Literature for peptidase S26.016: SpsB signal peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zhang,R., Jia,Y., Scaffidi,S.J., Madsen,J.J. and Yu,W.
    Signal peptidase SpsB coordinates staphylococcal cell cycle, surface protein septal trafficking, and LTA synthesis
    MBioe0267324-e0267324. PubMed  Europe PubMed DOI
  2. 2024
  3. Schum,D., Elsen,F.A.V., Ruddell,S., Schorpp,K., Junca,H., Musken,M., Chen,S.Y., Fiedler,M.K., Pickl,T., Pieper,D.H., Hadian,K., Zacharias,M. and Sieber,S.A.
    Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action
    JACS Au4, 3125-3134. PubMed  Europe PubMed DOI  I
  4. 2017
  5. Hazenbos,W.L., Skippington,E. and Tan,M.W.
    Staphylococcus aureus type I signal peptidase: essential or not essential, that's the question
    Microb Cell4, 108-111. PubMed  Europe PubMed DOI
  6. 2016
  7. Morisaki,J.H., Smith,P.A., Date,S.V., Kajihara,K.K., Truong,C.L., Modrusan,Z., Yan,D., Kang,J., Xu,M., Shah,I.M., Mintzer,R., Kofoed,E.M., Cheung,T.K., Arnott,D., Koehler,M.F., Heise,C.E., Brown,E.J., Tan,M.W. and Hazenbos,W.L.
    A putative bacterial ABC transporter circumvents the essentiality of signal peptidase
    MBio7, PubMed  Europe PubMed DOI  I
  8. Ting,Y.T., Harris,P.W.R., Batot,G., Brimble,M.A., Baker,E.N. and Young,P.G.
    Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization
    IUCrJ3, 10-19. PubMed  Europe PubMed DOI  S
  9. 2015
  10. Ting,Y.T., Batot,G., Baker,E.N. and Young,P.G.
    Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase from Staphylococcus aureus
    Acta Crystallogr F Struct Biol Commun71, 61-65. PubMed  Europe PubMed DOI  E
  11. 2012
  12. Harris,D.A. and Romesberg,F.E.
    SpsB signal peptidase
    [ISSN:978-0-12-407742-3]3, 3501-3508. DOI
  13. Schallenberger,M.A., Niessen,S., Shao,C., Fowler,B.J. and Romesberg,F.E.
    Type I signal peptidase and protein secretion in Staphylococcus aureus
    J Bacteriol194, 2677-2686. PubMed  Europe PubMed DOI  I
  14. Therien,A.G., Huber,J.L., Wilson,K.E., Beaulieu,P., Caron,A., Claveau,D., Deschamps,K., Donald,R.G., Galgoci,A.M., Gallant,M., Gu,X., Kevin,N.J., Lafleur,J., Leavitt,P.S., Lebeau-Jacob,C., Lee,S.S., Lin,M.M., Michels,A.A., Ogawa,A.M., Painter,R.E., Parish,C.A., Park,Y.W., Benton-Perdomo,L., Petcu,M., Phillips,J.W., Powles,M.A., Skorey,K.I., Tam,J., Tan,C.M., Young,K., Wong,S., Waddell,S.T. and Miesel,L.
    Broadening the spectrum of beta-lactam antibiotics through inhibition of signal peptidase type I
    Antimicrob Agents Chemother56, 4662-4670. PubMed  Europe PubMed DOI  I
  15. 2011
  16. Powers,M.E., Smith,P.A., Roberts,T.C., Fowler,B.J., King,C.C., Trauger,S.A., Siuzdak,G. and Romesberg,F.E.
    Type I signal peptidase and protein secretion in Staphylococcus epidermidis
    J Bacteriol193, 340-348. PubMed  Europe PubMed DOI  I
  17. Wormann,M.E., Reichmann,N.T., Malone,C.L., Horswill,A.R. and Grundling,A.
    Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase
    J Bacteriol193, 5279-5291. PubMed  Europe PubMed DOI
  18. 2009
  19. Bockstael,K., Geukens,N., Van Mellaert,L., Herdewijn,P., Anne,J. and Van Aerschot,A.
    Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis
    Microbiology (Reading)155, 3719-3729. PubMed  Europe PubMed DOI  I
  20. Bockstael,K., Geukens,N., Rao,C.V., Herdewijn,P., Anne,J. and Van Aerschot,A.
    An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors
    J Microbiol Methods78, 231-237. PubMed  Europe PubMed DOI  A
  21. Buzder-Lantos,P., Bockstael,K., Anne,J. and Herdewijn,P.
    Substrate based peptide aldehyde inhibits bacterial type I signal peptidase
    Bioorg Med Chem Lett19, 2880-2883. PubMed  Europe PubMed DOI  I
  22. Rao,S., Bockstael,K., Nath,S., Engelborghs,Y., Anne,J. and Geukens,N.
    Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB - implications for the search for novel antibiotics
    FEBS J276, 3222-3234. PubMed  Europe PubMed DOI  P
  23. 2007
  24. Kavanaugh,J.S., Thoendel,M. and Horswill,A.R.
    A role for type I signal peptidase in Staphylococcus aureus quorum sensing
    Mol Microbiol65, 780-798. PubMed  Europe PubMed DOI
  25. 2003
  26. Bruton,G., Huxley,A., O'Hanlon,P., Orlek,B., Eggleston,D., Humphries,J., Readshaw,S., West,A., Ashman,S., Brown,M., Moore,K., Pope,A., O'Dwyer,K. and Wang,L.
    Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors
    Eur J Med Chem38, 351-356. PubMed  Europe PubMed DOI  I
  27. 2002
  28. [YEAR:22-2-2002]Sharkov,N.A. and Cai,D.
    Discovery of substrate for type I signal peptidase SpsB from Staphylococcus aureus
    J Biol Chem277, 5796-5803. PubMed  Europe PubMed DOI
  29. 1996
  30. Cregg,K.M., Wilding,I. and Black,M.T.
    Molecular cloning and expression of the spsB gene encoding an essential type I signal peptidase from Staphylococcus aureus
    J Bacteriol178, 5712-5718. PubMed  Europe PubMed