Substrates for peptidase S16.001: Lon-A peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
glutaryl-Ala-Ala-Phe-NHNapOMe			glutaryl-Ala-Ala-Phe+NHNapOMe	S	Glt	Ala	Ala	Phe	NAP	-	-	-	Chung & Goldberg, 2004
protein ccdA	P62552	1-72	peptide-Leu16+Leu-peptide	P	Ser	Tyr	Gln	Leu	Leu	Lys	Ala	Tyr	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Leu17+Lys-peptide	P	Tyr	Gln	Leu	Leu	Lys	Ala	Tyr	Asp	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Ala19+Tyr-peptide	P	Leu	Leu	Lys	Ala	Tyr	Asp	Val	Asn	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Val28+Ser-peptide	P	Ser	Gly	Leu	Val	Ser	Thr	Thr	Met	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Ser29+Thr-peptide	P	Gly	Leu	Val	Ser	Thr	Thr	Met	Gln	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Thr30+Thr-peptide	P	Leu	Val	Ser	Thr	Thr	Met	Gln	Asn	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Thr31+Met-peptide	P	Val	Ser	Thr	Thr	Met	Gln	Asn	Glu	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Ala41+Glu-peptide	P	Arg	Leu	Arg	Ala	Glu	Arg	Trp	Lys	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Ala46+Glu-peptide	P	Arg	Trp	Lys	Ala	Glu	Asn	Gln	Glu	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Phe58+Ile-peptide	P	Val	Ala	Arg	Phe	Ile	Glu	Met	Asn	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Met61+Asn-peptide	P	Phe	Ile	Glu	Met	Asn	Gly	Ser	Phe	Van Melderen et al., 1996
protein ccdA	P62552	1-72	peptide-Ala66+Asp-peptide	P	Gly	Ser	Phe	Ala	Asp	Glu	Asn	Arg	Van Melderen et al., 1996
Suc-Phe-Leu-Phe-NHNapOMe			Suc-Phe-Leu-Phe+NHNapOMe	S	Suc	Phe	Leu	Phe	NAP	-	-	-	Chung & Goldberg, 2004
sulA protein	P08846		peptide-Leu67+Thr-peptide	P	Gln	Leu	Trp	Leu	Thr	Pro	Gln	Gln	Nishii et al., 2002	17705
sulA protein	P08846		peptide-Leu57+Gly-peptide	P	Leu	Gln	Gln	Leu	Gly	Gln	Gln	Ser	Nishii et al., 2002	17704
sulA protein	P08846		peptide-Ala80+Ser-peptide	P	Trp	Val	Gln	Ala	Ser	Gly	Leu	Pro	Nishii et al., 2002	17702
sulA protein	P08846		peptide-Leu158+Ser-peptide	P	Thr	Arg	Gln	Leu	Ser	Gly	Leu	Lys	Nishii et al., 2002	17703
sulA protein	P08846		peptide-Leu73+Ser-peptide	P	Gln	Gln	Lys	Leu	Ser	Arg	Glu	Trp	Nishii et al., 2002	17706
sulA protein	P08846		peptide-Leu94+Ser-peptide	P	Ile	Ser	Gln	Leu	Ser	Pro	Cys	His	Nishii et al., 2002	17707
Tyr(NO2)-Arg-Gly-Ile-Thr-Cys-Ser-Gly-Arg-Gln-Lys(Abz)			Tyr(NO2)-Arg-Gly-Ile-Thr-Cys+Ser-Gly-Arg-Gln-Lys(Abz)	N	Gly	Ile	Thr	Cys	Ser	Gly	Arg	Gln	Thomas-Wohlever & Lee, 2002