Literature for peptidase C01.032: cathepsin L

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Goto,A., Omori,K., Yamaguchi-Tomikawa,T., Kobayashi,H., Shinoda-Ito,Y., Hirai,K., Ikeda,A. and Takashiba,S.
Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways
Front Dent Med6, 1547222-1547222. PubMed Europe PubMed DOI
Modenbach,J.M., Moller,C., Asgarbeik,S., Geist,N., Rimkus,N., Dorr,M., Wolfgramm,H., Steil,L., Susemihl,A., Graf,L., Schmoker,O., Bottcher,D., Hammer,E., Glaubitz,J., Lammers,M., Delcea,M., Volker,U., Aghdassi,A.A., Lerch,M.M., Weiss,F.U., Bornscheuer,U.T. and Sendler,M.
Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis
Nat Commun16, 1702-1702. PubMed Europe PubMed DOI
Ntemafack,A., Dzelamonyuy,A., Nchinda,G. and Bopda Waffo,A.
Mapping Immunological, Host Receptor Binding Determinants, and Cathepsin Cleavage Site of EBOV Glycoprotein Utilizing the Qubevirus Platform
ACS Omega10, 14283-14295. PubMed Europe PubMed DOI
Paliwal,P., Desai,D. and Datta,M.
Novel selective and sensitive electrochemical sensor for detection of ovarian cancer biomarker, Cathepsin L
Bioelectrochemistry162, 108856-108856. PubMed Europe PubMed DOI

2024

Bestle,D., Bittel,L., Werner,A.D., Kamper,L., Dolnik,O., Krahling,V., Steinmetzer,T. and Bottcher-Friebertshauser,E.
Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage
Virus Res347, 199430-199430. PubMed Europe PubMed DOI K
Bolsinger,M.M., Drobny,A., Wilfling,S., Reischl,S., Krach,F., Moritz,R., Balta,D., Hehr,U., Sock,E., Bleibaum,F., Hanses,F., Winner,B., Huarcaya,S.P., Arnold,P. and Zunke,F.
SARS-CoV-2 Spike Protein Induces Time-Dependent CTSL Upregulation in HeLa Cells and Alveolarspheres
J Cell Biocheme30627-e30627. PubMed Europe PubMed DOI
Chiang,Y.R., Lin,H.T., Chang,C.W., Lin,S.M. and Lin,J.H.
Dynamic expression of cathepsin L in the black soldier fly (Hermetia illucens) gut during Escherichia coli challenge
PLoS ONE19, e0298338-e0298338. PubMed Europe PubMed DOI
Ciaglia,T., Vestuto,V., Di Sarno,V., Musella,S., Smaldone,G., Di Matteo,F., Napolitano,V., Miranda,M.R., Pepe,G., Basilicata,M.G., Novi,S., Capolupo,I., Bifulco,G., Campiglia,P., Gomez-Monterrey,I., Snoeck,R., Andrei,G., Manfra,M., Ostacolo,C., Lauro,G. and Bertamino,A.
Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization
Eur J Med Chem266, 116128-116128. PubMed Europe PubMed DOI I
Deng,W., Hu,X., Tian,X., Zhang,Y., Shang,W., Zhang,L. and Shang,L.
Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L
J Med Chem67, 17124-17143. PubMed Europe PubMed DOI I
Falke,S., Lieske,J., Herrmann,A., Loboda,J., Karnicar,K., Gunther,S., Reinke,P.Y.A., Ewert,W., Usenik,A., Lindic,N., Sekirnik,A., Dretnik,K., Tsuge,H., Turk,V., Chapman,H.N., Hinrichs,W., Ebert,G., Turk,D. and Meents,A.
Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors
J Med Chem67, 7048-7067. PubMed Europe PubMed DOI I
Jangra,S., Raghav,N., Wadhwa,D., Kumar,A., Bhattacharyya,S., Kumar,V. and Sheokand,J.
Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents
J Biomater Sci Polym Ed1-19. PubMed Europe PubMed DOI I
Kakizaki,M., Hashimoto,R., Nagata,N., Yamamoto,T., Okura,T., Katoh,H., Kitai,Y., Akahori,Y., Shirato,K., Ryo,A., Takayama,K. and Takeda,M.
The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids
J Virole0185324-e0185324. PubMed Europe PubMed DOI
Kim,M.J., Kim,S., Reinheckel,T. and Krainc,D.
Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase
JCI Insight9, PubMed Europe PubMed DOI
Lu,J., Liang,J., Xiao,G., He,Z., Yu,G., Zhang,L., Cai,C., Yi,G. and Xie,J.
Cathepsin L in Lung Adenocarcinoma: Prognostic Significance and Immunotherapy Response Through a Multi Omics Perspective
Cancer Inform23, 11769351241307492-11769351241307492. PubMed Europe PubMed DOI
Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X.
Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19
Med5, 42-61. PubMed Europe PubMed DOI I
Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X.
Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19
Med5, 169-171. PubMed Europe PubMed DOI I
Matouskova,Z., Orsaghova,K., Srb,P., Pytelkova,J., Kukacka,Z., Busa,M., Hajdusek,O., Sima,R., Fabry,M., Novak,P., Horn,M., Kopacek,P. and Mares,M.
An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans
Int J Mol Sci25, PubMed Europe PubMed DOI
Matsuki,A., Watanabe,Y., Hashimoto,S., Hoshino,A. and Matoba,S.
Cathepsin L prevents the accumulation of alpha-synuclein fibrils in the cell
Genes Cells29, 328-336. PubMed Europe PubMed DOI
Moller,C., Rimkus,N., Skala,F.F.O., Merouze,M., Bottcher,D., Dorr,M. and Bornscheuer,U.T.
Improved recombinant expression of soluble cathepsin B and L in Escherichia coli
Appl Microbiol Biotechnol108, 536-536. PubMed Europe PubMed DOI
Oliveira,B.R., Nehlmeier,I., Kempf,A.M., Venugopalan,V., Rehders,M., Ceniza,M.E.P., Cavalcanti,P.A.T.P., Hoffmann,M., Pohlmann,S. and Brix,K.
Cytoskeletal beta-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y
Biochimie226, 49-61. PubMed Europe PubMed DOI
Peng,Z., Luo,X.Y., Li,X., Li,Y., Wu,Y., Tian,Y., Pan,B., Petrovic,A., Kosanovic,D., Schermuly,R.T., Ruppert,C., Gunther,A., Zhang,Z., Qiu,C., Li,Y., Pu,J., Li,X. and Chen,A.F.
Cathepsin L Promotes Pulmonary Hypertension via BMPR2/GSDME-Mediated Pyroptosis
Hypertension81, 2430-2443. PubMed Europe PubMed DOI
Previti,S., Ettari,R., Calcaterra,E., Roggia,M., Natale,B., Weldert,A.C., Muller-Ruttloff,C., Salisch,F., Irto,A., Cigala,R.M., Ziebuhr,J., Schirmeister,T., Cosconati,S. and Zappala,M.
Identification of Dual Inhibitors Targeting Main Protease (M(pro)) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents
ACS Med Chem Lett15, 602-609. PubMed Europe PubMed DOI
Stuart,S., Tarade,D. and Ohh,M.
Cathepsins L and B target HIF1alpha for oxygen-independent proteolytic cleavage
Sci Rep14, 14799-14799. PubMed Europe PubMed DOI
Wu,Y., Jiang,D., Liu,Q., Yan,S., Liu,X., Wu,T., Sun,W. and Li,G.
Cathepsin L induces cellular senescence by upregulating CUX1 and p16(INK4a)
Aging (Albany NY)16, PubMed Europe PubMed DOI
Xie,X., Lan,Q., Zhao,J., Zhang,S., Liu,L., Zhang,Y., Xu,W., Shao,M., Peng,J., Xia,S., Zhu,Y., Zhang,K., Zhang,X., Zhang,R., Li,J., Dai,W., Ge,Z., Hu,S., Yu,C., Wang,J., Ma,D., Zheng,M., Yang,H., Xiao,G., Rao,Z., Lu,L., Zhang,L., Bai,F., Zhao,Y., Jiang,S. and Liu,H.
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
Signal Transduct Target Ther9, 54-54. PubMed Europe PubMed DOI I
Xu,B., Anderson,B.M., Mountford,S.J., Thompson,P.E., Mintern,J.D. and Edgington-Mitchell,L.E.
Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate
Biol Chem405, 351-365. PubMed Europe PubMed DOI
Yang,H., Zhou,J.N., Zhang,X.M., Ling,D.D., Sun,Y.B., Li,C.Y., Zhou,Q.Q., Shi,G.N., Wang,S.H., Lin,X.S., Fan,T., Wang,H.Y., Zeng,Q., Jia,Y.L., Xi,J.F., Jin,Y.G., Pei,X.T. and Yue,W.
Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS-CoV-2 Pseudovirus Entry into Lung ACE2(+) Cells
Adv Matere2310306-e2310306. PubMed Europe PubMed DOI
Zhang,K., Xu,R., Zheng,L., Zhang,H., Qian,Z., Li,C., Xue,M., He,Z., Ma,J., Li,Z., Chen,L., Ma,R. and Yao,B.
Elevated N-glycosylated cathepsin L impairs oocyte function and contributes to oocyte senescence during reproductive aging
Aging Celle14397-e14397. PubMed Europe PubMed DOI K
Zhang,Z., Wang,J., Shi,Y., Wang,B. and Wang,D.
Cathepsin L promotes oesophageal squamous cell carcinoma development and may be associated with tumour-associated macrophages
Heliyon10, e29273-e29273. PubMed Europe PubMed DOI
Zhou,W., You,B., Zheng,Y., Si,S., Li,Y. and Zhang,J.
Expression, purification, and biological activity evaluation of cathepsin L in mammalian cells
Biosci Biotechnol Biochem88, 405-411. PubMed Europe PubMed DOI
Zhou,W., You,B., Zhao,X., Si,S., Li,Y. and Zhang,J.
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors
SLAS Discov29, 100153-100153. PubMed Europe PubMed DOI I

2023

Abdelaziz,R.F., Hussein,A.M., Kotob,M.H., Weiss,C., Chelminski,K., Stojanovic,T., Studenik,C.R. and Aufy,M.
Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells
Int J Mol Sci24, PubMed Europe PubMed DOI
Doijen,J., Temmerman,K., Van den Eynde,C., Diels,A., Van den Broeck,N., Van Gool,M., Heo,I., Jaensch,S., Zwaagstra,M., Diosa Toro,M., Chiu,W., De Jonghe,S., Leyssen,P., Bojkova,D., Ciesek,S., Cinatl,J., Verschueren,L., Buyck,C., van Kuppeveld,F., Neyts,J., Van Loock,M. and Van Damme,E.
Identification of Z-Tyr-Ala-CHN(2), a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2
Microorganisms11, PubMed Europe PubMed DOI I
Ezz,M.A., Takahashi,M., Rivera,R.M. and Balboula,A.Z.
Cathepsin L regulates oocyte meiosis and preimplantation embryo development
Cell Prolife13526-e13526. PubMed Europe PubMed DOI
Fernandez-de-la-Pradilla,A., Royo,S., Schirmeister,T., Barthels,F., Swiderek,K., Gonzalez,F.V. and Moliner,V.
Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L
ACS Catal13, 13354-13368. PubMed Europe PubMed DOI
Grozdanic,M., Sobotic,B., Biasizzo,M., Sever,T., Vidmar,R., Vizovisek,M., Turk,B. and Fonovic,M.
Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer
Biol Chem405, 283-296. PubMed Europe PubMed DOI
Huang,H., Zhang,Y., Xu,X., Liu,Y., Zhao,J., Ma,L., Lei,J., Ge,W., Li,N., Ma,E., Li,Y. and Yuan,L.
Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells
Bioorg Med Chem Lett80, 129087-129087. PubMed Europe PubMed DOI I
Kondo,Y., Rajapakse,S. and Ogiwara,K.
Involvement of cathepsin L in the degradation and degeneration of postovulatory follicle of the medaka ovarydagger
Biol Reprod109, 904-917. PubMed Europe PubMed DOI
Li,Y., Wang,K., Sun,H., Wu,S., Wang,H., Shi,Y., Li,X., Yan,H., Yang,G., Wu,M., Li,Y., Ding,X., Si,S., Jiang,J., Du,Y., Li,Y. and Hong,B.
Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2
Antiviral Res214, 105606-105606. PubMed Europe PubMed DOI I
Mouawad,J.E., Sharma,S., Renaud,L., Pilewski,J.M., Nadig,S.N. and Feghali-Bostwick,C.
Reduced Cathepsin L Expression and Secretion into the Extracellular Milieu Contribute to Lung Fibrosis in Systemic Sclerosis
Rheumatology (Oxford)62, 1306-1316. PubMed Europe PubMed DOI
Tang,T.T., Li,S.M., Pan,B.W., Xiao,J.W., Pang,Y.X., Xie,S.X., Zhou,Y., Yang,J. and Wei,Y.
Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure-Activity Relationships
Molecules28, PubMed Europe PubMed DOI I
Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D.
Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
Commun Biol6, 450-450. PubMed Europe PubMed DOI
Wang,C., Ye,X., Ding,C., Zhou,M., Li,W., Wang,Y., You,Q., Zong,S., Peng,Q., Duanmu,D., Chen,H., Sun,B. and Qiao,J.
Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry
J Agric Food Chem71, 5535-5546. PubMed Europe PubMed DOI I

2022

Denamur,S., Chazeirat,T., Maszota-Zieleniak,M., Vives,R.R., Saidi,A., Zhang,F., Linhardt,R.J., Labarthe,F., Samsonov,S.A., Lalmanach,G. and Lecaille,F.
Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: Putative consequences in mucopolysaccharidosis
Carbohydr Polym293, 119734-119734. PubMed Europe PubMed DOI
Gaikwad,P. and Kemp,M.G.
Cathepsin L inhibition prevents the cleavage of multiple nuclear proteins upon lysis of quiescent human cells
MicroPubl Biol2022, PubMed Europe PubMed DOI
Islam,M.I., Nagakannan,P., Shcholok,T., Contu,F., Mai,S., Albensi,B.C., Del Bigio,M.R., Wang,J.F., Sharoar,M.G., Yan,R., Park,I.S. and Eftekharpour,E.
Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer's disease
Aging Cell21, e13531-e13531. PubMed Europe PubMed DOI
Kladnik,J., Dolinar,A., Kljun,J., Perea,D., Grau-Exposito,J., Genesca,M., Novinec,M., Buzon,M.J. and Turel,I.
Zinc pyrithione is a potent inhibitor of PL(Pro) and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication
J Enzyme Inhib Med Chem37, 2158-2168. PubMed Europe PubMed DOI
Kwon,C.W., Yeo,S. and Chang,P.S.
Characterization and molecular docking study of cathepsin L inhibitory peptides (SnuCalCpIs) from Calotropis procera R. Br
Sci Rep12, 5825-5825. PubMed Europe PubMed DOI I
Li,C., Liu,Z., Chen,M., Zhang,L., Shi,R. and Zhong,H.
Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence
Biology (Basel)12, PubMed Europe PubMed DOI
Meewan,I., Kattoula,J., Kattoula,J.Y., Skinner,D., Fajtova,P., Giardini,M.A., Woodworth,B., McKerrow,J.H., Lage de Siqueira-Neto,J., O'Donoghue,A.J. and Abagyan,R.
Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L
Pharmaceuticals (Basel)15, PubMed Europe PubMed DOI I
Mondal,S., Chen,Y., Lockbaum,G.J., Sen,S., Chaudhuri,S., Reyes,A.C., Lee,J.M., Kaur,A.N., Sultana,N., Cameron,M.D., Shaffer,S.A., Schiffer,C.A., Fitzgerald,K.A. and Thompson,P.R.
Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2
J Am Chem Soc144, 21035-21045. PubMed Europe PubMed DOI K I
Novinec,M., Bembic,P., Jankovic,M., Kisilak,M., Kljun,J. and Turel,I.
Kinetic Characterization of Cerium and Gallium Ions as Inhibitors of Cysteine Cathepsins L, K, and S
Int J Mol Sci23, PubMed Europe PubMed DOI
Wang,S., Luke,C.J., Pak,S.C., Shi,V., Chen,L., Moore,J., Andress,A.P., Jayachandran,K., Zhang,J., Huang,Y., Platik,M., Apicelli,A.A., Schwarz,J.K., Grigsby,P.W., Silverman,G.A. and Markovina,S.
SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation
Commun Biol5, 46-46. PubMed Europe PubMed DOI
Wang,X., Liu,D., Liu,F., Xiao,L., Ni,H., Qi,X., Xing,K., Cai,D., Sheng,X. and Guo,Y.
Cathepsin L involved in the freezing resistance of murine normal hatching embryos and dormant embryos
Reprod Biol22, 100612-100612. PubMed Europe PubMed DOI
Yang,W.L., Li,Q., Sun,J., Huat Tan,S., Tang,Y.H., Zhao,M.M., Li,Y.Y., Cao,X., Zhao,J.C. and Yang,J.K.
Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy
Comput Struct Biotechnol J20, 2442-2454. PubMed Europe PubMed DOI I
Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V.
Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases
ACS Chem Neurosci13, 245-256. PubMed Europe PubMed DOI
Yu,F., Pan,T., Huang,F., Ying,R., Liu,J., Fan,H., Zhang,J., Liu,W., Lin,Y., Yuan,Y., Yang,T., Li,R., Zhang,X., Lv,X., Chen,Q., Liang,A., Zou,F., Liu,B., Hu,F., Tang,X., Li,L., Deng,K., He,X., Zhang,H., Zhang,Y. and Ma,X.
Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L
Front Microbiol13, 884034-884034. PubMed Europe PubMed DOI I
Zhao,M.M., Zhu,Y., Zhang,L., Zhong,G., Tai,L., Liu,S., Yin,G., Lu,J., He,Q., Li,M.J., Zhao,R.X., Wang,H., Huang,W., Fan,C., Shuai,L., Wen,Z., Wang,C., He,X., Chen,Q., Liu,B., Xiong,X., Bu,Z., Wang,Y., Sun,F. and Yang,J.K.
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies
Cell Discov8, 53-53. PubMed Europe PubMed DOI

2021

Almasi,F. and Mohammadipanah,F.
Hypothetical targets and plausible drugs of coronavirus infection caused by SARS-CoV-2
Transbound Emerg Dis68, 318-332. PubMed Europe PubMed DOI
Berdowska,I. and Matusiewicz,M.
Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis - with impact on gastrointestinal tract
World J Gastroenterol27, 6590-6600. PubMed Europe PubMed DOI
Bollavaram,K., Leeman,T.H., Lee,M.W., Kulkarni,A., Upshaw,S.G., Yang,J., Song,H. and Platt,M.O.
Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V
Protein Sci PubMed Europe PubMed DOI
Breidenbach,J., Lemke,C., Pillaiyar,T., Schakel,L., Al Hamwi,G., Diett,M., Gedschold,R., Geiger,N., Lopez,V., Mirza,S., Namasivayam,V., Schiedel,A.C., Sylvester,K., Thimm,D., Vielmuth,C., Phuong Vu,L., Zyulina,M., Bodem,J., Gutschow,M. and Muller,C.E.
Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors
Angew Chem Int Ed Engl PubMed Europe PubMed DOI I
Caval,T., Hecht,E.S., Tang,W., Uy-Gomez,M., Nichols,A., Kil,Y.J., Sandoval,W., Bern,M. and Heck,A.J.R.
The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies
FEBS J PubMed Europe PubMed DOI
Choudhury,D. and Biswas,S.
Structure-guided protein engineering of human cathepsin L for efficient collagenolytic activity
Protein Eng Des Sel34, PubMed Europe PubMed DOI
Dominguez-Hernandez,E. and Ertbjerg,P.
Effect of LTLT heat treatment on cathepsin B and L activities and denaturation of myofibrillar proteins of pork
Meat Sci175, 108454-108454. PubMed Europe PubMed DOI
Eckl,K.M., Gruber,R., Brennan,L., Marriott,A., Plank,R., Moosbrugger-Martinz,V., Blunder,S., Schossig,A., Altmuller,J., Thiele,H., Nurnberg,P., Zschocke,J., Hennies,H.C. and Schmuth,M.
Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V
Front Genet12, 689940-689940. PubMed Europe PubMed DOI
Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J.
Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses
ACS Infect Dis7, 586-597. PubMed Europe PubMed DOI I
Huang,M., Chen,S.P., Dai,Y.Y., Yang,Y., Jiang,W., Wang,F., Zhang,J.X. and Zhu,Q.X.
[Cathepsin L mediates glomerular endothelial cell injury by cleavaging complement C3 in trichloroethylene-sensitized mice]
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi39, 5-11. PubMed Europe PubMed DOI
IstIflI,E.S., SihoGlu Tepe,A., Netz,P.A., SarikUrkcU,C., Kilic,I.H. and Tepe,B.
Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols
Turk J Biol45, 484-502. PubMed Europe PubMed DOI
Jackson,C.B., Farzan,M., Chen,B. and Choe,H.
Mechanisms of SARS-CoV-2 entry into cells
Nat Rev Mol Cell Biol PubMed Europe PubMed DOI V
Kim,J.Y., Lee,E.J., Ahn,Y., Park,S., Bae,Y.J., Kim,T.G. and Oh,S.H.
Cathepsin L, a Target of Hypoxia-Inducible Factor-1-alpha, Is Involved in Melanosome Degradation in Melanocytes
Int J Mol Sci22, PubMed Europe PubMed DOI
Li,Y., Ai,X., Zou,C., Liu,Y., Ma,L., Men,J., Liu,D., Sheng,L., Ruan,X., Liu,H., Li,W., Ma,E. and Yuan,L.
Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells
Bioorg Chem115, 105256-105256. PubMed Europe PubMed DOI I
Mellott,D.M., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D.H., Hsu,J., Zhu,J., Taylor,Z.W., Kocurek,K.I., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Yoon,M.C., Beck,S., Carlin,A.F., Clark,A.E., Beretta,L., Maneval,D., Hook,V., Frueh,F., Hurst,B.L., Wang,H., Raushel,F.M., O'Donoghue,A.J., de Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H.
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells
ACS Chem Biol16, 642-650. PubMed Europe PubMed DOI I
Munikishore,R., Wang,L.L., Zhang,S., Zhao,Q.S. and Zuo,Z.
An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94
Bioorg Chem116, 105317-105317. PubMed Europe PubMed DOI I
Nagahama,M., Kobayashi,K. and Takehara,M.
Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin
Toxins (Basel)13, PubMed Europe PubMed DOI
Pathak,M., Vani,V. and Seshagiri,P.B.
Expression and function of interleukin-1beta is required for hamster blastocyst hatching: Involvement of hatching-associated cathepsin proteases
Mol Reprod Dev88, 274-286. PubMed Europe PubMed DOI
Phan,H.A.T., Giannakoulias,S.G., Barrett,T.M., Liu,C. and Petersson,E.J.
Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L
Chem Sci12, 10825-10835. PubMed Europe PubMed DOI I
Reed,B., Crawford,F., Hill,R.C., Jin,N., White,J., Krovi,S.H., Marrack,P., Hansen,K. and Kappler,J.W.
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation
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Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms: A systematic review of in vitro and in vivo studies
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Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis
Int Immunopharmacol93, 107425-107425. PubMed Europe PubMed DOI
Steuten,K., Kim,H., Widen,J.C., Babin,B.M., Onguka,O., Lovell,S., Bolgi,O., Cerikan,B., Neufeldt,C.J., Cortese,M., Muir,R.K., Bennett,J.M., Geiss-Friedlander,R., Peters,C., Bartenschlager,R. and Bogyo,M.
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19
ACS Infect Dis PubMed Europe PubMed DOI
Valois,M.V., de Oliveira,C., Lapa,A.J., Souccar,C. and Oliva,M.L.V.
Bauhinia Protease Inhibitors Attenuate Gastric Ulcer by Blocking Neutrophil Enzymes
Planta Med87, 169-176. PubMed Europe PubMed DOI
Yang,J., Chen,T. and Zhou,Y.
Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes
Hereditas158, 4-4. PubMed Europe PubMed DOI
Yu,C., Wan,Y., Xu,W., Jin,X., Zhang,S., Xin,M., Jiang,H. and Cheng,X.
Increased Circulating Cathepsin L in Patients with Coronary Artery Disease
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Zhao,M.M., Yang,W.L., Yang,F.Y., Zhang,L., Huang,W.J., Hou,W., Fan,C.F., Jin,R.H., Feng,Y.M., Wang,Y.C. and Yang,J.K.
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
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2020

Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R.
Potential protease inhibitors and their combinations to block SARS-CoV-2
J Biomol Struct Dyn1-15. PubMed Europe PubMed DOI I
Arafet,K., Gonzalez,F.V. and Moliner,V.
Quantum mechanics/molecular mechanics studies of the mechanism of cysteine proteases inhibition by dipeptidyl nitroalkenes
Chemistry26, 2002-2012. PubMed Europe PubMed DOI I
Ashhurst,A.S., Tang,A.H., Fajtova,P., Yoon,M., Aggarwal,A., Stoye,A., Larance,M., Beretta,L., Drelich,A., Skinner,D., Li,L., Meek,T.D., McKerrow,J.H., Hook,V., Tseng,C.K., Turville,S., Gerwick,W.H., O'Donoghue,A.J. and Payne,R.J.
Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L
bioRxiv PubMed Europe PubMed DOI I
Barnett,B.P., Wahlin,K., Krawczyk,M., Spencer,D., Welsbie,D., Afshari,N. and Chao,D.
Potential of Ocular Transmission of SARS-CoV-2: A Review
Vision (Basel)4, PubMed Europe PubMed DOI V
Blaess,M., Kaiser,L., Sauer,M., Csuk,R. and Deigner,H.P.
COVID-19/SARS-CoV-2 Infection: Lysosomes and Lysosomotropism Implicate New Treatment Strategies and Personal Risks
Int J Mol Sci21, PubMed Europe PubMed DOI
Braz,H.L.B., Silveira,J.A.M., Marinho,A.D., de Moraes,M.E.A., Moraes Filho,M.O., Monteiro,H.S.A. and Jorge,R.J.B.
In silico study of azithromycin, chloroquine and hydroxychloroquine and their potential mechanisms of action against SARS-CoV-2 infection
Int J Antimicrob Agents106119-106119. PubMed Europe PubMed DOI
Brings,S., Fleming,T., Herzig,S., Nawroth,P.P. and Kopf,S.
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study
J Diabetes Complications107648-107648. PubMed Europe PubMed DOI
Chen,J., Zhang,L., Yang,N., Cao,M., Tian,M., Fu,Q., Su,B. and Li,C.
Characterization of the immune roles of cathepsin L in turbot (Scophthalmus maximus L.) mucosal immunity
Fish Shellfish Immunol97, 322-335. PubMed Europe PubMed DOI
Cianni,L., Rocho,F.D.R., Rosini,F., Bonatto,V., Ribeiro,J.F.R., Lameira,J., Leitao,A., Shamim,A. and Montanari,C.A.
Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases
Bioorg Chem101, 104039-104039. PubMed Europe PubMed DOI I
Dana,D. and Pathak,S.K.
A review of small molecule inhibitors and functional probes of human cathepsin L
Molecules25, PubMed Europe PubMed DOI V I
Eapen,M.S., Lu,W., Hackett,T.L., Singhera,G.K., Thompson,I.E., McAlinden,K.D., Hardikar,A., Weber,H.C., Haug,G., Wark,P.A.B., Chia,C. and Sohal,S.S.
Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections
Am J Physiol Lung Cell Mol Physiol PubMed Europe PubMed DOI
Filippova,I.Y., Dvoryakova,E.A., Sokolenko,N.I., Simonyan,T.R., Tereshchenkova,V.F., Zhiganov,N.I., Dunaevsky,Y.E., Belozersky,M.A., Oppert,B. and Elpidina,E.N.
New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family
Front Mol Biosci7, 578758-578758. PubMed Europe PubMed DOI
Fonseca Lameiro,R.D., Shamim,A., Rosini,F., Cendron,R., Jatai Batista,P.H. and Montanari,C.A.
Synthesis, biochemical evaluation and molecular modeling studies of nonpeptidic nitrile-based fluorinated compounds
Future Med Chem PubMed Europe PubMed DOI
Gomes,C.P., Fernandes,D.E., Casimiro,F., da Mata,G.F., Passos,M.T., Varela,P., Mastroianni-Kirsztajn,G. and Pesquero,J.B.
Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics
Front Cell Infect Microbiol10, 589505-589505. PubMed Europe PubMed DOI
Jaimes,J., Millet,J. and Whittaker,G.
Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site
SSRN3581359-3581359. PubMed Europe PubMed DOI
Kerslake,R., Hall,M., Randeva,H.S., Spandidos,D.A., Chatha,K., Kyrou,I. and Karteris,E.
Coexpression of peripheral olfactory receptors with SARSCoV2 infection mediators: Potential implications beyond loss of smell as a COVID19 symptom
Int J Mol Med46, 949-956. PubMed Europe PubMed DOI
Kodama,R.T., Kuniyoshi,A.K., da Silva,C.C.F., Cajado-Carvalho,D., Duzzi,B., Mariano,D.C., Pimenta,D.C., Borges,R., da Silva,W.D. and Portaro,F.C.V.
A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases
J Venom Anim Toxins Incl Trop Dis26, e20200037-e20200037. PubMed Europe PubMed DOI
Li,H., Xie,L., Chen,L., Zhang,L., Han,Y., Yan,Z. and Guo,X.
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer
Aging (Albany NY)12, 22370-22389. PubMed Europe PubMed DOI
Liu,H., Gai,S., Wang,X., Zeng,J., Sun,C., Zhao,Y. and Zheng,Z.
Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart
Cardiovasc Res116, 1733-1741. PubMed Europe PubMed DOI
Madadlou,A.
Food proteins are a potential resource for mining cathepsin L inhibitory drugs to combat SARS-CoV-2
Eur J Pharmacol885, 173499-173499. PubMed Europe PubMed DOI
Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H.
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
bioRxiv PubMed Europe PubMed DOI I
Mishra,C.B., Pandey,P., Sharma,R.D., Malik,M.Z., Mongre,R.K., Lynn,A.M., Prasad,R., Jeon,R. and Prakash,A.
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach
Brief Bioinform PubMed Europe PubMed DOI
Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S. and Singh,S.
Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases
Pharmaceuticals (Basel)14, PubMed Europe PubMed DOI
Niu,R., Wang,J., Geng,C., Li,Y., Dong,L., Liu,L., Chang,Y., Shen,J., Nie,Z., Zhang,Y. and Hu,B.
Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy
Aging (Albany NY)12, PubMed Europe PubMed DOI
Padmanabhan,P., Desikan,R. and Dixit,N.M.
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
PLoS Comput Biol16, e1008461-e1008461. PubMed Europe PubMed DOI
Parigiani,M.A., Ketscher,A., Timme,S., Bronsert,P., Schlimpert,M., Kammerer,B., Jacquel,A., Chaintreuil,P. and Reinheckel,T.
Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression
Cancers (Basel)12, PubMed Europe PubMed DOI K
Pritsch,I.C., Tikhonova,I.G., Jewhurst,H.L., Drysdale,O., Cwiklinski,K., Molento,M.B., Dalton,J.P. and Verissimo,C.M.
Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition
BMC Mol Cell Biol21, 90-90. PubMed Europe PubMed DOI
Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J.
Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity
Cancers (Basel)12, PubMed Europe PubMed DOI
Ribeiro,J.F.R., Cianni,L., Li,C., Warwick,T.G., De Vita,D., Rosini,F., Dos Reis Rocho,F., Martins,F.C.P., Kenny,P.W., Lameira,J., Leitao,A., Emsley,J. and Montanari,C.A.
Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor
Bioorg Med Chem28, 115743-115743. PubMed Europe PubMed DOI I
Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J.
Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L
Sci Adv PubMed Europe PubMed DOI I
Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J.
Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L
bioRxiv PubMed Europe PubMed DOI I
Seth,S., Batra,J. and Srinivasan,S.
COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response
Front Mol Biosci7, 215-215. PubMed Europe PubMed DOI V
Shi,X. and Zhang,Y.
A humanized antibody inhibitor for cathepsin L
Protein Sci29, 1924-1930. PubMed Europe PubMed DOI
Smith,D., Cwiklinski,K., Jewhurst,H., Tikhonova,I.G. and Dalton,J.P.
An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica
Sci Rep10, 20657-20657. PubMed Europe PubMed DOI
Toman,N.P., Kamenik,A.S., Santos,L.H., Hofer,F., Liedl,K.R. and Ferreira,R.S.
Profiling selectivity of chagasin mutants towards cysteine proteases cruzain or cathepsin L through molecular dynamics simulations
J Biomol Struct Dyn1-13. PubMed Europe PubMed DOI
Ulcakar,L. and Novinec,M.
Inhibition of Human Cathepsins B and L by Caffeic Acid and Its Derivatives
Biomolecules11, PubMed Europe PubMed DOI
Vargas-Alarcon,G., Posadas-Sanchez,R. and Ramirez-Bello,J.
Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies
Life Sci260, 118313-118313. PubMed Europe PubMed DOI
Vivek-Ananth,R.P., Rana,A., Rajan,N., Biswal,H.S. and Samal,A.
In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection
Molecules25, PubMed Europe PubMed DOI
Wang,Z., Xiang,Z., Zhu,T., Chen,J., Zhong,M.Z., Huang,J., Wang,K.S., Li,L., Sun,L.Q. and Zhou,W.B.
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer
Oncol Lett19, 167-176. PubMed Europe PubMed DOI

2019

Boudreau,P.D., Miller,B.W., McCall,L.I., Almaliti,J., Reher,R., Hirata,K., Le,T., Siqueira-Neto,J.L., Hook,V. and Gerwick,W.H.
Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain
J Med Chem62, 9026-9044. PubMed Europe PubMed DOI I
Dana,D., Garcia,J., Bhuiyan,A.I., Rathod,P., Joo,L., Novoa,D.A., Paroly,S., Fath,K.R., Chang,E.J. and Pathak,S.K.
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L
Bioorg Chem85, 505-514. PubMed Europe PubMed DOI L I
Luo,H., Tie,L., Cao,M., Hunter,A.K., Pabst,T.M., Du,J., Field,R., Li,Y. and Wang,W.K.
Cathepsin L causes proteolytic cleavage of Chinese hamste-ovary-cell expressed proteins during processing and storage: identification characterization and mitigation
Biotechnol Prog35, e2732-e2732. PubMed Europe PubMed DOI
Ma,K.X., Song,G.G., Wu,M., Zhang,H.C., Chen,G.W. and Liu,D.Z.
Identification of a potential tissue-specific biomarker cathepsin L-like gene from the planarian Dugesia japonica: molecular cloning, characterization, and expression in response to heavy metal exposure
Ecotoxicol Environ Saf180, 73-79. PubMed Europe PubMed DOI
Papanastasiou,M., Mullahoo,J., DeRuff,K.C., Bajrami,B., Karageorgos,I., Johnston,S.E., Peckner,R., Myers,S.A., Carr,S.A. and Jaffe,J.D.
Chasing tails: cathepsin-L improves structural analysis of histones by HX-MS
Mol Cell Proteomics18, 2089-2098. PubMed Europe PubMed DOI
Parks,A.N., Nahata,J., Edouard,N.E., Temenoff,J.S. and Platt,M.O.
Sequential, but not concurrent, incubation of cathepsin K and L with type I collagen results in extended proteolysis
Sci Rep9, 5399-5399. PubMed Europe PubMed DOI
Pranjol,M.Z.I., Gutowski,N.J., Hannemann,M. and Whatmore,J.L.
Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway
Curr Cancer Drug Targets19, 231-242. PubMed Europe PubMed DOI
Shockey,W.A., Kieslich,C.A., Wilder,C.L., Watson,V. and Platt,M.O.
Dynamic model of protease state and inhibitor trafficking to predict protease activity in breast cancer cells
Cell Mol Bioeng12, 275-288. PubMed Europe PubMed DOI I
Tokarzewicz,A., Romanowicz,L., Sankiewicz,A., Hermanowicz,A., Sobolewski,K. and Gorodkiewicz,E.
A new analytical method for determination of cathepsin L based on the surface plasmon resonance imaging biosensor
Int J Mol Sci20, PubMed Europe PubMed DOI A
Weiss-Sadan,T., Itzhak,G., Kaschani,F., Yu,Z., Mahameed,M., Anaki,A., Ben-Nun,Y., Merquiol,E., Tirosh,B., Kessler,B., Kaiser,M. and Blum,G.
Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation
Mol Cell Proteomics18, 1330-1344. PubMed Europe PubMed DOI I
Xue,Q., Wu,X.Q., Zhang,W.J., Deng,L.N. and Wu,M.M.
Cathepsin L-like cysteine proteinase genes are associated with the development and pathogenicity of pine wood nematode, Bursaphelenchus xylophilus
Int J Mol Sci20, PubMed Europe PubMed DOI
Yuan,L., Liu,J., He,W., Bao,Y., Sheng,L., Zou,C., Hu,B., Ge,W., Liu,Y., Wang,J., Lin,B., Li,Y. and Ma,E.
Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells
Bioorg Chem84, 239-253. PubMed Europe PubMed DOI I
Yuan,L., Zou,C., Ge,W., Liu,Y., Hu,B., Wang,J., Lin,B., Li,Y. and Ma,E.
A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis
Bioorg Chem103417-103417. PubMed Europe PubMed DOI I

2018

Aich,P. and Biswas,S.
Highly conserved Arg residue of ERFNIN motif of pro-domain is important for pH-induced zymogen activation process in cysteine cathepsins K and L
Cell Biochem Biophys76, 219-229. PubMed Europe PubMed DOI
Douglas,S.A., Lamothe,S.E., Singleton,T.S., Averett,R.D. and Platt,M.O.
Human cathepsins K, L, and S: related proteases, but unique fibrinolytic activity
Biochim Biophys Acta1862, 1925-1932. PubMed Europe PubMed DOI
Freeley,S., Cardone,J., Gunther,S.C., West,E.E., Reinheckel,T., Watts,C., Kemper,C. and Kolev,M.V.
Asparaginyl endopeptidase (legumain) supports human Th1 induction via cathepsin L-mediated intracellular C3 activation
Front Immunol9, 2449-2449. PubMed Europe PubMed DOI
Huisman,M., Kodanko,J.P., Arora,K., Herroon,M., Alnaed,M., Endicott,J., Podgorski,I. and Kodanko,J.J.
Affinity-enhanced luminescent Re(I)- and Ru(II)-based inhibitors of the cysteine protease cathepsin L
Inorg Chem57, 7881-7891. PubMed Europe PubMed DOI I
Peyer,S.M., Kremer,N. and McFall-Ngai,M.J.
Involvement of a host cathepsin L in symbiont-induced cell death
Microbiologyopene00632-e00632. PubMed Europe PubMed DOI
Podvin,S., Wojnicz,A. and Hook,V.
Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production
Heliyon4, e00673-e00673. PubMed Europe PubMed DOI
Poreba,M., Rut,W., Vizovisek,M., Groborz,K., Kasperkiewicz,P., Finlay,D., Vuori,K., Turk,D., Turk,B., Salvesen,G.S. and Drag,M.
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes
Chem Sci9, 2113-2129. PubMed Europe PubMed DOI L
Streubel,M.K., Bischof,J., Weiss,R., Duschl,J., Liedl,W., Wimmer,H., Breitenbach,M., Weber,M., Geltinger,F., Richter,K. and Rinnerthaler,M.
Behead and live long or the tale of cathepsin L
Yeast35, 237-249. PubMed Europe PubMed DOI

2017

Dai,L.S., Chu,S.H., Yu,X.M. and Li,Y.Y.
A role of cathepsin L gene in innate immune response of crayfish (Procambarus clarkii)
Fish Shellfish Immunol71, 246-254. PubMed Europe PubMed DOI
Dos Santos,D.A., Deobald,A.M., Cornelio,V.E., Avila,R.M.D., Cornea,R.C., Bernasconi,G.C.R., Paixao,M.W., Vieira,P.C. and Correa,A.G.
Asymmetric synthesis and evaluation of epoxy-alpha-acyloxycarboxamides as selective inhibitors of cathepsin L
Bioorg Med Chem25, 4620-4627. PubMed Europe PubMed DOI I
Giroud,M., Ivkovic,J., Martignoni,M., Fleuti,M., Trapp,N., Haap,W., Kuglstatter,A., Benz,J., Kuhn,B., Schirmeister,T. and Diederich,F.
Inhibition of the cysteine protease human cathepsin L by triazine nitriles: amide???heteroarene pi-stacking interactions and chalcogen bonding in the S3 pocket
ChemMedChem12, 257-270. PubMed Europe PubMed DOI I
Hashimoto,Y.
Gelatin zymography using leupeptin for the detection of various cathepsin L forms
Methods Mol Biol1594, 243-254. PubMed Europe PubMed DOI L I
Kikuta,S., Murai,Y. and Tanaka,E.
Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons
Neurosci Lett636, 120-126. PubMed Europe PubMed DOI I
Kuhn,B., Tichy,M., Wang,L., Robinson,S., Martin,R.E., Kuglstatter,A., Benz,J., Giroud,M., Schirmeister,T., Abel,R., Diederich,F. and Hert,J.
Prospective evaluation of free energy calculations for the prioritization of cathepsin L inhibitors
J Med Chem60, 2485-2497. PubMed Europe PubMed DOI I
Lee,C.W., Stankowski,J.N., Chew,J., Cook,C.N., Lam,Y.W., Almeida,S., Carlomagno,Y., Lau,K.F., Prudencio,M., Gao,F.B., Bogyo,M., Dickson,D.W. and Petrucelli,L.
The lysosomal protein cathepsin L is a progranulin protease
Mol Neurodegener12, 55-55. PubMed Europe PubMed DOI
Li,Y.Y., Fang,J. and Ao,G.Z.
Cathepsin B and L inhibitors: a patent review (2010 - present)
Expert Opin Ther Pat27, 643-656. PubMed Europe PubMed DOI V I
Liang,F.R., Hong,Y.H., Ye,C.C., Deng,H., Yuan,J.P., Hao,Y.F. and Wang,J.H.
Molecular characterization and gene expression of cathepsin L in Nile tilapia (Oreochromis niloticus)
Fish Shellfish Immunol67, 280-292. PubMed Europe PubMed DOI
McGlinchey,R.P., Dominah,G.A. and Lee,J.C.
Taking a bite out of amyloid: mechanistic insights into alpha-synuclein degradation by cathepsin L
Biochemistry56, 3881-3884. PubMed Europe PubMed DOI
Parker,E.N., Odutola,S.O., Wang,Y., Strecker,T.E., Mukherjee,R., Shi,Z., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L
Bioorg Med Chem Lett27, 1304-1310. PubMed Europe PubMed DOI I
Qi,Z., Huang,B., Zhang,Q., Wang,Z., Wang,P. and Gao,Q.
Molecular characterization, expression and evolutionary analysis of 3 cathepsin genes (CTSH, CTSL and CTSS) from Chinese giant salamander (Andrias davidianus)
Gene Rep7, 25-31. DOI
Qiao,Y., Wang,J., Mao,Y., Liu,M., Song,X., Su,Y., Wang,C. and Zheng,Z.
Identification and molecular characterization of cathepsin L gene and its expression analysis during early ontogenetic development of kuruma shrimp Marsupenaeus japonicus
Acta Oceanol Sin36, 52-60. DOI
Xu,S., Zhang,H., Yang,X., Qian,Y. and Xiao,Q.
Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-kappaB pathways
Neurobiol Aging62, 159-167. PubMed Europe PubMed DOI T

2016

Burton,L.J., Dougan,J., Jones,J., Smith,B.N., Randle,D., Henderson,V. and Odero-Marah,V.A.
Targeting the nuclear cathepsin L- CCAAT-displacement protein/cut homeobox transcription factor-epithelial mesenchymal transition pathway in prostate and breast cancer cells with Z-FY-CHO inhibitor
Mol Cell Biol37, e00297-16.-e00297-16. PubMed Europe PubMed DOI I
Castro-Gomes,T., Corrotte,M., Tam,C. and Andrews,N.W.
Plasma membrane repair is regulated extracellularly by proteases released from lysosomes
PLoS ONE11, e0152583-e0152583. PubMed Europe PubMed DOI
Garsen,M., Rops,A.L., Dijkman,H., Willemsen,B., van Kuppevelt,T.H., Russel,F.G., Rabelink,T.J., Berden,J.H., Reinheckel,T. and van der Vlag,J.
Cathepsin L is crucial for the development of early experimental diabetic nephropathy
Kidney Int90, 1012-1022. PubMed Europe PubMed DOI T
Giroud,M., Harder,M., Kuhn,B., Haap,W., Trapp,N., Schweizer,W.B., Schirmeister,T. and Diederich,F.
Fluorine scan of inhibitors of the cysteine protease human cathepsin L: dipolar and quadrupolar effects in the pi-stacking of fluorinated phenyl rings on peptide amide bonds
ChemMedChem11, 1042-1047. PubMed Europe PubMed DOI I
Hofmann,N., Galetskiy,D., Rauch,D., Wittmann,T., Marquardt,A., Griese,M. and Zarbock,R.
Analysis of the proteolytic processing of ABCA3: identification of cleavage site and involved proteases
PLoS ONE11, e0152594-e0152594. PubMed Europe PubMed DOI P
Mori,J., Tanikawa,C., Funauchi,Y., Lo,P.H., Nakamura,Y. and Matsuda,K.
Cystatin C as a p53-inducible apoptotic mediator that regulates cathepsin L activity
Cancer Sci107, 298-306. PubMed Europe PubMed DOI
Ohrvik,H., Logeman,B., Turk,B., Reinheckel,T. and Thiele,D.J.
Cathepsin protease controls copper and cisplatin accumulation via cleavage of the Ctr1 metal-binding ectodomain
J Biol Chem291, 13905-13916. PubMed Europe PubMed DOI
Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J.
Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones
RSC Adv6, 34588-34599. DOI I
Shirato,K., Kanou,K., Kawase,M. and Matsuyama,S.
Clinical isolates of human coronavirus 229E bypass the endosome for cell entry
J Virol91, e01387-16-e01387-16. PubMed Europe PubMed DOI
Sosnowski,P. and Turk,D.
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of cathepsin L
FEBS Lett590, 1253-1261. PubMed Europe PubMed DOI S
Sudhan,D.R., Pampo,C., Rice,L. and Siemann,D.W.
Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model
Int J Cancer138, 2665-2677. PubMed Europe PubMed DOI I
Sudhan,D.R., Rabaglino,M.B., Wood,C.E. and Siemann,D.W.
Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94
Clin Exp Metastasis33, 461-473. PubMed Europe PubMed DOI I
Tamhane,T., Lllukkumbura,R., Lu,S., Maelandsmo,G.M., Haugen,M.H. and Brix,K.
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells
Biochimie122, 208-218. PubMed Europe PubMed DOI
Ueki,N., Wang,W., Swenson,C., McNaughton,C., Sampson,N.S. and Hayman,M.J.
Synthesis and preclinical evaluation of a highly improved anticancer prodrug activated by histone deacetylases and cathepsin L
Theranostics6, 808-816. PubMed Europe PubMed DOI I
Withana,N.P., Garland,M., Verdoes,M., Ofori,L.O., Segal,E. and Bogyo,M.
Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes
Nat Protoc11, 184-191. PubMed Europe PubMed DOI L
Withana,N.P., Ma,X., McGuire,H.M., Verdoes,M., van der Linden,W.A., Ofori,L.O., Zhang,R., Li,H., Sanman,L.E., Wei,K., Yao,S., Wu,P., Li,F., Huang,H., Xu,Z., Wolters,P.J., Rosen,G.D., Collard,H.R., Zhu,Z., Cheng,Z. and Bogyo,M.
Non-invasive imaging of idiopathic pulmonary fibrosis using cathepsin protease probes
Sci Rep6, 19755-19755. PubMed Europe PubMed DOI L
Yang,J., Liu,H., Zheng,G., Xiang,X., Lv,Z. and Wang,T.
Cathepsin L of the sea cucumber Apostichopus japonicus-molecular characterization and transcriptional response to Vibrio splendidus infection
Fish Shellfish Immunol49, 387-395. PubMed Europe PubMed DOI
Zhang,H., Zhang,L., Wei,L., Gao,X., Tang,L., Gong,W., Min,N., Zhang,L. and Yuan,Y.
Knockdown of cathepsin L sensitizes ovarian cancer cells to chemotherapy
Oncol Lett11, 4235-4239. PubMed Europe PubMed DOI K
Zhou,N., Pan,T., Zhang,J., Li,Q., Zhang,X., Bai,C., Huang,F., Peng,T., Zhang,J., Liu,C., Tao,L. and Zhang,H.
Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)
J Biol Chem291, 9218-9232. PubMed Europe PubMed DOI I

2015

Andrault,P.M., Samsonov,S.A., Weber,G., Coquet,L., Nazmi,K., Bolscher,J.G., Lalmanach,A.C., Jouenne,T., Bromme,D., Pisabarro,M.T., Lalmanach,G. and Lecaille,F.
Antimicrobial peptide LL-37 is both a substrate of cathepsins S and K and a selective inhibitor of cathepsin L
Biochemistry54, 2785-2798. PubMed Europe PubMed DOI
Brindle,N.R., Joyce,J.A., Rostker,F., Lawlor,E.R., Swigart-Brown,L., Evan,G., Hanahan,D. and Shchors,K.
Deficiency for the cysteine protease cathepsin L impairs myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer
PLoS ONE10, e0120348- PubMed Europe PubMed DOI K
Celis-Barros,C., Saavedra-Rivas,L., Salgado,J.C., Cassels,B.K. and Zapata-Torres,G.
Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition
J Comput Aided Mol Des29, 37-46. PubMed Europe PubMed DOI I
Corry,J., Johnson,S.M., Cornwell,J. and Peeples,M.E.
Preventing cleavage of the respiratory syncytial virus attachment protein in Vero cells rescues the infectivity of progeny virus for primary human airway cultures
J Virol90, 1311-1320. PubMed Europe PubMed DOI
Gu,Y.H., Kanazawa,M., Hung,S.Y., Wang,X., Fukuda,S., Koziol,J.A. and del Zoppo,G.J.
Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia
J Cereb Blood Flow Metab35, 1888-1900. PubMed Europe PubMed DOI
Hashimoto,Y., Kondo,C. and Katunuma,N.
An active 32-kDa cathepsin L is secreted directly from HT 1080 fibrosarcoma cells and not via lysosomal exocytosis
PLoS ONE10, e0145067-e0145067. PubMed Europe PubMed DOI
Hou,L., Cooley,J., Swanson,R., Ong,P.C., Pike,R.N., Bogyo,M., Olson,S.T. and Remold-O'Donnell,E.
The protease cathepsin L regulates Th17 cell differentiation
J Autoimmun65, 56-63. PubMed Europe PubMed DOI
Korenc,M., Lenarcic,B. and Novinec,M.
Human cathepsin L, a papain-like collagenase without proline specificity
FEBS J282, 4328-4340. PubMed Europe PubMed DOI
McGlinchey,R.P. and Lee,J.C.
Cysteine cathepsins are essential in lysosomal degradation of alpha-synuclein
Proc Natl Acad Sci U S A112, 9322-9327. PubMed Europe PubMed DOI P
Ofori,L.O., Withana,N.P., Prestwood,T.R., Verdoes,M., Brady,J.J., Winslow,M.M., Sorger,J. and Bogyo,M.
Design of protease activated optical contrast agents that exploit a latent lysosomotropic effect for use in fluorescence-guided surgery
ACS Chem Biol10, 1977-1988. PubMed Europe PubMed DOI L
Parker,E.N., Song,J., Kishore Kumar,G.D., Odutola,S.O., Chavarria,G.E., Charlton-Sevcik,A.K., Strecker,T.E., Barnes,A.L., Sudhan,D.R., Wittenborn,T.R., Siemann,D.W., Horsman,M.R., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L
Bioorg Med Chem23, 6974-6992. PubMed Europe PubMed DOI I
Rodrigues,T., Lin,Y.C., Hartenfeller,M., Renner,S., Lim,Y.F. and Schneider,G.
Repurposing de novo designed entities reveals phosphodiesterase 3B and cathepsin L modulators
Chem Commun (Camb)51, 7478-7481. PubMed Europe PubMed DOI
Shen,J.D., Cai,Q.F., Yan,L.J., Du,C.H., Liu,G.M., Su,W.J., Ke,C. and Cao,M.J.
Cathepsin L is an immune-related protein in Pacific abalone (Haliotis discus hannai) - purification and characterization
Fish Shellfish Immunol47, 986-995. PubMed Europe PubMed DOI
Sudhan,D.R. and Siemann,D.W.
Cathepsin L targeting in cancer treatment
Pharmacol Ther155, 105-116. PubMed Europe PubMed DOI
Sun,B.G. and Hu,Y.H.
Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus)
Fish Physiol Biochem41, 1463-1473. PubMed Europe PubMed DOI
Vizovisek,M., Vidmar,R., Van Quickelberghe,E., Impens,F., Andjelkovic,U., Sobotic,B., Stoka,V., Gevaert,K., Turk,B. and Fonovic,M.
Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S
Proteomics15, 2479-2490. PubMed Europe PubMed DOI P
Wang,H., Sang,N., Zhang,C., Raghupathi,R., Tanzi,R.E. and Saunders,A.
Cathepsin L mediates the degradation of novel APP C-terminal fragments
Biochemistry54, 2806-2816. PubMed Europe PubMed DOI I
Wang,R., Song,L., Su,B., Zhao,H., Zhang,D., Peatman,E. and Li,C.
Mucosal expression signatures of two cathepsin L in channel catfish (Ictalurus punctatus) following bacterial challenge
Fish Shellfish Immunol47, 582-589. PubMed Europe PubMed DOI
Yang,N., Wang,P., Wang,W.J., Song,Y.Z. and Liang,Z.Q.
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-kappaB signaling pathway
Acta Pharmacol Sin36, 400-410. PubMed Europe PubMed DOI I
Zhang,Q., Han,M., Wang,W., Song,Y., Chen,G., Wang,Z. and Liang,Z.
Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor-beta-mediated epithelial-mesenchymal transition
Oncol Rep33, 1851-1859. PubMed Europe PubMed DOI

2014

Chua,K.C., Pietsch,M., Zhang,X., Hautmann,S., Chan,H.Y., Bruning,J.B., Gutschow,M. and Abell,A.D.
Macrocyclic protease inhibitors with reduced peptide character
Angew Chem Int Ed Engl53, 7828-7831. PubMed Europe PubMed DOI I
Dana,D., De,S., Rathod,P., Davalos,A.R., Novoa,D.A., Paroly,S., Torres,V.M., Afzal,N., Lankalapalli,R.S., Rotenberg,S.A., Chang,E.J., Subramaniam,G. and Kumar,S.
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L - a hybrid design approach
Chem Commun (Camb)50, 10875-10878. PubMed Europe PubMed DOI I
Duarte,L.F., Young,A.R., Wang,Z., Wu,H.A., Panda,T., Kou,Y., Kapoor,A., Hasson,D., Mills,N.R., Ma'ayan,A., Narita,M. and Bernstein,E.
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme
Nat Commun5, 5210-5210. PubMed Europe PubMed DOI
Elshabrawy,H.A., Fan,J., Haddad,C.S., Ratia,K., Broder,C.C., Caffrey,M. and Prabhakar,B.S.
Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay
J Virol88, 4353-4365. PubMed Europe PubMed DOI I
Hu,X., Hu,X., Hu,B., Wen,C., Xie,Y., Wu,D., Tao,Z., Li,A. and Gao,Q.
Molecular cloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata
Fish Shellfish Immunol40, 446-454. PubMed Europe PubMed DOI
Kumaresan,V., Bhatt,P., Palanisamy,R., Gnanam,A.J., Pasupuleti,M. and Arockiaraj,J.
A murrel cysteine protease, cathepsin L: Bioinformatics characterization, gene expression and proteolytic activity
Biologia69, 395-406. DOI
Legowska,M., Wysocka,M., Burster,T., Pikula,M., Rolka,K. and Lesner,A.
Ultrasensitive internally quenched substrates of human cathepsin L
Anal Biochem466, 30-37. PubMed Europe PubMed DOI A
Miller,B., Friedman,A.J., Choi,H., Hogan,J., McCammon,J.A., Hook,V. and Gerwick,W.H.
The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L
J Nat Prod77, 92-99. PubMed Europe PubMed DOI I
Muller,S., Faulhaber,A., Sieber,C., Pfeifer,D., Hochberg,T., Gansz,M., Deshmukh,S.D., Dauth,S., Brix,K., Saftig,P., Peters,C., Henneke,P. and Reinheckel,T.
The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction
FASEB J28, 162-175. PubMed Europe PubMed DOI
Pietra,D., Borghini,A., Ricci,C. and Bianucci,A.M.
Enzyme kinetics studies on 29-kDa human liver cathepsin L
Chem Biol Drug Des84, 648-658. PubMed Europe PubMed DOI
Ramalho,S.D., De Sousa,L.R., Nebo,L., Maganhi,S.H., Caracelli,I., Zukerman-Schpector,J., Lima,M.I., Alves,M.F., da Silva,M.F., Fernandes,J.B. and Vieira,P.C.
Triterpenoids as novel natural inhibitors of human cathepsin L
Chem Biodivers11, 1354-1363. PubMed Europe PubMed DOI I
Shivanna,V., Kim,Y. and Chang,K.O.
Endosomal acidification and cathepsin L activity is required for calicivirus replication
Virology464-465, 287-295. PubMed Europe PubMed DOI
Tholen,M., Hillebrand,L.E., Tholen,S., Sedelmeier,O., Arnold,S.J. and Reinheckel,T.
Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo
Nat Commun5, 4931-4931. PubMed Europe PubMed DOI
Tholen,S., Biniossek,M.L., Gansz,M., Ahrens,T.D., Schlimpert,M., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O.
Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis
Cell Mol Life Sci71, 899-916. PubMed Europe PubMed DOI K

2013

Arockiaraj,J., Gnanam,A.J., Muthukrishnan,D., Thirumalai,M.K., Pasupuleti,M., Milton,J. and Kasi,M.
Macrobrachium rosenbergii cathepsin L: molecular characterization and gene expression in response to viral and bacterial infections
Microbiol Res168, 569-579. PubMed Europe PubMed DOI
Badano,M.N., Camicia,G.L., Lombardi,G., Maglioco,A., Cabrera,G., Costa,H., Meiss,R.P., Piazzon,I. and Nepomnaschy,I.
B-cell lymphopoiesis is regulated by cathepsin L
PLoS ONE8, e61347-e61347. PubMed Europe PubMed DOI
Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y.
Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors
Bioorg Chem51, 24-30. PubMed Europe PubMed DOI I
Brocklehurst,K. and Philpott,M.P.
Cysteine proteases: mode of action and role in epidermal differentiation
Cell Tissue Res351, 237-244. PubMed Europe PubMed DOI
Ehmke,V., Winkler,E., Banner,D.W., Haap,W., Schweizer,W.B., Rottmann,M., Kaiser,M., Freymond,C., Schirmeister,T. and Diederich,F.
Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L
ChemMedChem8, 967-975. PubMed Europe PubMed DOI I
Grotsky,D.A., Gonzalez-Suarez,I., Novell,A., Neumann,M.A., Yaddanapudi,S.C., Croke,M., Martinez-Alonso,M., Redwood,A.B., Ortega-Martinez,S., Feng,Z., Lerma,E., Ramon,Y.C., Zhang,J., Matias-Guiu,X., Dusso,A. and Gonzalo,S.
BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells
J Cell Biol200, 187-202. PubMed Europe PubMed DOI
Niu,D., Jin,K., Wang,L., Feng,B. and Li,J.
Molecular characterization and expression analysis of four cathepsin L genes in the razor clam, Sinonovacula constricta
Fish Shellfish Immunol35, 581-588. PubMed Europe PubMed DOI
Ohkouchi,S., Shibata,M., Sasaki,M., Koike,M., Safig,P., Peters,C., Nagata,S. and Uchiyama,Y.
Biogenesis and proteolytic processing of lysosomal DNase II
PLoS ONE8, e59148-e59148. PubMed Europe PubMed DOI
Song,J., Jones,L.M., Chavarria,G.E., Charlton-Sevcik,A.K., Jantz,A., Johansen,A., Bayeh,L., Soeung,V., Snyder,L.K., Lade,S.D., Jr., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks
Bioorg Med Chem Lett23, 2801-2807. PubMed Europe PubMed DOI I
Tholen,S., Biniossek,M.L., Gansz,M., Gomez-Auli,A., Bengsch,F., Noel,A., Kizhakkedathu,J.N., Boerries,M., Busch,H., Reinheckel,T. and Schilling,O.
Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome
Mol Cell Proteomics12, 611-625. PubMed Europe PubMed DOI K
Torkar,A., Lenarcic,B., Lah,T., Dive,V. and Devel,L.
Identification of new peptide amides as selective cathepsin L inhibitors: The first step towards selective irreversible inhibitors?
Bioorg Med Chem Lett23, 2968-2973. PubMed Europe PubMed DOI I
Wang,Y.R., Qin,S., Han,R., Wu,J.C., Liang,Z.Q., Qin,Z.H. and Wang,Y.
Cathepsin L plays a role in quinolinic acid-induced NF-Kappab activation and excitotoxicity in rat striatal neurons
PLoS ONE8, e75702-e75702. PubMed Europe PubMed DOI I
Wei,D.H., Jia,X.Y., Liu,Y.H., Guo,F.X., Tang,Z.H., Li,X.H., Wang,Z., Liu,L.S., Wang,G.X., Jian,Z.S. and Ruan,C.G.
Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis
Int J Mol Med31, 400-406. PubMed Europe PubMed DOI
Xu,X., Greenland,J., Baluk,P., Adams,A., Bose,O., McDonald,D.M. and Caughey,G.H.
Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis
Am J Respir Cell Mol Biol49, 437-444. PubMed Europe PubMed DOI

2012

Benavides,F., Perez,C., Blando,J., Contreras,O., Shen,J., Coussens,L.M., Fischer,S.M., Kusewitt,D.F., Digiovanni,J. and Conti,C.J.
Protective role of cathepsin L in mouse skin carcinogenesis
Mol Carcinog51, 352-361. PubMed Europe PubMed DOI M
Chavarria,G.E., Horsman,M.R., Arispe,W.M., Kumar,G.D., Chen,S.E., Strecker,T.E., Parker,E.N., Chaplin,D.J., Pinney,K.G. and Trawick,M.L.
Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L
Eur J Med Chem58, 568-572. PubMed Europe PubMed DOI I
Ehmke,V., Quinsaat,J.E., Rivera-Fuentes,P., Heindl,C., Freymond,C., Rottmann,M., Brun,R., Schirmeister,T. and Diederich,F.
Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors
Org Biomol Chem10, 5764-5768. PubMed Europe PubMed DOI I
Gnirss,K., Kuhl,A., Karsten,C., Glowacka,I., Bertram,S., Kaup,F., Hofmann,H. and Pohlmann,S.
Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression
Virology424, 3-10. PubMed Europe PubMed DOI
Hook,V., Funkelstein,L., Wegrzyn,J., Bark,S., Kindy,M. and Hook,G.
Cysteine cathepsins in the secretory vesicle produce active peptides: cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease
Biochim Biophys Acta1824, 89-104. PubMed Europe PubMed DOI
Hook,V.Y.H.
Prohormone thiol protease
[ISSN:978-0-12-407743-0]3, 1817-1821. DOI
Hu,Y., Ji,R., Jiang,H., Zhang,J., Chen,J. and Ye,X.
Participation of cathepsin L in modori phenomenon in carp (Cyprinus carpio) surimi gel
Food Chem134, 2014-2020. PubMed Europe PubMed DOI
Kirschke,H.
Cathepsin L
[ISSN:978-0-12-407743-0]3, 1808-1817. DOI
Liang,J.Z., Rao,Y.Z., Lun,Z.R. and Yang,T.B.
Cathepsin L in the orange-spotted grouper, Epinephelus coioides: molecular cloning and gene expression after a Vibrio anguillarum challenge
Fish Physiol Biochem38, 1795-1806. PubMed Europe PubMed DOI
Marques,E.F., Bueno,M.A., Duarte,P.D., Silva,L.R., Martinelli,A.M., Dos Santos,C.Y., Severino,R.P., Bromme,D., Vieira,P.C. and Correa,A.G.
Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V
Eur J Med Chem54, 10-21. PubMed Europe PubMed DOI I
Mbewe-Campbell,N., Wei,Z., Zhang,K., Friese,R.S., Mahata,M., Schork,A.J., Rao,F., Chiron,S., Biswas,N., Kim,H.S., Mahata,S.K., Waalen,J., Nievergelt,C.M., Hook,V.Y. and O'Connor,D.T.
Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure
J Hypertens30, 1961-1969. PubMed Europe PubMed DOI
Morin,V., Sanchez-Rubio,A., Aze,A., Iribarren,C., Fayet,C., Desdevises,Y., Garcia-Huidobro,J., Imschenetzky,M., Puchi,M. and Geneviere,A.M.
The protease degrading sperm histones post-fertilization in sea urchin eggs is a nuclear cathepsin L that is further required for embryo development
PLoS ONE7, e46850-e46850. PubMed Europe PubMed DOI
Na,Z., Li,L., Uttamchandani,M. and Yao,S.Q.
Microarray-guided discovery of two-photon (2P) small molecule probes for live-cell imaging of cysteinyl cathepsin activities
Chem Commun (Camb)48, 7304-7306. PubMed Europe PubMed DOI I
Reif,M.M., Mach,L. and Oostenbrink,C.
Molecular insight into propeptide-protein interactions in cathepsins L and O
Biochemistry51, 8636-8653. PubMed Europe PubMed DOI
Schurigt,U., Eilenstein,R., Gajda,M., Leipner,C., Sevenich,L., Reinheckel,T., Peters,C., Wiederanders,B. and Brauer,R.
Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment
Inflamm Res61, 1021-1029. PubMed Europe PubMed DOI
Song,J., Jones,L.M., Kumar,G.D.K., Conner,E.S., Bayeh,L., Chavarria,G.E., Charlton-Sevcik,A.K., Chen,S.E., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L
ACS Med Chem Lett3, 450-453. PubMed Europe PubMed DOI I
Torkar,A., Bregant,S., Devel,L., Novinec,M., Lenarcic,B., Lah,T. and Dive,V.
A novel photoaffinity-based probe for selective detection of cathepsin L active form
Chembiochem13, 2616-2621. PubMed Europe PubMed DOI
Yamaguchi,M., Date,A., Sasaki,M., Makino,T. and Shimizu,T.
Noninvasive biosensor for cathepsin L in the stratum corneum
Skin Res Technol18, 332-338. PubMed Europe PubMed DOI A

2011

Adams-Cioaba,M.A., Krupa,J.C., Xu,C., Mort,J.S. and Min,J.
Structural basis for the recognition and cleavage of histone H3 by cathepsin L
Nat Commun2, 197-197. PubMed Europe PubMed DOI S
Biniossek,M.L., Nagler,D.K., Becker-Pauly,C. and Schilling,O.
Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S
J Proteome Res10, 5363-5373. PubMed Europe PubMed DOI P
Chen,L., Zhang,M. and Sun,L.
Identification and expressional analysis of two cathepsins from half-smooth tongue sole (Cynoglossus semilaevis)
Fish Shellfish Immunol31, 1270-1277. PubMed Europe PubMed DOI
Chung,J.H., Im,E.K., Jin,T., Lee,S.M., Kim,S.H., Choi,E.Y., Shin,M.J., Lee,K.H. and Jang,Y.
Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration
Exp Mol Med43, 179-188. PubMed Europe PubMed DOI
Funkelstein,L. and Hook,V.
The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression
Methods Mol Biol768, 107-125. PubMed Europe PubMed DOI
Gonzalez-Suarez,I., Redwood,A.B., Grotsky,D.A., Neumann,M.A., Cheng,E.H., Stewart,C.L., Dusso,A. and Gonzalo,S.
A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair
EMBO J30, 3383-3396. PubMed Europe PubMed DOI
Hardegger,L.A., Kuhn,B., Spinnler,B., Anselm,L., Ecabert,R., Stihle,M., Gsell,B., Thoma,R., Diez,J., Benz,J., Plancher,J.M., Hartmann,G., Isshiki,Y., Morikami,K., Shimma,N., Haap,W., Banner,D.W. and Diederich,F.
Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments
ChemMedChem6, 2048-2054. PubMed Europe PubMed DOI S
Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B.
Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C
J Immunol186, 7136-7143. PubMed Europe PubMed DOI
Savalas,L.R., Gasnier,B., Damme,M., Lubke,T., Wrocklage,C., Debacker,C., Jezegou,A., Reinheckel,T., Hasilik,A., Saftig,P. and Schroder,B.
Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L
Biochem J439, 113-128. PubMed Europe PubMed DOI
Schechter,I. and Ziv,E.
Cathepsins S, B and L with aminopeptidases display beta-secretase activity associated with the pathogenesis of Alzheimer's disease
Biol Chem392, 555-569. PubMed Europe PubMed DOI
Shenoy,R.T. and Sivaraman,J.
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors
J Struct Biol173, 14-19. PubMed Europe PubMed DOI I
Sun,J., Sukhova,G.K., Zhang,J., Chen,H., Sjoberg,S., Libby,P., Xiang,M., Wang,J., Peters,C., Reinheckel,T. and Shi,G.P.
Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice
Arterioscler Thromb Vasc Biol31, 2500-2508. PubMed Europe PubMed DOI K
Sun,M., Chen,M., Liu,Y., Fukuoka,M., Zhou,K., Li,G., Dawood,F., Gramolini,A. and Liu,P.P.
Cathepsin-L contributes to cardiac repair and remodelling post-infarction
Cardiovasc Res89, 374-383. PubMed Europe PubMed DOI K
Tholen,S., Biniossek,M.L., Gessler,A.L., Muller,S., Weisser,J., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O.
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts
Biol Chem392, 961-971. PubMed Europe PubMed DOI K
Whang,I., De Zoysa,M., Nikapitiya,C., Lee,Y., Kim,Y., Lee,S., Oh,C., Jung,S.J., Oh,M.J., Choi,C.Y., Yeo,S.Y., Kim,B.S., Kim,S.J. and Lee,J.
Molecular characterization and expression analysis of cathepsin B and L cysteine proteases from rock bream (Oplegnathus fasciatus)
Fish Shellfish Immunol30, 763-772. PubMed Europe PubMed DOI
Xiang,B., Fei,X., Zhuang,W., Fang,Y., Qin,Z. and Liang,Z.
Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells
Brain Res1387, 29-38. PubMed Europe PubMed DOI I

2010

Ahn,S.J., Sung,J.H., Kim,N.Y., Lee,A.R., Jeon,S.J., Lee,J.S., Kim,J.K., Chung,J.K. and Lee,H.H.
Molecular cloning, expression, and characterization of cathepsin L from mud loach (Misgurnus mizolepis)
Appl Biochem Biotechnol162, 1858-1871. PubMed Europe PubMed DOI
Ceru,S., Konjar,S., Maher,K., Repnik,U., Krizaj,I., Bencina,M., Renko,M., Nepveu,A., Zerovnik,E., Turk,B. and Kopitar-Jerala,N.
Stefin B interacts with histones and cathepsin L in the nucleus
J Biol Chem285, 10078-10086. PubMed Europe PubMed DOI
Dennemarker,J., Lohmuller,T., Muller,S., Aguilar,S.V., Tobin,D.J., Peters,C. and Reinheckel,T.
Impaired turnover of autophagolysosomes in cathepsin L deficiency
Biol Chem391, 913-922. PubMed Europe PubMed DOI K
Dennemarker,J., Lohmuller,T., Mayerle,J., Tacke,M., Lerch,M.M., Coussens,L.M., Peters,C. and Reinheckel,T.
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis
Oncogene29, 1611-1621. PubMed Europe PubMed DOI K
Fortenberry,Y.M., Brandal,S., Bialas,R.C. and Church,F.C.
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration
Biochim Biophys Acta1800, 580-590. PubMed Europe PubMed DOI
Frizler,M., Stirnberg,M., Sisay,M.T. and Gutschow,M.
Development of nitrile-based peptidic inhibitors of cysteine cathepsins
Curr Top Med Chem10, 294-322. PubMed Europe PubMed DOI T I
Funkelstein,L., Beinfeld,M., Minokadeh,A., Zadina,J. and Hook,V.
Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides
Neuropeptides44, 457-466. PubMed Europe PubMed DOI
Higgins,W.J., Fox,D.M., Kowalski,P.S., Nielsen,J.E. and Worrall,D.M.
Heparin enhances serpin inhibition of the cysteine protease cathepsin L
J Biol Chem285, 3722-3729. PubMed Europe PubMed DOI
Hood,C.L., Abraham,J., Boyington,J.C., Leung,K., Kwong,P.D. and Nabel,G.J.
Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity
J Virol84, 2972-2982. PubMed Europe PubMed DOI
Hsing,L.C., Kirk,E.A., McMillen,T.S., Hsiao,S.H., Caldwell,M., Houston,B., Rudensky,A.Y. and LeBoeuf,R.C.
Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse
J Autoimmun34, 96-104. PubMed Europe PubMed DOI
Hu,Y., Morioka,K. and Itoh,Y.
Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste
J Sci Food Agric90, 370-375. PubMed Europe PubMed DOI
Kishore Kumar,G.D., Chavarria,G.E., Charlton-Sevcik,A.K., Arispe,W.M., Macdonough,M.T., Strecker,T.E., Chen,S.E., Siim,B.G., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
Bioorg Med Chem Lett20, 1415-1419. PubMed Europe PubMed DOI I
Kistler,A.D., Peev,V., Forst,A.L., El Hindi,S., Altintas,M.M. and Reiser,J.
Enzymatic disease of the podocyte
Pediatr Nephrol25, 1017-1023. PubMed Europe PubMed DOI
Konjar,S., Sutton,V.R., Hoves,S., Repnik,U., Yagita,H., Reinheckel,T., Peters,C., Turk,V., Turk,B., Trapani,J.A. and Kopitar-Jerala,N.
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L
Immunology131, 257-267. PubMed Europe PubMed DOI
Kumar,G.D., Chavarria,G.E., Charlton-Sevcik,A.K., Yoo,G.K., Song,J., Strecker,T.E., Siim,B.G., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L
Bioorg Med Chem Lett20, 6610-6615. PubMed Europe PubMed DOI I
Lankelma,J.M., Voorend,D.M., Barwari,T., Koetsveld,J., Van der Spek,A.H., De Porto,A.P., Van Rooijen,G. and Van Noorden,C.J.
Cathepsin L, target in cancer treatment?
Life Sci86, 225-233. PubMed Europe PubMed DOI
Minokadeh,A., Funkelstein,L., Toneff,T., Hwang,S.R., Beinfeld,M., Reinheckel,T., Peters,C., Zadina,J. and Hook,V.
Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression
Mol Cell Neurosci43, 98-107. PubMed Europe PubMed DOI K
Sansanwal,P., Shukla,A.A., Das,T.K. and Chauhan,S.S.
Truncated human cathepsin L, encoded by a novel splice variant, exhibits altered subcellular localization and cytotoxicity
Protein Pept Lett17, 238-245. PubMed Europe PubMed DOI R
Sevenich,L., Hagemann,S., Stoeckle,C., Tolosa,E., Peters,C. and Reinheckel,T.
Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice
Biochimie92, 1674-1680. PubMed Europe PubMed DOI
Shah,P.P., Wang,T., Kaletsky,R.L., Myers,M.C., Purvis,J.E., Jing,H., Huryn,D.M., Greenbaum,D.C., Smith,A.B., III, Bates,P. and Diamond,S.L.
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells
Mol Pharmacol78, 319-324. PubMed Europe PubMed DOI I
Shimada,N., Ohno-Matsui,K., Iseki,S., Koike,M., Uchiyama,Y., Wang,J., Yoshida,T., Sato,T., Peters,C., Mochizuki,M. and Morita,I.
Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization
Am J Pathol176, 2571-2580. PubMed Europe PubMed DOI
Wartmann,T., Mayerle,J., Kahne,T., Sahin-Toth,M., Ruthenburger,M., Matthias,R., Kruse,A., Reinheckel,T., Peters,C., Weiss,F.U., Sendler,M., Lippert,H., Schulz,H.U., Aghdassi,A., Dummer,A., Teller,S., Halangk,W. and Lerch,M.M.
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice
Gastroenterology138, 726-737. PubMed Europe PubMed DOI
Yamada,A., Ishimaru,N., Arakaki,R., Katunuma,N. and Hayashi,Y.
Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity
PLoS ONE5, e12894-e12894. PubMed Europe PubMed DOI I
Yamazaki,Y., Kamei,Y., Sugita,S., Akaike,F., Kanai,S., Miura,S., Hirata,Y., Troen,B.R., Kitamura,T., Nishino,I., Suganami,T., Ezaki,O. and Ogawa,Y.
The cathepsin L gene is a direct target of FOXO1 in skeletal muscle
Biochem J427, 171-178. PubMed Europe PubMed DOI
Zeeuwen,P.L., van Vlijmen-Willems,I.M., Cheng,T., Rodijk-Olthuis,D., Hitomi,K., Hara-Nishimura,I., John,S., Smyth,N., Reinheckel,T., Hendriks,W.J. and Schalkwijk,J.
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea
FASEB J24, 3744-3755. PubMed Europe PubMed DOI K

2009

Ahimbisibwe,J.B., Inoue,K. and Aoki,T.
Detection of cathepsin L in red cell membranes from fish blood
Fish Sci76, 155-159. DOI
Asaad,N., Bethel,P.A., Coulson,M.D., Dawson,J.E., Ford,S.J., Gerhardt,S., Grist,M., Hamlin,G.A., James,M.J., Jones,E.V., Karoutchi,G.I., Kenny,P.W., Morley,A.D., Oldham,K., Rankine,N., Ryan,D., Wells,S.L., Wood,L., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S.
Dipeptidyl nitrile inhibitors of cathepsin L
Bioorg Med Chem Lett19, 4280-4283. PubMed Europe PubMed DOI I
Beinfeld,M.C., Funkelstein,L., Foulon,T., Cadel,S., Kitagawa,K., Toneff,T., Reinheckel,T., Peters,C. and Hook,V.
Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies
Peptides30, 1882-1891. PubMed Europe PubMed DOI K I
Bethel,P.A., Gerhardt,S., Jones,E.V., Kenny,P.W., Karoutchi,G.I., Morley,A.D., Oldham,K., Rankine,N., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S.
Design of selective cathepsin inhibitors
Bioorg Med Chem Lett19, 4622-4625. PubMed Europe PubMed DOI I
Biswas,N., Rodriguez-Flores,J.L., Courel,M., Gayen,J.R., Vaingankar,S.M., Mahata,M., Torpey,J.W., Taupenot,L., O'Connor,D.T. and Mahata,S.K.
Cathepsin L colocalizes with chromogranin A in chromaffin vesicles to generate active peptides
Endocrinology150, 3547-3557. PubMed Europe PubMed DOI
Fei,X.F., Qin,Z.H., Xiang,B., Li,L.Y., Han,F., Fukunaga,K. and Liang,Z.Q.
Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine
Brain Res1264, 85-97. PubMed Europe PubMed DOI
Fonovic,U.P. and Kos,J.
Efficient removal of cathepsin L from active cathepsin X using immunoprecipitation technique
Acta Chim Slov56, 985-988.
Jordans,S., Jenko-Kokalj,S., Kuhl,N.M., Tedelind,S., Sendt,W., Bromme,D., Turk,D. and Brix,K.
Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions
BMC Biochem10, 23-23. PubMed Europe PubMed DOI
Liu,Y., Li,X., Peng,D., Tan,Z., Liu,H., Qing,Y., Xue,Y. and Shi,G.P.
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease
Am J Cardiol103, 476-481. PubMed Europe PubMed DOI
Luft,F.C.
From furless to heartless - unraveling the diverse functions of cathepsin L
J Mol Med (Berl)87, 225-227. PubMed Europe PubMed DOI K
Rebbaa,A., Dyskin,E., Dier,E., Gallati,C., Honko,C., Simone,T., Yalcin,M., Sudha,T. and Mousa,S.A.
Antiproliferative, antiangiogenesis, and reversal of chemoresistance by specific cathepsin L inhibitors
J Clin Oncol27, e14643-e14643. PubMed Europe PubMed I
Rebbaa,A., Chu,F., Sudha,T., Gallati,C., Dier,U., Dyskin,E., Yalcin,M., Bianchini,C., Shaker,O. and Mousa,S.A.
The anti-angiogenic activity of NSITC, a specific cathepsin L inhibitor
Anticancer Res29, 4473-4481. PubMed Europe PubMed I
Schilling,K., Korner,A., Sehmisch,S., Kreusch,A., Kleint,R., Benedix,Y., Schlabrakowski,A. and Wiederanders,B.
Selectivity of propeptide-enzyme interaction in cathepsin L-like cysteine proteases
Biol Chem390, 167-174. PubMed Europe PubMed DOI
See,V., Free,P., Cesbron,Y., Nativo,P., Shaheen,U., Rigden,D.J., Spiller,D.G., Fernig,D.G., White,M.R., Prior,I.A., Brust,M., Lounis,B. and Levy,R.
Cathepsin L digestion of nanobioconjugates upon endocytosis
ACS Nano3, 2461-2468. PubMed Europe PubMed DOI
Shenoy,R.T., Chowdhury,S.F., Kumar,S., Joseph,L., Purisima,E.O. and Sivaraman,J.
A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
J Med Chem52, 6335-6346. PubMed Europe PubMed DOI S I
Takahashi,K., Ueno,T., Tanida,I., Minematsu-Ikeguchi,N., Murata,M. and Kominami,E.
Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis
Biol Pharm Bull32, 475-479. PubMed Europe PubMed DOI I
Tang,Q., Cai,J., Shen,D., Bian,Z., Yan,L., Wang,Y.X., Lan,J., Zhuang,G.Q., Ma,W.Z. and Wang,W.
Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling
J Mol Med (Berl)87, 249-260. PubMed Europe PubMed DOI
Ueno,T. and Takahashi,K.
A cathepsin L-specific inhibitor preferentially inhibits degradation of autophagosomal LC3 and GABARAP in HeLa and Huh-7 cells
Autophagy5, 878-879. PubMed Europe PubMed I
Visone,T., Charron,M. and Wright,W.W.
Activation and repression domains within the promoter of the rat cathepsin L gene orchestrate Sertoli cell-specific and stage-specific gene transcription in transgenic mice
Biol Reprod81, 571-579. PubMed Europe PubMed DOI
Yoshii,H., Kamiyama,H., Minematsu,K., Goto,K., Mizota,T., Oishi,K., Katunuma,N., Yamamoto,N. and Kubo,Y.
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells
Virology394, 227-234. PubMed Europe PubMed DOI I

2008

Abboud-Jarrous,G., Atzmon,R., Peretz,T., Palermo,C., Gadea,B.B., Joyce,J.A. and Vlodavsky,I.
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment
J Biol Chem283, 18167-18176. PubMed Europe PubMed DOI
Bosch,B.J., Bartelink,W. and Rottier,P.J.
Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide
J Virol82, 8887-8890. PubMed Europe PubMed DOI
Chowdhury,S.F., Joseph,L., Kumar,S., Tulsidas,S.R., Bhat,S., Ziomek,E., Menard,R., Sivaraman,J. and Purisima,E.O.
Exploring inhibitor binding at the S' subsites of cathepsin L
J Med Chem51, 1361-1368. PubMed Europe PubMed DOI S I
Duncan,E.M., Muratore-Schroeder,T.L., Cook,R.G., Garcia,B.A., Shabanowitz,J., Hunt,D.F. and Allis,C.D.
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation
Cell135, 284-294. PubMed Europe PubMed DOI P
Fairhead,M., Johnson,K.A., Kowatz,T., McMahon,S.A., Carter,L.G., Oke,M., Liu,H., Naismith,J.H. and van der Walle,C.F.
Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras
Chem Commun (Camb)2008, 1765-1767. PubMed Europe PubMed DOI S
Fairhead,M. and van der Walle,C.F.
The heavy-light chain loop of human cathepsin-L modulates its activity and stability
Protein Pept Lett15, 47-53. PubMed Europe PubMed DOI
Fairhead,M., Kelly,S.M. and van der Walle,C.F.
A heparin binding motif on the pro-domain of human procathepsin L mediates zymogen destabilization and activation
Biochem Biophys Res Commun366, 862-867. PubMed Europe PubMed DOI
Funkelstein,L., Toneff,T., Hwang,S.R., Reinheckel,T., Peters,C. and Hook,V.
Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression
J Neurochem106, 384-391. PubMed Europe PubMed DOI K
Funkelstein,L., Toneff,T., Mosier,C., Hwang,S.R., Beuschlein,F., Lichtenauer,U.D., Reinheckel,T., Peters,C. and Hook,V.
Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression
J Biol Chem283, 35652-35659. PubMed Europe PubMed DOI I
Hook,V., Funkelstein,L., Lu,D., Bark,S., Wegrzyn,J. and Hwang,S.R.
Proteases for processing proneuropeptides into peptide neurotransmitters and hormones
Annu Rev Pharmacol Toxicol48, 393-423. PubMed Europe PubMed DOI
Jean,D., Rousselet,N. and Frade,R.
Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region
Biochem J413, 125-134. PubMed Europe PubMed DOI
Myers,M.C., Shah,P.P., Diamond,S.L., Huryn,D.M. and Smith,A.B., III
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor
Bioorg Med Chem Lett18, 210-214. PubMed Europe PubMed DOI I
Myers,M.C., Shah,P.P., Beavers,M.P., Napper,A.D., Diamond,S.L., Smith,A.B., III and Huryn,D.M.
Design, synthesis, and evaluation of inhibitors of cathepsin L: exploiting a unique thiocarbazate chemotype
Bioorg Med Chem Lett18, 3646-3651. PubMed Europe PubMed DOI I
Schaschke,N., Assfalg-Machleidt,I. and Machleidt,W.
Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions
Chembiochem9, 1721-1724. PubMed Europe PubMed DOI I
Shah,P.P., Myers,M.C., Beavers,M.P., Purvis,J.E., Jing,H., Grieser,H.J., Sharlow,E.R., Napper,A.D., Huryn,D.M., Cooperman,B.S., Smith,A.B., III and Diamond,S.L.
Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L
Mol Pharmacol74, 34-41. PubMed Europe PubMed DOI S I
Yadav,M.R., Shinde,A.K., Chouhan,B.S., Giridhar,R. and Menard,R.
Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors
J Enzyme Inhib Med Chem23, 190-197. PubMed Europe PubMed DOI I
Zhu,S., Wei,L., Yamasaki,K. and Gallo,R.L.
Activation of cathepsin L by the cathelin-like domain of protegrin-3
Mol Immunol45, 2531-2536. PubMed Europe PubMed DOI

2007

Boudreau,F., Lussier,C.R., Mongrain,S., Darsigny,M., Drouin,J.L., Doyon,G., Suh,E.R., Beaulieu,J.F., Rivard,N. and Perreault,N.
Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia
FASEB J21, 3853-3865. PubMed Europe PubMed DOI K
Burden,R.E., Snoddy,P., Jefferies,C.A., Walker,B. and Scott,C.J.
Inhibition of cathepsin L-like proteases by cathepsin V propeptide
Biol Chem388, 541-545. PubMed Europe PubMed DOI
Charron,M., Chern,J.Y. and Wright,W.W.
The cathepsin L first intron stimulates gene expression in rat Sertoli cells
Biol Reprod76, 813-824. PubMed Europe PubMed DOI
Goulet,B., Sansregret,L., Leduy,L., Bogyo,M., Weber,E., Chauhan,S.S. and Nepveu,A.
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation
Mol Cancer Res5, 899-907. PubMed Europe PubMed DOI
Hwang,S.R., Garza,C., Mosier,C., Toneff,T., Wunderlich,E., Goldsmith,P. and Hook,V.
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion
J Biol Chem282, 9556-9563. PubMed Europe PubMed DOI
Kramer,G., Paul,A., Kreusch,A., Schuler,S., Wiederanders,B. and Schilling,K.
Optimized folding and activation of recombinant procathepsin L and S produced in Escherichia coli
Protein Expr Purif54, 147-156. PubMed Europe PubMed DOI E
Mori,Y., Yamashita,T., Tanaka,Y., Tsuda,Y., Abe,T., Moriishi,K. and Matsuura,Y.
Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells
J Virol81, 8477-8487. PubMed Europe PubMed DOI
Ruettger,A. and Wiederanders,B.
Microplate assay for cathepsin detection in viable cells using derivatives of 4-methoxy-beta-naphthylamide
Curr Protoc Protein SciUnit 21.21, Unit 21.21- PubMed Europe PubMed DOI A
Sever,S., Altintas,M.M., Nankoe,S.R., Moller,C.C., Ko,D., Wei,C., Henderson,J., del Re,E.C., Hsing,L., Erickson,A., Cohen,C.D., Kretzler,M., Kerjaschki,D., Rudensky,A., Nikolic,B. and Reiser,J.
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease
J Clin Invest117, 2095-2104. PubMed Europe PubMed DOI
Spira,D., Stypmann,J., Tobin,D.J., Petermann,I., Mayer,C., Hagemann,S., Vasiljeva,O., Gunther,T., Schule,R., Peters,C. and Reinheckel,T.
Cell type-specific functions of the lysosomal protease cathepsin L in the heart
J Biol Chem282, 37045-37052. PubMed Europe PubMed DOI
Stahl,S., Reinders,Y., Asan,E., Mothes,W., Conzelmann,E., Sickmann,A. and Felbor,U.
Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes
Biochim Biophys Acta1774, 1237-1246. PubMed Europe PubMed DOI K
Tingaud-Sequeira,A. and Cerda,J.
Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme
Gene386, 98-106. PubMed Europe PubMed DOI
Walz,M., Kellermann,S., Bylaite,M., Andree,B., Ruther,U., Paus,R., Kloepper,J.E., Reifenberger,J. and Ruzicka,T.
Expression of the human cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis
Exp Dermatol16, 715-723. PubMed Europe PubMed DOI
Yang,M., Zhang,Y., Pan,J., Sun,J., Liu,J., Libby,P., Sukhova,G.K., Doria,A., Katunuma,N., Peroni,O.D., Guerre-Millo,M., Kahn,B.B., Clement,K. and Shi,G.P.
Cathepsin L activity controls adipogenesis and glucose tolerance
Nat Cell Biol9, 970-977. PubMed Europe PubMed DOI K I
Yang,Z. and Cox,J.L.
Cathepsin L increases invasion and migration of B16 melanoma
Cancer Cell Int7, 8-8. PubMed Europe PubMed DOI

2006

[YEAR:15-1-2006]Benavides,F., Perez,C., Blando,J., Guenet,J.L. and Conti,C.J.
The radiation-induced nackt (nkt) allele is a loss-of-function mutation of the mouse cathepsin L gene
J Immunol176, 702-703. PubMed Europe PubMed M
Bulynko,Y.A., Hsing,L.C., Mason,R.W., Tremethick,D.J. and Grigoryev,S.A.
Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin
Mol Cell Biol26, 4172-4184. PubMed Europe PubMed DOI
Caserman,S., Kenig,S., Sloane,B.F. and Lah,T.T.
Cathepsin L splice variants in human breast cell lines
Biol Chem387, 629-634. PubMed Europe PubMed DOI R
[YEAR:24-3-2006]Cheng,T., Hitomi,K., van Vlijmen-Willems,I.M., de Jongh,G.J., Yamamoto,K., Nishi,K., Watts,C., Reinheckel,T., Schalkwijk,J. and Zeeuwen,P.L.
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification
J Biol Chem281, 15893-15899. PubMed Europe PubMed DOI
[YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S.
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities
J Biol Chem281, 12824-12832. PubMed Europe PubMed DOI P
Goulet,B., Truscott,M. and Nepveu,A.
A novel proteolytically processed CDP/Cux isoform of 90 kDa is generated by cathepsin L
Biol Chem387, 1285-1293. PubMed Europe PubMed DOI
Hashimoto,Y., Kondo,C., Kojima,T., Nagata,H., Moriyama,A., Hayakawa,T. and Katunuma,N.
Significance of 32-kDa cathepsin L secreted from cancer cells
Cancer Biother Radiopharm21, 217-224. PubMed Europe PubMed DOI
[YEAR:31-10-2006]Jean,D., Rousselet,N. and Frade,R.
Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms
Oncogene25, 1474-1484. PubMed Europe PubMed DOI
Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D.
Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins
Biol Chem387, 1295-1303. PubMed Europe PubMed DOI P
[YEAR:13-12-2006]Liu,H., Yin,L., Zhang,N., Li,S. and Ma,C.
Purification and characterization of cathepsin L from the muscle of silver carp (Hypophthalmichthys molitrix)
J Agric Food Chem54, 9584-9591. PubMed Europe PubMed DOI
[YEAR:24-6-2006]Liu,J., Sukhova,G.K., Yang,J.T., Sun,J., Ma,L., Ren,A., Xu,W.H., Fu,H., Dolganov,G.M., Hu,C., Libby,P. and Shi,G.P.
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
Atherosclerosis184, 302-311. PubMed Europe PubMed DOI
Petermann,I., Mayer,C., Stypmann,J., Biniossek,M.L., Tobin,D.J., Engelen,M.A., Dandekar,T., Grune,T., Schild,L., Peters,C. and Reinheckel,T.
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice
FASEB J20, 1266-1268. PubMed Europe PubMed DOI K
Ruttger,A., Mollenhauer,J., Loser,R., Gutschow,M. and Wiederanders,B.
Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide
Biotechniques41, 469-473. PubMed Europe PubMed DOI A
Sevenich,L., Pennacchio,L.A., Peters,C. and Reinheckel,T.
Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice
Biol Chem387, 885-891. PubMed Europe PubMed DOI K
[YEAR:25-8-2006]Vicik,R., Busemann,M., Gelhaus,C., Stiefl,N., Scheiber,J., Schmitz,W., Schulz,F., Mladenovic,M., Engels,B., Leippe,M., Baumann,K. and Schirmeister,T.
Aziridide-based inhibitors of cathepsin L: synthesis, inhibition activity, and docking studies
ChemMedChem1, 1126-1141. PubMed Europe PubMed DOI I
Zajc,I., Hreljac,I. and Lah,T.
Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics
Anticancer Res26, 3357-3364. PubMed Europe PubMed

2005

[YEAR:10-2-2005]Gordon,P.V., Paxton,J.B., Kuemmerle,J.F. and Fox,N.S.
A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells
Am J Physiol Gastrointest Liver Physiol289, G79-G87. PubMed Europe PubMed DOI
Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y.
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)
Am J Pathol167, 1713-1728. PubMed Europe PubMed DOI K
[YEAR:1-10-2005]Maehr,R., Mintern,J.D., Herman,A.E., Lennon-Dumenil,A.M., Mathis,D., Benoist,C. and Ploegh,H.L.
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
J Clin Invest115, 2934-2943. PubMed Europe PubMed DOI
[YEAR:3-11-2005]Marquis,R.W., James,I., Zeng,J., Trout,R.E., Thompson,S., Rahman,A., Yamashita,D.S., Xie,R., Ru,Y., Gress,C.J., Blake,S., Lark,M.A., Hwang,S.M., Tomaszek,T., Offen,P., Head,M.S., Cummings,M.D. and Veber,D.F.
Azepanone-based inhibitors of human cathepsin L
J Med Chem48, 6870-6878. PubMed Europe PubMed DOI I
Nishinaka,T., Song,J., Lum,K. and Chiu,R.
Molecular cloning of cDNA for SPase, a monkey cathepsin L orthologue
DNA Seq16, 147-150. PubMed Europe PubMed DOI
Pager,C.T. and Dutch,R.E.
Cathepsin L is involved in proteolytic processing of the Hendra virus fusion protein
J Virol79, 12714-12720. PubMed Europe PubMed DOI
Puzer,L., Vercesi,J., Alves,M.F., Barros,N.M., Araujo,M.S., Aparecida Juliano,M., Reis,M.L., Juliano,L. and Carmona,A.K.
A possible alternative mechanism of kinin generation in vivo by cathepsin L
Biol Chem386, 699-704. PubMed Europe PubMed DOI
[YEAR:1-8-2005]Reinheckel,T., Hagemann,S., Dollwet-Mack,S., Martinez,E., Lohmuller,T., Zlatkovic,G., Tobin,D.J., Maas-Szabowski,N. and Peters,C.
The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling
J Cell Sci118, 3387-3395. PubMed Europe PubMed DOI
Rocken,C., Menard,R., Buhling,F., Vockler,S., Raynes,J., Stix,B., Kruger,S., Roessner,A. and Kahne,T.
Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation
Ann Rheum Dis64, 808-815. PubMed Europe PubMed DOI
[YEAR:4-8-2005]Simmons,G., Gosalia,D.N., Rennekamp,A.J., Reeves,J.D., Diamond,S.L. and Bates,P.
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
Proc Natl Acad Sci U S A102, 11876-11881. PubMed Europe PubMed DOI
Urbich,C., Heeschen,C., Aicher,A., Sasaki,K., Bruhl,T., Farhadi,M.R., Vajkoczy,P., Hofmann,W.K., Peters,C., Pennacchio,L.A., Abolmaali,N.D., Chavakis,E., Reinheckel,T., Zeiher,A.M. and Dimmeler,S.
Cathepsin L is required for endothelial progenitor cell-induced neovascularization
Nat Med11, 206-213. PubMed Europe PubMed DOI

2004

Collette,J., Bocock,J.P., Ahn,K., Chapman,R.L., Godbold,G., Yeyeodu,S. and Erickson,A.H.
Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L
Int Rev Cytol241, 1-51. PubMed Europe PubMed DOI
[YEAR:1-11-2004]Collette,J., Ulku,A.S., Der,C.J., Jones,A. and Erickson,A.H.
Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells
Int J Cancer112, 190-199. PubMed Europe PubMed DOI
[YEAR:16-8-2004]Goulet,B. and Nepveu,A.
Complete and limited proteolysis in cell cycle progression
Cell Cycle3, 986-989. PubMed Europe PubMed
[YEAR:23-4-2004]Goulet,B., Baruch,A., Moon,N.S., Poirier,M., Sansregret,L.L., Erickson,A., Bogyo,M. and Nepveu,A.
A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor
Mol Cell14, 207-219. PubMed Europe PubMed DOI
Hook,V., Yasothornsrikul,S., Greenbaum,D., Medzihradszky,K.F., Troutner,K., Toneff,T., Bundey,R., Logrinova,A., Reinheckel,T., Peters,C. and Bogyo,M.
Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones
Biol Chem385, 473-480. PubMed Europe PubMed DOI
Hook,V.Y.H.
Prohormone thiol protease
[ISSN:0-12-079610-4]2, 1408-1413. V
Hu,K.J. and Leung,P.C.
Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte
Comp Biochem Physiol B Biochem Mol Biol137, 21-33. PubMed Europe PubMed DOI
Kirschke,H.
Cathepsin L
[ISSN:0-12-079610-4]2, 1097-1102. V
Onishi,K., Li,Y., Ishii,K., Hisaeda,H., Tang,L., Duan,X., Dainichi,T., Maekawa,Y., Katunuma,N. and Himeno,K.
Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection
Microbes Infect6, 468-474. PubMed Europe PubMed DOI I
[YEAR:15-10-2004]Puzer,L., Cotrin,S.S., Alves,M.F., Egborge,T., Araujo,M.S., Juliano,M.A., Juliano,L., Bromme,D. and Carmona,A.K.
Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L
Arch Biochem Biophys430, 274-283. PubMed Europe PubMed DOI
[YEAR:15-12-2004]Ravanko,K., Jarvinen,K., Helin,J., Kalkkinen,N. and Holtta,E.
Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts
Cancer Res64, 8831-8838. PubMed Europe PubMed DOI
[YEAR:1-1-2004]Rousselet,N., Mills,L., Jean,D., Tellez,C., Bar-Eli,M. and Frade,R.
Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment
Cancer Res64, 146-151. PubMed Europe PubMed DOI
Schedel,J., Seemayer,C.A., Pap,T., Neidhart,M., Kuchen,S., Michel,B.A., Gay,R.E., Muller-Ladner,U., Gay,S. and Zacharias,W.
Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis
Gene Ther11, 1040-1047. PubMed Europe PubMed DOI
Sentandreu,M.A., Aubry,L. and Ouali,A.
A rapid purification procedure for cathepsin L from bovine species and production of specific antibodies
J Sci Food Agric84, 2052-2060.
[YEAR:22-11-2004]Soukenik,M., Diehl,A., Leidert,M., Sievert,V., Bussow,K., Leitner,D., Labudde,D., Ball,L.J., Lechner,A., Nagler,D.K. and Oschkinat,H.
The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L
FEBS Lett576, 358-362. PubMed Europe PubMed DOI
[YEAR:16-10-2004]Sriraman,V. and Richards,J.S.
Cathepsin L gene expression and promoter activation in rodent granulosa cells
Endocrinology145, 582-591. PubMed Europe PubMed DOI
Wille,A., Gerber,A., Heimburg,A., Reisenauer,A., Peters,C., Saftig,P., Reinheckel,T., Welte,T. and Buhling,F.
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells
Biol Chem385, 665-670. PubMed Europe PubMed DOI

2003

[YEAR:20-1-2003]Beers,C., Honey,K., Fink,S., Forbush,K. and Rudensky,A.
Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages
J Exp Med197, 169-179. PubMed Europe PubMed DOI
Charron,M., DeCerbo,J.N. and Wright,W.W.
A GC-box within the proximal promoter region of the rat cathepsin L gene activates transcription in Sertoli cells of sexually mature rats
Biol Reprod68, 1649-1656. PubMed Europe PubMed DOI
Charron,M., Folmer,J.S. and Wright,W.W.
A 3-kilobase region derived from the rat cathepsin L gene directs in vivo expression of a reporter gene in sertoli cells in a manner comparable to that of the endogenous gene
Biol Reprod68, 1641-1648. PubMed Europe PubMed DOI
Desmazes,C., Galineau,L., Gauthier,F., Bromme,D. and Lalmanach,G.
Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L
Eur J Biochem270, 171-178. PubMed Europe PubMed DOI
Levicar,N., Dewey,R.A., Daley,E., Bates,T.E., Davies,D., Kos,J., Pilkington,G.J. and Lah,T.T.
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis
Cancer Gene Ther10, 141-151. PubMed Europe PubMed DOI K
[YEAR:26-6-2003]Ohashi,K., Naruto,M., Nakaki,T. and Sano,E.
Identification of interleukin-8 converting enzyme as cathepsin L
Biochim Biophys Acta1649, 30-39. PubMed Europe PubMed DOI
[YEAR:4-12-2003]Seth,P., Mahajan,V.S. and Chauhan,S.S.
Transcription of human cathepsin L mRNA species hCATL B from a novel alternative promoter in the first intron of its gene
Gene321, 83-91. PubMed Europe PubMed DOI
[YEAR:24-6-2003]Welss,T., Sun,J., Irving,J.A., Blum,R., Smith,A.I., Whisstock,J.C., Pike,R.N., von Mikecz,A., Ruzicka,T., Bird,P.I. and Abts,H.F.
Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis
Biochemistry42, 7381-7389. PubMed Europe PubMed DOI
Wright,W.W., Smith,L., Kerr,C. and Charron,M.
Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis
Biol Reprod68, 680-687. PubMed Europe PubMed DOI
[YEAR:5-8-2003]Yasothornsrikul,S., Greenbaum,D., Medzihradszky,K.F., Toneff,T., Bundey,R., Miller,R., Schilling,B., Petermann,I., Dehnert,J., Logvinova,A., Goldsmith,P., Neveu,J.M., Lane,W.S., Gibson,B., Reinheckel,T., Peters,C., Bogyo,M. and Hook,V.
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter
Proc Natl Acad Sci U S A100, 9590-9595. PubMed Europe PubMed DOI

2002

[YEAR:26-6-2002]Arora,S. and Chauhan,S.S.
Identification and characterization of a novel human cathepsin L splice variant
Gene293, 123-131. PubMed Europe PubMed DOI R
Benavides,F., Starost,M.F., Flores,M., Gimenez-Conti,I.B., Guenet,J.L. and Conti,C.J.
Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation
Am J Pathol161, 693-703. PubMed Europe PubMed DOI K M
[YEAR:21-11-2002]Chowdhury,S.F., Sivaraman,J., Wang,J., Devanathan,G., Lachance,P., Qi,H., Menard,R., Lefebvre,J., Konishi,Y., Cygler,M., Sulea,T. and Purisima,E.O.
Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
J Med Chem45, 5321-5329. PubMed Europe PubMed DOI S I
[YEAR:5-7-2002]Ebert,D.H., Deussing,J., Peters,C. and Dermody,T.S.
Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells
J Biol Chem277, 24609-24617. PubMed Europe PubMed DOI
[YEAR:11-6-2002]Felbor,U., Kessler,B., Mothes,W., Goebel,H.H., Ploegh,H.L., Bronson,R.T. and Olsen,B.R.
Neuronal loss and brain atrophy in mice lacking cathepsins B and L
Proc Natl Acad Sci U S A99, 7883-7888. PubMed Europe PubMed DOI K
[YEAR:4-11-2002]Fiebiger,E., Maehr,R., Villadangos,J., Weber,E., Erickson,A., Bikoff,E., Ploegh,H.L. and Lennon-Dumenil,A.M.
Invariant chain controls the activity of extracellular cathepsin L
J Exp Med196, 1263-1269. PubMed Europe PubMed DOI
[YEAR:1-10-2002]Guillaume-Rousselet,N., Jean,D. and Frade,R.
Cloning and characterization of anti-cathepsin L single chain variable fragment whose expression inhibits procathepsin L secretion in human melanoma cells
Biochem J367, 219-227. PubMed Europe PubMed DOI
[YEAR:20-5-2002]Honey,K., Nakagawa,T., Peters,C. and Rudensky,A.
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands
J Exp Med195, 1349-1358. PubMed Europe PubMed DOI
[YEAR:1-1-2002]Jean,D., Guillaume,N. and Frade,R.
Characterization of human cathepsin L promoter and identification of binding sites for NF-Y, Sp1 and Sp3 that are essential for its activity
Biochem J361, 173-184. PubMed Europe PubMed DOI
Nishimura,F., Naruishi,H., Naruishi,K., Yamada,T., Sasaki,J., Peters,C., Uchiyama,Y. and Murayama,Y.
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice
Am J Pathol161, 2047-2052. PubMed Europe PubMed DOI
Siavash,H., Lopes,M., Norris,K., Hebert,C., Nikitakis,N. and Sauk,J.J.
Inhibition of cysteine proteinases by autolytic digestion is mediated by CBP2/Hsp47
Connect Tissue Res43, 589-594. PubMed Europe PubMed
[YEAR:30-4-2002]Stypmann,J., Glaser,K., Roth,W., Tobin,D.J., Petermann,I., Matthias,R., Monnig,G., Haverkamp,W., Breithardt,G., Schmahl,W., Peters,C. and Reinheckel,T.
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L
Proc Natl Acad Sci U S A99, 6234-6239. PubMed Europe PubMed DOI K
Tobin,D.J., Foitzik,K., Reinheckel,T., Mecklenburg,L., Botchkarev,V.A., Peters,C. and Paus,R.
The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling
Am J Pathol160, 1807-1821. PubMed Europe PubMed DOI
[YEAR:1-11-2002]Warner,J.B., Thalhauser,C., Tao,K. and Sahagian,G.G.
Role of N-linked oligosaccharide flexibility in mannose phosphorylation of lysosomal enzyme cathepsin L
J Biol Chem277, 41897-41905. PubMed Europe PubMed DOI

2001

Abudula,A., Rommerskirch,W., Weber,E., Gunther,D. and Wiederanders,B.
Splice variants of human cathepsin L mRNA show different expression rates
Biol Chem382, 1583-1591. PubMed Europe PubMed DOI R
[YEAR:5-9-2001]Bakhshi,R., Goel,A., Seth,P., Chhikara,P. and Chauhan,S.S.
Cloning and characterization of human cathepsin L promoter
Gene275, 93-101. PubMed Europe PubMed DOI
Benavides,F., Venables,A., Poetschke Klug,H., Glasscock,E., Rudensky,A., Gomez,M., Martin Palenzuela,N., Guenet,J.L., Richie,E.R. and Conti,C.J.
The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (Ctsl) gene
Immunogenetics53, 233-242. PubMed Europe PubMed DOI
Harrison,M.T. and McCoy,K.L.
Immunosuppression by arsenic: a comparison of cathepsin L inhibition and apoptosis
Int Immunopharmacol1, 647-656. PubMed Europe PubMed DOI
[YEAR:22-6-2001]Honey,K., Duff,M., Beers,C., Brissette,W.H., Elliott,E.A., Peters,C., Maric,M., Cresswell,P. and Rudensky,A.
Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes
J Biol Chem276, 22573-22578. PubMed Europe PubMed DOI K
[YEAR:13-4-2001]James,I.E., Marquis,R.W., Blake,S.M., Hwang,S.M., Gress,C.J., Ru,Y., Zembryki,D., Yamashita,D.S., McQueney,M.S., Tomaszek,T.A., Oh,H.J., Gowen,M., Veber,D.F. and Lark,M.W.
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro
J Biol Chem276, 11507-11511. PubMed Europe PubMed DOI I
Krueger,S., Kellner,U., Buehling,F. and Roessner,A.
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype
Cancer Gene Ther8, 522-528. PubMed Europe PubMed DOI
[YEAR:1-8-2001]Lennon-Dumenil,A.M., Roberts,R.A., Valentijn,K., Driessen,C., Overkleeft,H.S., Erickson,A., Peters,P.J., Bikoff,E., Ploegh,H.L. and Bryant,P.W.
The p41 isoform of invariant chain is a chaperone for cathepsin L
EMBO J20, 4055-4064. PubMed Europe PubMed DOI
[YEAR:1-6-2001]Melo,R.L., Alves,L.C., Del Nery,E., Juliano,L. and Juliano,M.A.
Synthesis and hydrolysis by cysteine and serine proteases of short internally quenched fluorogenic peptides
Anal Biochem293, 71-77. PubMed Europe PubMed DOI
Reinheckel,T., Deussing,J., Roth,W. and Peters,C.
Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L
Biol Chem382, 735-741. PubMed Europe PubMed DOI K
Visessanguan,W., Menino,A.R., Kim,S.M. and An,H.
Cathepsin L: A predominant heat-activated proteinase in arrowtooth flounder muscle
J Agric Food Chem49, 2633-2640. PubMed Europe PubMed DOI

2000

[YEAR:15-3-2000]Felbor,U., Dreier,L., Bryant,R.A., Ploegh,H.L., Olsen,B.R. and Mothes,W.
Secreted cathepsin L generates endostatin from collagen XVIII
EMBO J19, 1187-1194. PubMed Europe PubMed DOI
Guay,J., Falgueyret,J.P., Ducret,A., Percival,M.D. and Mancini,J.A.
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides
Eur J Biochem267, 6311-6318. PubMed Europe PubMed DOI
Jacobsen,W., Christians,U. and Benet,L.Z.
In vitro evaluation of the disposition of a novel cysteine protease inhibitor
Drug Metab Dispos28, 1343-1351. PubMed Europe PubMed I
Kirschke,H., Eerola,R., Hopsu-Havu,V.K., Bromme,D. and Vuorio,E.
Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells
Eur J Cancer36, 787-795. PubMed Europe PubMed DOI
[YEAR:15-7-2000]Krupa,J.C. and Mort,J.S.
Optimization of detergents for the assay of cathepsins B, L, S, and K
Anal Biochem283, 99-103. PubMed Europe PubMed DOI A
[YEAR:7-8-2000]Lynas,J.F., Hawthorne,S.J. and Walker,B.
Development of peptidyl alpha-keto-beta-aldehydes as new inhibitors of cathepsin L - comparisons of potency and selectivity profiles with cathepsin B
Bioorg Med Chem Lett10, 1771-1773. PubMed Europe PubMed DOI I
[YEAR:1-4-2000]Portaro,F.C., Santos,A.B., Cezari,M.H., Juliano,M.A., Juliano,L. and Carmona,E.
Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates
Biochem J347, 123-129. PubMed Europe PubMed DOI
Roth,W., Deussing,J., Botchkarev,V.A., Pauly-Evers,M., Saftig,P., Hafner,A., Schmidt,P., Schmahl,W., Scherer,J., Anton-Lamprecht,I., von Figura,K., Paus,R. and Peters,C.
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling
FASEB J14, 2075-2086. PubMed Europe PubMed DOI K M

1999

Ando,R., Sakaki,T., Morinaka,Y., Takahashi,C., Tamao,Y., Yoshii,N., Katayama,S., Saito,K.I., Tokuyama,H., Isaka,M. and Nakamura,E.
Cyclopropenone-containing cysteine proteinase inhibitors. Synthesis and enzyme inhibitory activities
Bioorg Med Chem7, 571-579. PubMed Europe PubMed I
Baer,G.S., Ebert,D.H., Chung,C.J., Erickson,A.H. and Dermody,T.S.
Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly
J Virol73, 9532-9543. PubMed Europe PubMed
[YEAR:15-2-1999]Guncar,G., Pungercic,G., Klemencic,I., Turk,V. and Turk,D.
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S
EMBO J18, 793-803. PubMed Europe PubMed DOI S
Hook,V.Y., Tezapsidis,N., Hwang,S.R., Sei,C., Byrne,M. and Yasothornsrikul,S.
alpha1-Antichymotrypsin-like proteins I and II purified from bovine adrenal medulla are enriched in chromaffin granules and inhibit the proenkephalin processing enzyme "prohormone thiol protease"
J Neurochem73, 59-69. PubMed Europe PubMed DOI
[YEAR:10-9-1999]Katunuma,N., Murata,E., Kakegawa,H., Matsui,A., Tsuzuki,H., Tsuge,H., Turk,D., Turk,V., Fukushima,M., Tada,Y. and Asao,T.
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo
FEBS Lett458, 6-10. PubMed Europe PubMed DOI I
Matsumoto,K., Mizoue,K., Kitamura,K., Tse,W.C., Huber,C.P. and Ishida,T.
Structural basis of inhibition of cysteine proteases by E-64 and its derivatives
Biopolymers51, 99-107. PubMed Europe PubMed DOI I
Ogino,T., Kaji,T., Kawabata,M., Satoh,K., Tomoo,K., Ishida,T., Yamazaki,H., Ishidoh,K. and Kominami,E.
Function of the propeptide region in recombinant expression of active procathepsin L in Escherichia coli
J Biochem126, 78-83. PubMed Europe PubMed E
[YEAR:16-7-1999]Popovic,T., Cimerman,N., Dolenc,I., Ritonja,A. and Brzin,J.
Cathepsin L is capable of truncating cystatin C of 11 N-terminal amino acids
FEBS Lett455, 92-96. PubMed Europe PubMed DOI
Werle,B., Staib,A., Julke,B., Ebert,W., Zladoidsky,P., Sekirnik,A., Kos,J. and Spiess,E.
Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extracts
Biol Chem380, 1109-1116. PubMed Europe PubMed DOI A
[YEAR:8-6-1999]Yasothornsrikul,S., Aaron,W., Toneff,T. and Hook,V.Y.
Evidence for the proenkephalin processing enzyme prohormone thiol protease (PTP) as a multicatalytic cysteine protease complex: activation by glutathione localized to secretory vesicles
Biochemistry38, 7421-7430. PubMed Europe PubMed DOI

1998

[YEAR:18-9-1998]Le Boulay,C., Sellos,D. and Van Wormhoudt,A.
Cathepsin L gene organization in crustaceans
Gene218, 77-84. PubMed Europe PubMed DOI

1997

Dalton,J.P., Clough,K.A., Jones,M.K. and Brindley,P.J.
The cysteine proteinases of Schistosoma mansoni cercariae
Parasitology114, 105-112. PubMed Europe PubMed DOI
Fujishima,A., Imai,Y., Nomura,T., Fujisawa,Y., Yamamoto,Y. and Sugawara,T.
The crystal structure of human cathepsin L complexed with E-64
FEBS Lett407, 47-50. PubMed Europe PubMed DOI S I
[YEAR:18-9-1997]Ishidoh,K., Taniguchi,S. and Kominami,E.
Egr family member proteins are involved in the activation of the cathepsin L gene in v-src-transformed cells
Biochem Biophys Res Commun238, 665-669. PubMed Europe PubMed DOI
Matsumoto,I., Emori,Y., Abe,K. and Arai,S.
Characterization of a gene family encoding cysteine proteinases of Sitophilus zeamais (maize weevil), and analysis of the protein distribution in various tissues including alimentary tract and germ cells
J Biochem121, 464-476. PubMed Europe PubMed

1996

Carmona,E., Dufour,E., Plouffe,C., Takebe,S., Mason,P., Mort,J.S. and Menard,R.
Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteases
Biochemistry35, 8149-8157. PubMed Europe PubMed DOI
Coulombe,R., Grochulski,P., Sivaraman,J., Menard,R., Mort,J.S. and Cygler,M.
Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment
EMBO J15, 5492-5503. PubMed Europe PubMed E S
Coulombe,R., Li,Y., Takebe,S., Menard,R., Mason,P., Mort,J.S. and Cygler,M.
Crystallization and preliminary X-ray diffraction studies of human procathepsin L
Proteins25, 398-400. PubMed Europe PubMed DOI S
Dalton,J.P., McGonigle,S., Rolph,T.P. and Andrews,S.J.
Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin
Infect Immun64, 5066-5074. PubMed Europe PubMed
Dalton,J.P., Clough,K.A., Jones,M.K. and Brindley,P.J.
Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni
Infect Immun64, 1328-1334. PubMed Europe PubMed
Dehrmann,F.M., Elliott,E. and Dennison,C.
Reductive activation markedly increases the stability of cathepsins B and L to extracellular ionic conditions
Biol Chem Hoppe Seyler377, 391-394. PubMed Europe PubMed
[YEAR:7-10-1996]Rescheleit,D.K., Rommerskirch,W.J. and Wiederanders,B.
Sequence analysis and distribution of two new human cathepsin L splice variants
FEBS Lett394, 345-348. PubMed Europe PubMed DOI R
Ritonja,A., Coetzer,T.H., Pike,R.N. and Dennison,C.
The amino acid sequences, structure comparisons and inhibition kinetics of sheep cathepsin L and sheep stefin B
Comp Biochem Physiol B Biochem Mol Biol114, 193-198. PubMed Europe PubMed DOI
Volkel,H., Kurz,U., Linder,J., Klumpp,S., Gnau,V., Jung,G. and Schultz,J.E.
Cathepsin L is an intracellular and extracellular protease in Paramecium tetraurelia. Purification, cloning, sequencing and specific inhibition by its expressed propeptide
Eur J Biochem238, 198-206. PubMed Europe PubMed

1995

Dolinar,M., Maganja,D.B. and Turk,V.
Expression of full-length human procathepsin L cDNA in Escherichia coli and refolding of the expression product
Biol Chem Hoppe Seyler376, 385-388. PubMed Europe PubMed E
Kawada,A., Hara,K., Hiruma,M., Noguchi,H. and Ishibashi,A.
Rat epidermal cathepsin L-like proteinase: Purification and some hydrolytic properties toward filaggrin and synthetic substrates
J Biochem118, 332-337. PubMed Europe PubMed
[YEAR:4-8-1995]Martichonok,V., Plouffe,C., Storer,A.C., Menard,R. and Jones,J.B.
Aziridine analogs of [[trans-(epoxysuccinyl)-L-leucyl]amino]-4-guanidinobutane (E-64) as inhibitors of cysteine proteases
J Med Chem38, 3078-3085. PubMed Europe PubMed I
McDonald,J.K. and Emerick,J.M.
Purification and characterization of procathepsin L, a self-processing zymogen of guinea pig spermatozoa that acts on a cathepsin D assay substrate
Arch Biochem Biophys323, 409-422. PubMed Europe PubMed DOI A
Takeda,A., Yamamoto,T., Nakamura,Y., Takahashi,T. and Hibino,T.
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L
FEBS Lett359, 78-80. PubMed Europe PubMed DOI
Werle,B., Ebert,W., Klein,W. and Spiess,E.
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue
Biol Chem Hoppe Seyler376, 157-164. PubMed Europe PubMed I

1994

Bromme,D., Bonneau,P.R., Lachance,P. and Storer,A.C.
Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity
J Biol Chem269, 30238-30242. PubMed Europe PubMed
[YEAR:1-7-1994]Dowd,A.J., Smith,A.M., McGonigle,S. and Dalton,J.P.
Purification and characterisation of a second cathepsin L proteinase secreted by the parasitic trematode Fasciola hepatica
Eur J Biochem223, 91-98. PubMed Europe PubMed DOI
Gour-Salin,B.J., Lachance,P., Bonneau,P.R., Storer,A.C., Kirschke,H. and Bromme,D.
E-64 analogs as inhibitors of cathepsin L and cathepsin S: importance of the S2-P2 interactions for potency and selectivity
Bioorg Chem22, 227-241. I
Kirschke,H. and Wiederanders,B.
Cathepsin S and related lysosomal endopeptidases
Methods Enzymol244, 500-511. PubMed Europe PubMed DOI V
[YEAR:15-5-1994]Tao,K., Stearns,N.A., Dong,J., Wu,Q.L. and Sahagian,G.G.
The proregion of cathepsin L is required for proper folding, stability, and ER exit
Arch Biochem Biophys311, 19-27. PubMed Europe PubMed DOI

1993

[YEAR:25-9-1993]Hook,V.Y., Purviance,R.T., Azaryan,A.V., Hubbard,G. and Krieger,T.J.
Purification and characterization of alpha 1-antichymotrypsin-like protease inhibitor that regulates prohormone thiol protease involved in enkephalin precursor processing
J Biol Chem268, 20570-20577. PubMed Europe PubMed
[YEAR:3-5-1993]Ishidoh,K., Takeda-Ezaki,M. and Kominami,E.
Procathepsin L-specific antibodies that recognize procathepsin L but not cathepsin L
FEBS Lett322, 79-82. PubMed Europe PubMed DOI
Kane,S.E.
Mouse procathepsin L lacking a functional glycosylation site is properly folded, stable, and secreted by NIH 3T3 cells
J Biol Chem268, 11456-11462. PubMed Europe PubMed
Menard,R., Carmona,E., Plouffe,C., Bromme,D., Konishi,Y., Lefebvre,J. and Storer,A.C.
The specificity of the S1' subsite of cysteine proteases
FEBS Lett328, 107-110. PubMed Europe PubMed DOI

1992

Dolenc,I., Ritonja,A., Colic,A., Podobnik,M., Ogrinc,T. and Turk,V.
Bovine cathepsins S and L: isolation and amino acid sequences
Biol Chem Hoppe Seyler373, 407-412. PubMed Europe PubMed
Pike,R.N., Coetzer,T.H. and Dennison,C.
Proteolytically active complexes of cathepsin L and a cysteine proteinase inhibitor; purification and demonstration of their formation in vitro
Arch Biochem Biophys294, 623-629. PubMed Europe PubMed DOI

1991

Ritonja,A., Colic,A., Dolenc,I., Ogrinc,T., Podobnik,M. and Turk,V.
The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L
FEBS Lett283, 329-331. PubMed Europe PubMed DOI
Tchoupe,J.R., Moreau,T., Gauthier,F. and Bieth,J.G.
Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group
Biochim Biophys Acta1076, 149-151. PubMed Europe PubMed DOI A

1990

Nguyen,Q., Mort,J.S. and Roughley,P.J.
Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B
Biochem J266, 569-573. PubMed Europe PubMed
Stearns,N.A., Dong,J.M., Pan,J.X., Brenner,D.A. and Sahagian,G.G.
Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels
Arch Biochem Biophys283, 447-457. PubMed Europe PubMed DOI

1989

Fan,Y.S., Byers,M.G., Eddy,R.L., Joseph,L., Sukhatme,V., Chan,S.J. and Shows,T.B.
Cathepsin L (CTSL) is located in the chromosome 9q21-q22 region; a related sequence is located on chromosome 10
Cytogenet Cell Genet51, 996-996.
Mason,R.W., Wilcox,D., Wikstrom,P. and Shaw,E.N.
The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor
Biochem J257, 125-129. PubMed Europe PubMed
Pike,R. and Dennison,C.
A high yield method for the isolation of sheep's liver cathepsin L
Prep Biochem19, 231-245. PubMed Europe PubMed DOI
[YEAR:16-10-1989]Rozhin,J., Wade,R.L., Honn,K.V. and Sloane,B.F.
Membrane-associated cathepsin L: a role in metastasis of melanomas
Biochem Biophys Res Commun164, 556-561. PubMed Europe PubMed
Smith,S.M. and Gottesman,M.M.
Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli
J Biol Chem264, 20487-20495. PubMed Europe PubMed E
[YEAR:1-8-1989]Wiederanders,B. and Kirschke,H.
The processing of a cathepsin L precursor in vitro
Arch Biochem Biophys272, 516-521. PubMed Europe PubMed

1988

Crawford,C., Mason,R.W., Wikstrom,P. and Shaw,E.
The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B
Biochem J253, 751-758. PubMed Europe PubMed I
Hiwasa,T., Sakiyama,S., Yokoyama,S., Ha,J.M., Fujita,J., Noguchi,S., Bando,Y., Kominami,E. and Katunuma,N.
Inhibition of cathepsin L-induced degradation of epidermal growth factor receptors by c-Ha-ras gene products
Biochem Biophys Res Commun151, 78-85. PubMed Europe PubMed
Joseph,L.J., Chang,L.C., Stamenkovich,D. and Sukhatme,V.P.
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts
J Clin Invest81, 1621-1629. PubMed Europe PubMed DOI
Ritonja,A., Popovic,T., Kotnik,M., Machleidt,W. and Turk,V.
Amino acid sequences of the human kidney cathepsins H and L
FEBS Lett228, 341-345. PubMed Europe PubMed

1987

Dufour,E., Obled,A., Valin,C., Bechet,D., Ribadeau-Dumas,B. and Huet,J.C.
Purification and amino acid sequence of chicken liver cathepsin L
Biochemistry26, 5689-5695. PubMed Europe PubMed

1986

Gal,S. and Gottesman,M.M.
The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity
Biochem Biophys Res Commun139, 156-162. PubMed Europe PubMed P
Johnson,D.A., Barrett,A.J. and Mason,R.W.
Cathepsin L inactivates alpha1-proteinase inhibitor by cleavage in the reactive site region
J Biol Chem261, 14748-14751. PubMed Europe PubMed
Kirschke,H., Schmidt,I. and Wiederanders,B.
Cathepsin S. The cysteine proteinase from bovine lymphoid tissue is distinct from cathepsin L (EC 3.4.22.15)
Biochem J240, 455-459. PubMed Europe PubMed

1985

Etherington,D.J., Maciewicz,R.A., Mason,R.W., Taylor,M.A. and Wardale,R.J.
A comparative study of cathepsins N and L and their distribution in different tissues
Prog Clin Biol Res180, 223-224. PubMed Europe PubMed
Mason,R.W., Green,G.D. and Barrett,A.J.
Human liver cathepsin L
Biochem J226, 233-241. PubMed Europe PubMed

1984

Hook,V.Y. and Loh,Y.P.
Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary
Proc Natl Acad Sci U S A81, 2776-2780. PubMed Europe PubMed I

1982

[YEAR:22-2-1982]Pagano,M. and Engler,R.
Inhibition of human liver cathepsin L by alpha-thiol proteinase inhibitor
FEBS Lett138, 307-310. PubMed Europe PubMed

1981

Barrett,A.J. and Kirschke,H.
Cathepsin B, cathepsin H and cathepsin L
Methods Enzymol80, 535-561. PubMed Europe PubMed DOI V
[YEAR:17-3-1981]Gottesman,M.M. and Cabral,F.
Purification and characterization of a transformation-dependent protein secreted by cultured murine fibroblasts
Biochemistry20, 1659-1665. PubMed Europe PubMed
Kargel,H.J., Dettmer,R., Etzold,G., Kirschke,H., Bohley,P. and Langner,J.
Action of rat liver cathepsin L on glucagon
Acta Biol Med Ger40, 1139-1143. PubMed Europe PubMed

1980

[YEAR:28-3-1980]Hibino,T., Fukuyama,K. and Epstein,W.L.
In vitro and in vivo inhibition of rat liver cathepsin L by epidermal proteinase inhibitor
Biochem Biophys Res Commun93, 440-447. PubMed Europe PubMed
Kargel,H.J., Dettmer,R., Etzold,G., Kirschke,H., Bohley,P. and Langner,J.
Action of cathepsin L on the oxidized B-chain of bovine insulin
FEBS Lett114, 257-260. PubMed Europe PubMed

1978

Gottesman,M.M.
Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts
Proc Natl Acad Sci U S A75, 2767-2771. PubMed Europe PubMed

1976

Kirschke,H., Langner,J., Wiederanders,B., Ansorge,S., Bohley,P. and Broghammer,U.
[Intracellular protein breakdown. VII. Cathepsin L and H; two new proteinases from rat liver lysosomes]
Acta Biol Med Ger35, 285-299. PubMed Europe PubMed