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Alpha-7 nicotinic acetylcholine receptor bound to alpha-bungarotoxin in a resting state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7koo
Q-score: 0.517
Noviello CM, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, Sine SM, Hibbs RE
Cell (2021) 184 pp. 2121- [ Pubmed: 33735609 DOI: doi:10.1016/j.cell.2021.02.049 ]
- Calcium ion (40 Da, Ligand)
- Alpha-bungarotoxin isoform v31 (Complex)
- Complex between alpha-bungarotoxin and the human alpha-7 nicotinic acetylcholine receptor (Complex)
- Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562 fusion (63 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562 fusion (Complex from Homo sapiens)
- Alpha-bungarotoxin isoform v31 (7 kDa, Protein from Bungarus multicinctus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Alpha-7 nicotinic acetylcholine receptor bound to epibatidine in a desensitized state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7koq
Q-score: 0.472
Noviello CM, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, Sine SM, Hibbs RE
Cell (2021) 184 pp. 2121- [ Pubmed: 33735609 DOI: doi:10.1016/j.cell.2021.02.049 ]
- Alpha 7 nicotinic receptor in complex with the agonist epibatidine (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562 fusion (63 kDa, Protein from Homo sapiens)
- Epibatidine (208 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and PNU-120596 in the activated state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7kox
Q-score: 0.481
Noviello CM, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, Sine SM, Hibbs RE
Cell (2021) 184 pp. 2121- [ Pubmed: 33735609 DOI: doi:10.1016/j.cell.2021.02.049 ]
- Calcium ion (40 Da, Ligand)
- Alpha-7 nicotinic receptor in complex with epibatidine and pnu-120596 (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562 fusion (63 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Epibatidine (208 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 6pv7
Q-score: 0.501
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501- [ DOI: doi:10.1016/j.neuron.2019.07.030 Pubmed: 31488329 ]
- Igg2b fab heavy chain (23 kDa, Protein from house mouse)
- Nonane (128 Da, Ligand)
- Fusion protein of neuronal acetylcholine receptor subunit beta-4 and soluble cytochrome b562 (61 kDa, Protein from Homo sapiens)
- Human alpha3beta4 nicotinic acetylcholine receptor (Complex)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Igg2b/kappa antibody (Complex)
- (s)-3-(1-methylpyrrolidin-2-yl)pyridine (162 Da, Ligand)
- Water (18 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-3 (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit alpha-3 and soluble cytochrome b562 (60 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-4 (Complex)
- Human alpha3beta4 nicotinic receptor in complex with fab fragments and bound to nicotine (Complex from Homo sapiens)
- Kappa fab light chain (Complex)
- Kappa fab light chain (23 kDa, Protein from house mouse)
- Igg2b heavy chain (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 6pv8
Q-score: 0.416
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501- [ DOI: doi:10.1016/j.neuron.2019.07.030 Pubmed: 31488329 ]
- Igg2b fab heavy chain (23 kDa, Protein from house mouse)
- (3-endo)-n-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine (309 Da, Ligand)
- Fusion protein of neuronal acetylcholine receptor subunit beta-4 and soluble cytochrome b562 (61 kDa, Protein from Homo sapiens)
- Human alpha3beta4 nicotinic acetylcholine receptor (Complex)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Igg2b/kappa antibody (Complex)
- Neuronal acetylcholine receptor subunit alpha-3 (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit alpha-3 and soluble cytochrome b562 (60 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-4 (Complex)
- Kappa fab light chain (Complex)
- Kappa fab light chain (23 kDa, Protein from house mouse)
- Water (18 Da, Ligand)
- Igg2b heavy chain (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Human alpha3beta4 nicotinic receptor in complex with fab fragments and bound to at-1001 (Complex from Homo sapiens)
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501-511.e6 [ DOI: doi:10.1016/j.neuron.2019.07.030 Pubmed: 31488329 ]
Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001 in saposin nanodiscs
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501-511.e6 [ DOI: doi:10.1016/j.neuron.2019.07.030 Pubmed: 31488329 ]