IPD-KIR

Release 2.7.1 (16 February 2018)

Following feedback from users we have reviewed the mark up of the intron-exon boundaries and pseudo-exons in the 2.7.0 release.  In addition we have identified several cases where existing alleles can be extended or have required sequence corrections to these regions.  The following report details these changes for specific genes and, where required, specific alleles for these genes.  Please note that no new alleles have been added to the database and this version acts as an update to the existing 2.7.0 release.

KIR2DL3

In the genomic alignments the position of the final exon boundary has been moved to the first stop codon present in the reference allele (KIR2DL3*0010101).  This has resulted in the removal of 24bp from the KIR2DL3_gen.fasta for alleles which share the same stop codon as the reference.  For alleles which have an alternative stop codon to the reference this sequence is correctly included.

KIR2DL4

The sequence of KIR2DL4*00502 has been removed from the KIR2DL4_gen.fasta, KIR2DL4_nuc.fasta and KIR2DL4_prot.fasta as this allele was deleted and should not have been included in these files.

Allele	IPD-KIR Acc No	Date	EMBL/Genbank	Comments
2DL4*0080104	KIR00213	23-12-2006	EF095157	Genomic Sequence Extended
2DL4*0274	KIR00675	18-04-2013	JX523637	Protein Sequence Corrected

KIR2DL5

Allele	IPD-KIR Acc No	Date	EMBL/Genbank	Comments
2DL5A*00103	KIR00260	24-09-2007	EF473258 EF102434	Genomic Sequence Extended

KIR2DS4

Allele	IPD-KIR Acc No	Date	EMBL/Genbank	Comments
2DS4*0040101	KIR00089	28-06-2003	EU143322 AJ620615 AY366246 GU182349	Sequence extended from position 871 to 893
2DS4*0060101	KIR00090	28-06-2003	EU143324 AJ620616 GU182343	Sequence extended from position 1 to 20 and position 871 to 893
2DS4*0060102	KIR00651	31-03-2010	GU182346	Genomic Sequence Corrected

KIR3DS1

The Exon/Intron boundaries in the genomic alignments have been corrected.  This has corrected the sequence in the KIR3DS1_gen.fasta file.

KIR3DL1

The sequence of KIR3DL2*00108 has been removed from the KIR3DL2_gen.fasta, KIR3DL2_nuc.fasta and KIR3DL2_prot.fasta as this allele was deleted and should not be included in these files. The sequences of KIR3DL1*05902, KIR3DL1*060, KIR3DL1*061 and KIR3DL1*098 have been extended in the KIR3DL1_gen.fasta to include the alternative stop codon for these alleles.

KIR3DL3

The Pseudo-Exon 3 correctly  marked up in the KIR3DL3 genomic alignments.  Resulting in corrections to the subsequent genomic sequence.

Allele	IPD-KIR Acc No	Date	EMBL/Genbank	Comments
3DL3*00202	KIR00079	28-06-2003	AF204912 AF204913 AF204914 AY987940	Sequence extended from position 35 to 49 and Genomic Sequence Corrected
3DL3*00206	KIR00218	30-01-2007	AM493896 EF153460 GU182354	Sequence extended from postion 1230 to 1233 Genomic Sequence Corrected

Release 2.7.0 (14 July 2017)

The KIR3DL2*06201 allele name was initially incorrectly listed as KIR3DL2*01 in the 2.7.0 release.

New Sequences
Allele	IPD-KIR Acc No	Date	EMBL/Genbank	Comments
2DL1*00304	KIR00897	30-10-2015	KT438851
2DL1*00305	KIR00898	30-10-2015	KT438852
2DL1*027	KIR00798	30-09-2014	LM656208
2DL1*028	KIR00799	30-09-2014	LM656209
2DL1*029	KIR00800	30-09-2014	LM656210
2DL1*030	KIR00817	30-11-2014	KP025959
2DL1*031	KIR00818	30-11-2014	KP025960
2DL1*032N	KIR00865	30-05-2015	KP893536
2DL1*033	KIR00899	30-10-2015	KT438853
2DL1*034	KIR00900	30-10-2015	KT438854
2DL2*00103	KIR00850	28-02-2015	KP260924
2DL3*00502	KIR00806	30-09-2014	LM656211
2DL3*01802	KIR00895	31-07-2015	KT023603
2DL3*033	KIR00849	28-02-2015	HG931348
2DL3*034	KIR00879	30-05-2015	KP784272
2DL4*00503	KIR00901	30-10-2015	KT438855
2DL4*00504	KIR00902	30-10-2015	KT438856
2DL4*00603	KIR00913	09-03-2016	KU845269
2DL4*028	KIR00748	15-02-2014	KF941350
2DL4*029	KIR00826	30-11-2014	LM656220
2DL4*030	KIR00830	30-11-2014	LM656222
2DL4*031	KIR00828	30-11-2014	LM656221
2DL4*032	KIR00904	30-10-2015	KT438858
2DL4*033	KIR00905	30-10-2015	KT438859
2DL4*034	KIR00903	30-10-2015	KT438857
2DL4*035	KIR00909	30-11-2015	LN907284
2DL4*036	KIR00912	09-03-2016	KU845268
2DL4*037	KIR00914	09-03-2016	KU845270
2DL4*038	KIR00928	09-03-2016	KU845267
2DL5A*021	KIR00882	30-05-2015	KP784273
2DL5A*022	KIR00907	30-10-2015	KT438863
2DL5B*00203	KIR00802	30-09-2014	LM656213
2DL5B*00804	KIR00805	30-09-2014	LM656217
2DL5B*01304	KIR00801	30-09-2014	LM656212
2DL5B*019	KIR00803	30-09-2014	LM656215
2DL5B*020	KIR00804	30-09-2014	LM656216
2DP1*00203	KIR00880	30-05-2015	KP784307
2DP1*00204	KIR00892	31-07-2015	KP784309
2DP1*015	KIR00861	30-05-2015	KP784306
2DP1*016	KIR00881	30-05-2015	KP784275
2DP1*017	KIR00884	30-05-2015	KP784308
2DP1*018	KIR00886	30-05-2015	KP784274
2DP1*019	KIR00894	31-07-2015	KP784310
2DS1*009	KIR00797	30-09-2014	LM656207
2DS2*009	KIR00906	30-10-2015	KT438862
2DS3*008	KIR00885	30-05-2015	KP784269
2DS4*00105	KIR00820	30-11-2014	KP025962
2DS4*017	KIR00819	30-11-2014	KP025961
2DS4*018	KIR00821	30-11-2014	KP025963
2DS5*013	KIR00822	12-08-2014	LM656218
2DS5*014	KIR00824	30-11-2014	LM656219
2DS5*015	KIR00878	30-05-2015	KP784270
2DS5*016	KIR00893	31-07-2015	KP784271
3DL1*00103	KIR00809	30-11-2014	LN606766
3DL1*00104	KIR00857	30-05-2015	KP784298
3DL1*00105	KIR00877	30-05-2015	KP784297
3DL1*00404	KIR00854	30-05-2015	KP784290
3DL1*00504	KIR00855	30-05-2015	KP784291
3DL1*00505	KIR00873	30-05-2015	KP784294
3DL1*0150103	KIR00755	19-05-2014	KJ593155
3DL1*0150212	KIR00760	19-05-2014	KJ593153
3DL1*01506	KIR00872	30-05-2015	KP784293
3DL1*0250102	KIR00756	19-05-2014	KJ593157
3DL1*0250103	KIR00757	19-05-2014	KJ593158
3DL1*02702	KIR00745	15-02-2014	KF941347
3DL1*0310102	KIR00763	15-07-2014	KJ593156
3DL1*03502	KIR00747	15-02-2014	KF941349
3DL1*05902	KIR00860	30-05-2015	KP784300
3DL1*080	KIR00744	15-02-2014	KF941346
3DL1*081N	KIR00746	15-02-2014	KF941348
3DL1*086	KIR00767	15-07-2014	KM026529
3DL1*087	KIR00766	15-07-2014	KJ593159
3DL1*088	KIR00810	30-11-2014	LN606767
3DL1*088	KIR00810	04-01-2017	LT630474
3DL1*089	KIR00811	30-11-2014	LN606768
3DL1*090	KIR00812	30-11-2014	LN606769
3DL1*091	KIR00813	30-11-2014	LN606770
3DL1*092	KIR00814	30-11-2014	LN606771
3DL1*093	KIR00815	30-11-2014	LN606772
3DL1*094N	KIR00816	30-11-2014	LN606773
3DL1*096	KIR00866	30-05-2015	KP784285
3DL1*097	KIR00867	30-05-2015	KP784286
3DL1*098	KIR00868	30-05-2015	KP784301
3DL1*099	KIR00869	30-05-2015	KP784288
3DL1*100	KIR00859	30-05-2015	KP784299
3DL1*101	KIR00870	30-05-2015	KP784292
3DL1*102	KIR00875	30-05-2015	KP784295
3DL1*103	KIR00876	30-05-2015	KP784296
3DL1*109	KIR00890	31-07-2015	KP784287
3DL2*00105	KIR00796	30-09-2014	KJ535482
3DL2*00105	KIR00796	25-11-2014	LN650688
3DL2*00106	KIR00789	30-09-2014	KJ535483
3DL2*00107	KIR00832	30-11-2014	LN649144
3DL2*00109	KIR00937	04-04-2016	LN999797
3DL2*00203	KIR00770	30-09-2014	KJ535501
3DL2*00204	KIR00847	30-11-2014	LN649156
3DL2*00303	KIR00774	30-09-2014	KJ535488
3DL2*00304	KIR00783	30-09-2014	KJ535495
3DL2*00602	KIR00930	04-04-2016	LN999785
3DL2*00703	KIR00778	30-09-2014	KJ535489
3DL2*00704	KIR00808	30-11-2014	LN606764 LN649158
3DL2*00705	KIR00823	30-11-2014	LN649139
3DL2*00706	KIR00841	21-10-2015	KT899864
3DL2*00706	KIR00841	30-11-2014	LN649150
3DL2*00707	KIR00844	21-10-2015	KT899868
3DL2*00707	KIR00844	30-11-2014	LN649153
3DL2*00708	KIR00915	16-12-2015	LN995833
3DL2*00709	KIR00927	26-02-2016	LN999788
3DL2*01002	KIR00784	30-09-2014	KJ535498
3DL2*01003	KIR00840	30-11-2014	LN649149
3DL2*01004	KIR00883	30-05-2015	KP784304
3DL2*01004	KIR00883	22-02-2016	LN999790
3DL2*01902	KIR00931	31-03-2016	LN999792
3DL2*04302	KIR00936	04-04-2016	LN999787
3DL2*06002	KIR00934	01-04-2016	LN999795
3DL2*064	KIR00793	30-09-2014	KJ535477
3DL2*065	KIR00794	30-09-2014	KJ535476
3DL2*066	KIR00795	30-09-2014	KJ535478
3DL2*067	KIR00768	30-09-2014	KJ535481
3DL2*068	KIR00769	30-09-2014	KJ535494
3DL2*070	KIR00772	30-09-2014	KJ535491
3DL2*071	KIR00773	30-09-2014	KJ535486
3DL2*072	KIR00775	30-09-2014	KJ535492
3DL2*073	KIR00776	30-09-2014	KJ535485
3DL2*074	KIR00777	30-09-2014	KJ535493
3DL2*075	KIR00779	30-09-2014	KJ535499
3DL2*076	KIR00780	30-09-2014	KJ535500
3DL2*077	KIR00781	30-09-2014	KJ535497
3DL2*078	KIR00782	30-09-2014	KJ535503
3DL2*079	KIR00785	30-09-2014	KJ535496
3DL2*07902	KIR00929	31-03-2016	LN999794
3DL2*080	KIR00786	30-09-2014	KJ535487
3DL2*081	KIR00787	30-09-2014	KJ535484
3DL2*082	KIR00788	30-09-2014	KJ535502
3DL2*083	KIR00807	21-10-2015	KT899867
3DL2*083	KIR00807	30-11-2014	KJ535480
3DL2*084	KIR00825	17-09-2015	KT438861
3DL2*084	KIR00825	30-11-2014	LN649140
3DL2*085	KIR00827	30-11-2014	LN649141
3DL2*086	KIR00829	30-11-2014	LN649142
3DL2*087	KIR00831	30-11-2014	LN649143
3DL2*088	KIR00834	30-11-2014	LN649145
3DL2*089	KIR00836	30-11-2014	LN649146
3DL2*090	KIR00838	30-11-2014	LN649147
3DL2*091	KIR00839	17-09-2015	KT438860
3DL2*091	KIR00839	30-11-2014	LN649148
3DL2*092	KIR00842	30-11-2014	LN649151
3DL2*093	KIR00843	21-10-2015	KT899866
3DL2*093	KIR00843	30-11-2014	LN649152
3DL2*094	KIR00845	30-11-2014	LN649154
3DL2*096	KIR00848	30-11-2014	LN649157
3DL2*097	KIR00862	30-05-2015	KP784302
3DL2*098	KIR00888	31-07-2015	KP784303
3DL2*099	KIR00908	30-11-2015	KT899865
3DL2*10001	KIR00910	09-12-2015	KP784305
3DL2*10002	KIR00938	29-04-2016	LN999798
3DL2*101	KIR00911	15-12-2015	LN995832
3DL2*102	KIR00916	16-12-2015	LN995834
3DL2*103	KIR00924	22-02-2016	LN999791
3DL2*104	KIR00925	23-02-2016	LN999783
3DL2*105	KIR00926	25-02-2016	LN999796
3DL2*10601	KIR00932	31-03-2016	LN999786
3DL2*10701	KIR00933	31-03-2016	LN999782
3DL2*10801	KIR00935	01-04-2016	LN999781
3DL2*109	KIR00939	29-04-2016	LN999784
3DL3*00211	KIR00790	30-09-2014	KF421590
3DL3*01003	KIR00923	02-02-2016	KU529275
3DL3*02602	KIR00919	02-02-2016	KU529271
3DL3*04802	KIR00917	02-02-2016	KU529269
3DL3*04902	KIR00791	30-09-2014	KF421592
3DL3*058	KIR00792	30-09-2014	KF421591
3DL3*059	KIR00833	30-11-2014	LM656224
3DL3*060	KIR00835	30-11-2014	LM656225
3DL3*061	KIR00837	30-11-2014	LM656226
3DL3*062	KIR00920	02-02-2016	KU529272
3DL3*063	KIR00918	02-02-2016	KU529270
3DL3*064	KIR00921	02-02-2016	KU529273
3DL3*065	KIR00922	02-02-2016	KU529274
3DP1*01002	KIR00864	30-05-2015	KP893537
3DP1*015	KIR00863	30-05-2015	KP893538
3DS1*01304	KIR00853	30-05-2015	KP784279
3DS1*01305	KIR00887	31-07-2015	KP784278
3DS1*01306	KIR00891	31-07-2015	KP784276
3DS1*01307	KIR00896	31-07-2015	KP784284
3DS1*104	KIR00852	30-05-2015	KP784277
3DS1*105	KIR00856	30-05-2015	KP784280
3DS1*106	KIR00858	30-05-2015	KP784283
3DS1*107	KIR00871	30-05-2015	KP784281
3DS1*108	KIR00874	30-05-2015	KP784282
Sequences Pending
Allele	Comments
2DL1*00306
2DL1*02202
2DL1*035
2DL1*036
2DL3*035
2DL5B*00805
2DP1*020
2DP1*021
2DP1*022
2DP1*023
2DP1*024
2DS4*00106
2DS5*017
3DL1*110
3DL1*111
3DL2*11001
3DL2*11002
3DL3*066
3DL3*067
3DL3*068
3DL3*069
3DL3*070
Modified Sequences
Allele	IPD-KIR Acc No	Comments
3DL1*0010102	KIR00434	Sequence extended from position 1159 to 1335
3DL1*0070103	KIR00712	Sequence extended from position 1 to 70
3DL1*095	KIR00851	Sequence extended from position 1 to 1335
3DL2*0020103	KIR00463	Sequence extended from position 1193 to 1368
3DL2*021	KIR00210	Sequence extended from position 1 to 34 and position 1362 to 1368
3DL2*069	KIR00771	Sequence extended from position 1 to 1368
3DL2*095	KIR00846	Sequence extended from position 1 to 1368
3DP1*013	KIR00698	Sequence extended from position 36 to 74 and position 76 to 77
3DP1*014	KIR00705	Sequence extended from position 36 to 74 and position 76 to 77
Deleted Sequences
Allele	IPD-KIR Acc No	Comments
None