Substrates for peptidase S32.002: porcine reproductive and respiratory syndrome virus nsp4 peptidase

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
mRNA-decapping enzyme 1A	I3LHS8	1-580	peptide-Glu238+Ser-peptide	P	NT	Val	Gly	Leu	Glu	Ser	Glu	Glu	Val	Tao et al., 2018
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3859	peptide-Gly1462+Gly-peptide	N		Lys	Thr	Thr	Gly	Gly	Ala	Ser	Tyr	Ziebuhr et al., 2000
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3859	peptide-Glu1693+Gly-peptide	P		Ser	Leu	Leu	Glu	Gly	Ala	Phe	Arg	Tian et al., 2009
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3859	peptide-Glu2066+Gly-peptide	N		Tyr	Phe	Ala	Glu	Gly	Asn	Leu	Arg	Ziebuhr et al., 2000
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3859	peptide-Glu2082+Ser-peptide	N		Met	Asn	Asn	Glu	Ser	Leu	Thr	Ala	Ziebuhr et al., 2000
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3859	peptide-Glu2351+Ala-peptide	N		Asn	Cys	Leu	Glu	Ala	Ala	Lys	Leu	Ziebuhr et al., 2000
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3885	peptide-Glu3037+Gly-peptide	N		Ser	His	Asn	Glu	Gly	Lys	Lys	Phe	Ziebuhr et al., 2000
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3885	peptide-Glu3479+Gly-peptide	N		Ala	Ser	Leu	Glu	Gly	Ser	Cys	Met	Ziebuhr et al., 2000
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3885	peptide-Glu3703+Gly-peptide	P		Phe	Gln	Leu	Glu	Gly	Leu	Thr	Trp	Tian et al., 2009
porcine reproductive and respiratory syndrome virus nsp4 peptidase	Q04561	1-3859	peptide-Glu1896+Gly-peptide	P	NT	Pro	Val	Val	Glu	Gly	Gly	Leu	Ser	Tian et al., 2009