Release 2.7.1 (16 February 2018)

Following feedback from users we have reviewed the mark up of the intron-exon boundaries and pseudo-exons in the 2.7.0 release.  In addition we have identified several cases where existing alleles can be extended or have required sequence corrections to these regions.  The following report details these changes for specific genes and, where required, specific alleles for these genes.  Please note that no new alleles have been added to the database and this version acts as an update to the existing 2.7.0 release.

KIR2DL3

In the genomic alignments the position of the final exon boundary has been moved to the first stop codon present in the reference allele (KIR2DL3*0010101).  This has resulted in the removal of 24bp from the KIR2DL3_gen.fasta for alleles which share the same stop codon as the reference.  For alleles which have an alternative stop codon to the reference this sequence is correctly included.

KIR2DL4

The sequence of KIR2DL4*00502 has been removed from the KIR2DL4_gen.fasta, KIR2DL4_nuc.fasta and KIR2DL4_prot.fasta as this allele was deleted and should not have been included in these files.

Allele IPD-KIR Acc No Date EMBL/Genbank Comments
2DL4*0080104KIR00213 23-12-2006 EF095157
Genomic Sequence Extended
2DL4*0274KIR00675 18-04-2013 JX523637
Protein Sequence Corrected

KIR2DL5

Allele IPD-KIR Acc No Date EMBL/Genbank Comments
2DL5A*00103KIR00260 24-09-2007  EF473258
EF102434
Genomic Sequence Extended

KIR2DS4

Allele IPD-KIR Acc No Date EMBL/Genbank Comments
2DS4*0040101KIR00089 28-06-2003   EU143322
AJ620615
AY366246
GU182349
Sequence extended from position 871 to 893
2DS4*0060101KIR00090 28-06-2003   EU143324
AJ620616
GU182343
Sequence extended from position 1 to 20 and position 871 to 893
2DS4*0060102KIR00651 31-03-2010 GU182346 Genomic Sequence Corrected

KIR3DS1

The Exon/Intron boundaries in the genomic alignments have been corrected.  This has corrected the sequence in the KIR3DS1_gen.fasta file.

KIR3DL1

The sequence of KIR3DL2*00108 has been removed from the KIR3DL2_gen.fasta, KIR3DL2_nuc.fasta and KIR3DL2_prot.fasta as this allele was deleted and should not be included in these files. The sequences of KIR3DL1*05902, KIR3DL1*060, KIR3DL1*061 and KIR3DL1*098 have been extended in the KIR3DL1_gen.fasta to include the alternative stop codon for these alleles.

KIR3DL3

The Pseudo-Exon 3 correctly  marked up in the KIR3DL3 genomic alignments.  Resulting in corrections to the subsequent genomic sequence.

Allele IPD-KIR Acc No Date EMBL/Genbank Comments
3DL3*00202KIR00079 28-06-2003   AF204912
AF204913
AF204914
AY987940
Sequence extended from position 35 to 49 and Genomic Sequence Corrected
3DL3*00206KIR00218 30-01-2007 AM493896
EF153460
GU182354
Sequence extended from postion 1230 to 1233 Genomic Sequence Corrected

Release 2.7.0 (14 July 2017)

The KIR3DL2*06201 allele name was initially incorrectly listed as KIR3DL2*01 in the 2.7.0 release.


New Sequences
Allele IPD-KIR Acc No Date EMBL/Genbank Comments
2DL1*00304KIR00897 30-10-2015 KT438851
2DL1*00305KIR00898 30-10-2015 KT438852
2DL1*027KIR00798 30-09-2014 LM656208
2DL1*028KIR00799 30-09-2014 LM656209
2DL1*029KIR00800 30-09-2014 LM656210
2DL1*030KIR00817 30-11-2014 KP025959
2DL1*031KIR00818 30-11-2014 KP025960
2DL1*032NKIR00865 30-05-2015 KP893536
2DL1*033KIR00899 30-10-2015 KT438853
2DL1*034KIR00900 30-10-2015 KT438854
2DL2*00103KIR00850 28-02-2015 KP260924
2DL3*00502KIR00806 30-09-2014 LM656211
2DL3*01802KIR00895 31-07-2015 KT023603
2DL3*033KIR00849 28-02-2015 HG931348
2DL3*034KIR00879 30-05-2015 KP784272
2DL4*00503KIR00901 30-10-2015 KT438855
2DL4*00504KIR00902 30-10-2015 KT438856
2DL4*00603KIR00913 09-03-2016 KU845269
2DL4*028KIR00748 15-02-2014 KF941350
2DL4*029KIR00826 30-11-2014 LM656220
2DL4*030KIR00830 30-11-2014 LM656222
2DL4*031KIR00828 30-11-2014 LM656221
2DL4*032KIR00904 30-10-2015 KT438858
2DL4*033KIR00905 30-10-2015 KT438859
2DL4*034KIR00903 30-10-2015 KT438857
2DL4*035KIR00909 30-11-2015 LN907284
2DL4*036KIR00912 09-03-2016 KU845268
2DL4*037KIR00914 09-03-2016 KU845270
2DL4*038KIR00928 09-03-2016 KU845267
2DL5A*021KIR00882 30-05-2015 KP784273
2DL5A*022KIR00907 30-10-2015 KT438863
2DL5B*00203KIR00802 30-09-2014 LM656213
2DL5B*00804KIR00805 30-09-2014 LM656217
2DL5B*01304KIR00801 30-09-2014 LM656212
2DL5B*019KIR00803 30-09-2014 LM656215
2DL5B*020KIR00804 30-09-2014 LM656216
2DP1*00203KIR00880 30-05-2015 KP784307
2DP1*00204KIR00892 31-07-2015 KP784309
2DP1*015KIR00861 30-05-2015 KP784306
2DP1*016KIR00881 30-05-2015 KP784275
2DP1*017KIR00884 30-05-2015 KP784308
2DP1*018KIR00886 30-05-2015 KP784274
2DP1*019KIR00894 31-07-2015 KP784310
2DS1*009KIR00797 30-09-2014 LM656207
2DS2*009KIR00906 30-10-2015 KT438862
2DS3*008KIR00885 30-05-2015 KP784269
2DS4*00105KIR00820 30-11-2014 KP025962
2DS4*017KIR00819 30-11-2014 KP025961
2DS4*018KIR00821 30-11-2014 KP025963
2DS5*013KIR00822 12-08-2014 LM656218
2DS5*014KIR00824 30-11-2014 LM656219
2DS5*015KIR00878 30-05-2015 KP784270
2DS5*016KIR00893 31-07-2015 KP784271
3DL1*00103KIR00809 30-11-2014 LN606766
3DL1*00104KIR00857 30-05-2015 KP784298
3DL1*00105KIR00877 30-05-2015 KP784297
3DL1*00404KIR00854 30-05-2015 KP784290
3DL1*00504KIR00855 30-05-2015 KP784291
3DL1*00505KIR00873 30-05-2015 KP784294
3DL1*0150103KIR00755 19-05-2014 KJ593155
3DL1*0150212KIR00760 19-05-2014 KJ593153
3DL1*01506KIR00872 30-05-2015 KP784293
3DL1*0250102KIR00756 19-05-2014 KJ593157
3DL1*0250103KIR00757 19-05-2014 KJ593158
3DL1*02702KIR00745 15-02-2014 KF941347
3DL1*0310102KIR00763 15-07-2014 KJ593156
3DL1*03502KIR00747 15-02-2014 KF941349
3DL1*05902KIR00860 30-05-2015 KP784300
3DL1*080KIR00744 15-02-2014 KF941346
3DL1*081NKIR00746 15-02-2014 KF941348
3DL1*086KIR00767 15-07-2014 KM026529
3DL1*087KIR00766 15-07-2014 KJ593159
3DL1*088KIR00810 30-11-2014 LN606767
3DL1*088KIR00810 04-01-2017 LT630474
3DL1*089KIR00811 30-11-2014 LN606768
3DL1*090KIR00812 30-11-2014 LN606769
3DL1*091KIR00813 30-11-2014 LN606770
3DL1*092KIR00814 30-11-2014 LN606771
3DL1*093KIR00815 30-11-2014 LN606772
3DL1*094NKIR00816 30-11-2014 LN606773
3DL1*096KIR00866 30-05-2015 KP784285
3DL1*097KIR00867 30-05-2015 KP784286
3DL1*098KIR00868 30-05-2015 KP784301
3DL1*099KIR00869 30-05-2015 KP784288
3DL1*100KIR00859 30-05-2015 KP784299
3DL1*101KIR00870 30-05-2015 KP784292
3DL1*102KIR00875 30-05-2015 KP784295
3DL1*103KIR00876 30-05-2015 KP784296
3DL1*109KIR00890 31-07-2015 KP784287
3DL2*00105KIR00796 30-09-2014 KJ535482
3DL2*00105KIR00796 25-11-2014 LN650688
3DL2*00106KIR00789 30-09-2014 KJ535483
3DL2*00107KIR00832 30-11-2014 LN649144
3DL2*00109KIR00937 04-04-2016 LN999797
3DL2*00203KIR00770 30-09-2014 KJ535501
3DL2*00204KIR00847 30-11-2014 LN649156
3DL2*00303KIR00774 30-09-2014 KJ535488
3DL2*00304KIR00783 30-09-2014 KJ535495
3DL2*00602KIR00930 04-04-2016 LN999785
3DL2*00703KIR00778 30-09-2014 KJ535489
3DL2*00704KIR00808 30-11-2014 LN606764
LN649158
3DL2*00705KIR00823 30-11-2014 LN649139
3DL2*00706KIR00841 21-10-2015 KT899864
3DL2*00706KIR00841 30-11-2014 LN649150
3DL2*00707KIR00844 21-10-2015 KT899868
3DL2*00707KIR00844 30-11-2014 LN649153
3DL2*00708KIR00915 16-12-2015 LN995833
3DL2*00709KIR00927 26-02-2016 LN999788
3DL2*01002KIR00784 30-09-2014 KJ535498
3DL2*01003KIR00840 30-11-2014 LN649149
3DL2*01004KIR00883 30-05-2015 KP784304
3DL2*01004KIR00883 22-02-2016 LN999790
3DL2*01902KIR00931 31-03-2016 LN999792
3DL2*04302KIR00936 04-04-2016 LN999787
3DL2*06002KIR00934 01-04-2016 LN999795
3DL2*064KIR00793 30-09-2014 KJ535477
3DL2*065KIR00794 30-09-2014 KJ535476
3DL2*066KIR00795 30-09-2014 KJ535478
3DL2*067KIR00768 30-09-2014 KJ535481
3DL2*068KIR00769 30-09-2014 KJ535494
3DL2*070KIR00772 30-09-2014 KJ535491
3DL2*071KIR00773 30-09-2014 KJ535486
3DL2*072KIR00775 30-09-2014 KJ535492
3DL2*073KIR00776 30-09-2014 KJ535485
3DL2*074KIR00777 30-09-2014 KJ535493
3DL2*075KIR00779 30-09-2014 KJ535499
3DL2*076KIR00780 30-09-2014 KJ535500
3DL2*077KIR00781 30-09-2014 KJ535497
3DL2*078KIR00782 30-09-2014 KJ535503
3DL2*079KIR00785 30-09-2014 KJ535496
3DL2*07902KIR00929 31-03-2016 LN999794
3DL2*080KIR00786 30-09-2014 KJ535487
3DL2*081KIR00787 30-09-2014 KJ535484
3DL2*082KIR00788 30-09-2014 KJ535502
3DL2*083KIR00807 21-10-2015 KT899867
3DL2*083KIR00807 30-11-2014 KJ535480
3DL2*084KIR00825 17-09-2015 KT438861
3DL2*084KIR00825 30-11-2014 LN649140
3DL2*085KIR00827 30-11-2014 LN649141
3DL2*086KIR00829 30-11-2014 LN649142
3DL2*087KIR00831 30-11-2014 LN649143
3DL2*088KIR00834 30-11-2014 LN649145
3DL2*089KIR00836 30-11-2014 LN649146
3DL2*090KIR00838 30-11-2014 LN649147
3DL2*091KIR00839 17-09-2015 KT438860
3DL2*091KIR00839 30-11-2014 LN649148
3DL2*092KIR00842 30-11-2014 LN649151
3DL2*093KIR00843 21-10-2015 KT899866
3DL2*093KIR00843 30-11-2014 LN649152
3DL2*094KIR00845 30-11-2014 LN649154
3DL2*096KIR00848 30-11-2014 LN649157
3DL2*097KIR00862 30-05-2015 KP784302
3DL2*098KIR00888 31-07-2015 KP784303
3DL2*099KIR00908 30-11-2015 KT899865
3DL2*10001KIR00910 09-12-2015 KP784305
3DL2*10002KIR00938 29-04-2016 LN999798
3DL2*101KIR00911 15-12-2015 LN995832
3DL2*102KIR00916 16-12-2015 LN995834
3DL2*103KIR00924 22-02-2016 LN999791
3DL2*104KIR00925 23-02-2016 LN999783
3DL2*105KIR00926 25-02-2016 LN999796
3DL2*10601KIR00932 31-03-2016 LN999786
3DL2*10701KIR00933 31-03-2016 LN999782
3DL2*10801KIR00935 01-04-2016 LN999781
3DL2*109KIR00939 29-04-2016 LN999784
3DL3*00211KIR00790 30-09-2014 KF421590
3DL3*01003KIR00923 02-02-2016 KU529275
3DL3*02602KIR00919 02-02-2016 KU529271
3DL3*04802KIR00917 02-02-2016 KU529269
3DL3*04902KIR00791 30-09-2014 KF421592
3DL3*058KIR00792 30-09-2014 KF421591
3DL3*059KIR00833 30-11-2014 LM656224
3DL3*060KIR00835 30-11-2014 LM656225
3DL3*061KIR00837 30-11-2014 LM656226
3DL3*062KIR00920 02-02-2016 KU529272
3DL3*063KIR00918 02-02-2016 KU529270
3DL3*064KIR00921 02-02-2016 KU529273
3DL3*065KIR00922 02-02-2016 KU529274
3DP1*01002KIR00864 30-05-2015 KP893537
3DP1*015KIR00863 30-05-2015 KP893538
3DS1*01304KIR00853 30-05-2015 KP784279
3DS1*01305KIR00887 31-07-2015 KP784278
3DS1*01306KIR00891 31-07-2015 KP784276
3DS1*01307KIR00896 31-07-2015 KP784284
3DS1*104KIR00852 30-05-2015 KP784277
3DS1*105KIR00856 30-05-2015 KP784280
3DS1*106KIR00858 30-05-2015 KP784283
3DS1*107KIR00871 30-05-2015 KP784281
3DS1*108KIR00874 30-05-2015 KP784282
Sequences Pending
Allele Comments
2DL1*00306
2DL1*02202
2DL1*035
2DL1*036
2DL3*035
2DL5B*00805
2DP1*020
2DP1*021
2DP1*022
2DP1*023
2DP1*024
2DS4*00106
2DS5*017
3DL1*110
3DL1*111
3DL2*11001
3DL2*11002
3DL3*066
3DL3*067
3DL3*068
3DL3*069
3DL3*070
Modified Sequences
Allele IPD-KIR Acc No Comments
3DL1*0010102KIR00434 Sequence extended from position 1159 to 1335
3DL1*0070103KIR00712 Sequence extended from position 1 to 70
3DL1*095KIR00851 Sequence extended from position 1 to 1335
3DL2*0020103KIR00463 Sequence extended from position 1193 to 1368
3DL2*021KIR00210 Sequence extended from position 1 to 34 and position 1362 to 1368
3DL2*069KIR00771 Sequence extended from position 1 to 1368
3DL2*095KIR00846 Sequence extended from position 1 to 1368
3DP1*013KIR00698 Sequence extended from position 36 to 74 and position 76 to 77
3DP1*014KIR00705 Sequence extended from position 36 to 74 and position 76 to 77
Deleted Sequences
Allele IPD-KIR Acc No Comments
None

Further Information

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