PDBsum entry: 1tqw

Hydrolase

PDB id: 1tqw

Contents

Protein chain

1014 a.a. *

Ligands

NAG

BLT

MRD ×2

Metals

_ZN

Waters ×1091

* Residue conservation analysis

PDB id:

1tqw

Name:

Hydrolase

Title:

Golgi alpha-mannosidase ii in complex with a diastereomer of salacinol

Structure:

Alpha-mannosidase ii. Chain: a. Fragment: family 38 catalytic domain. Synonym: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase golgi alpha-mannosidase ii, aman ii. Engineered: yes. Mutation: yes

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: alpha-man-ii, gmii, cg18474/cg18802/cg8139. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: s2 cells

Resolution:

1.20Å R-factor: 0.175 R-free: 0.184

Authors:

D.A.Kuntz,A.Ghavami,B.D.Johnston,B.M.Pinto,D.R.Rose

Key ref:

D.A.Kuntz et al. (2005). Insights into the mechanism of drosophila melanogaster golgi a-Mannosidase ii through crystallographic analysis of the interactions with analogues of the naturally occurring glycomimetic salacinol. Tetrahedron asymmetry, 16, 25-32.