EMD-26100

Single-particle
2.4 Å
EMD-26100
3D View Gallery
Deposition: 30/01/2022
Map released: 17/05/2023
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-26100

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7trp summary report (pdf.gz) Map-7trp FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator LY2033298

EMD-26100

Single-particle
2.4 Å
EMD-26100
3D View Gallery
Deposition: 30/01/2022
Map released: 17/05/2023
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: M4 mAChR bound to agonist iperoxo and the PAM LY2033298 in complex with dominant negative Galpha-i1, Gbeta1, Ggamma2, and scFv16
Fitted models: 7trp

Deposition Authors: Vuckovic Z, Mobbs JI

Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor
Thal DM
(2023) eLife
ISSN: 2050-084X