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Inhibitors for peptidase C01.032: cathepsin L

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma
MERID Inhibitor Inhibitor name Ki Conditions Reference
I02.036 FhKT1 (Fasciola hepatica) 1.6 nm Smith et al., 2016
I02.056 HWTI trypsin inhibitor (Ornithoctonus huwena) Kodama et al., 2020
I03.012 cruzipain inhibitor (Bauhinia bauhinioides) 0.22 nM De Oliveira et al., 2001
I03.016 Bauhinia trypsin/plasma kallikrein inhibitor 0.2 nM Valois et al., 2020
I04.004 protein C inhibitor Fortenberry et al., 2010
I04.008 squamous cell carcinoma antigen 1 0.064 nM Takeda et al., 1995
I04.017 serpin B13 Jayakumar et al., 2003
I04.033 myeloid and erythroid nuclear termination stage-specific protein (Gallus gallus)  
I04.036 colligin 2 Siavash et al., 2002
I04.041 serpin srp-2 (Caenorhabditis elegans) Pak et al., 2002
I04.042 serpinb3b (Mus musculus) Sakata et al., 2004
I04.048 endopin 2C Hwang et al., 2005
I04.081 serpin SRP-6 (Caenorhabditis elegans) Luke et al., 2007
I25.001 cystatin A 1.3 nM Barrett et al., 1986
I25.003 cystatin B 0.23 nM Barrett et al., 1986
I25.004 cystatin C <0.005 nM Abrahamson, 1994
I25.005 cystatin D 25 nM Abrahamson, 1994
I25.006 cystatin 6 1.78 nM Cheng et al., 2006
I25.007 cystatin F 0.31 nM Ni et al., 1998
I25.011 ovocystatin 0.019 nM Barrett et al., 1986
I25.014 phytocystatin CaneCPI-2 0.17 nM Shibao et al., 2020
I25.014 phytocystatin CaneCPI-3 0.6 nM Shibao et al., 2020
I25.014 phytocystatin CaneCPI-5 0.34 nM Shibao et al., 2020
I25.014 phytocystatin CaneCPI-6 6.94 nM Shibao et al., 2020
I25.014 phytocystatin CPI-2 ({Citrus sinensis}) 0.018 nM Schneider et al., 2020
I25.016 kininogen inhibitor unit 2 0.14 nM Barrett et al., 1986
I25.017 kininogen inhibitor unit 3 0.005 nM Barrett et al., 1986
I25.018 T-kininogen inhibitor unit 2 Moreau et al., 1988
I25.019 T-kininogen inhibitor unit 3 Moreau et al., 1988
I25.022 histidine-rich glycoprotein inhibitor unit 1 0.1 nM Marks et al., 1988
I25.033 phytocystatin (Actinidia sp.) 0.001 nM Rassam & Laing, 2004
I25.045 caneCPI cystatin (Saccharum sp.) 0.021 nM Gianotti et al., 2008
I25.045 caneCPI cystatin (Saccharum sp.) CaneCPI-4 0.021 nM Shibao et al., 2020
I25.049 sialostatin L (Ixodes scapularis) Kotsyfakis et al., 2006
I25.049 sialostatin L (Ixodes scapularis) cystatin 2b ({Rhipicephalus microplus}) 2.48 nM <%Parizi et al., 2015%>
I25.049 sialostatin L (Ixodes scapularis) cystatin 2a ({Ixodes ovatus}) 4.39 nM <%Parizi et al., 2015%>
I25.049 sialostatin L (Ixodes scapularis) cystatin 2c ({Rhipicephalus microplus}) 28.45 nM <%Parizi et al., 2015%>
I25.049 sialostatin L (Ixodes scapularis) ricistatin ({Ixodes ricinus}) 8.43 nM Martins et al., 2023
I25.051 cystatin Hv-CPI1 (Hordeum vulgare) CaneCPI-1 0.6 nM Shibao et al., 2020
I25.054 cystatin Hv-CPI5 (Hordeum vulgare) CPI-1 ({Citrus clementina}) 0.19 nM Schneider et al., 2020
I25.064 cystatin RHcyst-1 (Rhipicephalus haemaphysaloides) Rhcyst-1 <%Wang et al., 2015%>
I25.068 TK-cystatin (Thelohanellus kitauei) <%Zhang et al., 2020%>
I25.UPA subfamily I25A unassigned peptidase inhibitors FhCyLS-2 ({Fasciola hepatica}) Busa et al., 2023
I25.UPB subfamily I25B unassigned peptidase inhibitors CPI-1 ({Citrus sinensis}) 0.028 nM Schneider et al., 2020
I25.UPB subfamily I25B unassigned peptidase inhibitors CPI-2 ({Citrus clementina}) 0.006 nM Schneider et al., 2020
I25.UPB subfamily I25B unassigned peptidase inhibitors CPI-3 ({Citrus clementina}) 0.1 nM Schneider et al., 2020
I29.001 cathepsin L propeptide 0.12 nM Guay et al., 2000
I29.002 cytotoxic T-lymphocyte antigen-2 alpha 24 nM Delaria et al., 1994
I29.004 cathepsin S propeptide 0.46 nM Guay et al., 2000
I29.005 Bombyx-type cysteine peptidase inhibitor 0.036 nM Kurata et al., 2001
I29.007 cathepsin K propeptide 3.6-6.3 nM Guay et al., 2000
I29.008 cytotoxic T-lymphocyte antigen-2 beta 25 nM Delaria et al., 1994
I29.009 crammer peptidase inhibitor 0.43 nM Deshapriya et al., 2007
I29.010 cathepsin V propeptide 9.8 nM Burden et al., 2007
I29.UPW family I29 unassigned peptidase inhibitors cathepsin L3 propeptide ({Fasciola hepatica}) Pritsch et al., 2020
I31.002 MHC II invariant chain p41 form 1.7 pM Bevec et al., 1996
I31.006 testican-1 0.7 nM Bocock et al., 2003
I31.UPW family I31 unassigned peptidase inhibitors thyropin ({Ixodes ricinus}) Matouskova et al., 2024
I31.UPW family I31 unassigned peptidase inhibitors EpCAM (Epithelial cell adhesion molecule) Sankpal %etla, 2021
I39.001 alpha-2-macroglobulin Barrett, 1981
I48.001 clitocypin 0.41 nM Brzin et al., 2000
I71.001 falstatin 0.032 nM Pandey et al., 2006
I81.001 toxostatin-1 (Toxoplasma gondii) Huang et al., 2009
I85.001 macrocypin 1 3.81 nm natural inhibitor Sabotic et al., 2009
I85.002 macrocypin 3 0.31 nm recombinant form Sabotic et al., 2009
I85.003 macrocypin 4 2.76 nm recombinant form Sabotic et al., 2009
calpain inhibitor IV Angliker et al., 1992
CLIK-071 Katunuma et al., 1999
CLIK-195 CLIK-195 Katunuma et al., 2003
CLIK-195 Kihara et al., 2002
KGP94 Chavarria et al., 2012
gallinamide A 9000 Miller et al., 2014
small-molecule inhibitors of cysteine peptidases Z-Phe-Gly-NHO-Bz  
small-molecule inhibitors of cysteine peptidases vinyl ester compound 23 Shah et al., 2010
small-molecule inhibitors of cysteine peptidases gallinamide A 9000 M-1s-1 Miller et al., 2014
small-molecule inhibitors of cysteine peptidases ortho-benzyloxyl phenylacetyl derivative 1 Yuan et al., 2018
small-molecule inhibitors of cysteine peptidases p-toluenesulfonyl derivative 3 Yuan et al., 2018
small-molecule inhibitors of cysteine peptidases Caffeic acid Ulcakar & Novinec, 2020
small-molecule inhibitors of cysteine peptidases azanitrile 8 Breidenbach et al., 2021
small-molecule inhibitors of cysteine peptidases Z-Tyr-Ala-CHN(2) Doijen et al., 2023
small-molecule inhibitors of cysteine peptidases CV11 Ciaglia et al., 2024
small-molecule inhibitors of cysteine peptidases RI175 Meewan et al., 2022
small-molecule inhibitors of cysteine peptidases RI173 Meewan et al., 2022
small-molecule inhibitors of cysteine peptidases RI172 Meewan et al., 2022
small-molecule inhibitors of cysteine peptidases Z-Phe-Tyr-CHO Zhou et al., 2024
small-molecule inhibitors of cysteine peptidases IMB 8015 Zhou et al., 2024
small-molecule inhibitors of cysteine peptidases SM141 Mondal et al., 2022
small-molecule inhibitors of cysteine peptidases SM142 Mondal et al., 2022
small-molecule inhibitors of cysteine peptidases Teicoplanin Yu et al., 2022
small-molecule inhibitors of cysteine peptidases daptomycin Yang et al., 2022
small-molecule inhibitors of cysteine peptidases peptide R(S) 1A Phan et al., 2021
small-molecule inhibitors of cysteine peptidases VPC285786 Smith et al., 2026
leupeptin Kirschke et al., 1976
leupeptin leupeptin hemisulfate Yang et al., 2022
boceprevir Hu et al., 2021
aldehyde, ketone, glyoxal, or semicarbazone inhibitors of cysteine peptidases peptidomimetic alpha-ketoamide compound 14a Xie et al., 2024
aldehyde, ketone, glyoxal, or semicarbazone inhibitors of cysteine peptidases peptidomimetic alpha-ketoamide compound 14b Xie et al., 2024
aldehyde, ketone, glyoxal, or semicarbazone inhibitors of cysteine peptidases tripeptide aldehyde D6-3 Deng et al., 2024
SJA6017 Inoue et al., 2003
ALLN 0.5 nM Sasaki et al., 1990
ALLN Yang et al., 2022
ALLM 0.6 nM Sasaki et al., 1990
ALLM Hu et al., 2021
calpeptin Yang et al., 2022
nitrile inhibitors of cysteine peptidases compound 35 9.3 (pKi) Ribeiro et al., 2020
nitrile inhibitors of cysteine peptidases compound 36 9.8 (pKi) Ribeiro et al., 2020
NapSul-Ile-Trp-CHO Rebbaa et al., 2009
Z-FY-CHO 0.6nM Shenoy & Sivaraman, 2011
peptidyl cyclopropenone inhibitor of cysteine peptidase compound 8f Ando et al., 1999
GC376 Hu et al., 2021
calpain inhibitor XII  
calpain inhibitor XII Hu et al., 2021
proteasome inhibitor aldehydes Falke et al., 2024
MG132 Yang et al., 2022
E64 half-time: 0.7s at 10 microM inhibitor Salvesen & Nagase, 2001
E64d Tamai et al., 1986
CLIK148 Tsuge et al., 1999
CLIK148 CLIK-148 Katunuma et al., 2003
CAA0225 Takahashi et al., 2009
AM4299 AM4299A Morishita et al., 1994
AM4299 AM4299B Morishita et al., 1994
CLIK-066 Katunuma et al., 1999
CLIK-088 Katunuma et al., 1999
CLIK-112 Katunuma et al., 1999
CLIK-121 Katunuma et al., 1999
CLIK-181 Katunuma et al., 1999
CLIK-185 Katunuma et al., 1999
CLIK-187 Katunuma et al., 1999
Z-Phe-Tyr(OBut)-CHN(2) Shaw et al., 1993
BIL-DMK diazomethane inhibitor of cysteine peptidases Falgueyret et al., 2004
BIL-DMK diazomethane inhibitor of cysteine peptidases Z-Phe-Ala fluoromethyl ketone  
Z-Leu-Leu-Tyr-FMK Angliker et al., 1992
Z-FA-FMK Yang et al., 2022
Z-DEVD-FMK z-DEVD-cmk k2/K1 = 36000 M-1s-1 Rozman-Pungercar et al., 2003
Ac-YVAD-CMK k2/K1 = 1900 M-1s-1 Rozman-Pungercar et al., 2003
Z-Phe-Phe-fluoromethane Wang et al., 2013
peptide isostere cysteine peptidase inhibitors omicsynin B4 Li et al., 2023
K777 Jacobsen et al., 2000
peptide inhibitors of cysteine peptidases propeptide-based inhibitor biphenyl-4-yl-acetaldehyde-Cys-D-Arg-Tyr-2-phenylethylamine Chowdhury et al., 2002
peptide inhibitors of cysteine peptidases peptide SnuCalCpI03 ({Calotropis procera}) Kwon et al., 2022
peptide inhibitors of cysteine peptidases peptide SnuCalCpI15 ({Calotropis procera}) Kwon et al., 2022
allicin Waag et al., 2010
resveratrol miyabenol C Wang et al., 2023
resveratrol trans-epsilon-viniferin Wang et al., 2023
metal-containing inhibitor of threonine peptidase (general) zinc pyrithione Kladnik et al., 2022
LI25.002 kininogen 0.017 nM Barrett et al., 1986
LI25.003 T-kininogen 0.18 nM Moreau et al., 1988
LI31.001 equistatin 0.051 nM Lenarcic et al., 1997
S60.001 lactoferrin  

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