PDBsum entry: 2alw

Hydrolase

PDB id: 2alw

Contents

Protein chain

1014 a.a. *

Ligands

NAG

MNM

MPD

Metals

_ZN

Waters ×1073

* Residue conservation analysis

PDB id:

2alw

Name:

Hydrolase

Title:

Golgi alpha-mannosidase ii complex with noeuromycin

Structure:

Alpha-mannosidase ii. Chain: a. Fragment: catalytic domain. Synonym: mannosyl-oligosaccharide 1,3-1,6- alpha-mannosidas golgi alpha-mannosidase ii, aman ii. Engineered: yes

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: gmii. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: s2 cells.

Resolution:

1.86Å R-factor: 0.141 R-free: 0.181

Authors:

D.A.Kuntz,M.B.Bols,H.Liu,D.R.Rose

Key ref:

D.A.Kuntz et al. (2006). The role of the active site zn in the catalytic mechanism of the gh38 golgi alpha-Mannosidase ii: implications from noeuromycin inhibition. Biocatal.Biotransfor., 34, 55-61.