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Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8uf7
Q-score: 0.36
Kumar S, Summers B, Basore K, Pengo V, Flaumenhaft R, Pozzi N
Blood (2024) 143 pp. 2005-2011 [ Pubmed: 38437497 DOI: doi:10.1182/blood.2023022942 ]
- Prothrombin (65 kDa, Protein from Homo sapiens)
- Pomab light chain (23 kDa, Protein from Mus musculus)
- Pomab heavy chain (23 kDa, Protein from Mus musculus)
- Complex of fab fragment of pomab with human prothrombin (120 kDa, Complex from Mus musculus)
The structure of h12-LOX in monomeric form
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8ghb
Q-score: 0.533
Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A
Blood (2023) 142 pp. 1233-1242 [ Pubmed: 37506345 DOI: doi:10.1182/blood.2023020441 ]
- Monomeric human 12-lipoxygenase (75 kDa, Complex from Homo sapiens)
- Polyunsaturated fatty acid lipoxygenase alox12 (76 kDa, Protein from Homo sapiens)
- Fe (ii) ion (55 Da, Ligand)
The structure of h12-LOX in dimeric form
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8ghc
Q-score: 0.615
Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A
Blood (2023) 142 pp. 1233-1242 [ Pubmed: 37506345 DOI: doi:10.1182/blood.2023020441 ]
- Dimeric human 12-lipoxygenase (150 kDa, Complex from Homo sapiens)
- Polyunsaturated fatty acid lipoxygenase alox12 (76 kDa, Protein from Homo sapiens)
- Fe (ii) ion (55 Da, Ligand)
The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8ghd
Q-score: 0.654
Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A
Blood (2023) 142 pp. 1233-1242 [ Pubmed: 37506345 DOI: doi:10.1182/blood.2023020441 ]
- Polyunsaturated fatty acid lipoxygenase alox12 (76 kDa, Protein from Homo sapiens)
- Fe (ii) ion (55 Da, Ligand)
- Arachidonic acid (304 Da, Ligand)
- Hexameric human 12-lipoxygenase in complex with inhibitor ml355 and arachidonic acid (450 kDa, Complex from Homo sapiens)
- N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamide (441 Da, Ligand)
The structure of h12-LOX in tetrameric form bound to endogenous inhibitor oleoyl-CoA
Resolution: 2.05 Å
EM Method: Single-particle
Fitted PDBs: 8ghe
Q-score: 0.624
Mobbs JI, Black KA, Tran M, Burger WAC, Venugopal H, Holman TR, Holinstat M, Thal DM, Glukhova A
Blood (2023) 142 pp. 1233-1242 [ Pubmed: 37506345 DOI: doi:10.1182/blood.2023020441 ]
- Water (18 Da, Ligand)
- Polyunsaturated fatty acid lipoxygenase alox12 (76 kDa, Protein from Homo sapiens)
- Fe (ii) ion (55 Da, Ligand)
- S-{(3r,5r,9r)-1-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9z)-octadec-9-enethioate (non-preferred name) (1 kDa, Ligand)
- Tetrameric human 12-lipoxygenase bound to endogenous inhibitor oleoyl-coa (300 kDa, Complex from Homo sapiens)
Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor
Resolution: 4.23 Å
EM Method: Single-particle
Fitted PDBs: 8g6i
Q-score: 0.15
Childers KC, Avery NG, Estrada Alamo KA, Davulcu O, Haynes RM, Lollar P, Doering CB, Coxon CH, Spiegel PC
Blood (2023) 142 pp. 197-201 [ DOI: doi:10.1182/blood.2023020181 Pubmed: 37192299 ]
- Nb33 heavy chain (22 kDa, Protein from Homo sapiens)
- Coagulation factor viii chimera from human and pig (168 kDa, Protein from Homo sapiens)
- Nb33 light chain (22 kDa, Protein from Homo sapiens)
- Structure of coagulation factor viii bound to a patient-derived anti-c1 domain antibody inhibitor (220 kDa, Complex from Homo sapiens)
Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 2.85 angstron resolution (1 unit)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7wpp
Q-score: 0.481
Zeng J, Shu Z, Liang Q, Zhang J, Wu W, Wang X, Zhou A
Blood (2022) 139 pp. 3314-3324 [ DOI: doi:10.1182/blood.2021014729 Pubmed: 35148377 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vwf d'd3-d1d2 complex (1 unit) (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Von willebrand factor (54 kDa, Protein from Homo sapiens)
- Von willebrand antigen 2 (81 kDa, Protein from Homo sapiens)
Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 3.27 angstron resolution (2 units)
Resolution: 3.267 Å
EM Method: Single-particle
Fitted PDBs: 7wpq
Q-score: 0.427
Zeng J, Shu Z, Liang Q, Zhang J, Wu W, Wang X, Zhou A
Blood (2022) 139 pp. 3314-3324 [ DOI: doi:10.1182/blood.2021014729 Pubmed: 35148377 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vwf d'd3-d1d2 complex (2 units) (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Von willebrand factor (54 kDa, Protein from Homo sapiens)
- Von willebrand antigen 2 (81 kDa, Protein from Homo sapiens)
VWF D'D3 dimer complexed with D1D2 at 4.39 angstron resolution(VWF tube)
Resolution: 4.39 Å
EM Method: Single-particle
Fitted PDBs: 7wpr
Q-score: 0.164
Zeng J, Shu Z, Liang Q, Zhang J, Wu W, Wang X, Zhou A
Blood (2022) 139 pp. 3314-3324 [ DOI: doi:10.1182/blood.2021014729 Pubmed: 35148377 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vwf d'd3-d1d2 complex (8-9 units) (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Von willebrand factor (54 kDa, Protein from Homo sapiens)
- Von willebrand antigen 2 (81 kDa, Protein from Homo sapiens)
Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (7 units)
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 7wps
Q-score: 0.182
Zeng J, Shu Z, Liang Q, Zhang J, Wu W, Wang X, Zhou A
Blood (2022) 139 pp. 3314-3324 [ DOI: doi:10.1182/blood.2021014729 Pubmed: 35148377 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vwf d'd3-d1d2 complex (7 unit) (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Von willebrand factor (54 kDa, Protein from Homo sapiens)
- Von willebrand antigen 2 (81 kDa, Protein from Homo sapiens)