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Substrates for peptidase S26.016: SpsB signal peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
77 kDa membrane protein Q5HEI2 1-684 peptide-Ala30+Ala-peptide P Glu Ala Ser Ala Ala Ala Lys Pro Bruton et al., 2003
Ac-Ala-Gly-Leu-Ile-Ala-Arg-Ala-Val-Thr-Ser-Gly-Ala-NH2 Ac-Ala-Gly-Leu-Ile-Ala-Arg-Ala+Val-Thr-Ser-Gly-Ala-NH2 S Ile Ala Arg Ala Val Thr Ser Gly Sharkov & Cai, 2002
Ac-Ala-Gly-Pro-Arg-Pro-Thr-Arg-Ile-Ala-Phe-Gly-Ala-NH2 Ac-Ala+Gly-Pro-Arg-Pro-Thr-Arg-Ile-Ala-Phe-Gly-Ala-NH2 S - - Ac Ala Gly Pro Arg Pro Sharkov & Cai, 2002
Ac-Ala-Gly-Pro-Thr-Ala-Arg-Ala-Val-Thr-Ser-Gly-Ala-NH2 Ac-Ala-Gly-Pro-Thr-Ala-Arg-Ala+Val-Thr-Ser-Gly-Ala-NH2 S Thr Ala Arg Ala Val Thr Ser Gly Sharkov & Cai, 2002
Ac-Ala-Gly-Ser-Ala-Ser-Ala-Leu-Ala-Lys-Ile-Gly-Ala-NH2 Ac-Ala-Gly-Ser-Ala-Ser-Ala-Leu-Ala+Lys-Ile-Gly-Ala-NH2 S Ser Ala Leu Ala Lys Ile Gly Ala Sharkov & Cai, 2002
Ac-Ala-Gly-Val-Pro-Pro-Leu-Phe-Ala-Met-Leu-Gly-Ala-NH2 Ac-Ala-Gly-Val-Pro-Pro-Leu-Phe-Ala+Met-Leu-Gly-Ala-NH2 S Pro Leu Phe Ala Met Leu Gly Ala Sharkov & Cai, 2002
alpha-hemolysin P09616 1-319 peptide-Ala26+Ala-peptide P NT Val Ala Gly Ala Ala Asp Ser Asp Gray & Kehoe, 1984
beta-lactamase P00807 1-281 peptide-Ala24+Lys-peptide P NT Ser Ser His Ala Lys Glu Leu Asn Ambler 1975
chemotaxis inhibitory protein A6QIG7 1-149 peptide-Ala28+Phe-peptide P NT Ser Ala Lys Ala Phe Thr Phe Glu de et al., 2004
Decanoyl-Leu-Thr-Asn-Thr-Ala-Lys-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Asn-Thr-Ala-Lys-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Thr Ala Lys Ala Ala Ser Lys Ile Bruton et al., 2003
Decanoyl-Leu-Thr-Asn-Thr-Ala-Lys-Ala-Glu-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Asn-Thr-Ala-Lys-Ala+Glu-Ser-Lys-Ile-Asp-Asp-OH S Thr Ala Lys Ala Glu Ser Lys Ile Bruton et al., 2003
Decanoyl-Leu-Thr-Pro-Thr-Ala-Arg-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Pro-Thr-Gln-Ala-Arg-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Thr Ala Arg Ala Ala Ser Lys Ile Bruton et al., 2003
Decanoyl-Leu-Thr-Pro-Thr-Ala-Asn-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Pro-Thr-Gln-Ala-Asn-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Thr Ala Asn Ala Ala Ser Lys Ile Bruton et al., 2003
Decanoyl-Leu-Thr-Pro-Thr-Ala-Asp-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Pro-Thr-Gln-Ala-Asp-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Thr Ala Lys Ala Ala Ser Lys Ile Bruton et al., 2003
Decanoyl-Leu-Thr-Pro-Thr-Ala-Leu-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Pro-Thr-Gln-Ala-Leu-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Thr Ala Leu Ala Ala Ser Lys Ile Bruton et al., 2003
Decanoyl-Leu-Thr-Pro-Thr-Ala-Lys-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Pro-Thr-Ala-Lys-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Thr Ala Lys Ala Ala Ser Lys Ile Bruton et al., 2003
Decanoyl-Leu-Thr-Pro-Thr-Ala-Lys-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Pro-Thr-Ala-Lys-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Thr Ala Lys Ala Ala Ser Lys Ile Bruton et al., 2003
Decanoyl-Leu-Thr-Pro-Thr-Gln-Ala-Lys-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Decanoyl-Leu-Thr-Pro-Thr-Gln-Ala-Lys-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Gln Ala Lys Ala Ala Ser Lys Ile Bruton et al., 2003
enterotoxin type A P0A0L2 1-257 peptide-Gly24+Ser-peptide P NT Leu Val Asn Gly Ser Glu Lys Ser Huang et al., 1987
enterotoxin type B P01552 1-266 peptide-Ala27+Glu-peptide P NT Asn Val Leu Ala Glu Ser Gln Pro Huang & Bergdoll, 1970
enterotoxin type C-1 P01553 1-266 peptide-Ala27+Glu-peptide P NT Asn Val Leu Ala Glu Ser Gln Pro Schmidt & Spero, 1983
enterotoxin type C-2 P34071 1-266 peptide-Ala27+Glu-peptide P NT Asn Val Leu Ala Glu Ser Gln Pro Bohach & Schlievert, 1989
enterotoxin type D P20723 1-258 peptide-Ala25+Asn-peptide P NT Asn Val Lys Ala Asn Glu Asn Ile Bruton et al., 2003
enterotoxin type E P12993 1-257 peptide-Lys27+Ser-peptide P NT Gly Ser Glu Lys Ser Glu Glu Ile Couch et al., 1988
epidermal cell differentiation inhibitor P24121 1-247 peptide-Ala35+Ala-peptide P NT Thr Ser Leu Ala Ala Asp Val Lys Sugai et al., 1990
exfoliative toxin A P09331 1-280 peptide-Ala38+Glu-peptide P NT His Ala Lys Ala Glu Val Ser Ala Bruton et al., 2003
exfoliative toxin B P09332 1-277 peptide-Ala31+Lys-peptide P NT Thr Leu Gln Ala Lys Glu Tyr Ser Bruton et al., 2003
fibronectin-binding protein A P14738 1-1018 peptide-Ala36+Ala-peptide P NT Lys Glu Ala Ala Ala Ser Glu Gln Bruton et al., 2003
gamma-hemolysin component A P0A074 1-309 peptide-Ala29+Glu-peptide P NT Ile Ser Lys Ala Glu Asn Lys Ile Kamio et al., 1993
glycyl-glycine endopeptidase lytM O33599 1-316 peptide-Ala25+Ala-peptide P NT Gln Ala Asp Ala Ala Glu Thr Thr Ramadurai & Jayaswal, 1997
Hexanoyl-Leu-Thr-Pro-Thr-Gln-Ala-Lys-Ala-Ala-Ser-Lys-Ile-Asp-Asp-OH Hexanoyl-Leu-Thr-Pro-Thr-Gln-Ala-Lys-Ala+Ala-Ser-Lys-Ile-Asp-Asp-OH S Gln Ala Lys Ala Ala Ser Lys Ile Bruton et al., 2003
immunodominant staphylococcal antigen B Q9LAB5 1-175 peptide-Ala36+Ala-peptide P NT Gln Ala Gln Ala Ala Ile Thr Pro Lorenz et al., 2000
leukocidin-F subunit P31715 1-323 peptide-Asn25+Ala-peptide P NT Gly Thr Ala Asn Ala Glu Gly Lys Rahman et al., 1992
leukocidin-S subunit P31716 1-315 peptide-Ala29+Ala-peptide P NT Asn Ala Lys Ala Ala Asn Asp Thr Rahman et al., 1991
phospholipase C P09978 1-330 peptide-Ala34+Glu-peptide P NT Ser Ala Lys Ala Glu Ser Lys Lys Bruton et al., 2003
probable transglycosylase isaA Q2FV52 1-233 peptide-Ala29+Ala-peptide P NT Gln Ala His Ala Ala Glu Val Asn Ziebandt et al., 2001
probable transglycosylase isaA P60158 1-233 peptide-Ala29+Ala-peptide P NT Gln Ala His Ala Ala Glu Val Asn Lorenz et al., 2000
probable transglycosylase isaA Q5HCY1 1-233 peptide-Ala29+Ala-peptide P NT Gln Ala His Ala Ala Glu Val Asn Ziebandt et al., 2001
probable transglycosylase sceD Q5HEA4 1-231 peptide-Ala27+Ser-peptide P NT Glu Ala His Ala Ser Glu Ala Asp Ziebandt et al., 2001
protein A Q53759 1-454 peptide-Ala48+Ala-peptide P NT Ala Ala Asn Ala Ala Gln His Asp Bruton et al., 2003
protein map Q53599 1-689 peptide-Ala30+Ala-peptide P NT Glu Ala Ser Ala Ala Ala Lys Gln Joensson et al., 1995
serine protease splA Q2FXC2 1-235 peptide-Ala35+Glu-peptide P NT Ile Ala Lys Ala Glu Lys Asn Val Reed et al., 2001
serine protease splB Q2FXC3 1-240 peptide-Ala36+Glu-peptide P NT Thr Ala Lys Ala Glu Asn Asn Val Reed et al., 2001
serine protease splC Q2FXC4 1-239 peptide-Ala36+Glu-peptide P NT Ile Ala Asn Ala Glu Lys Asn Val Reed et al., 2001
serine protease splF Q2FXC8 1-239 peptide-Ala36+Glu-peptide P NT Thr Ala Lys Ala Glu Asn Thr Val Reed et al., 2001
staphopain B Q2FZL3 1-393 peptide-Ala36+Asp-peptide P NT Lys Ala Lys Ala Asp Ser His Ser Rice et al., 2001
staphylocoagulase P07767 1-658 peptide-Ala26+Ile-peptide P NT Lys Ala Asp Ala Ile Val Thr Lys Kawabata et al., 1986
staphylokinase P68802 1-163 peptide-Ala27+Ser-peptide P NT Glu Val Ser Ala Ser Ser Ser Phe Bruton et al., 2003
toxic shock syndrome toxin-1 P06886 1-234 peptide-Ala40+Ser-peptide P NT Thr Ala Lys Ala Ser Thr Asn Asp Bruton et al., 2003

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