The IPD-MHC Database provides a centralised repository for sequences of the Major Histocompatibility Complex (MHC) from a number of different species. Through a number of international collaborations IPD is able to provide the MHC sequences of different species. The sequences provided by each group are curated by experts in the field and then submitted to the central database.
IPD-MHC Announcement, December 2015
- The IPD-MHC Project and underlying infrastructure is currently undergoing a major rebuild. This is to cope with the increase volume of data, to include all updated information for all species and to streamline the release process.
- In the interim period, any updates to the various projects will be published as either downloadble PDFs of the nomenclature reports and tables or as a set of FASTA files in the appropriate subdirectory of the FTP server.
- We apologise for the inconvenience caused during this period, however the project requires this input to move forward and provide the community with the quality of data required.
- This work is made possible by support from The Pirbright Institute, the BBSRC, and Anthony Nolan.
Nomenclature for MHC genes and alleles in species other than humans and mice has historically been overseen either informally by groups generating sequences, or by formal nomenclature committees set up by the International Society for Animal Genetics (ISAG). This work is now overseen by the Comparative MHC Nomenclature Committee and is supported by ISAG and the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS).
ISAG/IUIS-VIC Comparative MHC Nomenclature Committee report, 2005Immunogenetics (2006), 57: 953958
The following groups have provided data. The individual group pages provide further data on the species included, nomenclature and access to the sequences.
Official Species Designations
Full details of all the species included in IPD-MHC and their official designations are available here. If you are working on MHC nomenclature and your species is not represented above please complete the following form, which will submit a request for a new 4 letter code to the Comparitive MHC Nomenclature Committee. Nomenclature committees representing different species or groups should also contact IPD Support for further information about the inclusion of their sequences into the IPD-MHC Database.
Development of the IPD-MHC database has been undertaken by the following individuals.
Nolan Research Institute
- Steven GE Marsh
- James Robinson
- European Bioinformatics
- Peter Stoehr
- Rodrigo Lopez
- Hamish McWilliam