Literature for peptidase S26.016: SpsB signal peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Park,Y., Sisley,T.A., Stone,M.C., Corrigan,R.M., Vickery,C.R., Grundling,A. and Walker,S. SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB in Staphylococcus aureus Proc Natl Acad Sci U S A (2025) 122, e2426464122-e2426464122. PubMed Europe PubMed DOI PMC EPMC
Zhang,R., Jia,Y., Scaffidi,S.J., Madsen,J.J. and Yu,W. Signal peptidase SpsB coordinates staphylococcal cell cycle, surface protein septal trafficking, and LTA synthesis MBio (2025) , e0267324-e0267324. PubMed Europe PubMed DOI

2024

Schum,D., Elsen,F.A.V., Ruddell,S., Schorpp,K., Junca,H., Musken,M., Chen,S.Y., Fiedler,M.K., Pickl,T., Pieper,D.H., Hadian,K., Zacharias,M. and Sieber,S.A. Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action JACS Au (2024) 4, 3125-3134. PubMed Europe PubMed DOI PMC EPMC I

2017

Hazenbos,W.L., Skippington,E. and Tan,M.W. Staphylococcus aureus type I signal peptidase: essential or not essential, that's the question Microb Cell (2017) 4, 108-111. PubMed Europe PubMed DOI PMC EPMC

2016

Morisaki,J.H., Smith,P.A., Date,S.V., Kajihara,K.K., Truong,C.L., Modrusan,Z., Yan,D., Kang,J., Xu,M., Shah,I.M., Mintzer,R., Kofoed,E.M., Cheung,T.K., Arnott,D., Koehler,M.F., Heise,C.E., Brown,E.J., Tan,M.W. and Hazenbos,W.L. A putative bacterial ABC transporter circumvents the essentiality of signal peptidase MBio (2016) 7 PubMed Europe PubMed DOI I
Ting,Y.T., Harris,P.W.R., Batot,G., Brimble,M.A., Baker,E.N. and Young,P.G. Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization IUCrJ (2016) 3, 10-19. PubMed Europe PubMed DOI S

2015

Ting,Y.T., Batot,G., Baker,E.N. and Young,P.G. Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase from Staphylococcus aureus Acta Crystallogr F Struct Biol Commun (2015) 71, 61-65. PubMed Europe PubMed DOI E

2012

Harris,D.A. and Romesberg,F.E. SpsB signal peptidase [ISSN:978-0-12-407742-3] (2012) 3, 3501-3508. DOI
Schallenberger,M.A., Niessen,S., Shao,C., Fowler,B.J. and Romesberg,F.E. Type I signal peptidase and protein secretion in Staphylococcus aureus J Bacteriol (2012) 194, 2677-2686. PubMed Europe PubMed DOI I
Therien,A.G., Huber,J.L., Wilson,K.E., Beaulieu,P., Caron,A., Claveau,D., Deschamps,K., Donald,R.G., Galgoci,A.M., Gallant,M., Gu,X., Kevin,N.J., Lafleur,J., Leavitt,P.S., Lebeau-Jacob,C., Lee,S.S., Lin,M.M., Michels,A.A., Ogawa,A.M., Painter,R.E., Parish,C.A., Park,Y.W., Benton-Perdomo,L., Petcu,M., Phillips,J.W., Powles,M.A., Skorey,K.I., Tam,J., Tan,C.M., Young,K., Wong,S., Waddell,S.T. and Miesel,L. Broadening the spectrum of beta-lactam antibiotics through inhibition of signal peptidase type I Antimicrob Agents Chemother (2012) 56, 4662-4670. PubMed Europe PubMed DOI I

2011

Powers,M.E., Smith,P.A., Roberts,T.C., Fowler,B.J., King,C.C., Trauger,S.A., Siuzdak,G. and Romesberg,F.E. Type I signal peptidase and protein secretion in Staphylococcus epidermidis J Bacteriol (2011) 193, 340-348. PubMed Europe PubMed DOI I
Wormann,M.E., Reichmann,N.T., Malone,C.L., Horswill,A.R. and Grundling,A. Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase J Bacteriol (2011) 193, 5279-5291. PubMed Europe PubMed DOI

2009

Bockstael,K., Geukens,N., Rao,C.V., Herdewijn,P., Anne,J. and Van Aerschot,A. An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors J Microbiol Methods (2009) 78, 231-237. PubMed Europe PubMed DOI A
Bockstael,K., Geukens,N., Van Mellaert,L., Herdewijn,P., Anne,J. and Van Aerschot,A. Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis Microbiology (Reading) (2009) 155, 3719-3729. PubMed Europe PubMed DOI I
Buzder-Lantos,P., Bockstael,K., Anne,J. and Herdewijn,P. Substrate based peptide aldehyde inhibits bacterial type I signal peptidase Bioorg Med Chem Lett (2009) 19, 2880-2883. PubMed Europe PubMed DOI I
Rao,S., Bockstael,K., Nath,S., Engelborghs,Y., Anne,J. and Geukens,N. Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB - implications for the search for novel antibiotics FEBS J (2009) 276, 3222-3234. PubMed Europe PubMed DOI P

2007

Kavanaugh,J.S., Thoendel,M. and Horswill,A.R. A role for type I signal peptidase in Staphylococcus aureus quorum sensing Mol Microbiol (2007) 65, 780-798. PubMed Europe PubMed DOI

2003

Bruton,G., Huxley,A., O'Hanlon,P., Orlek,B., Eggleston,D., Humphries,J., Readshaw,S., West,A., Ashman,S., Brown,M., Moore,K., Pope,A., O'Dwyer,K. and Wang,L. Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors Eur J Med Chem (2003) 38, 351-356. PubMed Europe PubMed DOI I

2002

[YEAR:22-2-2002]Sharkov,N.A. and Cai,D. Discovery of substrate for type I signal peptidase SpsB from Staphylococcus aureus J Biol Chem (22-2-2002) 277, 5796-5803. PubMed Europe PubMed DOI

1996

Cregg,K.M., Wilding,I. and Black,M.T. Molecular cloning and expression of the spsB gene encoding an essential type I signal peptidase from Staphylococcus aureus J Bacteriol (1996) 178, 5712-5718. PubMed Europe PubMed PMC EPMC