTSS) is highly expressed in temozolomide-resistant glioblastoma T98G cells and associated with poor prognosis]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi36, 924-929. PubMed Europe PubMed
McDowell,S.H., Gallaher,S.A., Burden,R.E. and Scott,C.J.
Leading the invasion: The role of Cathepsin S in the tumour microenvironment
Biochim Biophys Acta Mol Cell Res1867, 118781-118781. PubMed Europe PubMed DOI
Michiels,T.J.M., Meiring,H.D., Jiskoot,W., Kersten,G.F.A. and Metz,B.
Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S
Sci Rep10, 11535-11535. PubMed Europe PubMed DOI
Montague-Cardoso,K. and Malcangio,M.
Cathepsin S as a potential therapeutic target for chronic pain
Med Drug Discov7, 100047-100047. PubMed Europe PubMed DOI
Moore,R.M., Katri,R., Kumar,D., Mansour,J.M., Mercer,B. and Moore,J.J.
alpha-Lipoic acid blocks the GMCSF induced protease/protease inhibitor spectrum associated with fetal membrane weakening in-vitro
Placenta97, 79-88. PubMed Europe PubMed DOI
Ni,H., Xu,S., Chen,H. and Dai,Q.
Nicotine Modulates CTSS (Cathepsin S) Synthesis and Secretion Through Regulating the Autophagy-Lysosomal Machinery in Atherosclerosis
Arterioscler Thromb Vasc BiolATVBAHA120314053-ATVBAHA120314053. PubMed Europe PubMed DOI
Pantazopoulos,H., Gisabella,B., Rexrode,L., Benefield,D., Yildiz,E., Seltzer,P., Valeri,J., Chelini,G., Reich,A., Ardelt,M. and Berretta,S.
Circadian Rhythms of Perineuronal Net Composition
eNeuro7, PubMed Europe PubMed DOI
Peng,K., Liu,H., Yan,B., Meng,X.W., Song,S.Y., Ji,F.H. and Xia,Z.
Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis
J Cell Physiol PubMed Europe PubMed DOI
Pierre,O., Fouchard,M., Buscaglia,P., Le Goux,N., Leschiera,R., Mignen,O., Fluhr,J.W., Misery,L. and Le Garrec,R.
Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling
Cells9, PubMed Europe PubMed DOI
Schade,M., Merla,B., Lesch,B., Wagener,M., Timmermanns,S., Pletinckx,K. and Hertrampf,T.
Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors
J Med Chem63, 11801-11808. PubMed Europe PubMed DOI
Smith,D., Cwiklinski,K., Jewhurst,H., Tikhonova,I.G. and Dalton,J.P.
An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica
Sci Rep10, 20657-20657. PubMed Europe PubMed DOI
van Dalen,F.J., Bakkum,T., Van Leeuwen,T., Groenewold,M., Deu,E., Koster,A.J., van Kasteren,S.I. and Verdoes,M.
Application of a Highly Selective Cathepsin S Two-step Activity-Based Probe in Multicolor Bio-Orthogonal Correlative Light-Electron Microscopy
Front Chem8, 628433-628433. PubMed Europe PubMed DOI I
Wang,H., Wang,Z., Wang,L., Sun,L., Liu,W., Li,Q. and Wang,J.
IL-6 promotes collagen-induced arthritis by activating the NLRP3 inflammasome through the cathepsin B/S100A9-mediated pathway
Int Immunopharmacol88, 106985-106985. PubMed Europe PubMed DOI
Wartenberg,M., Andrault,P.M., Saidi,A., Bigot,P., Nadal-Desbarats,L., Lecaille,F. and Lalmanach,G.
Oxidation of cathepsin S by major chemicals of cigarette smoke
Free Radic Biol Med150, 53-65. PubMed Europe PubMed DOI
Wen,W., Sun,H., Yang,Y., Jia,Y., Fang,F., Qin,Y., Zhang,M. and Wei,Y.
Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes
Dis Markers2020, 8819134-8819134. PubMed Europe PubMed DOI

2019

Baranov,M.V., Bianchi,F., Schirmacher,A., van Aart,M.A.C., Maassen,S., Muntjewerff,E.M., Dingjan,I., Ter Beest,M., Verdoes,M., Keyser,S.G.L., Bertozzi,C.R., Diederichsen,U. and van den Bogaart,G.
The phosphoinositide kinase PIKfyve promotes cathepsin-S-mediated major histocompatibility complex class II antigen presentation
iScience11, 160-177. PubMed Europe PubMed DOI
Chang,C.J., Hsu,H.C., Ho,W.J., Chang,G.J., Pang,J.S., Chen,W.J., Huang,C.C. and Lai,Y.J.
Cathepsin S promotes the development of pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol317, L1-L1. PubMed Europe PubMed DOI
Chaput,L., Selwa,E., Elisee,E. and Iorga,B.I.
Blinded evaluation of cathepsin S inhibitors from the D3RGC3 dataset using molecular docking and free energy calculations
J Comput Aided Mol Des33, 93-103. PubMed Europe PubMed DOI I
Chung,K., Pitcher,T., Grant,A.D., Hewitt,E., Lindstrom,E. and Malcangio,M.
Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour
Neurobiol Pain6, 100032-100032. PubMed Europe PubMed DOI
Doherty,D.F., Nath,S., Poon,J., Foronjy,R.F., Ohlmeyer,M., Dabo,A.J., Salathe,M., Birrell,M., Belvisi,M., Baumlin,N., Kim,M.D., Weldon,S., Taggart,C. and Geraghty,P.
Protein phosphatase 2A reduces cigarette smoke-induced cathepsin S and loss of lung function
Am J Respir Crit Care Med200, 51-62. PubMed Europe PubMed DOI K
He,X., Man,V.H., Ji,B., Xie,X.Q. and Wang,J.
Calculate protein-ligand binding affinities with the extended linear interaction energy method: application on the cathepsin S set in the D3R Grand Challenge 3
J Comput Aided Mol Des33, 105-117. PubMed Europe PubMed DOI I
Kim,S., Jin,H., Seo,H.R., Lee,H.J. and Lee,Y.S.
Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation
Cell Death Differ26, 812-825. PubMed Europe PubMed DOI
Klinngam,W., Janga,S.R., Lee,C., Ju,Y., Yarber,F., Shah,M., Guo,H., Wang,D., MacKay,J.A., Edman,M.C. and Hamm-Alvarez,S.F.
Inhibition of cathepsin S reduces lacrimal gland inflammation and increases tear flow in a mouse model of Sjogren's syndrome
Sci Rep9, 9559-9559. PubMed Europe PubMed DOI I
Lin,H.H., Chen,S.J., Shen,M.R., Huang,Y.T., Hsieh,H.P., Lin,S.Y., Lin,C.C., Chang,W.W. and Chang,J.Y.
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca(2+) entry
Biochim Biophys Acta1866, 118517-118517. PubMed Europe PubMed DOI K
Shockey,W.A., Kieslich,C.A., Wilder,C.L., Watson,V. and Platt,M.O.
Dynamic model of protease state and inhibitor trafficking to predict protease activity in breast cancer cells
Cell Mol Bioeng12, 275-288. PubMed Europe PubMed DOI I
Small,D.M., Brown,R.R., Doherty,D.F., Abladey,A., Zhou-Suckow,Z., Delaney,R.J., Kerrigan,L., Dougan,C.M., Borensztajn,K.S., Holsinger,L., Booth,R., Scott,C.J., Lopez-Campos,G., Elborn,J.S., Mall,M.A., Weldon,S. and Taggart,C.C.
Targeting of cathepsin S reduces cystic fibrosis-like lung disease
Eur Respir J53, 1801523-1801523. PubMed Europe PubMed DOI K I
Sugiyama,A., Mitsui,A., Okada,M. and Yamawaki,H.
Cathepsin S degrades arresten and canstatin in infarcted area after myocardial infarction in rats
J Vet Med Sci81, 522-531. PubMed Europe PubMed DOI
Wang,G.H., He,S.W., Du,X., Xie,B., Gu,Q.Q., Zhang,M. and Hu,Y.H.
Characterization, expression, enzymatic activity, and functional identification of cathepsin S from black rockfish Sebastes schlegelii
Fish Shellfish Immunol93, 623-630. PubMed Europe PubMed DOI
Wartenberg,M., Saidi,A., Galibert,M., Joulin-Giet,A., Burlaud-Gaillard,J., Lecaille,F., Scott,C.J., Aucagne,V., Delmas,A.F. and Lalmanach,G.
Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe
Biochimie166, 84-93. PubMed Europe PubMed DOI L
Xiao,L., Han,X., Wang,X.E., Li,Q., Chen,Y., Cui,Y. and Chen,Y.
Cathepsin S in the spinal microglia facilitates morphine-induced antinociceptive tolerance in rats
Neurosci Lett690, 225-231. PubMed Europe PubMed DOI
Xu,W., Yu,C., Piao,L., Inoue,A., Wang,H., Meng,X., Li,X., Cui,L., Umegaki,H., Shi,G.P., Murohara,T., Kuzuya,M. and Cheng,X.W.
Cathepsin S-mediated negative regulation of Wnt5a/SC35 activation contributes to ischemia-induced neovascularization in aged mice
Circ J83, 2537-2546. PubMed Europe PubMed DOI
Yang,Y., Lu,J., Yang,C. and Zhang,Y.
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S
J Comput Aided Mol Des33, 1095-1105. PubMed Europe PubMed DOI P
Yao,X., Cheng,F., Yu,W., Rao,T., Li,W., Zhao,S., Zhou,X. and Ning,J.
Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis
Mol Med Rep20, 141-150. PubMed Europe PubMed DOI

2018

Aich,P. and Biswas,S.
Highly conserved Arg residue of ERFNIN motif of pro-domain is important for pH-induced zymogen activation process in cysteine cathepsins K and L
Cell Biochem Biophys76, 219-229. PubMed Europe PubMed DOI
Chen,C.Y., Chen,C.Y., Liu,C.C. and Chen,C.P.
Omega-3 polyunsaturated fatty acids reduce preterm labor by inhibiting trophoblast cathepsin S and inflammasome activation
Clin Sci (Lond)132, 2221-2239. PubMed Europe PubMed DOI I
Douglas,S.A., Lamothe,S.E., Singleton,T.S., Averett,R.D. and Platt,M.O.
Human cathepsins K, L, and S: related proteases, but unique fibrinolytic activity
Biochim Biophys Acta1862, 1925-1932. PubMed Europe PubMed DOI
Edman,M.C., Janga,S.R., Meng,Z., Bechtold,M., Chen,A.F., Kim,C., Naman,L., Sarma,A., Teekappanavar,N., Kim,A.Y., Madrigal,S., Singh,S., Ortiz,E., Christianakis,S., Arkfeld,D.G., Mack,W.J., Heur,M., Stohl,W. and Hamm-Alvarez,S.F.
Increased cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjogren's syndrome patients
Sci Rep8, 11044-11044. PubMed Europe PubMed DOI
Gautam,J., Banskota,S., Lee,H., Lee,Y.J., Jeon,Y.H., Kim,J.A. and Jeong,B.S.
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis
Exp Mol Med50, 118-118. PubMed Europe PubMed DOI
Kubo,K., Kawato,Y., Nakamura,K., Nakajima,Y., Nakagawa,T.Y., Hanaoka,K., Oshima,S., Fukahori,H., Inami,M., Morokata,T. and Higashi,Y.
Effective suppression of donor specific antibody production by cathepsin S inhibitors in a mouse transplantation model
Eur J Pharmacol838, 145-152. PubMed Europe PubMed DOI I
Memmert,S., Nokhbehsaim,M., Damanaki,A., Nogueira,A.V.B., Papadopoulou,A.K., Piperi,C., Basdra,E.K., Rath-Deschner,B., Gotz,W., Cirelli,J.A., Jager,A. and Deschner,J.
Role of cathepsin S In periodontal wound healing-an in vitro study on human PDL cells
BMC Oral Health18, 60-60. PubMed Europe PubMed DOI
Tber,Z., Wartenberg,M., Jacques,J.E., Roy,V., Lecaille,F., Warszycki,D., Bojarski,A.J., Lalmanach,G. and Agrofoglio,L.A.
Selective inhibition of human cathepsin S by 2,4,6-trisubstituted 1,3,5-triazine analogs
Bioorg Med Chem26, 4310-4319. PubMed Europe PubMed DOI I
Yuan,L., Sheng,L., He,W., Zou,C., Hu,B., Liu,J., Ge,W., Liu,Y., Wang,J. and Ma,E.
Discovery of novel cathepsin inhibitors with potent anti-metastatic effects in breast cancer cells
Bioorg Chem81, 672-680. PubMed Europe PubMed DOI I

2017

Ahmad,S. and Siddiqi,M.I.
Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor
J Mol Model23, 92-92. PubMed Europe PubMed DOI I
Galibert,M., Wartenberg,M., Lecaille,F., Saidi,A., Mavel,S., Joulin-Giet,A., Korkmaz,B., Bromme,D., Aucagne,V., Delmas,A.F. and Lalmanach,G.
Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S
Eur J Med Chem144, 201-210. PubMed Europe PubMed DOI I
Hsieh,M.J., Lin,C.W., Chen,M.K., Chien,S.Y., Lo,Y.S., Chuang,Y.C., Hsi,Y.T., Lin,C.C., Chen,J.C. and Yang,S.F.
Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways
Sci Rep7, 45039-45039. PubMed Europe PubMed DOI I
Lau,A., Singh,V., Soualhine,H. and Hmama,Z.
Expression of cathepsin S in BCG converts it into a pro-apoptotic and highly immunogenic strain
Vaccine35, 2060-2068. PubMed Europe PubMed DOI U
Li,G.Y., Fu,M., Qin,M. and Xue,L.M.
High expression of human cathepsin S by recombinant Pichia pastoris with cod skin as an organic co-nitrogen source
J Mol Microbiol Biotechnol27, 363-370. PubMed Europe PubMed DOI E
Nubling,G., Schuberth,M., Feldmer,K., Giese,A., Holdt,L.M., Teupser,D. and Lorenzl,S.
Cathepsin S increases tau oligomer formation through limited cleavage but only IL-6 not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy
Exp Brain Res235, 2407-2412. PubMed Europe PubMed DOI
Qi,Z., Huang,B., Zhang,Q., Wang,Z., Wang,P. and Gao,Q.
Molecular characterization, expression and evolutionary analysis of 3 cathepsin genes (CTSH, CTSL and CTSS) from Chinese giant salamander (Andrias davidianus)
Gene Rep7, 25-31. DOI
Regmi,S.C., Samsom,M.L., Heynen,M.L., Jay,G.D., Sullivan,B.D., Srinivasan,S., Caffery,B., Jones,L. and Schmidt,T.A.
Degradation of proteoglycan 4/lubricin by cathepsin S: potential mechanism for diminished ocular surface lubrication in Sjogren's syndrome
Exp Eye Res161, 1-9. PubMed Europe PubMed DOI
Takayama,F., Zhang,X., Hayashi,Y., Wu,Z. and Nakanishi,H.
Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice
Biochem Biophys Res Commun490, 447-452. PubMed Europe PubMed DOI K
Tato,M., Kumar,S.V., Liu,Y., Mulay,S.R., Moll,S., Popper,B., Eberhard,J.N., Thomasova,D., Rufer,A.C., Gruner,S., Haap,W., Hartmann,G. and Anders,H.J.
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury
Sci Rep7, 2775-2775. PubMed Europe PubMed DOI I
Thanei,S., Theron,M., Silva,A.P., Reis,B., Branco,L., Schirmbeck,L., Kolb,F.A., Haap,W., Schindler,T. and Trendelenburg,M.
Cathepsin S inhibition suppresses autoimmune-triggered inflammatory responses in macrophages
Biochem Pharmacol146, 151-164. PubMed Europe PubMed DOI I
Wang,Y., Liu,X., Lv,S., Ren,J. and Ke,F.
Identification and activity of a paralog of cathepsin S from yellow catfish (Pelteobagrus fulvidraco) involved in immune response
Fish Shellfish Immunol61, 16-23. PubMed Europe PubMed DOI
Yan,X., Wu,C., Chen,T., Santos,M.M., Liu,C.L., Yang,C., Zhang,L., Ren,J., Liao,S., Guo,H., Sukhova,G.K. and Shi,G.P.
Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis
Mol Immunol82, 66-74. PubMed Europe PubMed DOI I
Ye,L., Xiao,L., Yang,S.Y., Duan,J.J., Chen,Y., Cui,Y. and Chen,Y.
Cathepsin S in the spinal microglia contributes to remifentanil-induced hyperalgesia in rats
Neuroscience344, 265-275. PubMed Europe PubMed DOI

2016

Akkari,L., Gocheva,V., Quick,M.L., Kester,J.C., Spencer,A.K., Garfall,A.L., Bowman,R.L. and Joyce,J.A.
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer
Genes Dev30, 220-232. PubMed Europe PubMed DOI K
Dong,X., Ye,Z., Song,L., Su,B., Zhao,H., Peatman,E. and Li,C.
Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge
Fish Shellfish Immunol48, 112-118. PubMed Europe PubMed DOI
Fan,W., Shi,W., Zhang,W., Jia,Y., Zhou,Z., Brusnahan,S.K. and Garrison,J.C.
Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer
Biomaterials103, 101-115. PubMed Europe PubMed DOI L
Hewitt,E., Pitcher,T., Rizoska,B., Tunblad,K., Henderson,I., Sahlberg,B.L., Grabowska,U., Classon,B., Edenius,C., Malcangio,M. and Lindstrom,E.
Selective cathepsin S inhibition with MIV-247 attenuates mechanical allodynia and enhances the antiallodynic effects of gabapentin and pregabalin in a mouse model of neuropathic pain
J Pharmacol Exp Ther358, 387-396. PubMed Europe PubMed DOI I
Huang,C.C., Lee,C.C., Lin,H.H. and Chang,J.Y.
Cathepsin S attenuates endosomal EGFR signalling: a mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors
Sci Rep6, 29256-29256. PubMed Europe PubMed DOI I
Ihmaid,S.K., Ahmed,H.E., Zayed,M.F. and Abadleh,M.M.
Self organizing map-based classification of cathepsin K and S inhibitors with different selectivity profiles using different structural molecular fingerprints: design and application for discovery of novel hits
Molecules21, 175-175. PubMed Europe PubMed DOI I
Kumar Vr,S., Darisipudi,M.N., Steiger,S., Devarapu,S.K., Tato,M., Kukarni,O.P., Mulay,S.R., Thomasova,D., Popper,B., Demleitner,J., Zuchtriegel,G., Reichel,C., Cohen,C.D., Lindenmeyer,M.T., Liapis,H., Moll,S., Reid,E., Stitt,A.W., Schott,B., Gruner,S., Haap,W., Ebeling,M., Hartmann,G. and Anders,H.J.
Cathepsin S cleavage of protease-activated receptor-2 on endothelial cells promotes microvascular diabetes complications
J Am Soc Nephrol27, 1635-1649. PubMed Europe PubMed DOI
Nikolic-Paterson,D.J.
Cathepsin S-dependent protease-activated receptor-2 activation: a new mechanism of endothelial dysfunction
J Am Soc Nephrol27, 1577-1579. PubMed Europe PubMed DOI
Plebanek,E., Chevrier,F., Roy,V., Garenne,T., Lecaille,F., Warszycki,D., Bojarski,A.J., Lalmanach,G. and Agrofoglio,L.A.
Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S
Eur J Med Chem121, 12-20. PubMed Europe PubMed DOI I
Steimle,A., Gronbach,K., Beifuss,B., Schafer,A., Harmening,R., Bender,A., Maerz,J.K., Lange,A., Michaelis,L., Maurer,A., Menz,S., McCoy,K., Autenrieth,I.B., Kalbacher,H. and Frick,J.S.
Symbiotic gut commensal bacteria act as host cathepsin S activity regulators
J Autoimmun75, 82-95. PubMed Europe PubMed DOI
Steimle,A., Kalbacher,H., Maurer,A., Beifuss,B., Bender,A., Schafer,A., Muller,R., Autenrieth,I.B. and Frick,J.S.
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells
J Immunol Methods432, 87-94. PubMed Europe PubMed DOI A
Sun,B.G. and Chi,H.
Cathepsin S of Sciaenops ocellatus: identification, transcriptional expression and enzymatic activity
Int J Biol Macromol82, 76-82. PubMed Europe PubMed DOI
Tjondrokoesoemo,A., Schips,T.G., Sargent,M.A., Vanhoutte,D., Kanisicak,O., Prasad,V., Lin,S.-C.J., Maillet,M. and Molkentin,J.D.
Cathepsin S contributes to the pathogenesis of muscular dystrophy in mice
J Biol Chem291, 9920-9928. PubMed Europe PubMed DOI
Wilkinson,R.D., Young,A., Burden,R.E., Williams,R. and Scott,C.J.
A bioavailable cathepsin S nitrile inhibitor abrogates tumor development
Mol Cancer15, 29-29. PubMed Europe PubMed DOI I
Woo,S.M., Min,K.J., Seo,B.R. and Kwon,T.K.
YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-kappaB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells
Oncotarget7, 61520-61532. PubMed Europe PubMed DOI
Wu,H., Cheng,X.W., Hu,L., Takeshita,K., Hu,C., Du,Q., Li,X., Zhu,E., Huang,Z., Yisireyili,M., Zhao,G., Piao,L., Inoue,A., Jiang,H., Lei,Y., Zhang,X., Liu,S., Dai,Q., Kuzuya,M., Shi,G.P. and Murohara,T.
Cathepsin S activity controls injury-related vascular repair in mice via the TLR2-mediated p38MAPK and PI3K-Akt/p-HDAC6 signaling pathway
Arterioscler Thromb Vasc Biol36, 1549-1557. PubMed Europe PubMed DOI
Zhou,P.P., Zhang,W.Y., Li,Z.F., Chen,Y.R., Kang,X.C. and Jiang,Y.X.
Association between SNPs in the promoter region in cathepsin S and risk of asthma in Chinese Han population
Eur Rev Med Pharmacol Sci20, 2070-2076. PubMed Europe PubMed M

2015

Andrault,P.M., Samsonov,S.A., Weber,G., Coquet,L., Nazmi,K., Bolscher,J.G., Lalmanach,A.C., Jouenne,T., Bromme,D., Pisabarro,M.T., Lalmanach,G. and Lecaille,F.
Antimicrobial peptide LL-37 is both a substrate of cathepsins S and K and a selective inhibitor of cathepsin L
Biochemistry54, 2785-2798. PubMed Europe PubMed DOI
Barlow,N., Nasser,Y., Zhao,P., Sharma,N., Guerrero-Alba,R., Edgington-Mitchell,L.E., Lieu,T., Veldhuis,N.A., Poole,D.P., Conner,J.W., Lindstrom,E., Craig,A.W., Graham,B., Vanner,S.J. and Bunnett,N.W.
Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe
Neurogastroenterol Motil27, 1675-1680. PubMed Europe PubMed DOI L I
Figueiredo,J.L., Aikawa,M., Zheng,C., Aaron,J., Lax,L., Libby,P., de Lima Filho,J.L., Gruener,S., Fingerle,J., Haap,W., Hartmann,G. and Aikawa,E.
Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease
Am J Pathol185, 1156-1166. PubMed Europe PubMed DOI I
Freier,R., Dall,E. and Brandstetter,H.
Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity
Sci Rep5, 12707-12707. PubMed Europe PubMed DOI
Kohl,F., Schmitz,J., Furtmann,N., Schulz-Fincke,A.C., Mertens,M.D., Kuppers,J., Benkhoff,M., Tobiasch,E., Bartz,U., Bajorath,J., Stirnberg,M. and Gutschow,M.
Design, characterization and cellular uptake studies of fluorescence-labeled prototypic cathepsin inhibitors
Org Biomol Chem13, 10310-10323. PubMed Europe PubMed DOI I
Li,C., Chen,Q., Jiang,Y. and Liu,Z.
Single nucleotide polymorphisms of cathepsin S and the risks of asthma attack induced by acaroid mites
Int J Clin Exp Med8, 1178-1187. PubMed Europe PubMed M
Li,Q., Ao,J., Mu,Y., Yang,Z., Li,T., Zhang,X. and Chen,X.
Cathepsin S, but not cathepsin L, participates in the MHC class II-associated invariant chain processing in large yellow croaker (Larimichthys crocea)
Fish Shellfish Immunol47, 743-750. PubMed Europe PubMed DOI
Li,X., Cheng,X.W., Hu,L., Wu,H., Guo-Ping, Hao,C.N., Jiang,H., Zhu,E., Huang,Z., Inoue,A., Sasaki,T., Du,Q., Takeshita,K., Okumura,K., Murohara,T. and Kuzuya,M.
Cathepsin S activity controls ischemia-induced neovascularization in mice
Int J Cardiol183C, 198-208. PubMed Europe PubMed DOI K
Oresic Bender,K., Ofori,L., van der Linden,W.A., Mock,E.D., Datta,G.K., Chowdhury,S., Li,H., Segal,E., Sanchez Lopez,M., Ellman,J.A., Figdor,C.G., Bogyo,M. and Verdoes,M.
Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization
J Am Chem Soc137, 4771-4777. PubMed Europe PubMed DOI A L
Reddy,V.B., Sun,S., Azimi,E., Elmariah,S.B., Dong,X. and Lerner,E.A.
Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs
Nat Commun6, 7864-7864. PubMed Europe PubMed DOI
Rupanagudi,K.V., Kulkarni,O.P., Lichtnekert,J., Darisipudi,M.N., Mulay,S.R., Schott,B., Gruner,S., Haap,W., Hartmann,G. and Anders,H.J.
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming
Ann Rheum Dis74, 452-463. PubMed Europe PubMed DOI I
Vazquez,R., Astorgues-Xerri,L., Bekradda,M., Gormley,J., Buick,R., Kerr,P., Cvitkovic,E., Raymond,E., D'Incalci,M., Frapolli,R. and Riveiro,M.E.
Fsn0503h antibody-mediated blockade of cathepsin S as a potential therapeutic strategy for the treatment of solid tumors
Biochimie108C, 101-107. PubMed Europe PubMed DOI
Wang,X., Xiong,L., Yu,G., Li,D., Peng,T., Luo,D. and Xu,J.
Cathepsin S silencing induces apoptosis of human hepatocellular carcinoma cells
Am J Transl Res7, 100-110. PubMed Europe PubMed
Wilkinson,R.D., Williams,R., Scott,C.J. and Burden,R.E.
Cathepsin S: therapeutic, diagnostic, and prognostic potential
Biol Chem396, 867-882. PubMed Europe PubMed DOI
Wilkinson,R.D., Magorrian,S.M., Williams,R., Young,A., Small,D.M., Scott,C.J. and Burden,R.E.
CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner
Oncotarget6, 29725-29739. PubMed Europe PubMed DOI
Zhang,L., Wang,H. and Xu,J.
Cathepsin S as a cancer target
Neoplasma62, 16-26. PubMed Europe PubMed DOI V T

2014

Cathepsin S mediates brain-specific breast cancer metastasis
Cancer Discov4, OF11-OF11. DOI
Battu,M.B., Chandra,A.M., Sriram,D. and Yogeeswari,P.
Pharmacophore-based 3DQSAR and molecular docking studies to identify new non-peptidic inhibitors of cathepsin S
Curr Med Chem21, 1910-1921. PubMed Europe PubMed I
Bernard,N.J.
Connective tissue diseases. Inhibiting cathepsin S to treat SLE and lupus nephritis
Nat Rev Rheumatol10, 66-66. PubMed Europe PubMed DOI I
Chua,K.C., Pietsch,M., Zhang,X., Hautmann,S., Chan,H.Y., Bruning,J.B., Gutschow,M. and Abell,A.D.
Macrocyclic protease inhibitors with reduced peptide character
Angew Chem Int Ed Engl53, 7828-7831. PubMed Europe PubMed DOI I
Elmariah,S.B., Reddy,V.B. and Lerner,E.A.
Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist
PLoS ONE9, e99702-e99702. PubMed Europe PubMed DOI
Hu,H.Y., Vats,D., Vizovisek,M., Kramer,L., Germanier,C., Wendt,K.U., Rudin,M., Turk,B., Plettenburg,O. and Schultz,C.
In vivo imaging of mouse tumors by a lipidated cathepsin S substrate
Angew Chem Int Ed Engl53, 7669-7673. PubMed Europe PubMed DOI L
Jadhav,P.K., Schiffler,M.A., Gavardinas,K., Kim,E.J., Matthews,D.P., Staszak,M.A., Coffey,D.S., Shaw,B.W., Cassidy,K.C., Brier,R.A., Zhang,Y., Christie,R.M., Matter,W.F., Qing,K., Durbin,J.D., Wang,Y. and Deng,G.G.
Discovery of cathepsin S inhibitor LY3000328 for the treatment of abdominal aortic aneurysm
ACS Med Chem Lett5, 1138-1142. PubMed Europe PubMed DOI I
Kim,M., Jeon,J., Baek,J., Choi,J., Park,E.J., Song,J., Bang,H., Suh,K.H., Kim,Y.H., Kim,J., Kim,D., Min,K.H. and Lee,K.-O.
Synthesis of vinyl sulfone-tethered proline derivatives as highly selective cathepsin S inhibitors
Bull Korean Chem Soc35, 345-346. DOI I
Lafarge,J.C., Pini,M., Pelloux,V., Orasanu,G., Hartmann,G., Venteclef,N., Sulpice,T., Shi,G.P., Clement,K. and Guerre-Millo,M.
Cathepsin S inhibition lowers blood glucose levels in mice
Diabetologia57, 1674-1683. PubMed Europe PubMed DOI I
Mall,M.A. and Schultz,C.
A new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease
Am J Respir Crit Care Med190, 126-127. PubMed Europe PubMed DOI
Payne,C.D., Deeg,M.A., Chan,M., Tan,L.H., LaBell,E.S., Shen,T. and DeBrota,D.J.
Pharmacokinetics and pharmacodynamics of the cathepsin S inhibitor, LY3000328, in healthy subjects
Br J Clin Pharmacol78, 1334-1342. PubMed Europe PubMed DOI I
Rauner,M., Foger-Samwald,U., Kurz,M.F., Brunner-Kubath,C., Schamall,D., Kapfenberger,A., Varga,P., Kudlacek,S., Wutzl,A., Hoger,H., Zysset,P.K., Shi,G.P., Hofbauer,L.C., Sipos,W. and Pietschmann,P.
Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture
Bone64, 281-287. PubMed Europe PubMed DOI
Samouillan,V., Revuelta-Lopez,E., Dandurand,J., Nasarre,L., Badimon,L., Lacabanne,C. and Llorente-Cortes,V.
Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: role of LRP1 and cathepsin S
Int J Biochem Cell Biol55, 209-219. PubMed Europe PubMed DOI
Sevenich,L., Bowman,R.L., Mason,S.D., Quail,D.F., Rapaport,F., Elie,B.T., Brogi,E., Brastianos,P.K., Hahn,W.C., Holsinger,L.J., Massague,J., Leslie,C.S. and Joyce,J.A.
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S
Nat Cell Biol16, 876-888. PubMed Europe PubMed DOI
Shi,H.T., Wang,Y., Jia,L.X., Qin,Y.W., Liu,Y., Li,H.H., Qi,Y.F. and Du,J.
Cathepsin S contributes to macrophage migration via degradation of elastic fibre integrity to facilitate vein graft neointimal hyperplasia
Cardiovasc Res101, 454-463. PubMed Europe PubMed DOI
Shi,W., Ogbomo,S.M., Wagh,N.K., Zhou,Z., Jia,Y., Brusnahan,S.K. and Garrison,J.C.
The influence of linker length on the properties of cathepsin S cleavable (177)Lu-labeled HPMA copolymers for pancreatic cancer imaging
Biomaterials35, 5760-5770. PubMed Europe PubMed DOI P
Tsai,J.Y., Lee,M.J., Chang,M.D., Wang,H.C., Lin,C.C. and Huang,H.
Effects of novel human cathepsin S inhibitors on cell migration in human cancer cells
J Enzyme Inhib Med Chem29, 538-546. PubMed Europe PubMed DOI I
Zhao,P., Lieu,T., Barlow,N., Metcalf,M., Veldhuis,N.A., Jensen,D.D., Kocan,M., Sostegni,S., Haerteis,S., Baraznenok,V., Henderson,I., Lindstrom,E., Guerrero-Alba,R., Valdez-Morales,E.E., Liedtke,W., McIntyre,P., Vanner,S.J., Korbmacher,C. and Bunnett,N.W.
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4
J Biol Chem289, 27215-27234. PubMed Europe PubMed DOI

2013

Caglic,D., Repnik,U., Jedeszko,C., Kosec,G., Miniejew,C., Kindermann,M., Vasiljeva,O., Turk,V., Wendt,K.U., Sloane,B.F., Goldring,M.B. and Turk,B.
The proinflammatory cytokines interleukin-1alpha and tumor necrosis factor alpha promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes
Biol Chem394, 307-316. PubMed Europe PubMed DOI
Chen,H., Wang,J., Xiang,M.X., Lin,Y., He,A., Jin,C.N., Guan,J., Sukhova,G.K., Libby,P., Wang,J.A. and Shi,G.P.
Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction
Cardiovasc Res100, 84-94. PubMed Europe PubMed DOI
Feth,M.P., Heyse,W., Baumgartner,B., Nagel,N., Tappertzhofen,C., Olpp,T., Jurascheck,J., Ulrich,J., Helmdach,L. and Petzoldt,C.
From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor
Eur J Pharm Biopharm83, 436-448. PubMed Europe PubMed DOI I
Fonovic,U.P., Jevnikar,Z. and Kos,J.
Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells
Biol Chem394, 1349-1352. PubMed Europe PubMed DOI
Hayashi,Y., Koyanagi,S., Kusunose,N., Okada,R., Wu,Z., Tozaki-Saitoh,H., Ukai,K., Kohsaka,S., Inoue,K., Ohdo,S. and Nakanishi,H.
The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S
Sci Rep3, 2744-2744. PubMed Europe PubMed DOI
Hilpert,H., Mauser,H., Humm,R., Anselm,L., Kuehne,H., Hartmann,G., Gruener,S., Banner,D.W., Benz,J., Gsell,B., Kuglstatter,A., Stihle,M., Thoma,R., Sanchez,R.A., Iding,H., Wirz,B. and Haap,W.
Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds
J Med Chem56, 9789-9801. PubMed Europe PubMed DOI I
Huang,C.C., Chen,K.L., Cheung,C.H. and Chang,J.Y.
Autophagy induced by cathepsin S inhibition induces early ROS production, oxidative DNA damage, and cell death via xanthine oxidase
Free Radic Biol Med65, 1473-1486. PubMed Europe PubMed DOI I
Kim,M., Jeon,J., Song,J., Suh,K.H., Kim,Y.H., Min,K.H. and Lee,K.O.
Synthesis of proline analogues as potent and selective cathepsin S inhibitors
Bioorg Med Chem Lett23, 3140-3144. PubMed Europe PubMed DOI I
Lecaille,F., Naudin,C., Sage,J., Joulin-Giet,A., Courty,A., Andrault,P.M., Veldhuizen,R.A., Possmayer,F. and Lalmanach,G.
Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties
Int J Biochem Cell Biol45, 1701-1709. PubMed Europe PubMed DOI
Ou,Z., Wang,G., Li,Q., Ma,Z., Lin,D., Dai,M. and Zou,F.
The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population
Gene526, 385-389. PubMed Europe PubMed DOI M
Pehere,A.D., Pietsch,M., Gutschow,M., Neilsen,P.M., Pedersen,D.S., Nguyen,S., Zvarec,O., Sykes,M.J., Callen,D.F. and Abell,A.D.
Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors
Chemistry19, 7975-7981. PubMed Europe PubMed DOI I
Sage,J., Mallevre,F., Barbarin-Costes,F., Samsonov,S.A., Gehrcke,J.P., Pisabarro,M.T., Perrier,E., Schnebert,S., Roget,A., Livache,T., Nizard,C., Lalmanach,G. and Lecaille,F.
Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity
Biochemistry52, 6487-6498. PubMed Europe PubMed DOI
Small,D.M., Burden,R.E., Jaworski,J., Hegarty,S.M., Spence,S., Burrows,J.F., McFarlane,C., Kissenpfennig,A., McCarthy,H.O., Johnston,J.A., Walker,B. and Scott,C.J.
Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization
Int J Cancer133, 2102-2112. PubMed Europe PubMed DOI K T
Wiener,J.J., Wickboldt,A.T., Nguyen,S., Sun,S., Rynberg,R., Rizzolio,M., Karlsson,L., Edwards,J.P. and Grice,C.A.
Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region
Bioorg Med Chem Lett23, 1070-1074. PubMed Europe PubMed DOI I
Xu,J., Wang,H., Ding,K., Lu,X., Li,T., Wang,J., Wang,C. and Wang,J.
Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice
Mediators Inflamm2013, 187873-187873. PubMed Europe PubMed DOI I

2012

Arnlov,J.
Cathepsin S as a biomarker: where are we now and what are the future challenges?
Biomark Med6, 9-11. PubMed Europe PubMed DOI
Barry,Z.T. and Platt,M.O.
Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation
J Biol Chem287, 27723-27730. PubMed Europe PubMed DOI
Burden,R.E., Gormley,J.A., Kuehn,D., Ward,C., Kwok,H.F., Gazdoiu,M., McClurg,A., Jaquin,T.J., Johnston,J.A., Scott,C.J. and Olwill,S.A.
Inhibition of cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas
Biochimie94, 487-493. PubMed Europe PubMed DOI
Chen,K.L., Chang,W.S., Cheung,C.H., Lin,C.C., Huang,C.C., Yang,Y.N., Kuo,C.P., Kuo,C.C., Chang,Y.H., Liu,K.J., Wu,C.M. and Chang,J.Y.
Targeting cathepsin S induces tumor cell autophagy via the EGFR-Erk signaling pathway
Cancer Lett317, 89-98. PubMed Europe PubMed DOI I
Clark,A.K. and Malcangio,M.
Microglial signalling mechanisms: cathepsin S and fractalkine
Exp Neurol234, 283-292. PubMed Europe PubMed DOI
Fan,Q., Wang,X., Zhang,H., Li,C., Fan,J. and Xu,J.
Silencing cathepsin S gene expression inhibits growth, invasion and angiogenesis of human hepatocellular carcinoma in vitro
Biochem Biophys Res Commun425, 703-710. PubMed Europe PubMed DOI K T
Frizler,M., Schmitz,J., Schulz-Fincke,A.C. and Gutschow,M.
Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F
J Med Chem55, 5982-5986. PubMed Europe PubMed DOI I
Fujii,H., Ivison,S.M., Shimizu,H., Kajiwara,R., Kariminia,A., Yan,M., Dutz,J.P. and Schultz,K.R.
Inhibition of cathepsin S reduces allogeneic T cell priming but not graft-versus-host disease against minor histocompatibility antigens
Biol Blood Marrow Transplant18, 546-556. PubMed Europe PubMed DOI I
Haerteis,S., Krappitz,M., Bertog,M., Krappitz,A., Baraznenok,V., Henderson,I., Lindstrom,E., Murphy,J.E., Bunnett,N.W. and Korbmacher,C.
Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S
Pflugers Arch464, 353-365. PubMed Europe PubMed DOI
Kim,N., Bae,K.B., Kim,M.O., Yu,D.H., Kim,H.J., Yuh,H.S., Ji,Y.R., Park,S.J., Kim,S., Son,K.H., Park,S.J., Yoon,D., Lee,D.S., Lee,S., Lee,H.S., Kim,T.Y. and Ryoo,Z.Y.
Overexpression of cathepsin S induces chronic atopic dermatitis in mice
J Invest Dermatol132, 1169-1176. PubMed Europe PubMed DOI
Kirschke,H.
Cathepsin S
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Moss,N., Xiong,Z., Burke,M., Cogan,D., Gao,D.A., Haverty,K., Heim-Riether,A., Hickey,E.R., Nagaraja,R., Netherton,M., O'Shea,K., Ramsden,P., Schwartz,R., Shih,D.T., Ward,Y., Young,E. and Zhang,Q.
Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement
Bioorg Med Chem Lett22, 7189-7193. PubMed Europe PubMed DOI I
Oliveira,M., Assis,D.M., Paschoalin,T., Miranda,A., Ribeiro,E.B., Juliano,M.A., Bromme,D., Christoffolete,M.A., Barros,N.M. and Carmona,A.K.
Cysteine cathepsin S processes leptin, inactivating its biological activity
J Endocrinol214, 217-224. PubMed Europe PubMed DOI
Pan,L., Li,Y., Jia,L., Qin,Y., Qi,G., Cheng,J., Qi,Y., Li,H. and Du,J.
Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation
PLoS ONE7, e35315-e35315. PubMed Europe PubMed DOI K
Qin,Y., Cao,X., Guo,J., Zhang,Y., Pan,L., Zhang,H., Li,H., Tang,C., Du,J. and Shi,G.P.
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice
Cardiovasc Res96, 401-410. PubMed Europe PubMed DOI K
Sage,J., Leblanc-Noblesse,E., Nizard,C., Sasaki,T., Schnebert,S., Perrier,E., Kurfurst,R., Bromme,D., Lalmanach,G. and Lecaille,F.
Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners
PLoS ONE7, e43494-e43494. PubMed Europe PubMed DOI
Stoeckle,C., Quecke,P., Ruckrich,T., Burster,T., Reich,M., Weber,E., Kalbacher,H., Driessen,C., Melms,A. and Tolosa,E.
Cathepsin S dominates autoantigen processing in human thymic dendritic cells
J Autoimmun38, 332-343. PubMed Europe PubMed DOI
Verdoes,M., Edgington,L.E., Scheeren,F.A., Leyva,M., Blum,G., Weiskopf,K., Bachmann,M.H., Ellman,J.A. and Bogyo,M.
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages
Chem Biol19, 619-628. PubMed Europe PubMed DOI L
Zhou,J., Li,L. and Cai,Z.H.
Identification of putative cathepsin S in mangrove red snapper Lutjanus argentimaculatus and its role in antigen presentation
Dev Comp Immunol37, 28-38. PubMed Europe PubMed DOI

2011

Baugh,M., Black,D., Westwood,P., Kinghorn,E., McGregor,K., Bruin,J., Hamilton,W., Dempster,M., Claxton,C., Cai,J., Bennett,J., Long,C., McKinnon,H., Vink,P., Hoed,L., Gorecka,M., Vora,K., Grant,E., Percival,M.D., Boots,A.M. and van Lierop,M.J.
Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity
J Autoimmun36, 201-209. PubMed Europe PubMed DOI I
Biniossek,M.L., Nagler,D.K., Becker-Pauly,C. and Schilling,O.
Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S
J Proteome Res10, 5363-5373. PubMed Europe PubMed DOI P
Caglic,D., Globisch,A., Kindermann,M., Lim,N.H., Jeske,V., Juretschke,H.P., Bartnik,E., Weithmann,K.U., Nagase,H., Turk,B. and Wendt,K.U.
Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation
Bioorg Med Chem19, 1055-1061. PubMed Europe PubMed DOI L
Deschamps,K., Cromlish,W., Weicker,S., Lamontagne,S., Huszar,S.L., Gauthier,J.Y., Mudgett,J.S., Guimond,A., Romand,R., Frossard,N., Percival,M.D., Slipetz,D. and Tan,C.M.
Genetic and pharmacological evaluation of cathepsin S in a mouse model of asthma
Am J Respir Cell Mol Biol45, 81-87. PubMed Europe PubMed DOI K I
Jiang,C., Sun,W., Zhou,X.P. and Yang,X.H.
Cathepsin S inhibitors and the structure-activity relationship: research advances
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Kerns,J.K., Nie,H., Bondinell,W., Widdowson,K.L., Yamashita,D.S., Rahman,A., Podolin,P.L., Carpenter,D.C., Jin,Q., Riflade,B., Dong,X., Nevins,N., Keller,P.M., Mitchell,L. and Tomaszek,T.
Azepanone-based inhibitors of human cathepsin S: optimization of selectivity via the P2 substituent
Bioorg Med Chem Lett21, 4409-4415. PubMed Europe PubMed DOI I
Kwok,H.F., Buick,R.J., Kuehn,D., Gormley,J.A., Doherty,D., Jaquin,T.J., McClurg,A., Ward,C., Byrne,T., Jaworski,J., Leung,K.L., Snoddy,P., McAnally,C., Burden,R.E., Gray,B., Lowry,J., Sermadiras,I., Gruszka,N., Courtenay-Luck,N., Kissenpfennig,A., Scott,C.J., Johnston,J.A. and Olwill,S.A.
Antibody targeting of cathepsin S induces antibody-dependent cellular cytotoxicity
Mol Cancer10, 147-147. PubMed Europe PubMed DOI
Lee-Dutra,A., Wiener,D.K. and Sun,S.
Cathepsin S inhibitors: 2004 - 2010
Expert Opin Ther Pat21, 311-337. PubMed Europe PubMed DOI V I
Loser,R.
Cathepsin S inhibitors: WO2010070615
Expert Opin Ther Pat21, 585-591. PubMed Europe PubMed DOI I
Schechter,I. and Ziv,E.
Cathepsins S, B and L with aminopeptidases display beta-secretase activity associated with the pathogenesis of Alzheimer's disease
Biol Chem392, 555-569. PubMed Europe PubMed DOI
Small,D.M., Burden,R.E. and Scott,C.J.
The emerging relevance of the cysteine protease cathepsin S in disease
Clin Rev Bone Miner Metab9, 122-132. DOI V
Sun,Y.N., Xu,T.J., Wang,J.X., Cheng,Y.Z. and Wang,R.X.
Sequence and expression analysis of cathepsin S gene in the miiuy croaker Miichthys miiuy
Fish Physiol Biochem37, 761-765. PubMed Europe PubMed DOI
Veilleux,A., Black,W.C., Gauthier,J.Y., Mellon,C., Percival,M.D., Tawa,P. and Falgueyret,J.P.
Probing cathepsin S activity in whole blood by the activity-based probe BIL-DMK: cellular distribution in human leukocyte populations and evidence of diurnal modulation
Anal Biochem411, 43-49. PubMed Europe PubMed DOI I

2010

Ameriks,M.K., Bembenek,S.D., Burdett,M.T., Choong,I.C., Edwards,J.P., Gebauer,D., Gu,Y., Karlsson,L., Purkey,H.E., Staker,B.L., Sun,S., Thurmond,R.L. and Zhu,J.
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors
Bioorg Med Chem Lett20, 4060-4064. PubMed Europe PubMed DOI I
Cai,J., Bennett,D.J., Rankovic,Z., Dempster,M., Fradera,X., Gillespie,J., Cumming,I., Finlay,W., Baugh,M., Boucharens,S., Bruin,J., Cameron,K.S., Hamilton,W., Kerr,J., Kinghorn,E., McGarry,G., Robinson,J., Scullion,P., Uitdehaag,J.C., van Zeeland,M., Potin,D., Saniere,L., Fouquet,A., Chevallier,F., Deronzier,H., Dorleans,C. and Nicolai,E.
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Bioorg Med Chem Lett20, 4447-4450. PubMed Europe PubMed DOI I
Cai,J., Baugh,M., Black,D., Long,C., Jonathan Bennett,D., Dempster,M., Fradera,X., Gillespie,J., Andrews,F., Boucharens,S., Bruin,J., Cameron,K.S., Cumming,I., Hamilton,W., Jones,P.S., Kaptein,A., Kinghorn,E., Maidment,M., Martin,I., Mitchell,A., Rankovic,Z., Robinson,J., Scullion,P., Uitdehaag,J.C., Vink,P., Westwood,P., van Zeeland,M., van Berkom,L., Bastiani,M. and Meulemans,T.
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
Bioorg Med Chem Lett20, 4350-4354. PubMed Europe PubMed DOI I
Cai,J., Robinson,J., Belshaw,S., Everett,K., Fradera,X., van Zeeland,M., van Berkom,L., van Rijnsbergen,P., Popplestone,L., Baugh,M., Dempster,M., Bruin,J., Hamilton,W., Kinghorn,E., Westwood,P., Kerr,J., Rankovic,Z., Arbuckle,W., Bennett,D.J., Jones,P.S., Long,C., Martin,I., Uitdehaag,J.C. and Meulemans,T.
Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors
Bioorg Med Chem Lett20, 6890-6894. PubMed Europe PubMed DOI I
Cai,J., Fradera,X., van Zeeland,M., Dempster,M., Cameron,K.S., Bennett,D.J., Robinson,J., Popplestone,L., Baugh,M., Westwood,P., Bruin,J., Hamilton,W., Kinghorn,E., Long,C. and Uitdehaag,J.C.
4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important
Bioorg Med Chem Lett20, 4507-4510. PubMed Europe PubMed DOI I
Chen,J.C., Uang,B.J., Lyu,P.C., Chang,J.Y., Liu,K.J., Kuo,C.C., Hsieh,H.P., Wang,H.C., Cheng,C.S., Chang,Y.H., Chang,M.D., Chang,W.S. and Lin,C.C.
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis
J Med Chem53, 4545-4549. PubMed Europe PubMed DOI I
Coppini,L.P., Barros,N.M., Oliveira,M., Hirata,I.Y., Alves,M.F., Paschoalin,T., Assis,D.M., Juliano,M.A., Puzer,L., Bromme,D. and Carmona,A.K.
Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor
Biol Chem391, 561-570. PubMed Europe PubMed DOI P
Frizler,M., Stirnberg,M., Sisay,M.T. and Gutschow,M.
Development of nitrile-based peptidic inhibitors of cysteine cathepsins
Curr Top Med Chem10, 294-322. PubMed Europe PubMed DOI T I
Isabel,E., Bateman,K.P., Chauret,N., Cromlish,W., Desmarais,S., Duong,l.T., Falgueyret,J.P., Gauthier,J.Y., Lamontagne,S., Lau,C.K., Leger,S., LeRiche,T., Levesque,J.F., Li,C.S., Masse,F., McKay,D.J., Mellon,C., Nicoll-Griffith,D.A., Oballa,R.M., Percival,M.D., Riendeau,D., Robichaud,J., Rodan,G.A., Rodan,S.B., Seto,C., Therien,M., Truong,V.L., Wesolowski,G., Young,R.N., Zamboni,R. and Black,W.C.
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor
Bioorg Med Chem Lett20, 887-892. PubMed Europe PubMed DOI I
Jobs,E., Riserus,U., Ingelsson,E., Helmersson,J., Nerpin,E., Jobs,M., Sundstrom,J., Lind,L., Larsson,A., Basu,S. and Arnlov,J.
Serum Cathepsin S Is Associated with Serum C-Reactive Protein and Interleukin-6 Independently of Obesity in Elderly Men
J Clin Endocrinol Metab95, 4460-4464. PubMed Europe PubMed DOI
Kim,N.Y., Ahn,S.J., Lee,A.R., Seo,J.S., Kim,M.S., Kim,J.K., Chung,J.K. and Lee,H.H.
Cloning, expression analysis and enzymatic characterization of cathepsin S from olive flounder (Paralichthys olivaceus)
Comp Biochem Physiol B Biochem Mol Biol157, 238-247. PubMed Europe PubMed DOI
Lee-Dutra,A., Wiener,D.K., Arienti,K.L., Liu,J., Mani,N., Ameriks,M.K., Axe,F.U., Gebauer,D., Desai,P.J., Nguyen,S., Randal,M., Thurmond,R.L., Sun,S., Karlsson,L., Edwards,J.P., Jones,T.K. and Grice,C.A.
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: Part 1
Bioorg Med Chem Lett20, 2370-2374. PubMed Europe PubMed DOI I
Li,C., Jiang,Y. and Li,L.
A hypothesis - peptide library generated by cathepsin S might be efficacious for allergen-specific immunotherapy
Vaccine28, 1135-1137. PubMed Europe PubMed DOI
Naour,N., Rouault,C., Fellahi,S., Lavoie,M.E., Poitou,C., Keophiphath,M., Eberle,D., Shoelson,S., Rizkalla,S., Bastard,J.P., Rabasa-Lhoret,R., Clement,K. and Guerre-Millo,M.
Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin S in adipose tissue and in circulation
J Clin Endocrinol Metab95, 1861-1868. PubMed Europe PubMed DOI
Oliveira,M., Torquato,R.J., Alves,M.F., Juliano,M.A., Bromme,D., Barros,N.M. and Carmona,A.K.
Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates
Peptides31, 562-567. PubMed Europe PubMed DOI A
Piovan,L., Alves,M.F.M., Juliano,L., Bromme,D., Cunha,R.L.O.R. and Andrade,L.H.
Chemoenzymatic synthesis of organoselenium(IV) compounds and their evaluation as cysteine protease inhibitors
J Braz Chem Soc21, 2108-2118. I
Reddy,V.B., Shimada,S.G., Sikand,P., LaMotte,R.H. and Lerner,E.A.
Cathepsin S elicits itch and signals via protease-activated receptors
J Invest Dermatol130, 1468-1470. PubMed Europe PubMed DOI
Samokhin,A.O., Lythgo,P.A., Gauthier,J.Y., Percival,M.D. and Bromme,D.
Pharmacological inhibition of cathepsin S decreases atherosclerotic lesions in Apoe-/- mice
J Cardiovasc Pharmacol56, 98-105. PubMed Europe PubMed DOI I
Ward,C., Kuehn,D., Burden,R.E., Gormley,J.A., Jaquin,T.J., Gazdoiu,M., Small,D., Bicknell,R., Johnston,J.A., Scott,C.J. and Olwill,S.A.
Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF
PLoS ONE5, e12543-e12543. PubMed Europe PubMed DOI
Wiener,D.K., Lee-Dutra,A., Bembenek,S., Nguyen,S., Thurmond,R.L., Sun,S., Karlsson,L., Grice,C.A., Jones,T.K. and Edwards,J.P.
Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors
Bioorg Med Chem Lett20, 2379-2382. PubMed Europe PubMed DOI I
Wiener,J.J., Sun,S. and Thurmond,R.L.
Recent advances in the design of cathepsin S inhibitors
Curr Top Med Chem10, 717-732. PubMed Europe PubMed DOI V I
Wiener,J.J., Wickboldt,A.T., Jr., Wiener,D.K., Lee-Dutra,A., Edwards,J.P., Karlsson,L., Nguyen,S., Sun,S., Jones,T.K. and Grice,C.A.
Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions
Bioorg Med Chem Lett20, 2375-2378. PubMed Europe PubMed DOI I
Yang,Y., Yixuan,Y., Lim,S.K., Kiat,L.S., Choong,L.Y., Yee,C.L., Lee,H., Huiyin,L., Chen,Y., Yunhao,C., Chong,P.K., Kuan,C.P., Ashktorab,H., Hassan,A., Wang,T.T., Ting,W.T., Salto-Tellez,M., Manuel,S.T., Yeoh,K.G., Guan,Y.K., Lim,Y.P. and Pin,L.Y.
Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins
J Proteome Res9, 4767-4778. PubMed Europe PubMed DOI

2009

Aikawa,E., Aikawa,M., Libby,P., Figueiredo,J.L., Rusanescu,G., Iwamoto,Y., Fukuda,D., Kohler,R.H., Shi,G.P., Jaffer,F.A. and Weissleder,R.
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
Circulation119, 1785-1794. PubMed Europe PubMed DOI K
Ameriks,M.K., Axe,F.U., Bembenek,S.D., Edwards,J.P., Gu,Y., Karlsson,L., Randal,M., Sun,S., Thurmond,R.L. and Zhu,J.
Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements
Bioorg Med Chem Lett19, 6131-6134. PubMed Europe PubMed DOI S I
Ameriks,M.K., Cai,H., Edwards,J.P., Gebauer,D., Gleason,E., Gu,Y., Karlsson,L., Nguyen,S., Sun,S., Thurmond,R.L. and Zhu,J.
Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: Optimization of cellular potency
Bioorg Med Chem Lett19, 6135-6139. PubMed Europe PubMed DOI I
Ayesa,S., Lindquist,C., Agback,T., Benkestock,K., Classon,B., Henderson,I., Hewitt,E., Jansson,K., Kallin,A., Sheppard,D. and Samuelsson,B.
Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: effect of sulfonamides P3 substituents on potency and selectivity
Bioorg Med Chem17, 1307-1324. PubMed Europe PubMed DOI I
Bethel,P.A., Gerhardt,S., Jones,E.V., Kenny,P.W., Karoutchi,G.I., Morley,A.D., Oldham,K., Rankine,N., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S.
Design of selective cathepsin inhibitors
Bioorg Med Chem Lett19, 4622-4625. PubMed Europe PubMed DOI I
Burden,R.E., Gormley,J.A., Jaquin,T.J., Small,D.M., Quinn,D.J., Hegarty,S.M., Ward,C., Walker,B., Johnston,J.A., Olwill,S.A. and Scott,C.J.
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis
Clin Cancer Res15, 6042-6051. PubMed Europe PubMed DOI T
Clark,A.K., Yip,P.K. and Malcangio,M.
The liberation of fractalkine in the dorsal horn requires microglial cathepsin S
J Neurosci29, 6945-6954. PubMed Europe PubMed DOI I
Costantino,C.M., Ploegh,H.L. and Hafler,D.A.
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells
J Immunol183, 945-952. PubMed Europe PubMed DOI
de Nooijer,R., Bot,I., von der Thusen,J.H., Leeuwenburgh,M.A., Overkleeft,H.S., Kraaijeveld,A.O., Dorland,R., van Santbrink,P.J., van Heiningen,S.H., Westra,M.M., Kovanen,P.T., Jukema,J.W., van der Wall,E.E., van Berkel,T.J., Shi,G.P. and Biessen,E.A.
Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis
Arterioscler Thromb Vasc Biol29, 188-194. PubMed Europe PubMed DOI
Jordans,S., Jenko-Kokalj,S., Kuhl,N.M., Tedelind,S., Sendt,W., Bromme,D., Turk,D. and Brix,K.
Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions
BMC Biochem10, 23-23. PubMed Europe PubMed DOI
Polyakova,O., Dear,D., Stern,I., Martin,S., Hirst,E., Bawumia,S., Nash,A., Dodson,G., Bronstein,I. and Bayley,P.M.
Proteolysis of prion protein by cathepsin S generates a soluble beta-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms
Eur Biophys J38, 209-218. PubMed Europe PubMed DOI
Schilling,K., Korner,A., Sehmisch,S., Kreusch,A., Kleint,R., Benedix,Y., Schlabrakowski,A. and Wiederanders,B.
Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases
Biol Chem390, 167-174. PubMed Europe PubMed DOI
Vinardell,T., Dejica,V., Poole,A.R., Mort,J.S., Richard,H. and Laverty,S.
Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis
Osteoarthritis Cartilage17, 375-383. PubMed Europe PubMed DOI

2008

Gupta,S., Singh,R.K., Dastidar,S. and Ray,A.
Cysteine cathepsin S as an immunomodulatory target: present and future trends
Expert Opin Ther Targets12, 291-299. PubMed Europe PubMed DOI
Irie,O., Yokokawa,F., Ehara,T., Iwasaki,A., Iwaki,Y., Hitomi,Y., Konishi,K., Kishida,M., Toyao,A., Masuya,K., Gunji,H., Sakaki,J., Iwasaki,G., Hirao,H., Kanazawa,T., Tanabe,K., Kosaka,T., Hart,T.W. and Hallett,A.
4-Amino-2-cyanopyrimidines: novel scaffold for nonpeptidic cathepsin S inhibitors
Bioorg Med Chem Lett18, 4642-4646. PubMed Europe PubMed DOI I
Irie,O., Ehara,T., Iwasaki,A., Yokokawa,F., Sakaki,J., Hirao,H., Kanazawa,T., Teno,N., Horiuchi,M., Umemura,I., Gunji,H., Masuya,K., Hitomi,Y., Iwasaki,G., Nonomura,K., Tanabe,K., Fukaya,H., Kosaka,T., Snell,C.R. and Hallett,A.
Discovery of selective and nonpeptidic cathepsin S inhibitors
Bioorg Med Chem Lett18, 3959-3962. PubMed Europe PubMed DOI I
Irie,O., Kosaka,T., Ehara,T., Yokokawa,F., Kanazawa,T., Hirao,H., Iwasaki,A., Sakaki,J., Teno,N., Hitomi,Y., Iwasaki,G., Fukaya,H., Nonomura,K., Tanabe,K., Koizumi,S., Uchiyama,N., Bevan,S.J., Malcangio,M., Gentry,C., Fox,A.J., Yaqoob,M., Culshaw,A.J. and Allan,H.
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain
J Med Chem51, 5502-5505. PubMed Europe PubMed DOI I
Irie,O., Kosaka,T., Kishida,M., Sakaki,J., Masuya,K., Konishi,K., Yokokawa,F., Ehara,T., Iwasaki,A., Iwaki,Y., Hitomi,Y., Toyao,A., Gunji,H., Teno,N., Iwasaki,G., Hirao,H., Kanazawa,T., Tanabe,K., Hiestand,P.C., Malcangio,M., Fox,A.J., Bevan,S.J., Yaqoob,M., Culshaw,A.J., Hart,T.W. and Hallett,A.
Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2
Bioorg Med Chem Lett18, 5280-5284. PubMed Europe PubMed DOI I
Lutzner,N. and Kalbacher,H.
Quantifying cathepsin S activity in antigen presenting cells using a novel specific substrate
J Biol Chem283, 36185-36194. PubMed Europe PubMed DOI A
Markt,P., McGoohan,C., Walker,B., Kirchmair,J., Feldmann,C., De Martino,G., Spitzer,G., Distinto,S., Schuster,D., Wolber,G., Laggner,C. and Langer,T.
Discovery of novel cathepsin S inhibitors by pharmacophore-based virtual high-throughput screening
J Chem Inf Model48, 1693-1705. PubMed Europe PubMed DOI I
Minematsu,N., Nakamura,H., Furuuchi,M., Nakajima,T., Takahashi,S., Tsujimura,S., Tateno,H. and Ishizaka,A.
Common functional polymorphisms in the cathepsin S promoter in Japanese subjects: possible contribution to pulmonary emphysema
Respirology13, 498-504. PubMed Europe PubMed DOI M
Spielmann,N., Mutch,D.M., Rousseau,F., Tores,F., Hager,J., Bertrais,S., Basdevant,A., Tounian,P., Dubern,B., Galan,P. and Clement,K.
Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations
Clin Genet74, 155-163. PubMed Europe PubMed DOI M
Tiribuzi,R., Martino,S., Ciraci,E., D'Angelo,F., Girolamo,D., Datti,A., Bottazzo,G.F., Berardi,A.C. and Orlacchio,A.
Non-redundant roles of cathepsins L, B and S in CD1a+ dendritic cells knocked-down for cathepsin S by RNA interference
Minerva Biotecnol20, 59-67.

2007

Alves,F.M., Hirata,I.Y., Gouvea,I.E., Alves,M.F., Meldal,M., Bromme,D., Juliano,L. and Juliano,M.A.
Controlled peptide solvation in portion-mixing libraries of FRET peptides: improved specificity determination for dengue 2 virus NS2B-NS3 protease and human cathepsin S
J Comb Chem9, 627-634. PubMed Europe PubMed DOI
Bekkali,Y., Thomson,D.S., Betageri,R., Emmanuel,M.J., Hao,M.H., Hickey,E., Liu,W., Patel,U., Ward,Y.D., Young,E.R., Nelson,R., Kukulka,A., Brown,M.L., Crane,K., White,D., Freeman,D.M., Labadia,M.E., Wildeson,J. and Spero,D.M.
Identification of a novel class of succinyl-nitrile-based cathepsin S inhibitors
Bioorg Med Chem Lett17, 2465-2469. PubMed Europe PubMed DOI I
Chatterjee,A.K., Liu,H., Tully,D.C., Guo,J., Epple,R., Russo,R., Williams,J., Roberts,M., Tuntland,T., Chang,J., Gordon,P., Hollenbeck,T., Tumanut,C., Li,J. and Harris,J.L.
Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S
Bioorg Med Chem Lett17, 2899-2903. PubMed Europe PubMed DOI I
Clark,A.K., Yip,P.K., Grist,J., Gentry,C., Staniland,A.A., Marchand,F., Dehvari,M., Wotherspoon,G., Winter,J., Ullah,J., Bevan,S. and Malcangio,M.
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
Proc Natl Acad Sci U S A104, 10655-10660. PubMed Europe PubMed DOI I
Gauthier,J.Y., Black,W.C., Courchesne,I., Cromlish,W., Desmarais,S., Houle,R., Lamontagne,S., Li,C.S., Masse,F., McKay,D.J., Ouellet,M., Robichaud,J., Truchon,J.F., Truong,V.L., Wang,Q. and Percival,M.D.
The identification of potent, selective, and bioavailable cathepsin S inhibitors
Bioorg Med Chem Lett17, 4929-4933. PubMed Europe PubMed DOI I
Hirakawa,H., Pierce,R.A., Bingol-Karakoc,G., Karaaslan,C., Weng,M., Shi,G.P., Saad,A., Weber,E., Mariani,T.J., Starcher,B., Shapiro,S.D. and Cataltepe,S.
Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury
Am J Respir Crit Care Med176, 778-785. PubMed Europe PubMed DOI
Inagaki,H., Tsuruoka,H., Hornsby,M., Lesley,S.A., Spraggon,G. and Ellman,J.A.
Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode
J Med Chem50, 2693-2699. PubMed Europe PubMed DOI I
Kramer,G., Paul,A., Kreusch,A., Schuler,S., Wiederanders,B. and Schilling,K.
Optimized folding and activation of recombinant procathepsin L and S produced in Escherichia coli
Protein Expr Purif54, 147-156. PubMed Europe PubMed DOI E
Naour,N., Taleb,S., Guerre-Millo,M. and Clement,K.
Does cathepsin S play a role in obesity? [Quelle implication pour la cathepsine S dans l'obesite?]
Obesite2, 260-264. DOI
Soualhine,H., Deghmane,A.E., Sun,J., Mak,K., Talal,A., Av-Gay,Y. and Hmama,Z.
Mycobacterium bovis bacillus Calmette-Guerin secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages
J Immunol179, 5137-5145. PubMed Europe PubMed
Taleb,S. and Clement,K.
Emerging role of cathepsin S in obesity and its associated diseases
Clin Chem Lab Med45, 328-332. PubMed Europe PubMed DOI
Wei,J., Pio,B.A., Cai,H., Meduna,S.P., Sun,S., Gu,Y., Jiang,W., Thurmond,R.L., Karlsson,L. and Edwards,J.P.
Pyrazole-based cathepsin S inhibitors with improved cellular potency
Bioorg Med Chem Lett17, 5525-5528. PubMed Europe PubMed DOI I

2006

[YEAR:10-1-2006]Alper,P.B., Liu,H., Chatterjee,A.K., Nguyen,K.T., Tully,D.C., Tumanut,C., Li,J., Harris,J.L., Tuntland,T., Chang,J., Gordon,P., Hollenbeck,T. and Karanewsky,D.S.
Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl
Bioorg Med Chem Lett16, 1486-1490. PubMed Europe PubMed DOI I
[YEAR:18-9-2006]Cheng,X.W., Obata,K., Kuzuya,M., Izawa,H., Nakamura,K., Asai,E., Nagasaka,T., Saka,M., Kimata,T., Noda,A., Nagata,K., Jin,H., Shi,G.P., Iguchi,A., Murohara,T. and Yokota,M.
Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure
Hypertension48, 979-987. PubMed Europe PubMed DOI
[YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S.
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities
J Biol Chem281, 12824-12832. PubMed Europe PubMed DOI P
[YEAR:28-3-2006]Desai,S.N., White,D.M., O'shea,K.M., Brown,M.L., Cywin,C.L., Spero,D.M. and Panzenbeck,M.J.
An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity
Eur J Pharmacol538, 168-174. PubMed Europe PubMed DOI I
[YEAR:20-3-2006]Flannery,T., McQuaid,S., McGoohan,C., McConnell,R.S., McGregor,G., Mirakhur,M., Hamilton,P., Diamond,J., Cran,G., Walker,B., Scott,C., Martin,L., Ellison,D., Patel,C., Nicholson,C., Mendelow,D., McCormick,D. and Johnston,P.G.
Cathepsin S expression: an independent prognostic factor in glioblastoma tumours - a pilot study
Int J Cancer119, 854-860. PubMed Europe PubMed DOI
[YEAR:1-2-2006]Grice,C.A., Tays,K., Khatuya,H., Gustin,D.J., Butler,C.R., Wei,J., Sehon,C.A., Sun,S., Gu,Y., Jiang,W., Thurmond,R.L., Karlsson,L. and Edwards,J.P.
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors
Bioorg Med Chem Lett16, 2209-2212. PubMed Europe PubMed DOI I
Kaulmann,G., Palm,G.J., Schilling,K., Hilgenfeld,R. and Wiederanders,B.
The crystal structure of a Cys25 -> Ala mutant of human procathepsin S elucidates enzyme-prosequence interactions
Protein Sci15, 2619-2629. PubMed Europe PubMed DOI S
Link,J.O. and Zipfel,S.
Advances in cathepsin S inhibitor design
Curr Opin Drug Discov Devel9, 471-482. PubMed Europe PubMed T I
Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D.
Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins
Biol Chem387, 1295-1303. PubMed Europe PubMed DOI P
Park,Y.G., Kim,Y.H., Kang,S.K. and Kim,C.H.
cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts
Int Immunopharmacol6, 947-956. PubMed Europe PubMed DOI
[YEAR:19-10-2006]Patterson,A.W., Wood,W.J., Hornsby,M., Lesley,S., Spraggon,G. and Ellman,J.A.
Identification of selective, nonpeptidic nitrile inhibitors of cathepsin S using the substrate activity screening method
J Med Chem49, 6298-6307. PubMed Europe PubMed DOI I
[YEAR:12-1-2006]Rodgers,K.J., Watkins,D.J., Miller,A.L., Chan,P.Y., Karanam,S., Brissette,W.H., Long,C.J. and Jackson,C.L.
Destabilizing role of cathepsin S in murine atherosclerotic plaques
Arterioscler Thromb Vasc Biol26, 851-856. PubMed Europe PubMed DOI
Ruckrich,T., Brandenburg,J., Cansier,A., Muller,M., Stevanovic,S., Schilling,K., Wiederanders,B., Beck,A., Melms,A., Reich,M., Driessen,C. and Kalbacher,H.
Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain
Biol Chem387, 1503-1511. PubMed Europe PubMed DOI P
Sugano,E., Tomita,H., Ishiguro,S., Isago,H. and Tamai,M.
Nitric oxide-induced accumulation of lipofuscin-like materials is caused by inhibition of cathepsin S
Curr Eye Res31, 607-616. PubMed Europe PubMed DOI
Sukhova,G.K. and Shi,G.P.
Do cathepsins play a role in abdominal aortic aneurysm pathogenesis?
Ann N Y Acad Sci1085, 161-169. PubMed Europe PubMed DOI
[YEAR:6-7-2006]Taleb,S., Cancello,R., Clement,K. and Lacasa,D.
Cathepsin S promotes human preadipocyte differentiation: possible involvement of fibronectin degradation
Endocrinology147, 4950-4959. PubMed Europe PubMed DOI
[YEAR:4-1-2006]Taleb,S., Cancello,R., Poitou,C., Rouault,C., Sellam,P., Levy,P., Bouillot,J.L., Coussieu,C., Basdevant,A., Guerre-Millo,M., Lacasa,D. and Clement,K.
Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese women
J Clin Endocrinol Metab91, 1042-1047. PubMed Europe PubMed DOI
[YEAR:27-7-2006]Tully,D.C., Liu,H., Chatterjee,A.K., Alper,P.B., Williams,J.A., Roberts,M.J., Mutnick,D., Woodmansee,D.H., Hollenbeck,T., Gordon,P., Chang,J., Tuntland,T., Tumanut,C., Li,J., Harris,J.L. and Karanewsky,D.S.
Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors
Bioorg Med Chem Lett16, 5107-5111. PubMed Europe PubMed DOI I
[YEAR:27-1-2006]Tully,D.C., Liu,H., Alper,P.B., Chatterjee,A.K., Epple,R., Roberts,M.J., Williams,J.A., Nguyen,K.T., Woodmansee,D.H., Tumanut,C., Li,J., Spraggon,G., Chang,J., Tuntland,T., Harris,J.L. and Karanewsky,D.S.
Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3
Bioorg Med Chem Lett16, 1975-1980. PubMed Europe PubMed DOI S I
[YEAR:27-7-2006]Tully,D.C., Liu,H., Chatterjee,A.K., Alper,P.B., Epple,R., Williams,J.A., Roberts,M.J., Woodmansee,D.H., Masick,B.T., Tumanut,C., Li,J., Spraggon,G., Hornsby,M., Chang,J., Tuntland,T., Hollenbeck,T., Gordon,P., Harris,J.L. and Karanewsky,D.S.
Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers
Bioorg Med Chem Lett16, 5112-5117. PubMed Europe PubMed DOI I
[YEAR:19-12-2006]Wang,B., Sun,J., Kitamoto,S., Yang,M., Grubb,A., Chapman,H.A., Kalluri,R. and Shi,G.P.
Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors
J Biol Chem281, 6020-6029. PubMed Europe PubMed DOI
[YEAR:1-1-2006]Wang,Y., Baron,R.M., Zhu,G., Joo,M., Christman,J.W., Silverman,E.S., Perrella,M.A., Riese,R.J. and Cernadas,M.
PU.1 Regulates cathepsin S expression in professional APCs
J Immunol176, 275-283. PubMed Europe PubMed

2005

[YEAR:1-2-2005]Beers,C., Burich,A., Kleijmeer,M.J., Griffith,J.M., Wong,P. and Rudensky,A.Y.
Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo
J Immunol174, 1205-1212. PubMed Europe PubMed
[YEAR:11-8-2005]Boes,M., van der Wel,N., Peperzak,V., Kim,Y.M., Peters,P.J. and Ploegh,H.
In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S
Eur J Immunol35, 2552-2562. PubMed Europe PubMed DOI
[YEAR:15-3-2005]Gustin,D.J., Sehon,C.A., Wei,J., Cai,H., Meduna,S.P., Khatuya,H., Sun,S., Gu,Y., Jiang,W., Thurmond,R.L., Karlsson,L. and Edwards,J.P.
Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors
Bioorg Med Chem Lett15, 1687-1691. PubMed Europe PubMed DOI I
Kitamura,H., Kamon,H., Sawa,S., Park,S.J., Katunuma,N., Ishihara,K., Murakami,M. and Hirano,T.
IL-6-STAT3 Controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells
Immunity23, 491-502. PubMed Europe PubMed DOI
[YEAR:15-11-2005]Liu,H., Tully,D.C., Epple,R., Bursulaya,B., Li,J., Harris,J.L., Williams,J.A., Russo,R., Tumanut,C., Roberts,M.J., Alper,P.B., He,Y. and Karanewsky,D.S.
Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1
Bioorg Med Chem Lett15, 4979-4984. PubMed Europe PubMed DOI I
[YEAR:28-6-2005]Taleb,S., Lacasa,D., Bastard,J.P., Poitou,C., Cancello,R., Pelloux,V., Viguerie,N., Benis,A., Zucker,J.D., Bouillot,J.L., Coussieu,C., Basdevant,A., Langin,D. and Clement,K.
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis
FASEB J19, 1540-1542. PubMed Europe PubMed DOI
Thurmond,R.L., Sun,S., Karlsson,L. and Edwards,J.P.
Cathepsin S inhibitors as novel immunomodulators
Curr Opin Investig Drugs6, 473-482. PubMed Europe PubMed I
[YEAR:14-2-2005]Vasiljeva,O., Dolinar,M., Pungercar,J.R., Turk,V. and Turk,B.
Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans
FEBS Lett579, 1285-1290. PubMed Europe PubMed DOI
[YEAR:1-2-2005]Yang,H., Kala,M., Scott,B.G., Goluszko,E., Chapman,H.A. and Christadoss,P.
Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis
J Immunol174, 1729-1737. PubMed Europe PubMed
Yasuda,Y., Kaleta,J. and Bromme,D.
The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics
Adv Drug Deliv Rev57, 973-993. PubMed Europe PubMed DOI T I

2004

[YEAR:11-12-2004]Golden,J.W., Bahe,J.A., Lucas,W.T., Nibert,M.L. and Schiff,L.A.
Cathepsin S supports acid-independent infection by some reoviruses
J Biol Chem279, 8547-8557. PubMed Europe PubMed DOI
Kirschke,H.
Cathepsin S
[ISSN:0-12-079610-4]2, 1104-1107. V
Liu,W. and Spero,D.M.
Cysteine protease cathepsin S as a key step in antigen presentation
Drug News Perspect17, 357-363. PubMed Europe PubMed DOI
Marquis,R.W.
Inhibition of the cysteine protease cathepsin K (EC 3.4.22.38)
Annu Rep Med Chem39, 79-98. DOI V I
Shen,L., Sigal,L.J., Boes,M. and Rock,K.L.
Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo
Immunity21, 155-165. PubMed Europe PubMed DOI
[YEAR:23-9-2004]Thurmond,R.L., Beavers,M.P., Cai,H., Meduna,S.P., Gustin,D.J., Sun,S., Almond,H.J., Karlsson,L. and Edwards,J.P.
Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S
J Med Chem47, 4799-4801. PubMed Europe PubMed DOI I
[YEAR:17-10-2004]Thurmond,R.L., Sun,S., Sehon,C.A., Baker,S.M., Cai,H., Gu,Y., Jiang,W., Riley,J.P., Williams,K.N., Edwards,J.P. and Karlsson,L.
Identification of a potent and selective noncovalent cathepsin S inhibitor
J Pharmacol Exp Ther308, 268-276. PubMed Europe PubMed DOI I

2003

Baker,S.M., Karlsson,L. and Thurmond,R.L.
Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S
Protein Expr Purif28, 93-101. PubMed Europe PubMed DOI
[YEAR:20-1-2003]Beers,C., Honey,K., Fink,S., Forbush,K. and Rudensky,A.
Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages
J Exp Med197, 169-179. PubMed Europe PubMed DOI
Flannery,T., Gibson,D., Mirakhur,M., McQuaid,S., Greenan,C., Trimble,A., Walker,B., McCormick,D. and Johnston,P.G.
The clinical significance of cathepsin S expression in human astrocytomas
Am J Pathol163, 175-182. PubMed Europe PubMed DOI
Henningsson,F., Wolters,P., Chapman,H.A., Caughey,G.H. and Pejler,G.
Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5
Biol Chem384, 1527-1531. PubMed Europe PubMed DOI
[YEAR:26-12-2003]Lindstedt,L., Lee,M., Oorni,K., Bromme,D. and Kovanen,P.T.
Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells
Biochem Biophys Res Commun312, 1019-1024. PubMed Europe PubMed DOI
[YEAR:25-3-2003]Pauly,T.A., Sulea,T., Ammirati,M., Sivaraman,J., Danley,D.E., Griffor,M.C., Kamath,A.V., Wang,I.K., Laird,E.R., Seddon,A.P., Menard,R., Cygler,M. and Rath,V.L.
Specificity determinants of human cathepsin S revealed by crystal structures of complexes
Biochemistry42, 3203-3213. PubMed Europe PubMed DOI S
[YEAR:21-3-2003]Shi,G.P., Sukhova,G.K., Kuzuya,M., Ye,Q., Du,J., Zhang,Y., Pan,J.H., Lu,M.L., Cheng,X.W., Iguchi,A., Perrey,S., Lee,A.M., Chapman,H.A. and Libby,P.
Deficiency of the cysteine protease cathepsin S impairs microvessel growth
Circ Res92, 493-500. PubMed Europe PubMed DOI K
Sukhova,G.K., Zhang,Y., Pan,J.H., Wada,Y., Yamamoto,T., Naito,M., Kodama,T., Tsimikas,S., Witztum,J.L., Lu,M.L., Sakara,Y., Chin,M.T., Libby,P. and Shi,G.P.
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice
J Clin Invest111, 897-906. PubMed Europe PubMed DOI
Wiendl,H., Lautwein,A., Mitsdorffer,M., Krause,S., Erfurth,S., Wienhold,W., Morgalla,M., Weber,E., Overkleeft,H.S., Lochmuller,H., Melms,A., Tolosa,E. and Driessen,C.
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies
J Neuroimmunol138, 132-143. PubMed Europe PubMed DOI

2002

Hou,W.S., Li,W., Keyszer,G., Weber,E., Levy,R., Klein,M.J., Gravallese,E.M., Goldring,S.R. and Bromme,D.
Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium
Arthritis Rheum46, 663-674. PubMed Europe PubMed DOI
Pluger,E.B., Boes,M., Alfonso,C., Schroter,C.J., Kalbacher,H., Ploegh,H.L. and Driessen,C.
Specific role for cathepsin S in the generation of antigenic peptides in vivo
Eur J Immunol32, 467-476. PubMed Europe PubMed DOI
Saegusa,K., Ishimaru,N., Yanagi,K., Arakaki,R., Ogawa,K., Saito,I., Katunuma,N. and Hayashi,Y.
Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity
J Clin Invest110, 361-369. PubMed Europe PubMed DOI I
Tobbell,D.A., Middleton,B.J., Raines,S., Needham,M.R., Taylor,I.W., Beveridge,J.Y. and Abbott,W.M.
Identification of in vitro folding conditions for procathepsin S and cathepsin S using fractional factorial screens
Protein Expr Purif24, 242-254. PubMed Europe PubMed DOI E
Turkenburg,J.P., Lamers,M.B., Brzozowski,A.M., Wright,L.M., Hubbard,R.E., Sturt,S.L. and Williams,D.H.
Structure of a Cys25->Ser mutant of human cathepsin S
Acta Crystallogr D Biol Crystallogr58, 451-455. PubMed Europe PubMed DOI S
[YEAR:5-12-2002]Ward,Y.D., Thomson,D.S., Frye,L.L., Cywin,C.L., Morwick,T., Emmanuel,M.J., Zindell,R., McNeil,D., Bekkali,Y., Giradot,M., Hrapchak,M., DeTuri,M., Crane,K., White,D., Pav,S., Wang,Y., Hao,M.H., Grygon,C.A., Labadia,M.E., Freeman,D.M., Davidson,W., Hopkins,J.L., Brown,M.L., Spero,D.M. and Giradot,M.
Design and synthesis of dipeptide nitriles as reversible and potent cathepsin S inhibitors
J Med Chem45, 5471-5482. PubMed Europe PubMed DOI I

2001

Beck,H., Schwarz,G., Schroter,C.J., Deeg,M., Baier,D., Stevanovic,S., Weber,E., Driessen,C. and Kalbacher,H.
Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro
Eur J Immunol31, 3726-3736. PubMed Europe PubMed DOI
[YEAR:22-6-2001]Honey,K., Duff,M., Beers,C., Brissette,W.H., Elliott,E.A., Peters,C., Maric,M., Cresswell,P. and Rudensky,A.
Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes
J Biol Chem276, 22573-22578. PubMed Europe PubMed DOI K
Mason,C.S., Lamers,M.B., Henderson,I.M., Monk,T. and Williams,D.H.
Baculoviral expression and characterization of rodent cathepsin S
Protein Expr Purif23, 45-54. PubMed Europe PubMed DOI
[YEAR:16-3-2001]Quraishi,O. and Storer,A.C.
Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family
J Biol Chem276, 8118-8124. PubMed Europe PubMed DOI
Riese,R.J., Shi,G.P., Villadangos,J., Stetson,D., Driessen,C., Lennon-Dumenil,A.M., Chu,C.L., Naumov,Y., Behar,S.M., Ploegh,H., Locksley,R. and Chapman,H.A.
Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S
Immunity15, 909-919. PubMed Europe PubMed DOI K
Wasselius,J., Hakansson,K., Johansson,K., Abrahamson,M. and Ehinger,B.
Identification and localization of retinal cystatin C
Invest Ophthalmol Vis Sci42, 1901-1906. PubMed Europe PubMed

2000

Guay,J., Falgueyret,J.P., Ducret,A., Percival,M.D. and Mancini,J.A.
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides
Eur J Biochem267, 6311-6318. PubMed Europe PubMed DOI
[YEAR:10-3-2000]Guo,Y.L., Kurz,U., Schultz,J.E., Lim,C.C., Wiederanders,B. and Schilling,K.
The alpha1/2 helical backbone of the prodomains defines the intrinsic inhibitory specificity in the cathepsin L-like cysteine protease subfamily
FEBS Lett469, 203-207. PubMed Europe PubMed DOI
Kreusch,S., Fehn,M., Maubach,G., Nissler,K., Rommerskirch,W., Schilling,K., Weber,E., Wenz,I. and Wiederanders,B.
An evolutionarily conserved tripartite tryptophan motif stabilizes the prodomains of cathepsin L-like cysteine proteases
Eur J Biochem267, 2965-2972. PubMed Europe PubMed DOI
[YEAR:15-7-2000]Krupa,J.C. and Mort,J.S.
Optimization of detergents for the assay of cathepsins B, L, S, and K
Anal Biochem283, 99-103. PubMed Europe PubMed DOI A
[YEAR:28-8-2000]Walker,B., Lynas,J.F., Meighan,M.A. and Bromme,D.
Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S
Biochem Biophys Res Commun275, 401-405. PubMed Europe PubMed DOI I

1999

[YEAR:15-11-1999]Driessen,C., Bryant,R.A., Lennon-Dumenil,A.M., Villadangos,J.A., Bryant,P.W., Shi,G.P., Chapman,H.A. and Ploegh,H.L.
Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells
J Cell Biol147, 775-790. PubMed Europe PubMed DOI
Liuzzo,J.P., Petanceska,S.S., Moscatelli,D. and Devi,L.A.
Inflammatory mediators regulate cathepsin S in macrophages and microglia: a role in attenuating heparan sulfate interactions
Mol Med5, 320-333. PubMed Europe PubMed
Liuzzo,J.P., Petanceska,S.S. and Devi,L.A.
Neurotrophic factors regulate cathepsin S in macrophages and microglia: a role in the degradation of myelin basic protein and amyloid beta peptide
Mol Med5, 334-343. PubMed Europe PubMed
Nissler,K., Strubel,W., Kreusch,S., Rommerskirch,W., Weber,E. and Wiederanders,B.
The half-life of human procathepsin S
Eur J Biochem263, 717-725. PubMed Europe PubMed DOI E
Werle,B., Staib,A., Julke,B., Ebert,W., Zladoidsky,P., Sekirnik,A., Kos,J. and Spiess,E.
Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extracts
Biol Chem380, 1109-1116. PubMed Europe PubMed DOI A

1998

McGrath,M.E., Palmer,J.T., Bromme,D. and Somoza,J.R.
Crystal structure of human cathepsin S
Protein Sci7, 1294-1302. PubMed Europe PubMed DOI S I
Rakoczy,P.E., Lai,M.C., Baines,M.G., Spilsbury,K. and Constable,I.J.
Expression of cathepsin S antisense transcripts by adenovirus in retinal pigment epithelial cells
Invest Ophthalmol Vis Sci39, 2095-2104. PubMed Europe PubMed K
[YEAR:1-8-1998]Sukhova,G.K., Shi,G.P., Simon,D.I., Chapman,H.A. and Libby,P.
Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
J Clin Invest102, 576-583. PubMed Europe PubMed DOI

1996

Bromme,D. and McGrath,M.E.
High level expression and crystallization of recombinant human cathepsin S
Protein Sci5, 789-791. PubMed Europe PubMed DOI E
Kopitar,G., Dolinar,M., Strukelj,B., Pungercar,J. and Turk,V.
Folding and activation of human procathepsin S from inclusion bodies produced in Escherichia coli
Eur J Biochem236, 558-562. PubMed Europe PubMed E

1994

Bromme,D., Bonneau,P.R., Lachance,P. and Storer,A.C.
Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity
J Biol Chem269, 30238-30242. PubMed Europe PubMed
Gour-Salin,B.J., Lachance,P., Bonneau,P.R., Storer,A.C., Kirschke,H. and Bromme,D.
E-64 analogs as inhibitors of cathepsin L and cathepsin S: importance of the S2-P2 interactions for potency and selectivity
Bioorg Chem22, 227-241. I
Kirschke,H. and Wiederanders,B.
Cathepsin S and related lysosomal endopeptidases
Methods Enzymol244, 500-511. PubMed Europe PubMed DOI V
Rakoczy,P.E., Mann,K., Cavaney,D.M., Robertson,T., Papadimitreou,J. and Constable,I.J.
Detection and possible functions of a cysteine protease involved in digestion of rod outer segments by retinal pigment epithelial cells
Invest Ophthalmol Vis Sci35, 4100-4108. PubMed Europe PubMed K
[YEAR:14-2-1994]Turk,B., Colic,A., Stoka,V. and Turk,V.
Kinetics of inhibition of bovine cathepsin S by bovine stefin B
FEBS Lett339, 155-159. PubMed Europe PubMed DOI

1993

Bromme,D., Bonneau,P.R., Lachance,P., Wiederanders,B., Kirschke,H., Peters,C., Thomas,D.Y., Storer,A.C. and Vernet,T.
Functional expression of human cathepsin S in Saccharomyces cerevisiae. Purification and characterization of the recombinant enzyme
J Biol Chem268, 4832-4838. PubMed Europe PubMed
Menard,R., Carmona,E., Plouffe,C., Bromme,D., Konishi,Y., Lefebvre,J. and Storer,A.C.
The specificity of the S1' subsite of cysteine proteases
FEBS Lett328, 107-110. PubMed Europe PubMed DOI
Shaw,E., Mohanty,S., Colic,A., Stoka,V. and Turk,V.
The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpain
FEBS Lett334, 340-342. PubMed Europe PubMed DOI I

1992

Dolenc,I., Ritonja,A., Colic,A., Podobnik,M., Ogrinc,T. and Turk,V.
Bovine cathepsins S and L: isolation and amino acid sequences
Biol Chem Hoppe Seyler373, 407-412. PubMed Europe PubMed
Shi,G.P., Munger,J.S., Meara,J.P., Rich,D.H. and Chapman,H.A.
Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease
J Biol Chem267, 7258-7262. PubMed Europe PubMed
Wiederanders,B., Bromme,D., Kirschke,H., von Figura,K., Schmidt,B. and Peters,C.
Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S
J Biol Chem267, 13708-13713. PubMed Europe PubMed

1991

Bromme,D., Rinne,R. and Kirschke,H.
Tight-binding inhibition of cathepsin S by cystatins
Biomed Biochim Acta50, 631-635. PubMed Europe PubMed
Ritonja,A., Colic,A., Dolenc,I., Ogrinc,T., Podobnik,M. and Turk,V.
The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L
FEBS Lett283, 329-331. PubMed Europe PubMed DOI
Wiederanders,B., Broemme,D., Kirschke,H., Kalkkinen,N., Rinne,A., Paquette,T. and Toothman,P.
Primary structure of bovine cathepsin S. Comparison to cathepsins L, H, B and papain
FEBS Lett286, 189-192. PubMed Europe PubMed DOI

1989

[YEAR:1-12-1989]Bromme,D., Steinert,A., Friebe,S., Fittkau,S., Wiederanders,B. and Kirschke,H.
The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B
Biochem J264, 475-481. PubMed Europe PubMed
[YEAR:1-12-1989]Kirschke,H., Wiederanders,B., Bromme,D. and Rinne,A.
Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins
Biochem J264, 467-473. PubMed Europe PubMed

1986

Kirschke,H., Schmidt,I. and Wiederanders,B.
Cathepsin S. The cysteine proteinase from bovine lymphoid tissue is distinct from cathepsin L (EC 3.4.22.15)
Biochem J240, 455-459. PubMed Europe PubMed

1975

Turnsek,T., Kregar,I. and Lebez,D.
Acid sulphydryl protease from calf lymph nodes
Biochim Biophys Acta403, 514-520. PubMed Europe PubMed