PDBe 6pv8

Electron Microscopy
3.87Å resolution

Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Neuronal acetylcholine receptor subunit alpha-3; Soluble cytochrome b562 Chains: A, D
Molecule details ›
Chains: A, D
Length: 525 amino acids
Theoretical weight: 60.09 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P32297 (Residues: 32-378, 434-505; Coverage: 88%)
  • Canonical: A0A3W4NZ06 (Residues: 23-127; Coverage: 99%)
Gene names: CHRNA3, CWJ32_12820, NACHRA3
Sequence domains:
Neuronal acetylcholine receptor subunit beta-4; Soluble cytochrome b562 Chains: B, C, E
Molecule details ›
Chains: B, C, E
Length: 538 amino acids
Theoretical weight: 61.34 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: A0A3W4NZ06 (Residues: 23-127; Coverage: 99%)
  • Canonical: P30926 (Residues: 22-361, 417-498; Coverage: 89%)
Gene names: CHRNB4, CWJ32_12820
Sequence domains:
IgG2b Fab heavy chain Chains: F, H
Molecule details ›
Chains: F, H
Length: 219 amino acids
Theoretical weight: 23.4 KDa
Source organism: Mus musculus
Kappa Fab light chain Chains: G, I
Molecule details ›
Chains: G, I
Length: 213 amino acids
Theoretical weight: 23.4 KDa
Source organism: Mus musculus

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.87Å
Relevant EMDB volumes: EMD-20488
Expression system: Homo sapiens