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EMD-40041

Single-particle
2.2 Å
EMD-40041
3D View Gallery
Deposition: 09/03/2023
Map released: 09/08/2023
Last modified: 11/10/2023
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-40041
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8ghd summary report (pdf.gz) Map and 8ghd FULL report (pdf.gz)
EMICSS annotations (xml)

The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid

EMD-40041

Single-particle
2.2 Å
EMD-40041
3D View Gallery
Deposition: 09/03/2023
Map released: 09/08/2023
Last modified: 11/10/2023
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Hexameric human 12-Lipoxygenase in complex with inhibitor ML355 and arachidonic acid
Fitted models: 8ghd

Deposition Authors: Black KA , Mobbs JI , Venugopal H , Thal DM , Glukhova A
Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Mobbs JI , Black KA , Tran M , Burger WAC , Venugopal H , Holman TR , Holinstat M , Thal DM , Glukhova A
(2023) Blood , 142 , 1233 - 1242
PUBMED: 37506345
DOI: doi:10.1182/blood.2023020441
ISSN: 1528-0020