Substrates for peptidase S08.052: cerevisin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Tyr-OEt [ATEE]			Ac-Tyr+OEt	S		-	-	Ac	Tyr	OEt	-	-	-	Jones & Naik, 2004
aminopeptidase I precursor	P14904	1-514	peptide-Leu45+Glu-peptide	P		Trp	Cys	Ile	Leu	Glu	His	Asn	Tyr		17514
Boc-Arg-Thr-Lys-Arg-NHMec			Boc-Arg-Thr-Lys-Arg+NHMec	S		Arg	Thr	Lys	Arg	AMC	-	-	-	Ladds & Davey, 2000
Boc-Gln-Arg-Arg-NHMec			Boc-Gln-Arg-Arg+NHMec	S		Boc	Gln	Arg	Arg	AMC	-	-	-	Ladds & Davey, 2000
Boc-Gly-Lys-Lys-NHMec			Boc-Gly-Lys-Lys+NHMec	S		Boc	Gly	Lys	Lys	AMC	-	-	-	Ladds & Davey, 2000
Bz-Arg-NHPhNO2 (BAPNA)			Bz-Arg+NHPhNO2	S		-	-	Bz	Arg	NAN	-	-	-	Kominani et al., 1981
Bz-Arg-OEt [BAEE]			Bz-Arg+OEt	S		-	-	Bz	Arg	OEt	-	-	-	Jones & Naik, 2004
Bz-Ile-Glu-Gly-Arg-NHPhNO2			Bz-Ile-Glu-Gly-Arg+NHPhNO2	S		Ile	Glu	Gly	Arg	NAN	-	-	-	Kominani et al., 1981
Bz-Tyr-NHPhNO2			Bz-Tyr-NHPhNO2	S		-	-	Bz	Tyr	NAN	-	-	-	Kominani et al., 1981
histone H3	P61830	1-136	peptide-Lys24+Ala-peptide	P	NT	Leu	Ala	Ser	Lys	Ala	Ala	Arg	Lys	Xue et al., 2014
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Val	Glu	Ala	Leu	Tyr	Leu	Val	Cya	Farley et al., 1987	24321
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Pro		24322
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln+His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Phe	Val	Asn	Gln	His	Leu	Cya	Gly		24323
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu+Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Gly	Ser	His	Leu	Val	Glu	Ala	Leu	Kominami et al., 1982	24324
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Kominami et al., 1982	24325
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu+Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Ala	Leu	Tyr	Leu	Val	Cya	Gly	Glu	Kominami et al., 1982	24326
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg+Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Cya	Gly	Glu	Arg	Gly	Phe	Phe	Tyr	Kominami et al., 1982	24327
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala	N		Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Lys	Kominami et al., 1982	24328
Leu-Trp-Met-Arg-Phe-Ala			Leu-Trp-Met-Arg+Phe-Ala	N		Leu	Trp	Met	Arg	Phe	Ala	-	-	Kominani et al., 1981
Leu-Trp-Met-Arg-Phe-Ala			Leu-Trp-Met-Arg+Phe-Ala	N		Leu	Trp	Met	Arg	Phe	Ala	-	-	Kominami et al., 1982
Z-Tyr-ONA			Z-Tyr+ONA	S		-	-	Z	Tyr	ONA	-	-	-	Jones & Naik, 2004