Ligand clusters for UniProt code Q24451

Ligand clusters for Q24451: Alpha-mannosidase 2 from Drosophila melanogaster

		Top 6 (of 20) ligand clusters Cluster 1. 64 ligand types 199 ligands Cluster 2. 1 ligand type 49 ligands Cluster 3. 2 ligand types 3 ligands Cluster 4. 2 ligand types 4 ligands Cluster 5. 2 ligand types 8 ligands Cluster 6. 2 ligand types 13 ligands
Representative protein: 2ow6A

Structures

PDB		Schematic diagram
2ow6A
3buiA
3ejtA
2f1bA
3ejuA
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Cluster 1 contains 64 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
_Zn		1. Metal: _ZN × 67 PDB codes: 1hty(A), 1hww(A), 1hxk(A), 1ps3(A), 1qwn(A), 1qwu(A), 1qx1(A), 1r33(A), 1r34(A), 1tqs(A), 1tqt(A), 1tqu(A), 1tqv(A), 1tqw(A), 2alw(A), 2f18(A), 2f1a(A), 2f1b(A), 2f7o(A), 2f7p(A), 2f7q(A), 2f7r(A), 2fyv(A), 2ow6(A), 2ow7(A), 3blb(A), 3bub(A), 3bud(A), 3bui(A), 3bup(A), 3buq(A), 3bvt(A), 3bvu(A), 3bvv(A), 3bvw(A), 3bvx(A), 3cv5(A), 3czn(A), 3czs(A), 3d4y(A), 3d4z(A), 3d50(A), 3d51(A), 3d52(A), 3ddf(A), 3ddg(A), 3dx0(A), 3dx1(A), 3dx2(A), 3dx3(A), 3dx4(A), 3ejp(A), 3ejq(A), 3ejr(A), 3ejs(A), 3ejt(A), 3eju(A), 6rpc(A), 6rqz(A), 6rrh(A), 6rrj(A), 6rrn(A), 6rru(A), 6rrw(A), 6rrx(A), 6rry(A), 6rs0(A).
		2. Ligand: TRS × 3 tromethamine 2-Amino-2-Hydroxymethyl-Propane-1,3-Diol PDB codes: 1hty(A), 1qwn(A), 3bui(A).
		3. Ligand: GUL × 2 (2r,3s,4r,5s)-2,6-Difluoro-2-(Hydroxymethyl)oxane-3,4, 5-Triol PDB codes: 1qwn(A), 1qwu(A).
		4. Ligand: DMJ × 1 1-Deoxymannojirimycin PDB code: 1hxk(A).
		5. Ligand: FMF × 1 2-Deoxy-2-Fluoro-Beta-D-Mannopyranosyl fluoride PDB code: 1qx1(A).
		6. Ligand: LKA × 1 5-Thio-Alpha-D-Mannopyranosylamine PDB code: 1r33(A).
		7. Ligand: AOL × 1 (1r,2r,3s,4s,5r)-5-Aminocyclopentane-1,2,3,4-Tetrol PDB code: 2f7q(A).
		8. Ligand: MNM × 1 (2s,3s,4r,5r)-2,3,4-Trihydroxy-5-Hydroxymethyl- Piperidine PDB code: 2alw(A).
		9. Ligand: SWA × 2 1s-8ab-Octahydro-Indolizidine-1a,2a,8b-Triol PDB codes: 1hww(A), 3blb(A).
		10. Ligand: NK1 × 1 (1r,5s,6s,7r,8s)-1-Thioniabicyclo[4.3.0]nonan-5,7,8- Triol PDB code: 2ow6(A).
		11. Ligand: KIF × 1 Kifunensine PDB code: 1ps3(A).
		12. Ligand: MRD × 13 (4r)-2-Methylpentane-2,4-Diol PDB codes: 1hty(A), 1hww(A), 1hxk(A), 1ps3(A), 1tqs(A), 1tqt(A), 1tqu(A), 1tqv(A), 1tqw(A), 2ow6(A), 2ow7(A), 3blb(A).
		13. Ligand: MPD × 14 (4s)-2-Methyl-2,4-Pentanediol PDB codes: 1qwn(A), 1qwu(A), 1qx1(A), 1r33(A), 1r34(A), 2alw(A), 2f18(A), 2f1a(A), 2f1b(A), 2f7o(A), 2f7p(A), 2f7q(A), 2f7r(A), 2fyv(A).
		14. Ligand: MSN × 1 (1r,2r,3r,4s,5r)-4-Amino-5-(Methylthio)cyclopentane-1, 2,3-Triol PDB code: 2f7o(A).
		15. Ligand: NK2 × 1 (1r,6s,7r,8s)-1-Thioniabicyclo[4.3.0]nonan-7,8-Diol PDB code: 2ow7(A).
		16. Ligand: W72 × 1 6-Deoxy-6-[(2r,3r,4r)-3,4-Dihydroxy-2-(Hydroxymethyl) pyrrolidin-1-Yl]-L-Gulonic acid PDB code: 2fyv(A).
		17. Ligand: SK3 × 1 (1r,2r,3s,4s,5r)-5-(Benzylamino)cyclopentane-1,2,3,4- Tetrol PDB code: 2f7r(A).
		18. Ligand: LKS × 1 N-[(1z)-2-Phenylethanimidoyl]-5-Thio-Alpha-D- Mannopyranosylamine PDB code: 1r34(A).
		19. Ligand: 2SK × 1 (1r,2r,3r,4s,5r)-4-(Benzylamino)-5-(Methylthio) cyclopentane-1,2,3-Triol PDB code: 2f7p(A).
		20. Ligand: GB3 × 1 (2r,3r,4s,5r)-2-({[(1r)-2-Hydroxy-1- Phenylethyl]amino}methyl)-5-Methylpyrrolidine-3,4-Diol PDB code: 2f1b(A).
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Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: NAG × 49 n-acetylglucosamine 2-Acetamido-2-Deoxy-Beta-D-Glucopyranose PDB codes: 1hty(A), 1hww(A), 1hxk(A), 1ps3(A), 1qwn(A), 1qwu(A), 1qx1(A), 1r33(A), 1r34(A), 1tqs(A), 1tqt(A), 1tqu(A), 1tqv(A), 1tqw(A), 2alw(A), 2f18(A), 2f1a(A), 2f1b(A), 2f7o(A), 2f7p(A), 2f7q(A), 2f7r(A), 2fyv(A), 2ow6(A), 2ow7(A), 3blb(A), 3bub(A), 3bud(A), 3bup(A), 3buq(A), 3bvt(A), 3bvu(A), 3cv5(A), 3czn(A), 3czs(A), 3d4y(A), 3d50(A), 3ddf(A), 3ddg(A), 3dx0(A), 3dx1(A), 3dx3(A), 3dx4(A), 3ejp(A), 3ejq(A), 3ejr(A), 3ejs(A), 3ejt(A), 3eju(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: SO4 × 1 Sulfate ion PDB code: 2ow7(A).
		2. Ligand: MPD × 2 (4s)-2-Methyl-2,4-Pentanediol PDB codes: 3d4y(A), 3dx2(A).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: MPD × 3 (4s)-2-Methyl-2,4-Pentanediol PDB codes: 3bvw(A), 3bvx(A), 3ddf(A).
		2. Ligand: EDO × 1 1,2-Ethanediol PDB code: 6rqz(A).

Cluster 5 contains 2 ligand types

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Ligand		Description
		1. Ligand: SIN × 4 succinic acid Succinic acid PDB codes: 6rpc(A), 6rqz(A), 6rrn(A), 6rry(A).
		2. Ligand: EDO × 4 1,2-Ethanediol PDB codes: 6rpc(A), 6rqz(A), 6rrx(A), 6rry(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: PO4 × 12 Phosphate ion PDB codes: 2f18(A), 2f1a(A), 2f7o(A), 2fyv(A), 2ow6(A), 3bud(A), 3bvt(A), 3bvu(A), 3bvv(A), 3ddg(A), 3dx1(A), 3dx3(A).
		2. Ligand: SO4 × 1 Sulfate ion PDB code: 3dx0(A).