Cryo-EM reconstruction of TMEM106B fold I-d filaments from case 18 with multiple system atrophy
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lövestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: 10.1038/s41586-022-04650-z Pubmed: 35344985 ]
Image sets:
TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
Resolution: 2.64 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qvc
Q-score: 0.617
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ Pubmed: 35344985 DOI: doi:10.1038/s41586-022-04650-z ]
- Transmembrane protein 106b (31 kDa, Protein from human)
- Tmem106b (Tissue from Homo sapiens)
TMEM106B filaments with Fold I-d from Multiple system atrophy (case 18)
Resolution: 3.64 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qvf
Q-score: 0.469
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ Pubmed: 35344985 DOI: doi:10.1038/s41586-022-04650-z ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from human)
TMEM106B filaments with Fold IIa from Multiple system atrophy (case 19)
Resolution: 3.38 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwg
Q-score: 0.53
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ Pubmed: 35344985 DOI: doi:10.1038/s41586-022-04650-z ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from human)
TMEM106B filaments with Fold IIb from Multiple system atrophy (case 19)
Resolution: 3.47 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwl
Q-score: 0.513
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ Pubmed: 35344985 DOI: doi:10.1038/s41586-022-04650-z ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from human)
TMEM106B filaments with Fold III from Multiple system atrophy (case 17)
Resolution: 2.76 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwm
Q-score: 0.671
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ Pubmed: 35344985 DOI: doi:10.1038/s41586-022-04650-z ]
- Transmembrane protein 106b (31 kDa, Protein from human)
- Tmem106b (Tissue from Homo sapiens)
Yang Y, Arseni D, Zhang WJ, Huang M, Lovestam SKA, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew S, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ DOI: 10.1126/science.abm7285 Pubmed: 35025654 ]
Image sets:
Yang Y, Arseni D, Zhang WJ, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew S, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ DOI: 10.1126/science.abm7285 Pubmed: 35025654 ]
Image sets:
Type I beta-amyloid 42 Filaments from Human Brain
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q4b
Q-score: 0.688
Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ Pubmed: 35025654 DOI: doi:10.1126/science.abm7285 ]
- Amyloid-beta precursor protein (4 kDa, Protein from Human)
- Unknown atom or ion (Ligand)
- Water (18 Da, Ligand)
- Beta-amyloid 42 filaments extracted from the human brain with alzheimer's disease (Tissue from Homo sapiens)
Type II beta-amyloid 42 Filaments from Human Brain
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q4m
Q-score: 0.631
Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ Pubmed: 35025654 DOI: doi:10.1126/science.abm7285 ]