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EMD-29524

Single-particle
2.45 Å
EMD-29524
3D View Gallery
Deposition: 23/01/2023
Map released: 13/09/2023
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-29524
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8fx5 summary report (pdf.gz) Map and 8fx5 FULL report (pdf.gz)
EMICSS annotations (xml)

Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline

EMD-29524

Single-particle
2.45 Å
EMD-29524
3D View Gallery
Deposition: 23/01/2023
Map released: 13/09/2023
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: M4 mAChR bound to agonist xanomeline in complex with dominant negative Galpha-i1, Gbeta1, Ggamma2, and scFv16
Fitted models: 8fx5

Deposition Authors: Vuckovic Z, Mobbs JI , Glukhova A , Sexton PM , Danev R , Thal DM
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR.
Burger WAC , Pham V, Vuckovic Z, Powers AS, Mobbs JI , Laloudakis Y, Glukhova A , Wootten D , Tobin AB , Sexton PM , Paul SM, Felder CC, Danev R , Dror RO , Christopoulos A , Valant C , Thal DM
(2023) Nat Commun , 14 , 5440 - 5440
PUBMED: 37673901
DOI: doi:10.1038/s41467-023-41199-5
ISSN: 2041-1723