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grant_code:"1055134"

Filter By

Current Database

  • EMDB [15]

Current status

  • REL [15]

Sample type

  • Complex [15]
  • Protein [15]
  • Ligand [9]

Organism

  • Homo sapiens [15]
  • Lama glama [7]
  • Mus musculus [5]
  • Synthetic construct [1]
  • Oncorhynchus sp. [1]

EM Method

  • Single-particle [15]

Resolution

  • ≥ 2Å and < 3Å [8]
  • ≥ 3Å and < 4Å [7]

Model molecular weight

  • 50-100 kDa [2]
  • 100-250 kDa [13]

Release Date

  • 2023 [5]
  • 2021 [2]
  • 2020 [5]
  • 2019 [1]
  • 2018 [2]

Author by name

  • Christopoulos A [11]
  • Sexton PM [11]
  • Wootten D [11]
  • Liang YL [10]
  • Danev R [9]
  • Belousoff MJ [7]
  • Glukhova A [7]
  • Miller LJ [7]
  • Furness SGB [6]
  • Thal DM [6]
  • Truong TT [6]
  • Zhao P [6]
  • Mobbs JI [5]
  • Vuckovic Z [5]
  • Hay DL [4]
  • Ang SY [3]
  • Egebjerg T [3]
  • Gloriam DE [3]
  • Khoshouei M [3]
  • Kooistra AJ [3]
  • Koole C [3]
  • Langmead CJ [3]
  • Reedtz-runge S [3]
  • Reynolds CA [3]
  • Senel P [3]
  • Stewart GD [3]
  • Underwood CR [3]
  • Venugopal H [3]
  • Wang MW [3]
  • Zhang X [3]
  • Baumeister W [2]
  • Cao J [2]
  • Clydesdale L [2]
  • Deganutti G [2]
  • Fletcher MM [2]
  • Garama DJ [2]
  • Gregory KJ [2]
  • Josephs TM [2]
  • Leach K [2]
  • Piper SJ [2]
  • Radjainia M [2]
  • Atanasio S [1]
  • Bell MG [1]
  • Burger WAC [1]
  • Carazo JM [1]
  • Christe ME [1]
  • Christopoulos G [1]
  • Dal Maso E [1]
  • Dror RO [1]
  • Felder CC [1]
  • Garcia-nafria J [1]
  • Hick CA [1]
  • Inoue A [1]
  • Julita V [1]
  • Laloudakis Y [1]
  • Lei S [1]
  • Paul SM [1]
  • Peat TS [1]
  • Pham V [1]
  • Plitzko JM [1]
  • Powers AS [1]
  • Ramirez-aportela E [1]
  • Sloop KW [1]
  • Tate CG [1]
  • Tobin AB [1]
  • Valant C [1]
  • Willard FS [1]
  • Xu HE [1]
  • Zhang Y [1]
  • Zhu Y [1]
  • Dal Maso E [1]

Author by ORCID

  • Wootten D [11]
  • Belousoff MJ [7]
  • Glukhova A [7]
  • Furness SGB [5]
  • Sexton PM [5]
  • Christopoulos A [4]
  • Kooistra AJ [3]
  • Danev R [3]
  • Reynolds CA [3]
  • Zhang X [3]
  • Gloriam DE [3]
  • Ang SY [3]
  • Hay DL [3]
  • Stewart GD [3]
  • Langmead CJ [3]
  • Piper SJ [2]
  • Fletcher MM [2]
  • Liang YL [2]
  • Deganutti G [2]
  • Cao J [2]
  • Thal DM [2]
  • Gregory KJ [2]
  • Garama DJ [2]
  • Josephs TM [2]
  • Leach K [2]
  • Mobbs JI [1]
  • Tobin AB [1]
  • Valant C [1]
  • Garcia-nafria J [1]
  • Plitzko JM [1]
  • Dror RO [1]
  • Peat TS [1]
  • Xu HE [1]
  • Ramirez-aportela E [1]
  • Burger WAC [1]
  • Zhang Y [1]

Journal

  • ELIFE [4]
  • MOL CELL [4]
  • BIORXIV [3]
  • NATURE [3]
  • SCIENCE [2]
  • ACS PHARMACOL TRANSL SCI [1]
  • NAT COMMUN [1]

Software

  • RELION [1]

Microscope

  • FEI TITAN KRIOS [8]
  • TFS KRIOS [7]

Electron Source

  • FIELD EMISSION GUN [15]

Film or detector model

  • GATAN K3 BIOQUANTUM 6K X 4K [7]
  • GATAN K3 6K X 4K [5]
  • GATAN K2 SUMMIT 4K X 4K [3]

External links

  • AlphaFold DB [15]
  • Gene Ontology [15]
  • InterPro [15]
  • PDB [15]
  • PDBe-Kb [15]
  • Pfam [15]
  • UniProt [15]
  • ChEMBL [9]
  • ChEBI [5]
  • DrugBank [5]
  • EMPIAR [5]
  • CATH [3]
  • SCOP2 [3]
  • Complex Portal [2]
Sort by: Download
Showing 1 - 10 of 15. Page 1 of 2
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Preview first 10
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EMD-29524
Download Map
3D View
Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline
Release date: Sept. 13, 2023
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 8fx5
Q-score: 0.595

Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM

Nat Commun (2023) 14 pp. 5440-5440 [ Pubmed: 37673901 DOI: doi:10.1038/s41467-023-41199-5 ]

EMD-26099
Download Map
3D View
Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo
Release date: May 17, 2023
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7trk
Q-score: 0.548

Thal DM

eLife (2023) [ ]

EMD-26100
Download Map
3D View
Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298
Release date: May 17, 2023
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7trp
Q-score: 0.561

Thal DM

eLife (2023) [ ]

EMD-26101
Download Map
3D View
Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154
Release date: May 17, 2023
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7trq
Q-score: 0.587

Thal DM

eLife (2023) [ ]

EMD-26102
Download Map
3D View
Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine
Release date: May 17, 2023
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7trs
Q-score: 0.503

Thal DM

eLife (2023) [ ]

EMD-22962
Download Map
3D View
Raw data
EMPIAR-10668
CryoEM structure of the apo-CGRP receptor in a detergent micelle
Release date: Feb. 24, 2021
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7knt
Q-score: 0.39

Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM

Science (2021) 372 [ DOI: doi:10.1126/science.abf7258 Pubmed: 33602864 ]

EMD-22963
Download Map
3D View
Raw data
EMPIAR-10671
CryoEM structure of the CGRP receptor with bound CGRP peptide in a detergent micelle
Release date: Feb. 24, 2021
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7knu
Q-score: 0.351

Josephs TM, Belousoff MJ, Liang YL, Piper SJ, Cao J, Garama DJ, Leach K, Gregory KJ, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM

Science (2021) 372 [ DOI: doi:10.1126/science.abf7258 Pubmed: 33602864 ]

EMD-21992
Download Map
3D View
Raw data
EMPIAR-10673
GLP-1 peptide hormone bound to Glucagon-Like peptide-1 GLP-1 Receptor
Release date: Sept. 9, 2020
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 6x18
Q-score: 0.563

Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D

Mol Cell (2020) 80 pp. 485- [ Pubmed: 33027691 DOI: doi:10.1016/j.molcel.2020.09.020 ]

EMD-21993
Download Map
3D View
Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 GLP-1 Receptor
Release date: Sept. 9, 2020
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 6x19
Q-score: 0.579

Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D

Mol Cell (2020) 80 pp. 485- [ Pubmed: 33027691 DOI: doi:10.1016/j.molcel.2020.09.020 ]

EMD-21994
Download Map
3D View
Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 GLP-1 Receptor
Release date: Sept. 9, 2020
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6x1a
Q-score: 0.522

Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D

Mol Cell (2020) 80 pp. 485- [ Pubmed: 33027691 DOI: doi:10.1016/j.molcel.2020.09.020 ]

Sort by: Download
Showing 1 - 10 of 15. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [15]

Current status

  • REL [15]

Sample type

  • Complex [15]
  • Protein [15]
  • Ligand [9]

Organism

  • Homo sapiens [15]
  • Lama glama [7]
  • Mus musculus [5]
  • Synthetic construct [1]
  • Oncorhynchus sp. [1]

EM Method

  • Single-particle [15]

Resolution

  • ≥ 2Å and < 3Å [8]
  • ≥ 3Å and < 4Å [7]

Model molecular weight

  • 50-100 kDa [2]
  • 100-250 kDa [13]

Release Date

  • 2023 [5]
  • 2021 [2]
  • 2020 [5]
  • 2019 [1]
  • 2018 [2]

Author by name

  • Christopoulos A [11]
  • Sexton PM [11]
  • Wootten D [11]
  • Liang YL [10]
  • Danev R [9]
  • Belousoff MJ [7]
  • Glukhova A [7]
  • Miller LJ [7]
  • Furness SGB [6]
  • Thal DM [6]
  • Truong TT [6]
  • Zhao P [6]
  • Mobbs JI [5]
  • Vuckovic Z [5]
  • Hay DL [4]
  • Ang SY [3]
  • Egebjerg T [3]
  • Gloriam DE [3]
  • Khoshouei M [3]
  • Kooistra AJ [3]
  • Koole C [3]
  • Langmead CJ [3]
  • Reedtz-runge S [3]
  • Reynolds CA [3]
  • Senel P [3]
  • Stewart GD [3]
  • Underwood CR [3]
  • Venugopal H [3]
  • Wang MW [3]
  • Zhang X [3]
  • Baumeister W [2]
  • Cao J [2]
  • Clydesdale L [2]
  • Deganutti G [2]
  • Fletcher MM [2]
  • Garama DJ [2]
  • Gregory KJ [2]
  • Josephs TM [2]
  • Leach K [2]
  • Piper SJ [2]
  • Radjainia M [2]
  • Atanasio S [1]
  • Bell MG [1]
  • Burger WAC [1]
  • Carazo JM [1]
  • Christe ME [1]
  • Christopoulos G [1]
  • Dal Maso E [1]
  • Dror RO [1]
  • Felder CC [1]
  • Garcia-nafria J [1]
  • Hick CA [1]
  • Inoue A [1]
  • Julita V [1]
  • Laloudakis Y [1]
  • Lei S [1]
  • Paul SM [1]
  • Peat TS [1]
  • Pham V [1]
  • Plitzko JM [1]
  • Powers AS [1]
  • Ramirez-aportela E [1]
  • Sloop KW [1]
  • Tate CG [1]
  • Tobin AB [1]
  • Valant C [1]
  • Willard FS [1]
  • Xu HE [1]
  • Zhang Y [1]
  • Zhu Y [1]
  • Dal Maso E [1]

Author by ORCID

  • Wootten D [11]
  • Belousoff MJ [7]
  • Glukhova A [7]
  • Furness SGB [5]
  • Sexton PM [5]
  • Christopoulos A [4]
  • Kooistra AJ [3]
  • Danev R [3]
  • Reynolds CA [3]
  • Zhang X [3]
  • Gloriam DE [3]
  • Ang SY [3]
  • Hay DL [3]
  • Stewart GD [3]
  • Langmead CJ [3]
  • Piper SJ [2]
  • Fletcher MM [2]
  • Liang YL [2]
  • Deganutti G [2]
  • Cao J [2]
  • Thal DM [2]
  • Gregory KJ [2]
  • Garama DJ [2]
  • Josephs TM [2]
  • Leach K [2]
  • Mobbs JI [1]
  • Tobin AB [1]
  • Valant C [1]
  • Garcia-nafria J [1]
  • Plitzko JM [1]
  • Dror RO [1]
  • Peat TS [1]
  • Xu HE [1]
  • Ramirez-aportela E [1]
  • Burger WAC [1]
  • Zhang Y [1]

Journal

  • ELIFE [4]
  • MOL CELL [4]
  • BIORXIV [3]
  • NATURE [3]
  • SCIENCE [2]
  • ACS PHARMACOL TRANSL SCI [1]
  • NAT COMMUN [1]

Software

  • RELION [1]

Microscope

  • FEI TITAN KRIOS [8]
  • TFS KRIOS [7]

Electron Source

  • FIELD EMISSION GUN [15]

Film or detector model

  • GATAN K3 BIOQUANTUM 6K X 4K [7]
  • GATAN K3 6K X 4K [5]
  • GATAN K2 SUMMIT 4K X 4K [3]

External links

  • AlphaFold DB [15]
  • Gene Ontology [15]
  • InterPro [15]
  • PDB [15]
  • PDBe-Kb [15]
  • Pfam [15]
  • UniProt [15]
  • ChEMBL [9]
  • ChEBI [5]
  • DrugBank [5]
  • EMPIAR [5]
  • CATH [3]
  • SCOP2 [3]
  • Complex Portal [2]