EMD-29524
Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline
EMD-29524
Single-particle2.45 Å
Deposition: 23/01/2023Map released: 13/09/2023
Last modified: 28/05/2025
Sample Organism:
Homo sapiens,
Mus musculus
Sample: M4 mAChR bound to agonist xanomeline in complex with dominant negative Galpha-i1, Gbeta1, Ggamma2, and scFv16
Fitted models: 8fx5
Deposition Authors: Vuckovic Z, Mobbs JI
,
Glukhova A ,
Sexton PM ,
Danev R ,
Thal DM
Sample: M4 mAChR bound to agonist xanomeline in complex with dominant negative Galpha-i1, Gbeta1, Ggamma2, and scFv16
Fitted models: 8fx5
Deposition Authors: Vuckovic Z, Mobbs JI
,
Glukhova A ,
Sexton PM ,
Danev R ,
Thal DM
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR.
Burger WAC ,
Pham V,
Vuckovic Z,
Powers AS,
Mobbs JI ,
Laloudakis Y,
Glukhova A ,
Wootten D ,
Tobin AB ,
Sexton PM ,
Paul SM,
Felder CC,
Danev R ,
Dror RO ,
Christopoulos A ,
Valant C ,
Thal DM
(2023) Nat Commun , 14 , 5440 - 5440
,
Pham V,
Vuckovic Z,
Powers AS,
Mobbs JI ,
Laloudakis Y,
Glukhova A ,
Wootten D ,
Tobin AB ,
Sexton PM ,
Paul SM,
Felder CC,
Danev R ,
Dror RO ,
Christopoulos A ,
Valant C ,
Thal DM
(2023) Nat Commun , 14 , 5440 - 5440
Grant Support:
- Wellcome Trust: 201529/Z/16/Z (United Kingdom)
- National Health and Medical Research Council (NHMRC, Australia): 1055134 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1150083 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1138448 (Australia)
- Australian Research Council (ARC): DE170100152 (Australia)
- Australian Research Council (ARC): IC200100052 (Australia)
- Japan Science and Technology: 18069571 (Japan)