Substrates for peptidase S54.009: PARL peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Presenilins-associated rhomboid-like protein, mitochondrial	Q9H300	1-379	peptide-Gly52+Phe-peptide	P	NT	Gln	Lys	Cys	Gly	Phe	Arg	Lys	Ala	Sík et al., 2004
Presenilins-associated rhomboid-like protein, mitochondrial	Q9H300	1-379	peptide-Ser77+Ala-peptide	P	NT	Tyr	Lys	Arg	Ser	Ala	Leu	Ile	Pro	Sík et al., 2004
Serine/threonine-protein kinase PINK1, mitochondrial	Q9BXM7	94-113	peptide-Ala103+Phe-peptide	P		Val	Phe	Leu	Ala	Phe	Gly	Leu	Gly	Deas et al., 2011