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Literature for peptidase S54.009: PARL peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. An,D., Zhang,C., Zhou,P., Wang,Y., Meng,S., Chen,Y., Xu,W., Xuan,J., Xiong,J., Cheng,J., Gao,R., Wang,J. and Chen,X.
    Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis
    CNS Neurosci Ther31, e70293-e70293. PubMed  Europe PubMed DOI  K
  2. Brassard,R., Arutyunova,E., Takyi,E., Espinoza-Fonseca,L.M., Young,H., Touret,N. and Lemieux,M.J.
    Transmembrane Parkinson's Disease mutation of PINK1 leads to altered mitochondrial anchoring
    J Biol Chem108253-108253. PubMed  Europe PubMed DOI
  3. Ludwig,K. and Heidorn-Czarna,M.
    Mitochondrial Proteases and Their Roles in Mitophagy in Plants, Animals, and Yeast
    Plant Cell Physiol PubMed  Europe PubMed DOI  V
  4. Wang,S., Wu,X., Bi,W., Xu,J., Hou,L., Li,G., Pan,Y., Zhang,H., Li,M., Du,S., Zhang,M., Liu,D., Jin,S., Shi,X., Tian,Y., Shuai,J., Plikus,M.V., Song,M., Zhou,Z., Yu,L., Lv,C. and Yu,Z.
    ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3
    Nat Commun16, 1406-1406. PubMed  Europe PubMed DOI
  5. Zhou,N., Liu,Z., Shi,Z., Luo,L., Xuan,M., Zhu,R., Hu,K., Zhu,X., Xu,W., Li,Y., Cao,Z. and Zhang,Y.
    PARL regulates porcine oocyte meiotic maturation by mediating mitochondrial activity
    Theriogenology235, 75-85. PubMed  Europe PubMed DOI
    6. 2024
  6. Bach,K., Dohnalek,J., Skerlova,J., Kuzmik,J., Polachova,E., Stanchev,S., Majer,P., Fanfrlik,J., Pecina,A., Rezac,J., Lepsik,M., Borshchevskiy,V., Polovinkin,V. and Strisovsky,K.
    Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency
    Eur J Med Chem275, 116606-116606. PubMed  Europe PubMed DOI
  7. Ji,S., Bach,K., Miriyala,V.M., Dohnalek,J., Riopedre-Fernandez,M., Lepsik,M., van de Plassche,M., Vanhoutte,R., Barniol-Xicota,M., Moreira,R., Strisovsky,K. and Verhelst,S.H.L.
    4-Oxo-beta-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL
    ACS Med Chem Lett15, 2101-2106. PubMed  Europe PubMed DOI  I
  8. Schumacher,S., Klose,L., Lambertz,J., Lutjohann,D., Biemann,R., Kuerten,S. and Fester,L.
    The mitochondrial protease PARL is required for spermatogenesis
    Commun Biol7, 44-44. PubMed  Europe PubMed DOI
    9. 2023
  9. Radaelli,E., Assenmacher,C.A., Verrelle,J., Banerjee,E., Manero,F., Khiati,S., Girona,A., Lopez-Lluch,G., Navas,P. and Spinazzi,M.
    Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis
    elife12, PubMed  Europe PubMed DOI
    10. 2022
  10. Siebert,V., Silber,M., Heuten,E., Muhle-Goll,C. and Lemberg,M.K.
    Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state
    J Biol Chem298, 102321-102321. PubMed  Europe PubMed DOI
    11. 2021
  11. Anzmann,A.F., Sniezek,O.L., Pado,A., Busa,V., Vaz,F.M., Kreimer,S.D., DeVine,L.R., Cole,R.N., Le,A., Kirsch,B.J., Claypool,S.M. and Vernon,H.J.
    Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by Cardiolipin-interacting small molecules
    J Biol Chem101005-101005. PubMed  Europe PubMed DOI
  12. Lysyk,L., Brassard,R., Arutyunova,E., Siebert,V., Jiang,Z., Takyi,E., Morrison,M., Young,H.S., Lemberg,M.K., O'Donoghue,A.J. and Lemieux,M.J.
    Insights into the catalytic properties of the mitochondrial rhomboid protease PARL
    J Biol Chem100383-100383. PubMed  Europe PubMed DOI
  13. Merhi,R., Kalyn,M., Zhu-Pawlowsky,A. and Ekker,M.
    Loss of parla Function Results in Inactivity, Olfactory Impairment, and Dopamine Neuron Loss in Zebrafish
    Biomedicines9, PubMed  Europe PubMed DOI
  14. Parsons,W.H., Rutland,N.T., Crainic,J.A., Cardozo,J.M., Chow,A.S., Andrews,C.L. and Sheehan,B.K.
    Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL
    Bioorg Med Chem Lett49, 128290-128290. PubMed  Europe PubMed DOI  I
    15. 2020
  15. Lysyk,L., Brassard,R., Touret,N. and Lemieux,M.J.
    PARL Protease: a glimpse at intramembrane proteolysis in the inner mitochondrial membrane
    J Mol Biol PubMed  Europe PubMed DOI
    16. 2019
  16. Spinazzi,M., Radaelli,E., Horre,K., Arranz,A.M., Gounko,N.V., Agostinis,P., Maia,T.M., Impens,F., Morais,V.A., Lopez-Lluch,G., Serneels,L., Navas,P. and De Strooper,B.
    PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome
    Proc Natl Acad Sci U S A116, 277-286. PubMed  Europe PubMed DOI  K
    17. 2018
  17. Saita,S., Tatsuta,T., Lampe,P.A., Konig,T., Ohba,Y. and Langer,T.
    PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria
    EMBO J37, e97909-e97909. PubMed  Europe PubMed DOI
    18. 2017
  18. Ishihara,N. and Mihara,K.
    PARL paves the way to apoptosis
    Nat Cell Biol19, 263-265. PubMed  Europe PubMed DOI
  19. Shi,G. and McQuibban,G.A.
    The mitochondrial rhomboid protease PARL is regulated by PDK2 to integrate mitochondrial quality control and metabolism
    Cell Rep18, 1458-1472. PubMed  Europe PubMed DOI
    20. 2016
  20. Spinazzi,M. and De Strooper,B.
    PARL: The mitochondrial rhomboid protease
    Semin Cell Dev Biol60, 19-28. PubMed  Europe PubMed DOI  V
  21. Wust,R., Maurer,B., Hauser,K., Woitalla,D., Sharma,M. and Kruger,R.
    Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease
    Neurobiol Aging39, e13-e15. PubMed  Europe PubMed DOI  M
    22. 2015
  22. Meissner,C., Lorenz,H., Hehn,B. and Lemberg,M.K.
    Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy
    Autophagy11, 1484-1498. PubMed  Europe PubMed DOI
    23. 2013
  23. Chan,E.Y. and McQuibban,G.A.
    The mitochondrial rhomboid protease: Its rise from obscurity to the pinnacle of disease-relevant genes
    Biochim Biophys Acta1828, 2916-2925. PubMed  Europe PubMed DOI
  24. Yamano,K. and Youle,R.J.
    PINK1 is degraded through the N-end rule pathway
    Autophagy9, 1758-1769. PubMed  Europe PubMed DOI
    25. 2012
  25. Sekine,S., Kanamaru,Y., Koike,M., Nishihara,A., Okada,M., Kinoshita,H., Kamiyama,M., Maruyama,J., Uchiyama,Y., Ishihara,N., Takeda,K. and Ichijo,H.
    Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5
    J Biol Chem287, 34635-34645. PubMed  Europe PubMed DOI
  26. Urban,S.
    Mammalian rhomboid proteases
    [ISSN:978-0-12-407742-3]3, 3573-3581. DOI
    27. 2011
  27. Deas,E., Plun-Favreau,H., Gandhi,S., Desmond,H., Kjaer,S., Loh,S.H., Renton,A.E., Harvey,R.J., Whitworth,A.J., Martins,L.M., Abramov,A.Y. and Wood,N.W.
    PINK1 cleavage at position A103 by the mitochondrial protease PARL
    Hum Mol Genet20, 867-879. PubMed  Europe PubMed DOI
  28. Heinitz,S., Klein,C. and Djarmati,A.
    The p.S77N presenilin-associated rhomboid-like protein mutation is not a frequent cause of early-onset Parkinson's disease
    Mov Disord26, 2441-2442. PubMed  Europe PubMed DOI  M
  29. Jeyaraju,D.V., McBride,H.M., Hill,R.B. and Pellegrini,L.
    Structural and mechanistic basis of Parl activity and regulation
    Cell Death Differ18, 1531-1539. PubMed  Europe PubMed DOI
  30. McQuibban,G.A. and Bulman,D.E.
    The PARLance of Parkinson disease
    Autophagy7, 790-792. PubMed  Europe PubMed DOI  V
  31. Meissner,C., Lorenz,H., Weihofen,A., Selkoe,D.J. and Lemberg,M.K.
    The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
    J Neurochem117, 856-867. PubMed  Europe PubMed DOI
  32. Rahman,M. and Kylsten,P.
    Rhomboid-7 over-expression results in Opa1-like processing and malfunctioning mitochondria
    Biochem Biophys Res Commun414, 315-320. PubMed  Europe PubMed DOI
  33. Shi,G., Lee,J.R., Grimes,D.A., Racacho,L., Ye,D., Yang,H., Ross,O.A., Farrer,M., McQuibban,G.A. and Bulman,D.E.
    Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease
    Hum Mol Genet20, 1966-1974. PubMed  Europe PubMed DOI  M
    34. 2010
  34. Civitarese,A.E., MacLean,P.S., Carling,S., Kerr-Bayles,L., McMillan,R.P., Pierce,A., Becker,T.C., Moro,C., Finlayson,J., Lefort,N., Newgard,C.B., Mandarino,L., Cefalu,W., Walder,K., Collier,G.R., Hulver,M.W., Smith,S.R. and Ravussin,E.
    Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL
    Cell Metab11, 412-426. PubMed  Europe PubMed DOI
  35. Curran,J.E., Jowett,J.B., Abraham,L.J., Diepeveen,L.A., Elliott,K.S., Dyer,T.D., Kerr-Bayles,L.J., Johnson,M.P., Comuzzie,A.G., Moses,E.K., Walder,K.R., Collier,G.R., Blangero,J. and Kissebah,A.H.
    Genetic variation in PARL influences mitochondrial content
    Hum Genet127, 183-190. PubMed  Europe PubMed DOI  M
  36. Jin,S.M., Lazarou,M., Wang,C., Kane,L.A., Narendra,D.P. and Youle,R.J.
    Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
    J Cell Biol191, 933-942. PubMed  Europe PubMed DOI
    37. 2009
  37. Hatunic,M., Stapleton,M., Hand,E., DeLong,C., Crowley,V.E. and Nolan,J.J.
    The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population
    Diabetes Res Clin Pract83, 316-319. PubMed  Europe PubMed DOI  M
    38. 2008
  38. Chao,J.R., Parganas,E., Boyd,K., Hong,C.Y., Opferman,J.T. and Ihle,J.N.
    Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons
    Nature452, 98-102. PubMed  Europe PubMed DOI
  39. Whitworth,A.J., Lee,J.R., Ho,V.M., Flick,R., Chowdhury,R. and McQuibban,G.A.
    Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
    Dis Model Mech1, 168-174. PubMed  Europe PubMed DOI
    40. 2007
  40. Pellegrini,L. and Scorrano,L.
    A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis
    Cell Death Differ14, 1275-1284. PubMed  Europe PubMed DOI
  41. Scorrano,L.
    Multiple functions of mitochondria-shaping proteins
    Novartis Found Symp287, 47-55. PubMed  Europe PubMed  K
    42. 2006
  42. [YEAR:14-7-2006]Cipolat,S., Rudka,T., Hartmann,D., Costa,V., Serneels,L., Craessaerts,K., Metzger,K., Frezza,C., Annaert,W., D'Adamio,L., Derks,C., Dejaegere,T., Pellegrini,L., D'Hooge,R., Scorrano,L. and De Strooper,B.
    Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
    Cell126, 163-175. PubMed  Europe PubMed DOI
  43. [YEAR:14-7-2006]Gottlieb,E.
    OPA1 and PARL keep a lid on apoptosis
    Cell126, 27-29. PubMed  Europe PubMed DOI
  44. Jeyaraju,D.V., Xu,L., Letellier,M.C., Bandaru,S., Zunino,R., Berg,E.A., McBride,H.M. and Pellegrini,L.
    Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology
    Proc Natl Acad Sci U S A103, 18562-18567. PubMed  Europe PubMed DOI
  45. [YEAR:23-5-2006]McQuibban,G.A., Lee,J.R., Zheng,L., Juusola,M. and Freeman,M.
    Normal mitochondrial dynamics requires Rhomboid-7 and affects Drosophila lifespan and neuronal function
    Curr Biol16, 982-989. PubMed  Europe PubMed DOI  K
    46. 2005
  46. [YEAR:24-2-2005]Walder,K., Kerr-Bayles,L., Civitarese,A., Jowett,J., Curran,J., Elliott,K., Trevaskis,J., Bishara,N., Zimmet,P., Mandarino,L., Ravussin,E., Blangero,J., Kissebah,A. and Collier,G.R.
    The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes
    Diabetologia48, 459-468. PubMed  Europe PubMed DOI
    47. 2004
  47. [YEAR:19-1-2004]Sik,A., Passer,B.J., Koonin,E.V. and Pellegrini,L.
    Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide
    J Biol Chem279, 15323-15329. PubMed  Europe PubMed DOI
    48. 2001
  48. Pellegrini,L., Passer,B.J., Canelles,M., Lefterov,I., Ganjei,J.K., Fowlkes,B.J., Koonin,E.V. and D'Adamio,L.
    PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2
    J Alzheimers Dis3, 181-190. PubMed  Europe PubMed

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