EMD-14174
TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
EMD-14174
Helical reconstruction2.64 Å
Deposition: 21/01/2022Map released: 09/03/2022
Last modified: 20/11/2024
Sample Organism:
Homo sapiens
Sample: TMEM106B
Fitted models: 7qvc
Deposition Authors: Lovestam S, Schweighauser M
Sample: TMEM106B
Fitted models: 7qvc
Deposition Authors: Lovestam S, Schweighauser M
Age-dependent formation of TMEM106B amyloid filaments in human brains.
Schweighauser M ,
Arseni D ,
Bacioglu M ,
Huang M ,
Lovestam S,
Shi Y ,
Yang Y ,
Zhang W ,
Kotecha A ,
Garringer HJ ,
Vidal R ,
Hallinan GI,
Newell KL,
Tarutani A ,
Murayama S,
Miyazaki M,
Saito Y,
Yoshida M,
Hasegawa K,
Lashley T ,
Revesz T,
Kovacs GG ,
van Swieten J,
Takao M,
Hasegawa M ,
Ghetti B ,
Spillantini MG,
Ryskeldi-Falcon B ,
Murzin AG,
Goedert M ,
Scheres SHW
(2022) Nature , 605 , 310 - 314
,
Arseni D ,
Bacioglu M ,
Huang M ,
Lovestam S,
Shi Y ,
Yang Y ,
Zhang W ,
Kotecha A ,
Garringer HJ ,
Vidal R ,
Hallinan GI,
Newell KL,
Tarutani A ,
Murayama S,
Miyazaki M,
Saito Y,
Yoshida M,
Hasegawa K,
Lashley T ,
Revesz T,
Kovacs GG ,
van Swieten J,
Takao M,
Hasegawa M ,
Ghetti B ,
Spillantini MG,
Ryskeldi-Falcon B ,
Murzin AG,
Goedert M ,
Scheres SHW
(2022) Nature , 605 , 310 - 314
Grant Support:
- Medical Research Council (MRC, United Kingdom): (United Kingdom)