Substrates for peptidase T01.010: proteasome subunit beta1c

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ac-Ala-Pro-norLeu-Leu-NHMec			Ac-Ala-Pro-norLeu-Leu+NHMec	S		Tyr	Val	Ala	Asp	AMC	-	-	-	Kisselev et al., 2003
Ac-Gly-Pro-Leu-Asp-NHMec			Ac-Gly-Pro-Leu-Asp+NHMec	S		Gly	Pro	Leu	Asp	AMC	-	-	-	Kisselev et al., 2003
Ac-Gly-Pro-Leu-Glu-NHMec			Ac-Gly-Pro-Leu-Glu+NHMec	S		Gly	Pro	Leu	Glu	AMC	-	-	-	Kisselev et al., 2003
Ac-Gly-Pro-Leu-Leu-NHMec			Ac-Gly-Pro-Leu-Leu+NHMec	S		Gly	Pro	Leu	Leu	AMC	-	-	-	Kisselev et al., 2003
Ac-norLeu-Pro-norLeu-Asp-NHMec			Ac-norLeu-Pro-norLeu-Asp+NHMec	S		Leu	Pro	Leu	Asp	AMC	-	-	-	Kisselev et al., 2003
Ac-Tyr-Val-Ala-Asp-NHMec			Ac-Tyr-Val-Ala-Asp+NHMec	S		Tyr	Val	Ala	Asp	AMC	-	-	-	Kisselev et al., 2003
Ac-Tyr-Val-Ala-Asp-NHMec			Ac-Tyr-Val-Ala-Asp+NHMec	S		Tyr	Val	Ala	Asp	AMC	-	-	-	Kisselev et al., 2003
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Asp25+Ser-peptide	N	MS	Gly	Pro	Val	Asp	Ser	Glu	Gln	Leu	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Glu43+Ala-peptide	N	MS	Cys	Leu	Gln	Glu	Ala	Arg	Glu	Arg	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Asp51+Phe-peptide	N	MS	Trp	Asn	Phe	Asp	Phe	Val	Thr	Glu	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Glu55+Thr-peptide	N	MS	Phe	Val	Thr	Glu	Thr	Pro	Leu	Glu	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Glu59+Gly-peptide	N	MS	Thr	Pro	Leu	Glu	Gly	Asn	Phe	Val	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Glu65+Arg-peptide	N	MS	Phe	Val	Trp	Glu	Arg	Val	Arg	Ser	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Asp85+Asp-peptide	N	MS	Arg	Ser	Arg	Asp	Asp	Leu	Gly	Gly	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Glu106+Asp-peptide	N	MS	Pro	Ala	Pro	Glu	Asp	His	Val	Ala	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Asp107+His-peptide	N	MS	Ala	Pro	Glu	Asp	His	Val	Ala	Leu	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Glu120+Arg-peptide	N	MS	Leu	Val	Ser	Glu	Arg	Pro	Glu	Asp	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Asp124+Ser-peptide	N	MS	Arg	Pro	Glu	Asp	Ser	Pro	Gly	Gly	Berko et al., 2012
immediate-early protein 1	P11210	162-186	peptide-Asp166+Met-peptide	N		Leu	Met	Tyr	Asp	Met	Tyr	Pro	His	Dick et al., 1998
Immediate-early protein 1	P11210	162-186	Peptide-Tyr168+Pro-Peptide	P	MS	Tyr	Asp	Met	Tyr	Pro	His	Phe	Met	Dick et al., 1998
Immediate-early protein 1	P11210	162-186	Peptide-Asp166+Met-Peptide	P	MS	Leu	Met	Tyr	Asp	Met	Tyr	Pro	His	Dick et al., 1998
Immediate-early protein 1	P11210	162-186	Arg-Leu-Met-Tyr165+Asp-Peptide	P	MS	Arg	Leu	Met	Tyr	Asp	Met	Tyr	Pro	Dick et al., 1998
nucleoprotein	P03466	140-163	peptide-Asp145+Ala-peptide	N		Asn	Leu	Asn	Asp	Ala	Thr	Tyr	Gln	Dick et al., 1998
Nucleoprotein	P03466	140-163	Peptide-Asp145+Ala-Peptide	N	MS	Asn	Leu	Asn	Asp	Ala	Thr	Tyr	Gln	Dick et al., 1998
ovalbumin	P01012	52-386	peptide-Asp96+Val-peptide	N		Lys	Pro	Asn	Asp	Val	Tyr	Ser	Phe	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu151+Ser-peptide	N		Ser	Trp	Val	Glu	Ser	Gln	Thr	Asn	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Asp168+Ser-peptide	N		Ser	Ser	Val	Asp	Ser	Gln	Thr	Ala	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu203+Gln-peptide	N		Arg	Val	Thr	Glu	Gln	Glu	Ser	Lys	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu232+Leu-peptide	N		Lys	Ile	Leu	Glu	Leu	Pro	Phe	Ala	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu249+Val-peptide	N		Leu	Pro	Asp	Glu	Val	Ser	Gly	Leu	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu254+Gln-peptide	N		Ser	Gly	Leu	Glu	Gln	Leu	Glu	Ser	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu263+Lys-peptide	N		Ile	Asn	Phe	Glu	Lys	Leu	Thr	Glu	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu275+Glu-peptide	N		Asn	Val	Met	Glu	Glu	Arg	Lys	Ile	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Asp305+Val-peptide	N		Gly	Ile	Thr	Asp	Val	Phe	Ser	Ser	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu320+Ser-peptide	N		Ser	Ser	Ala	Glu	Ser	Leu	Lys	Ile	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu334+Ile-peptide	N		Ala	His	Ala	Glu	Ile	Asn	Glu	Ala	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu337+Ala-peptide	N		Glu	Ile	Asn	Glu	Ala	Gly	Arg	Glu	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Glu341+Val-peptide	N		Ala	Gly	Arg	Glu	Val	Val	Gly	Ser	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Asp351+Ala-peptide	N		Ala	Gly	Val	Asp	Ala	Ala	Ser	Val	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Asp362+His-peptide	N		Phe	Arg	Ala	Asp	His	Pro	Phe	Leu	Berko et al., 2012
Z-Gly-Pro-Ala-Leu-Ala-pAb			Z-Gly-Pro-Ala-Leu+Ala-pAb	S		Gly	Pro	Ala	Leu	Ala	pAb	-	-	Dick et al., 1998
Z-Leu-Leu-Glu-NHNap			Z-Leu-Leu-Glu+NHNap	S		Z	Leu	Leu	Glu	NAP	-	-	-	Seemuller et al., 2004
Z-Leu-Leu-Glu-NHNap			Z-Leu-Leu-Glu+NHNap	S		Z	Leu	Leu	Glu	NAP	-	-	-	Dick et al., 1998